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Conserved domains on  [gi|488219347|ref|WP_002290555|]
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MULTISPECIES: galactose-6-phosphate isomerase subunit LacA [Bacilli]

Protein Classification

galactose-6-phosphate isomerase subunit LacA( domain architecture ID 10013099)

galactose-6-phosphate isomerase subunit LacA catalyzes the formation of D-tagatose 6-phosphate from D-galactose 6-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08621 PRK08621
galactose-6-phosphate isomerase subunit LacA; Reviewed
 1-141 3.66e-90

galactose-6-phosphate isomerase subunit LacA; Reviewed


:

Pssm-ID: 181505  Cd Length: 142  Bit Score: 257.72  E-value: 3.66e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDVTKDG-QDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:PRK08621   1 MAIIIGADKAGFELKEVVKDYLEDNKYEVVDVTEEGaEDFVDSTLAVAKEVNKSEDNLGIVIDAYGAGSFMVATKIKGMV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488219347  80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMC 141
Cdd:PRK08621  81 AAEVSDERSAYMTRGHNNARMITMGSEIVGDGLAKNIIKGFVEGKYDGGRHQIRVDMLNKMC 142
 
Name Accession Description Interval E-value
PRK08621 PRK08621
galactose-6-phosphate isomerase subunit LacA; Reviewed
 1-141 3.66e-90

galactose-6-phosphate isomerase subunit LacA; Reviewed


Pssm-ID: 181505  Cd Length: 142  Bit Score: 257.72  E-value: 3.66e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDVTKDG-QDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:PRK08621   1 MAIIIGADKAGFELKEVVKDYLEDNKYEVVDVTEEGaEDFVDSTLAVAKEVNKSEDNLGIVIDAYGAGSFMVATKIKGMV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488219347  80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMC 141
Cdd:PRK08621  81 AAEVSDERSAYMTRGHNNARMITMGSEIVGDGLAKNIIKGFVEGKYDGGRHQIRVDMLNKMC 142
lacA TIGR01118
galactose-6-phosphate isomerase, LacA subunit; This family contains members from low GC ...
 1-140 1.02e-84

galactose-6-phosphate isomerase, LacA subunit; This family contains members from low GC gram-positive bacteria. Galactose-6-phosphate isomerase is involved in lactose catabolism by the tagatose-6-phosphate pathway. [Energy metabolism, Biosynthesis and degradation of polysaccharides]


Pssm-ID: 130188  Cd Length: 141  Bit Score: 244.08  E-value: 1.02e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347    1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDVTK-DGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:TIGR01118   1 MAIIIGSDLAGKRLKDVIKNFLVDNGFEVIDVTEgDGQDFVDVTLAVASEVQKDEQNLGIVIDAYGAGSFMVATKIKGMI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488219347   80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKM 140
Cdd:TIGR01118  81 AAEVSDERSAYMTRGHNNARMITVGAEIVGDELAKNIVKAFVEGKYDGGRHQIRVDMLNKM 141
RpiB COG0698
Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
 1-140 1.27e-50

Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase RpiB is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440462  Cd Length: 149  Bit Score: 157.94  E-value: 1.27e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDV---TKDGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKG 77
Cdd:COG0698    1 MKIAIGSDHAGFELKEAIKEYLEEKGHEVVDFgtySEDSVDYPDFAIKVAEAVASGEADRGILICGTGIGMSIAANKVPG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488219347  78 MVAAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKM 140
Cdd:COG0698   81 IRAALCHDPYSARLAREHNDANVLCLGARVIGPELAKEIVDAFLATEFEGGRHQRRVDKISEL 143
LacAB_rpiB pfam02502
Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ...
 3-133 1.55e-47

Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).


Pssm-ID: 460573  Cd Length: 134  Bit Score: 149.84  E-value: 1.55e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347    3 IVVGADLKGTRLKDVVKNFLVEEGFEVIDV---TKDGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:pfam02502   1 IAIGSDHAGFELKEEIKEYLEEKGHEVIDFgtySEESVDYPDYAHKVAEAVASGEADRGILICGTGIGMSIAANKVPGIR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488219347   80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIR 133
Cdd:pfam02502  81 AALCHDPYSAKLAREHNDANVLCLGARVIGPELAKEIVDAFLNTEFEGGRHQRR 134
 
