|
Name |
Accession |
Description |
Interval |
E-value |
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
1-348 |
0e+00 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 725.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 1 MATGTLPDAGQILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMRESLQAGQGFTDNE 80
Cdd:PRK11073 1 MATGTLPDAGQILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMRESLQAGQGFTDNE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 81 VTLVVDGRAHILSLTAQSLAEGFILLELAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLAKALP 160
Cdd:PRK11073 81 VTLVIDGRSHILSLTAQRLPEGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 161 DPALLEYTQVIIEQADRLRNLVDRLLGPQRPGQHITQSIHQVAERVCQLVSLEKPDNVTLIRDYDPSLPELAHDPDQIEQ 240
Cdd:PRK11073 161 DPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKVAERVVQLVSLELPDNVRLIRDYDPSLPELAHDPDQIEQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 241 VLLNITRNALQALGETGGTITLRTRTAFQVTLHGMRYRLAARIDIEDDGPGVPTQLQDTVFYPMVSGREGGTGLGLSIAR 320
Cdd:PRK11073 241 VLLNIVRNALQALGPEGGTITLRTRTAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIAR 320
|
330 340
....*....|....*....|....*...
gi 488141943 321 NLIDQHSGKIEFNSWPGHTEFSVYLPIR 348
Cdd:PRK11073 321 NLIDQHSGKIEFTSWPGHTEFSVYLPIR 348
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
11-349 |
3.39e-142 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 406.92 E-value: 3.39e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 11 QILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMRESLQAGQGFTDNEVTLVV-DGRA 89
Cdd:COG3852 11 AILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRELLERALAEGQPVTEREVTLRRkDGEE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 90 HILSLTAQSLAE----GFILLELAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLAKALPDPALL 165
Cdd:COG3852 91 RPVDVSVSPLRDaegeGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLERELPDDELR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 166 EYTQVIIEQADRLRNLVDRLLGPQRPG--QHITQSIHQVAERVCQLVSLEKPDNVTLIRDYDPSLPELAHDPDQIEQVLL 243
Cdd:COG3852 171 EYTQLIIEEADRLNNLVDRLLSFSRPRppEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLPEVLGDPDQLIQVLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 244 NITRNALQALGEtGGTITLRTRTAFQVTLHGMRYRLAARIDIEDDGPGVPTQLQDTVFYPMVSGREGGTGLGLSIARNLI 323
Cdd:COG3852 251 NLVRNAAEAMPE-GGTITIRTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIV 329
|
330 340
....*....|....*....|....*..
gi 488141943 324 DQHSGKIEFNSWPG-HTEFSVYLPIRQ 349
Cdd:COG3852 330 EQHGGTIEVESEPGkGTTFRIYLPLEQ 356
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
11-347 |
7.18e-65 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 211.36 E-value: 7.18e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 11 QILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMRESLQAGQGftdnEVTLVVDGRAH 90
Cdd:COG5000 94 TILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQE----EIELTRDGRRT 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 91 ILSLTAQSLAEGFILLelapMDNQRRLsqeqlQHAQQVAA-RDLVRGLAHEIKNPLGGLRGAAQLLAKALPD------PA 163
Cdd:COG5000 170 LLVRASPLRDDGYVIV----FDDITEL-----LRAERLAAwGELARRIAHEIKNPLTPIQLSAERLRRKLADkleedrED 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 164 LLEYTQVIIEQADRLRNLVDRLL---GPQRPgQHITQSIHQVAERVCQLVSLE-KPDNVTLIRDYDPSLPELAHDPDQIE 239
Cdd:COG5000 241 LERALDTIIRQVDRLKRIVDEFLdfaRLPEP-QLEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDLPEVLADRDQLE 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 240 QVLLNITRNALQALGEtGGTITLRTRTAFQvtlhgmryrlAARIDIEDDGPGVPTQLQDTVFYPMVSGREGGTGLGLSIA 319
Cdd:COG5000 320 QVLINLLKNAIEAIEE-GGEIEVSTRREDG----------RVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIV 388
|
330 340
....*....|....*....|....*....
