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Conserved domains on  [gi|488160056|ref|WP_002231264|]
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iron chelate uptake ABC transporter family permease subunit [Yersinia pestis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD super family cl42614
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 2-110 5.24e-23

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG0609:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 90.90  E-value: 5.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGgvlSLGTPLLASLMALLACLPIYFLGQ 81
Cdd:COG0609   39 VLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLGGGLS---ALGLPLAAFLGALLAALLVYLLAR 115

                         90       100       110
                 ....*....|....*....|....*....|
gi 488160056  82 RQ-GMTPQILVLSGIVVLFFFQSLQSLMLF 110
Cdd:COG0609  116 RGgGLSPLRLVLAGVAVSALFSALTSLLLL 145
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 2-110 5.24e-23

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 90.90  E-value: 5.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGgvlSLGTPLLASLMALLACLPIYFLGQ 81
Cdd:COG0609   39 VLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLGGGLS---ALGLPLAAFLGALLAALLVYLLAR 115

                         90       100       110
                 ....*....|....*....|....*....|
gi 488160056  82 RQ-GMTPQILVLSGIVVLFFFQSLQSLMLF 110
Cdd:COG0609  116 RGgGLSPLRLVLAGVAVSALFSALTSLLLL 145
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 2-114 5.36e-18

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 77.57  E-value: 5.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056    2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGgvlSLGTPLLASLMALLACLPIYFLGQ 81
Cdd:pfam01032  46 VLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAILLGGSLS---LFALPLAAFIGALLAALLVYFLSR 122

                          90       100       110
                  ....*....|....*....|....*....|....
gi 488160056   82 -RQGMTPQILVLSGIVVLFFFQSLQSLMLFRPHQ 114
Cdd:pfam01032 123 gRGGASPLRLILAGIAVSALLSALTSLLLLLLNP 156
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
2-114 1.47e-14

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 68.71  E-value: 1.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGGVLSLGTPLLASLMALLAclpIYFLGQ 81
Cdd:PRK10577  66 LAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAAL---VFALAG 142

                         90       100       110
                 ....*....|....*....|....*....|....
gi 488160056  82 RQGMTPQILVLSGIVVLFFFQSL-QSLMLFRPHQ 114
Cdd:PRK10577 143 GKRLSPLRLVLAGMVVSLYLGALtTLLLLFNEQY 176
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 2-115 4.61e-10

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 55.26  E-value: 4.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGgvlSLGTPLLASLMALLACLPIYFLGQ 81
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLS---NYALGAFAFAGALAIALLVLLLAS 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 488160056  82 RQGMTPQILVLSGIVVLFFFQSLQSLMLFRPHQK 115
Cdd:cd06550   78 RGGLSPSKLILIGIVLSAFFSAGVILISLLSDDS 111
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 2-110 5.24e-23

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 90.90  E-value: 5.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGgvlSLGTPLLASLMALLACLPIYFLGQ 81
Cdd:COG0609   39 VLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLGGGLS---ALGLPLAAFLGALLAALLVYLLAR 115

                         90       100       110
                 ....*....|....*....|....*....|
gi 488160056  82 RQ-GMTPQILVLSGIVVLFFFQSLQSLMLF 110
Cdd:COG0609  116 RGgGLSPLRLVLAGVAVSALFSALTSLLLL 145
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 2-114 5.36e-18

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 77.57  E-value: 5.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056    2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGgvlSLGTPLLASLMALLACLPIYFLGQ 81
Cdd:pfam01032  46 VLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAILLGGSLS---LFALPLAAFIGALLAALLVYFLSR 122

                          90       100       110
                  ....*....|....*....|....*....|....
gi 488160056   82 -RQGMTPQILVLSGIVVLFFFQSLQSLMLFRPHQ 114
Cdd:pfam01032 123 gRGGASPLRLILAGIAVSALLSALTSLLLLLLNP 156
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 3-111 1.26e-14

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 68.22  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   3 LTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIItgfsVGGVLSLGTPLLASLMALLACLPIYFLGQR 82
Cdd:COG4779   78 LAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIV----VLGGSGLAVALGALAGGLATALLVYLLAWR 153

                         90       100
                 ....*....|....*....|....*....
gi 488160056  83 QGMTPQILVLSGIVVLFFFQSLQSLMLFR 111
Cdd:COG4779  154 GGVSGYRLILVGIGVSAMLTAVNSYLLTR 182
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
2-114 1.47e-14

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 68.71  E-value: 1.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGGVLSLGTPLLASLMALLAclpIYFLGQ 81
Cdd:PRK10577  66 LAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAAL---VFALAG 142

                         90       100       110
                 ....*....|....*....|....*....|....
gi 488160056  82 RQGMTPQILVLSGIVVLFFFQSL-QSLMLFRPHQ 114
Cdd:PRK10577 143 GKRLSPLRLVLAGMVVSLYLGALtTLLLLFNEQY 176
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
2-109 5.93e-14

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 66.79  E-value: 5.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAalsIITGFSVGGVLSLGTPLLASLMALLACLPIYFLGQ 81
Cdd:PRK10577 401 LLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGV---VLALFLVPGAGFGWLLAAALLGALAALALILLLAR 477

                         90       100
                 ....*....|....*....|....*...
gi 488160056  82 RQGMTPQILVLSGIVVLFFFQSLQSLML 109
Cdd:PRK10577 478 RGGFAPERLLLTGIALSALFTALIQLLL 505
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 2-60 8.78e-12

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 60.25  E-value: 8.78e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGGVLSLG 60
Cdd:COG4139   59 TLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLS 117
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 2-115 4.61e-10

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 55.26  E-value: 4.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITGFSVGgvlSLGTPLLASLMALLACLPIYFLGQ 81
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLS---NYALGAFAFAGALAIALLVLLLAS 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 488160056  82 RQGMTPQILVLSGIVVLFFFQSLQSLMLFRPHQK 115
Cdd:cd06550   78 RGGLSPSKLILIGIVLSAFFSAGVILISLLSDDS 111
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
2-60 5.74e-08

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 49.69  E-value: 5.74e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAAL------SIITGFSVGGVLSLG 60
Cdd:PRK11228  55 SLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALtsalspTPFAGYSLAFIAACG 119
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 2-50 1.33e-06

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 45.72  E-value: 1.33e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIITG 50
Cdd:PRK03784  62 TLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLG 110
btuC PRK09535
cobalamin ABC transporter permease BtuC;
3-109 2.64e-06

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 44.74  E-value: 2.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488160056   3 LTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIItgFSVggVLSLGTPLLASLMALLACLPIYFLGQR 82
Cdd:PRK09535 100 LLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIV--LPL--AVPFGLQAAAFAGALVAAFGVYAIATE 175

                         90       100
                 ....*....|....*....|....*...
gi 488160056  83 QGMTP-QILVLSGIVVLFFFQSLQSLML 109
Cdd:PRK09535 176 NGRTPvATLLLAGVAVQTFLGAVISYLL 203
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
2-47 5.18e-06

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 43.93  E-value: 5.18e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSI 47
Cdd:PRK10441  64 TLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGA 109
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
2-48 9.31e-06

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 43.11  E-value: 9.31e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 488160056   2 TLTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSII 48
Cdd:PRK09777  55 LLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALL 101
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
3-49 5.77e-03

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 35.07  E-value: 5.77e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 488160056   3 LTAVVVGASLGLAGLLMQTVLANPLASPYTLGISAAAGFGAALSIIT 49
Cdd:PRK10440  64 LMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVL 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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