Name Accession Description Interval E-value
PRK08621 PRK08621
galactose-6-phosphate isomerase subunit LacA; Reviewed
 1-141 3.66e-90

galactose-6-phosphate isomerase subunit LacA; Reviewed


Pssm-ID: 181505  Cd Length: 142  Bit Score: 257.72  E-value: 3.66e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDVTKDG-QDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:PRK08621   1 MAIIIGADKAGFELKEVVKDYLEDNKYEVVDVTEEGaEDFVDSTLAVAKEVNKSEDNLGIVIDAYGAGSFMVATKIKGMV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488219347  80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMC 141
Cdd:PRK08621  81 AAEVSDERSAYMTRGHNNARMITMGSEIVGDGLAKNIIKGFVEGKYDGGRHQIRVDMLNKMC 142
lacA TIGR01118
galactose-6-phosphate isomerase, LacA subunit; This family contains members from low GC ...
 1-140 1.02e-84

galactose-6-phosphate isomerase, LacA subunit; This family contains members from low GC gram-positive bacteria. Galactose-6-phosphate isomerase is involved in lactose catabolism by the tagatose-6-phosphate pathway. [Energy metabolism, Biosynthesis and degradation of polysaccharides]


Pssm-ID: 130188  Cd Length: 141  Bit Score: 244.08  E-value: 1.02e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347    1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDVTK-DGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:TIGR01118   1 MAIIIGSDLAGKRLKDVIKNFLVDNGFEVIDVTEgDGQDFVDVTLAVASEVQKDEQNLGIVIDAYGAGSFMVATKIKGMI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488219347   80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKM 140
Cdd:TIGR01118  81 AAEVSDERSAYMTRGHNNARMITVGAEIVGDELAKNIVKAFVEGKYDGGRHQIRVDMLNKM 141
PRK12613 PRK12613
galactose-6-phosphate isomerase subunit LacA; Provisional
 1-140 4.11e-75

galactose-6-phosphate isomerase subunit LacA; Provisional


Pssm-ID: 171609  Cd Length: 141  Bit Score: 219.80  E-value: 4.11e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDVTKDGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMVA 80
Cdd:PRK12613   1 MAIILGADAHGNALKELIKSFLQEEGYDIIDVTDINSDFIDNTLAVAKAVNEAEGRLGIMVDAYGAGPFMVATKLKGMVA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347  81 AEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKM 140
Cdd:PRK12613  81 AEVSDERSAYMTRGHNNARMITMGAEIVGPELAKNIAKGFVTGPYDGGRHQIRVDMLNKM 140
RpiB COG0698
Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
 1-140 1.27e-50

Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase RpiB is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440462  Cd Length: 149  Bit Score: 157.94  E-value: 1.27e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDV---TKDGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKG 77
Cdd:COG0698    1 MKIAIGSDHAGFELKEAIKEYLEEKGHEVVDFgtySEDSVDYPDFAIKVAEAVASGEADRGILICGTGIGMSIAANKVPG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488219347  78 MVAAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKM 140
Cdd:COG0698   81 IRAALCHDPYSARLAREHNDANVLCLGARVIGPELAKEIVDAFLATEFEGGRHQRRVDKISEL 143
LacAB_rpiB pfam02502
Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ...
 3-133 1.55e-47

Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).


Pssm-ID: 460573  Cd Length: 134  Bit Score: 149.84  E-value: 1.55e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347    3 IVVGADLKGTRLKDVVKNFLVEEGFEVIDV---TKDGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:pfam02502   1 IAIGSDHAGFELKEEIKEYLEEKGHEVIDFgtySEESVDYPDYAHKVAEAVASGEADRGILICGTGIGMSIAANKVPGIR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488219347   80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIR 133
Cdd:pfam02502  81 AALCHDPYSAKLAREHNDANVLCLGARVIGPELAKEIVDAFLNTEFEGGRHQRR 134
PRK05571 PRK05571
ribose-5-phosphate isomerase B; Provisional
 1-141 7.02e-36

ribose-5-phosphate isomerase B; Provisional


Pssm-ID: 235509  Cd Length: 148  Bit Score: 120.65  E-value: 7.02e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDV----TKDGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIK 76
Cdd:PRK05571   1 MKIAIGSDHAGFELKEEIIEHLEELGHEVIDLgpdsYDASVDYPDYAKKVAEAVVAGEADRGILICGTGIGMSIAANKVK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488219347  77 GMVAAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMC 141
Cdd:PRK05571  81 GIRAALCHDTYSAHLAREHNNANVLALGARVIGPELAKDIVDAFLATEFEGGRHQRRIDKIDEYE 145
rpiB_lacA_lacB TIGR00689
sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family ...
 3-137 1.00e-31

sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family act as sugar (pentose and/or hexose)-phosphate isomerases, including the LacA and LacB subunits of galactose-6-phosphate isomerases from Gram-positive bacteria and RpiB. RpiB is the second ribose phosphate isomerase of E. coli. It lacks homology to RpiA, its inducer is unknown (but is not ribose), and it can be replaced by the homologous galactose-6-phosphate isomerase of Streptococcus mutans, all of which suggests that the ribose phosphate isomerase activity of RpiB is a secondary function. On the other hand, there appear to be a significant number of species which contain rpiB, lack rpiA and seem to require rpi activity in order to complete the pentose phosphate pathway.