gi 488141943 320 RNLIDQHSGKIEFNSWPGH-TEFSVYLPI 347
Cdd:COG5000 389 KKIVEEHGGTIELESRPGGgTTFTIRLPL 417
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
9.78e-59 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 184.91 E-value: 9.78e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLLNITRNALQALGETGGTITLRTRTAFQVTLHGMRYRLAARIDIEDDGPGVPTQLQDTVFYPMVSGREGGTGLGLS 317
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGGEIILRTRTQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100
....*....|....*....|....*....
gi 488141943 318 IARNLIDQHSGKIEFNSWPGHTEFSVYLP 346
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
12-348 |
1.19e-55 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 191.33 E-value: 1.19e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 12 ILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLlgyFSLN---IVLMRESLQAGQGFTDNEVTLVVDGR 88
Cdd:PRK11360 267 ILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSEL---FPPNtpfASPLLDTLEHGTEHVDLEISFPGRDR 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 89 AHILSLTAQSLAEGF-----ILLELAPMDNQRRLsQEQLQHAQQVAAR-DLVRGLAHEIKNPLGGLRGAAQLLAKALPDP 162
Cdd:PRK11360 344 TIELSVSTSLLHNTHgemigALVIFSDLTERKRL-QRRVARQERLAALgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDP 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 163 ALLEYTQVIIEQADRLRNLVDRLLGPQRPGQHITQ--SIHQVAERVCQLV-SLEKPDNVTLIRDYDPSLPELAHDPDQIE 239
Cdd:PRK11360 423 PSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQpvSLNALVEEVLQLFqTAGVQARVDFETELDNELPPIWADPELLK 502
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 240 QVLLNITRNALQALgETGGTITLRTRTAFQVTLHgmryrlaarIDIEDDGPGVPTQLQDTVFYPMVSGREGGTGLGLSIA 319
Cdd:PRK11360 503 QVLLNILINAVQAI-SARGKIRIRTWQYSDGQVA---------VSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALS 572
|
330 340 350
....*....|....*....|....*....|
gi 488141943 320 RNLIDQHSGKIEFNSWPGH-TEFSVYLPIR 348
Cdd:PRK11360 573 QRIINAHGGDIEVESEPGVgTTFTLYLPIN 602
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
9-347 |
1.27e-53 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 180.38 E-value: 1.27e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 9 AGQILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMRESLQAGQGFTDNEVTLVVDGR 88
Cdd:COG4191 20 LALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 89 AHILSLTAQSLAEGFILLELAPMDNQRRLSQEQLQHAQQVAA-RDLVRGLAHEIKNPLGGLRGAAQLLAKALPDPA---- 163
Cdd:COG4191 100 ALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAAlGELAAGIAHEINNPLAAILGNAELLRRRLEDEPdpee 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 164 LLEYTQVIIEQADRLRNLVDRLL--GPQRPGQHITQSIHQVAERVCQLVSLE-KPDNVTLIRDYDPSLPELAHDPDQIEQ 240
Cdd:COG4191 180 LREALERILEGAERAAEIVRSLRafSRRDEEEREPVDLNELIDEALELLRPRlKARGIEVELDLPPDLPPVLGDPGQLEQ 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 241 VLLNITRNALQALGET-GGTITLRTRTAfqvtlHGMryrlaARIDIEDDGPGVPTQLQDTVFYPMVS--GREGGTGLGLS 317
Cdd:COG4191 260 VLLNLLINAIDAMEEGeGGRITISTRRE-----GDY-----VVISVRDNGPGIPPEVLERIFEPFFTtkPVGKGTGLGLS 329
|
330 340 350
....*....|....*....|....*....|.
gi 488141943 318 IARNLIDQHSGKIEFNSWPGH-TEFSVYLPI 347
Cdd:COG4191 330 ISYGIVEKHGGRIEVESEPGGgTTFTITLPL 360
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
114-348 |
9.91e-46 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 159.57 E-value: 9.91e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 114 QRRLSQEQLQHAQQVAArdlvrGLAHEIKNPLGGLRGAAQLLAKALPDPALLEYTQVIIEQADRLRNLVDRLLGPQRPG- 192
Cdd:COG5807 136 DKLLRSEKLSVAGELAA-----GIAHEIRNPLTSIKGFLQLLQESREDSEREEYFNIIISEIDRINTIITELLVLSKPKk 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 193 -QHITQSIHQVAERVCQLVSLE-KPDNVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQALgETGGTITLRTrtafqv 270
Cdd:COG5807 211 fNFKKLNLNDVLEDVIALLSTEaILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAM-ETGGNITIKT------ 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 271 tlhgmrYRLA--ARIDIEDDGPGVPTQLQDTVFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPI 347
Cdd:COG5807 284 ------YVEGdfVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKgTTFTIYLPL 357
|
.
