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Conserved domains on  [gi|488273802|ref|WP_002345010|]
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MULTISPECIES: antirestriction protein ArdA [Bacteria]

Protein Classification

antirestriction protein ArdA( domain architecture ID 10538058)

antirestriction protein ArdA allows associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems, assisting in the spread of resistance genes in bacteria

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 6-162 7.83e-46

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


:

Pssm-ID: 462130  Cd Length: 151  Bit Score: 147.00  E-value: 7.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802    6 VYIANLGKYNEGELVGAWFTFPIDFEEVKE---KIGLNDE-YEEYAIHDYE-LPFTVDEYTSISELNRLWEMVSELPEEL 80
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPADAEELQEalrRIGAEGEeYEEYAIHDYEgFGFTLGEYESIDELNELAALLEELAEHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802   81 QSELSALLT--HFSSIEELSEHQediiihsdcddmsDVARYYIEETGALGEVPASLQNYIDYESYGRDLDLSGTFISTNH 158
Cdd:pfam07275  81 LEEFEAAFEerYAGEYDSLIQNL-------------DYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDGDGVFTET 147


                  ....
gi 488273802  159 GIFE 162
Cdd:pfam07275 148 GYVE 151
 
Name Accession Description Interval E-value
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 6-162 7.83e-46

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 147.00  E-value: 7.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802    6 VYIANLGKYNEGELVGAWFTFPIDFEEVKE---KIGLNDE-YEEYAIHDYE-LPFTVDEYTSISELNRLWEMVSELPEEL 80
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPADAEELQEalrRIGAEGEeYEEYAIHDYEgFGFTLGEYESIDELNELAALLEELAEHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802   81 QSELSALLT--HFSSIEELSEHQediiihsdcddmsDVARYYIEETGALGEVPASLQNYIDYESYGRDLDLSGTFISTNH 158
Cdd:pfam07275  81 LEEFEAAFEerYAGEYDSLIQNL-------------DYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDGDGVFTET 147


                  ....
gi 488273802  159 GIFE 162
Cdd:pfam07275 148 GYVE 151
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
2-153 1.33e-23

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 90.76  E-value: 1.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802   2 DDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKI------GLNDEYEEYAIHDYE-LP-FTVDEYTSISELNRLWEMV 73
Cdd:COG4734    6 TTPRIYVACLAAYNNGSLHGKWIDATQDVEEIQEAIremladSPVEDAEEWAIHDYEgFPgATISEYESLEKVFELAEFI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802  74 SELPEELqselSALLTHFSSIEELSEHQEDIIIHSdCDDMSDVARYYIEETGALGEVPASLQNYIDYESYGRDLDLSGTF 153
Cdd:COG4734   86 EEHGEAF----AAWLDHFGGLEDAEEAFEDAYQGE-YDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFLSDYV 160
 
Name Accession Description Interval E-value
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 6-162 7.83e-46

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 147.00  E-value: 7.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802    6 VYIANLGKYNEGELVGAWFTFPIDFEEVKE---KIGLNDE-YEEYAIHDYE-LPFTVDEYTSISELNRLWEMVSELPEEL 80
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPADAEELQEalrRIGAEGEeYEEYAIHDYEgFGFTLGEYESIDELNELAALLEELAEHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802   81 QSELSALLT--HFSSIEELSEHQediiihsdcddmsDVARYYIEETGALGEVPASLQNYIDYESYGRDLDLSGTFISTNH 158
Cdd:pfam07275  81 LEEFEAAFEerYAGEYDSLIQNL-------------DYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDGDGVFTET 147


                  ....
gi 488273802  159 GIFE 162
Cdd:pfam07275 148 GYVE 151
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
2-153 1.33e-23

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 90.76  E-value: 1.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802   2 DDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKI------GLNDEYEEYAIHDYE-LP-FTVDEYTSISELNRLWEMV 73
Cdd:COG4734    6 TTPRIYVACLAAYNNGSLHGKWIDATQDVEEIQEAIremladSPVEDAEEWAIHDYEgFPgATISEYESLEKVFELAEFI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488273802  74 SELPEELqselSALLTHFSSIEELSEHQEDIIIHSdCDDMSDVARYYIEETGALGEVPASLQNYIDYESYGRDLDLSGTF 153
Cdd:COG4734   86 EEHGEAF----AAWLDHFGGLEDAEEAFEDAYQGE-YDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFLSDYV 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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