Pssm-ID: 129772  Cd Length: 144  Bit Score: 110.16  E-value: 1.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347    3 IVVGADLKGTRLKDVVKNFLVEEGFEVIDVTKDGQ---DFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:TIGR00689   1 IAIGSDHAGLELKSEIIEHLKQKGHEVIDCGTLYDervDYPDYAKLVADKVVAGEVSLGILICGTGIGMSIAANKFKGIR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 488219347   80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDML 137
Cdd:TIGR00689  81 AALCVDEYTAALARQHNDANVLCLGSRVVGVELALSIVDAFLTTQFEGGRHQRRIDKI 138
rpiB TIGR01120
ribose 5-phosphate isomerase B; Involved in the non-oxidative branch of the pentose phospate ...
 3-138 7.70e-27

ribose 5-phosphate isomerase B; Involved in the non-oxidative branch of the pentose phospate pathway. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 130190  Cd Length: 143  Bit Score: 97.68  E-value: 7.70e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347    3 IVVGADLKGTRLKDVVKNFLVEEGFEVIDVTKDGQ---DFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKIKGMV 79
Cdd:TIGR01120   2 IAIGSDHAGFILKEEIKAFLVERGVKVIDKGTWSSertDYPHYAKQVALAVAGGEVDGGILICGTGIGMSIAANKFAGIR 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488219347   80 AAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLN 138
Cdd:TIGR01120  82 AALCSEPYMAQMSRLHNDANVLCLGERVVGLELAKSIVDAWLGTQFEGGRHQQRVEAIT 140
PTZ00215 PTZ00215
ribose 5-phosphate isomerase; Provisional
 1-140 1.00e-21

ribose 5-phosphate isomerase; Provisional


Pssm-ID: 185516  Cd Length: 151  Bit Score: 84.69  E-value: 1.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVE--EGFEVIDV---TKDGQDFVDVTLAVASEVNKDEQNLGIVIDAYGAGPFMVATKI 75
Cdd:PTZ00215   3 KKVAIGSDHAGFDLKNEIIDYIKNkgKEYKIEDMgtyTAESVDYPDFAEKVCEEVLKGEADTGILVCGSGIGISIAANKV 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488219347  76 KGMVAAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKM 140
Cdd:PTZ00215  83 KGIRCALCHDHYTARMSRQHNNANVLAFGGRTTGIEVAKEIIDTFLSTPFEGGRHTERIDKISAI 147
PRK08622 PRK08622
galactose-6-phosphate isomerase subunit LacB; Reviewed
 1-125 2.01e-12

galactose-6-phosphate isomerase subunit LacB; Reviewed


Pssm-ID: 181506  Cd Length: 171  Bit Score: 60.82  E-value: 2.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDVTKdgQDFVDVTL-----AVASEVNKDEQNLGIVIDAYGAGPFMVATKI 75
Cdd:PRK08622   1 MKIAIGCDHIVTDEKMAVSDYLKSKGHEVIDVGT--YDFTRTHYpifgkKVGEAVASGEADLGVCICGTGVGISNAVNKV 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 488219347  76 KGMVAAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKY 125
Cdd:PRK08622  79 PGIRSALVRDMTSALYAKEELNANVIGFGGKITGELLMCDIIDAFINAEY 128
PRK12615 PRK12615
galactose-6-phosphate isomerase subunit LacB; Reviewed
 1-125 2.36e-07

galactose-6-phosphate isomerase subunit LacB; Reviewed


Pssm-ID: 171610  Cd Length: 171  Bit Score: 47.33  E-value: 2.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488219347   1 MAIVVGADLKGTRLKDVVKNFLVEEGFEVIDVTKDGQDFVDVTL---AVASEVNKDEQNLGIVIDAYGAGPFMVATKIKG 77
Cdd:PRK12615   1 MKIAIGCDHIVTNEKMAVSDFLKSKGYDVIDCGTYDHTRTHYPIfgkKVGEAVVNGQADLGVCICGTGVGINNAVNKVPG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 488219347  78 MVAAEVSDERSAYMTRGHNNSRMITVGAEIVGDELAKNIAKGFVNGKY 125
Cdd:PRK12615  81 IRSALVRDMTTALYAKEELNANVIGFGGKITGELLMCDIIDAFIKAEY 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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