gi 488141943 348 R 348
Cdd:COG5807 358 Y 358
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
21-348 |
2.18e-45 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 157.76 E-value: 2.18e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 21 LLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMRESLQAGQGFTDNEVTLVVDGRAHILSLTAQSLA 100
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 101 EGFILLELAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLAKAlPDPALLEYTQVIIEQADRLRN 180
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-LDEEQREYLETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 181 LVDRLL------GPQRPGQHITQSIHQVAERVCQLVS-LEKPDNVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQAl 253
Cdd:COG0642 160 LINDLLdlsrleAGKLELEPEPVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKY- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 254 GETGGTITLRTRTAfqvtlhgmryRLAARIDIEDDGPGVPTQLQDTVFYPMV----SGREGGTGLGLSIARNLIDQHSGK 329
Cdd:COG0642 239 TPEGGTVTVSVRRE----------GDRVRISVEDTGPGIPPEDLERIFEPFFrtdpSRRGGGTGLGLAIVKRIVELHGGT 308
|
330 340
....*....|....*....|
gi 488141943 330 IEFNSWPGH-TEFSVYLPIR 348
Cdd:COG0642 309 IEVESEPGKgTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
114-349 |
1.41e-42 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 147.75 E-value: 1.41e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 114 QRRLSQEQLQHAQQvAARDLVRGLAHEIKNPLGGLRGAAQLLAK--ALPDPALLEYTQVIIEQADRLRNLVDRLL----- 186
Cdd:COG2205 1 ELEEALEELEELER-LKSEFLANVSHELRTPLTSILGAAELLLDeeDLSPEERRELLEIIRESAERLLRLIEDLLdlsrl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 187 -GPQRPGQHITQSIHQVAERVCQLVSLEKPD-NVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQAlGETGGTITLRT 264
Cdd:COG2205 80 eSGKLSLELEPVDLAELLEEAVEELRPLAEEkGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKY-SPPGGTITISA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 265 RtafqvtlhgmRYRLAARIDIEDDGPGVPTQLQDTVFYPMV----SGREGGTGLGLSIARNLIDQHSGKIEFNSWPGH-T 339
Cdd:COG2205 159 R----------REGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgT 228
|
250
....*....|
gi 488141943 340 EFSVYLPIRQ 349
Cdd:COG2205 229 TFTVTLPLAE 238
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
11-349 |
1.96e-41 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 150.90 E-value: 1.96e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 11 QILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMR-ESLQAGQGFTDNEVTLVV-DGR 88
Cdd:COG5809 145 LIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFiSQLLKDGGIAQGEVRFWTkDGR 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 89 AHILSLTAQSLAEGFILLELAPM--D--NQRRLsQEQLQHAQ------QVAArdlvrGLAHEIKNPLGGLRGAAQLLaKA 158
Cdd:COG5809 225 WRLLEASGAPIKKNGEVDGIVIIfrDitERKKL-EELLRKSEklsvvgELAA-----GIAHEIRNPLTSLKGFIQLL-KD 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 159 LPDPALLEYTQVIIEQADRLRNLVDRLLGPQRP--GQHITQSIHQVAERVCQLVS---LEKpdNVTLIRDYDPSLPELAH 233
Cdd:COG5809 298 TIDEEQKTYLDIMLSELDRIESIISEFLVLAKPqaIKYEPKDLNTLIEEVIPLLQpqaLLK--NVQIELELEDDIPDILG 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALQALGEtGGTITLRTRtafqVTLHGmryrlAARIDIEDDGPGVPTQLQDTVFYPMVSGREGGTG 313
Cdd:COG5809 376 DENQLKQVFINLLKNAIEAMPE-GGNITIETK----AEDDD-----KVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTG 445
|
330 340 350
....*....|....*....|....*....|....*..
