SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal ...
312-1318
0e+00
SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal surface proteins with a complex (and somewhat variable) architecture that includes a crosswall-targeting N-terminal YSIRK domain, a C-terminal cell wall-anchoring LPXTG domain, and a central endo-alpha-N-acetylgalactosaminidase that removes an O-linked disaccharide from host glycoproteins.
The actual alignment was detected with superfamily member NF040533:
Pssm-ID: 439743 [Multi-domain] Cd Length: 1694 Bit Score: 642.01 E-value: 0e+00
Bacterial Ig-like domain (group 4); This family consists of bacterial domains with an Ig-like ...
241-299
2.52e-13
Bacterial Ig-like domain (group 4); This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.
:
Pssm-ID: 400079 [Multi-domain] Cd Length: 59 Bit Score: 65.80 E-value: 2.52e-13
SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal ...
312-1318
0e+00
SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal surface proteins with a complex (and somewhat variable) architecture that includes a crosswall-targeting N-terminal YSIRK domain, a C-terminal cell wall-anchoring LPXTG domain, and a central endo-alpha-N-acetylgalactosaminidase that removes an O-linked disaccharide from host glycoproteins.
Pssm-ID: 439743 [Multi-domain] Cd Length: 1694 Bit Score: 642.01 E-value: 0e+00
Endo-alpha-N-acetylgalactosaminidase; Virulence of pathogenic organizms such as the ...
565-839
1.06e-161
Endo-alpha-N-acetylgalactosaminidase; Virulence of pathogenic organizms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Swiss:B2DRU5, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor.
Pssm-ID: 432868 Cd Length: 273 Bit Score: 484.54 E-value: 1.06e-161
Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases; This family contains the ...
578-862
3.14e-114
Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases; This family contains the enzymatically active domain of cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins (EC:3.2.1.97). It has been classified as glycosyl hydrolase family 101 in the Cazy resource. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae and other commensal human bacteria is largely determined by their ability to degrade host glycoproteins and to metabolize the resultant carbohydrates.
Pssm-ID: 271203 Cd Length: 298 Bit Score: 359.66 E-value: 3.14e-114
Bacterial Ig-like domain (group 4); This family consists of bacterial domains with an Ig-like ...
241-299
2.52e-13
Bacterial Ig-like domain (group 4); This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.
Pssm-ID: 400079 [Multi-domain] Cd Length: 59 Bit Score: 65.80 E-value: 2.52e-13
SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal ...
312-1318
0e+00
SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal surface proteins with a complex (and somewhat variable) architecture that includes a crosswall-targeting N-terminal YSIRK domain, a C-terminal cell wall-anchoring LPXTG domain, and a central endo-alpha-N-acetylgalactosaminidase that removes an O-linked disaccharide from host glycoproteins.
Pssm-ID: 439743 [Multi-domain] Cd Length: 1694 Bit Score: 642.01 E-value: 0e+00
Endo-alpha-N-acetylgalactosaminidase; Virulence of pathogenic organizms such as the ...
565-839
1.06e-161
Endo-alpha-N-acetylgalactosaminidase; Virulence of pathogenic organizms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Swiss:B2DRU5, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor.
Pssm-ID: 432868 Cd Length: 273 Bit Score: 484.54 E-value: 1.06e-161
Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases; This family contains the ...
578-862
3.14e-114
Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases; This family contains the enzymatically active domain of cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins (EC:3.2.1.97). It has been classified as glycosyl hydrolase family 101 in the Cazy resource. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae and other commensal human bacteria is largely determined by their ability to degrade host glycoproteins and to metabolize the resultant carbohydrates.
Pssm-ID: 271203 Cd Length: 298 Bit Score: 359.66 E-value: 3.14e-114
Galactose mutarotase-like fold domain; This domain is found in ...
321-564
2.53e-59
Galactose mutarotase-like fold domain; This domain is found in endo-alpha-N-acetylgalactosaminidase present in Streptococcus pneumoniae. Endo-alpha-N-acetylgalactosaminidase is a cell surface-anchored glycoside hydrolase involved in the breakdown of mucin type O-linked glycans. The domain, known as domain 2, exhibits strong structural similarlity to the galactose mutarotase-like fold but lacks the active site residues. Domains, found in a number of glycoside hydrolases, structurally similar to domain 2 confer stability to the multidomain architectures.
Pssm-ID: 465638 Cd Length: 241 Bit Score: 204.10 E-value: 2.53e-59
Galactose-binding domain-like; Proteins containing a galactose-binding domain-like fold can be ...
1136-1310
2.20e-49
Galactose-binding domain-like; Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase, phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va, membrane-anchored ephrin for the Eph family of receptor tyrosine kinases, and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1. The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold.
Pssm-ID: 407821 Cd Length: 190 Bit Score: 173.70 E-value: 2.20e-49
Glycosyl hydrolase 101 beta sandwich domain; Virulence of pathogenic organizms such as the ...
845-956
7.57e-40
Glycosyl hydrolase 101 beta sandwich domain; Virulence of pathogenic organizms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Swiss:B2DRU5, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor. This domain represents C-terminal the beta sandwich domain.
Pssm-ID: 435916 Cd Length: 117 Bit Score: 143.40 E-value: 7.57e-40
Bacterial Ig-like domain (group 4); This family consists of bacterial domains with an Ig-like ...
241-299
2.52e-13
Bacterial Ig-like domain (group 4); This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.
Pssm-ID: 400079 [Multi-domain] Cd Length: 59 Bit Score: 65.80 E-value: 2.52e-13
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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