gi 488141943 314 LGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIRQ 349
Cdd:COG5809 446 LGLMVSYKIIEEHGGKITVESEVGKgTTFSITLPIKL 482
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
13-347 |
1.55e-40 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 148.73 E-value: 1.55e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 13 LNTLINS----ILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMR-ESLQAGQ---GFTDNEVTLv 84
Cdd:COG5805 159 LQTLIENspdlICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERiESITEVWqefIIEREIITK- 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 85 vDGRAHILSLTAQSLAEG--------FILLELApmdnQRRLSQEQLQH------AQQVAArdlvrGLAHEIKNPLGGLRG 150
Cdd:COG5805 238 -DGRIRYFEAVIVPLIDTdgsvkgilVILRDIT----EKKEAEELMARseklsiAGQLAA-----GIAHEIRNPLTSIKG 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 151 AAQLLAKALPDPAllEYTQVIIEQADRLRNLVDRLLGPQRPGQHI--TQSIHQVAERVcqlVSLEKPD----NVTLIRDY 224
Cdd:COG5805 308 FLQLLQPGIEDKE--EYFDIMLSELDRIESIISEFLALAKPQAVNkeKENINELIQDV---VTLLETEailhNIQIRLEL 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 225 DPSLPELAHDPDQIEQVLLNITRNALQALgETGGTITLRTRTAFQVTlhgmryrlaaRIDIEDDGPGVPTQLQDTVFYPM 304
Cdd:COG5805 383 LDEDPFIYCDENQIKQVFINLIKNAIEAM-PNGGTITIHTEEEDNSV----------IIRVIDEGIGIPEERLKKLGEPF 451
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 488141943 305 VSGREGGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPI 347
Cdd:COG5805 452 FTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKgTTFTITLPL 495
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
11-349 |
4.76e-39 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 142.77 E-value: 4.76e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 11 QILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMRESLQAGQGFTDNEVTLVVDGRAH 90
Cdd:COG5002 52 LALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 91 I-LSLTAQSLAEGFILLELAPMDNQRRLSQEQLQhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQLL--AKALPDPALLEY 167
Cdd:COG5002 132 GrLSLRLSALLLGLLLLAAVERDITELERLEQMR-------REFVANVSHELRTPLTSIRGYLELLldGAADDPEERREY 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 168 TQVIIEQADRLRNLVDRLL------GPQRPGQHITQSIHQVAERVCQLVSLEKPD-NVTLIRDYDPSLPELAHDPDQIEQ 240
Cdd:COG5002 205 LEIILEEAERLSRLVNDLLdlsrleSGELKLEKEPVDLAELLEEVVEELRPLAEEkGIELELDLPEDPLLVLGDPDRLEQ 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 241 VLLNITRNALQAlGETGGTITLRTRtafqvtlhgmRYRLAARIDIEDDGPGVPTQLQDTV---FY---PMVSGREGGTGL 314
Cdd:COG5002 285 VLTNLLDNAIKY-TPEGGTITVSLR----------EEDDQVRISVRDTGIGIPEEDLPRIferFYrvdKSRSRETGGTGL 353
|
330 340 350
....*....|....*....|....*....|....*.
gi 488141943 315 GLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIRQ 349
Cdd:COG5002 354 GLAIVKHIVEAHGGRIWVESEPGKgTTFTITLPLAR 389
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
88-348 |
1.72e-31 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 125.18 E-value: 1.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 88 RAHILSLTAQSLAEGFILLELAPMDNQRRLSQEQLQHAQQV-AARDLVRGLAHEIKNPLGGLRGAAQL-LAKALPDPALL 165
Cdd:PRK13837 407 PAGELQLLELALDCLAHAIERRRLETERDALERRLEHARRLeAVGTLASGIAHNFNNILGAILGYAEMaLNKLARHSRAA 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 166 EYTQVIIEQADRLRNLVDRLLGPQRPGQHITQSI---HQVAERVCQL-VSLekPDNVTLIRDYDPSLPELAHDPDQIEQV 241
Cdd:PRK13837 487 RYIDEIISAGARARLIIDQILAFGRKGERNTKPFdlsELVTEIAPLLrVSL--PPGVELDFDQDQEPAVVEGNPAELQQV 564
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 242 LLNITRNALQALGEtGGTITLRTR----TAFQVTLHG-MRYRLAARIDIEDDGPGVPTQLQDTVFYPMVSGREGGTGLGL 316
Cdd:PRK13837 565 LMNLCSNAAQAMDG-AGRVDISLSraklRAPKVLSHGvLPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGL 643
|
250 260 270
....*....|....*....|....*....|...
gi 488141943 317 SIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIR 348
Cdd:PRK13837 644 ATVHGIVSAHAGYIDVQSTVGRgTRFDVYLPPS 676
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
13-349 |
5.72e-31 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 121.78 E-value: 5.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 13 LNTLINSILLLDDDLAIHYANPAAQQLLA---QSSRKLFGTPLPDLLGYFSLNIvlmreslqagqgftdNEVTLVVDGRA 89
Cdd:COG5808 132 MDYIRALINILDPDKYIEIVDQNGQSVFTsghREESKSVSNKLDKVPWEVEVYP---------------NPVTNDELGQA 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 90 HILSLTAQSLAEGFILLELAPMDNQRRLSQEQLQ---HAQQVAAR-DLVRGLAHEIKNPLGGLRGAAQLLAKALPDPALL 165
Cdd:COG5808 197 LAIRKLIILVLISIIFLLLQYNLLKRKTLLERVIqeiNTQKLELIgTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQ 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 166 EYTQVIIEQADRLRNLVDRLLGPQRPG---------QHITQSIHQVAERVCQL----VSLEKPDNVTLIRdydpslpela 232
Cdd:COG5808 277 KYFDIIQEEIQRINQIVSEFLVLGKPTakklelddlNELIEEILSIIDSEANLknirVEKQSLDEPLHIK---------- 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 233 HDPDQIEQVLLNITRNALQALGEtGGTITLrtrtafQVTLHGMRyrlaARIDIEDDGPGVPTQLQDTVFYPMVSGREGGT 312
Cdd:COG5808 347 CDKDRIKQVLLNLIKNAIEAMKE-GGKLTI------SIENDDEK----AVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGT 415
|
330 340 350
....*....|....*....|....*....|....*...
gi 488141943 313 GLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIRQ 349
Cdd:COG5808 416 GLGLSVCKRIVEMHGGEIDIESEEGKgTTFTIRLPLKK 453
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
115-347 |
7.15e-29 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 116.04 E-value: 7.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 115 RRLSQEQLQHAQQVAAR-DLVRGLAHEIKNPLGGLRGAAQLLAKALP----DPALleyTQVIIEQADRLRNLVDRLLGPQ 189
Cdd:PRK10364 221 RQLLQDEMKRKEKLVALgHLAAGVAHEIRNPLSSIKGLAKYFAERAPaggeAHQL---AQVMAKEADRLNRVVSELLELV 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 190 RPGQHITQS--IHQVAERVCQLVSLE-KPDNVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQALGEtGGTITlrtrt 266
Cdd:PRK10364 298 KPTHLALQAvdLNDLINHSLQLVSQDaNSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQ-HGVIS----- 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 267 aFQVTLHGMRYRLAARidieDDGPGVPTQLQDTVFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYL 345
Cdd:PRK10364 372 -VTASESGAGVKISVT----DSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKgATFTLWL 446
|
..
gi 488141943 346 PI 347
Cdd:PRK10364 447 PV 448
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
234-348 |
7.43e-26 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 99.65 E-value: 7.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALQAlGETGGTITLRTRTAfqvtlhgmryRLAARIDIEDDGPGVPTQLQDTVFYPMVSGRE---- 309
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKY-TPEGGRITVTLERD----------GDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrk 70
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 488141943 310 -GGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIR 348
Cdd:smart00387 71 iGGTGLGLSIVKKLVELHGGEISVESEPGGgTTFTITLPLE 111
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
120-346 |
1.83e-23 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 99.94 E-value: 1.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 120 EQLQHAQQVAArdlvrGLAHEIKNPLGGLRGAAQLL-AKALPDPALLEYTQVIIEQADRLRNLVDRLLGPQRPGQHITQS 198
Cdd:COG5806 196 EKLEVVSELAA-----SIAHEVRNPLTVVRGFIQLLqEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPEKLEK 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 199 IHqVAERVCQLVSLEKP----DNVTLIRDYDPSLpELAHDPDQIEQVLLNITRNALQALgETGGTITLrtrtafQVTLHG 274
Cdd:COG5806 271 ID-VSEELEHVIDVLSPyanmNNVEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAM-PNGGTLTI------DVSIDK 341
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488141943 275 MRyrlaARIDIEDDGPGV-PTQLQD--TVFYpmvSGREGGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLP 346
Cdd:COG5806 342 NK----VIISIKDTGVGMtKEQLERlgEPYF---STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKgTTFTITLP 410
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
134-348 |
5.08e-21 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 93.76 E-value: 5.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 134 VRGLAHEIKNPLGGLRGAAQLLAKALPDPALLEYTQVIIEQADRLRNLVDRLLG----PQRPGQHITQSI-------HQV 202
Cdd:PRK11100 260 VQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLElarlEQRQELEVLEPValaalleELV 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 203 AERVCQLVSlekpDNVTLirDYDPSLPELAHDPDQIEQVLLNITRNALqALGETGGTITLRTRTafqvtlHGMRYRLAar 282
Cdd:PRK11100 340 EAREAQAAA----KGITL--RLRPDDARVLGDPFLLRQALGNLLDNAI-DFSPEGGTITLSAEV------DGEQVALS-- 404
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488141943 283 idIEDDGPGVPTQLQDTV---FY--PMVSGREGGTGLGLSIARNLIDQHSGKIEF-NSWPGHTEFSVYLPIR 348
Cdd:PRK11100 405 --VEDQGPGIPDYALPRIferFYslPRPANGRKSTGLGLAFVREVARLHGGEVTLrNRPEGGVLATLTLPRH 474
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
12-348 |
2.38e-20 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 91.06 E-value: 2.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 12 ILNTLINSILLLDDDLAIHYANPAAQQLLAQSsrkLFGTPLPDLLGYFSLNIVLMRESLQAGQGFTDNEVTLVVDGRAHI 91
Cdd:COG3290 89 VLESIREGVIAVDRDGRITLINDAARRLLGLD---AIGRPIDEVLAEVLETGERDEEILLNGRVLVVNRVPIRDDGRVVG 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 92 LSLTAQSLAEgfillelapmdnqRRLSQEQLQHAQQVAarDLVRGLAHEIKNPLGGLRGAAQLLAkalpDPALLEYtqvI 171
Cdd:COG3290 166 AVATFRDRTE-------------LERLEEELEGVKELA--EALRAQRHDFRNHLHTISGLLQLGE----YDEALEY---I 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 172 IEQADRLRNLVDRLLgpqrpgQHITQSIhqVAERVCQLVSLEKPDNVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQ 251
Cdd:COG3290 224 DEISEELQELIDSLL------SRIGNPV--LAALLLGKAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIE 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 252 ALGETG---GTITLRtrtafqVTLHGMRYRlaarIDIEDDGPGVPTQLQDTVFYPMVSGREG-GTGLGLSIARNLIDQHS 327
Cdd:COG3290 296 AVEKLPeeeRRVELS------IRDDGDELV----IEVEDSGPGIPEELLEKIFERGFSTKLGeGRGLGLALVKQIVEKYG 365
|
330 340
....*....|....*....|..
gi 488141943 328 GKIEFNSWPGH-TEFSVYLPIR 348
Cdd:COG3290 366 GTIEVESEEGEgTVFTVRLPKE 387
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
234-349 |
4.85e-20 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 83.96 E-value: 4.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALQALGEtGGTITLRTRTAFQVtlhgmryrlaaRIDIEDDGPGVPTQLQDTVFYPMVSG---REG 310
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAK-AGEITVTLSEGGEL-----------TLTVEDNGIGIPPEDLPRIFEPFSTAdkrGGG 69
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488141943 311 GTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIRQ 349
Cdd:pfam02518 70 GTGLGLSIVRKLVELLGGTITVESEPGGgTTVTLTLPLAQ 109
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
12-349 |
5.12e-20 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 91.00 E-value: 5.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 12 ILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMRESLQAGQGFTDNEVTLVVDGRAHI 91
Cdd:COG4251 165 ALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILL 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 92 LSLTAQSLAEGFILLELAPMDNQRRLSQEQLQHAQQvAARDLVRGLAHEIKNPLGGLRGAAQLLAKAL---PDPALLEYT 168
Cdd:COG4251 245 LLLLILVLELLELRLELEELEEELEERTAELERSNE-ELEQFAYVASHDLREPLRKISGFSQLLEEDYgdkLDEEGREYL 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 169 QVIIEQADRLRNLVDRLLG----PQRPGQHITQSIHQVAERVCQLVSLE-KPDNVTLIRDydpSLPELAHDPDQIEQVLL 243
Cdd:COG4251 324 ERIRDAAERMQALIDDLLAysrvGRQELEFEPVDLNELLEEVLEDLEPRiEERGAEIEVG---PLPTVRGDPTLLRQVFQ 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 244 NITRNAL--QALGETGgtitlrtrtafQVTLHGMRYRLAARIDIEDDGPGVPTQLQDTVFYPM--VSGRE--GGTGLGLS 317
Cdd:COG4251 401 NLISNAIkySRPGEPP-----------RIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFqrLHSRDeyEGTGIGLA 469
|
330 340 350
....*....|....*....|....*....|...
gi 488141943 318 IARNLIDQHSGKIEFNSWPGH-TEFSVYLPIRQ 349
Cdd:COG4251 470 IVKKIVERHGGRIWVESEPGEgATFYFTLPKAP 502
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
88-348 |
1.96e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.50 E-value: 1.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 88 RAHILSLTAQSLAEgfiLLELAPMDNQRRLSQEQLQHAQQVaardLVRGLAHEIKNPLGGLRGAAQLLAKALPDPALLEY 167
Cdd:PRK11466 409 REQLAAQVKARTAE---LQELVIEHRQARAEAEKASQAKSA----FLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDD 481
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 168 TQVIIEQADRLRNLVDRLLG----------------PQRPGQHITQSIHQVAERVcqlvsleKPDNVTLIRDYDPSLPE- 230
Cdd:PRK11466 482 LRAITDSGESLLTILNDILDysaieaggknvsvsdePFEPRPLLESTLQLMSGRV-------KGRPIRLATDIADDLPTa 554
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 231 LAHDPDQIEQVLLNITRNALQALGEtgGTITLRTRTAFQVTLhgmryrlaarIDIEDDGPGVPTQLQDTVFYPMV--SGR 308
Cdd:PRK11466 555 LMGDPRRIRQVITNLLSNALRFTDE--GSIVLRSRTDGEQWL----------VEVEDSGCGIDPAKLAEIFQPFVqvSGK 622
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 488141943 309 EGGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIR 348
Cdd:PRK11466 623 RGGTGLGLTISSRLAQAMGGELSATSTPEVgSCFCLRLPLR 663
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
238-346 |
9.01e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 77.92 E-value: 9.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLLNITRNALQALGEtgGTITLRTRTafqVTLHGMRYRLaaRIDIEDDGPGVPTQLQDTVFYPMV------SGREGG 311
Cdd:cd16922 1 LRQILLNLLGNAIKFTEE--GEVTLRVSL---EEEEEDGVQL--RFSVEDTGIGIPEEQQARLFEPFSqadsstTRKYGG 73
|
90 100 110
....*....|....*....|....*....|....*.
gi 488141943 312 TGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLP 346
Cdd:cd16922 74 TGLGLAISKKLVELMGGDISVESEPGQgSTFTFTLP 109
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
235-347 |
1.24e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 77.46 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 235 PDQIEQVLLNITRNALQALGETGgTITLRTrtafqvtlhgMRYRLAARIDIEDDGPGVPTQLQDTVFYPMVSGREG--GT 312
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRG-RITIRT----------WAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVgeGT 69
|
90 100 110
....*....|....*....|....*....|....*.
gi 488141943 313 GLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPI 347
Cdd:cd16943 70 GLGLSLSYRIIQKHGGTIRVASVPGGgTRFTIILPI 105
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
116-347 |
5.42e-16 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 78.07 E-value: 5.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 116 RLSQEQLQHAQQVAARD-LVRGLAHEIKNPLGGLRGAAQLLAKALPDPALLEYTQVI---IEQADRLRNLVDRLL----- 186
Cdd:PRK09303 136 VLRQENETLLEQLKFKDrVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIeqlQDQARRQLEEIERLItdlle 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 187 -GPQRPGQHITQSIHQVAERVCQLVSLE-----KPDNVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQALGEtGGTI 260
Cdd:PRK09303 216 vGRTRWEALRFNPQKLDLGSLCQEVILElekrwLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPE-GGTI 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 261 TL----RTRTAFQVTlhgmryrlaaridIEDDGPGVPTQLQDTVFYPMV----SGREGGTGLGLSIARNLIDQHSGKIEF 332
Cdd:PRK09303 295 TLsmlhRTTQKVQVS-------------ICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVRVHYGQIWV 361
|
250
....*....|....*.
gi 488141943 333 NSWPGH-TEFSVYLPI 347
Cdd:PRK09303 362 DSEPGQgSCFHFTLPV 377
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
115-347 |
6.20e-16 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 78.56 E-value: 6.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 115 RRLSQEQLQHAQQVAA-RDLVRGLAHEIKNPLGGLRGAAQLLAKALPDPALLeyTQVIIEQADRLRNLVDR-------LL 186
Cdd:PRK13557 147 RRDAEDALRQAQKMEAlGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDAD--RGRMARSVENIRAAAERaatltqqLL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 187 GPQRPgQHI---TQSIHQVAERVCQLVSLEKPDNVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQALGEtGGTITLR 263
Cdd:PRK13557 225 AFARK-QRLegrVLNLNGLVSGMGELAERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPE-GGRVTIR 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 264 TR--------TAFQVTLHGMRYrlaARIDIEDDGPGVPTQLQDTVFYPMVSGR-EG-GTGLGLSIARNLIDQHSGKIEFN 333
Cdd:PRK13557 303 TRnveiededLAMYHGLPPGRY---VSIAVTDTGSGMPPEILARVMDPFFTTKeEGkGTGLGLSMVYGFAKQSGGAVRIY 379
|
250
....*....|....*
gi 488141943 334 SWPGH-TEFSVYLPI 347
Cdd:PRK13557 380 SEVGEgTTVRLYFPA 394
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
9.07e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 69.35 E-value: 9.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLLNITRNALQALGE---TGGTITLRTRTAfqvtlhGMRYrlaARIDIEDDGPGVPTQLQDTVFYPMVSGREGGTGL 314
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEggcERRELTIRTSPA------DDRA---VTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGM 71
|
90 100 110
....*....|....*....|....*....|...
gi 488141943 315 GLSIARNLIDQHSGKIEFNSWP-GHTEFSVYLP 346
Cdd:cd16920 72 GLSICRSIIEAHGGRLSVESPAgGGATFQFTLP 104
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-337 |
8.72e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 66.79 E-value: 8.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALQALGETG---GTITLRTRTAFQVTLhgmryrlaaRIDIEDDGPGVPTQLQDTVFYPMVSGREG 310
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPsdvGEVRIRVEADQDGRI---------VLIVCDNGKGFPREMRHRATEPYVTTRPK 71
|
90 100
....*....|....*....|....*..
gi 488141943 311 GTGLGLSIARNLIDQHSGKIEFNSWPG 337
Cdd:cd16944 72 GTGLGLAIVKKIMEEHGGRISLSNREA 98
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
239-346 |
1.49e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 63.55 E-value: 1.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 239 EQVLLNITRNALQALGEtGGTITLRTRTAFQVTLHGMRYR--LAAR---IDIEDDGPGVPTQLQDTVFYPMVSGRE--GG 311
Cdd:cd16919 2 ELAILNLAVNARDAMPE-GGRLTIETSNQRVDADYALNYRdlIPGNyvcLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 488141943 312 TGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLP 346
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVgTTVRIYLP 116
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
131-186 |
3.59e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 61.07 E-value: 3.59e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 488141943 131 RDLVRGLAHEIKNPLGGLRGAAQLLAKALPDPALLEYTQVIIEQADRLRNLVDRLL 186
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLL 58
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
112-330 |
3.06e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 64.32 E-value: 3.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 112 DNQRRLSQEQLQHAQQVAAR-DLVRGLAHEIKNPLGGLRGAAQLLAKAL---PDPALLEYTQVIIEQADRLRNLVDRLLG 187
Cdd:COG4192 414 EKNLRQTQDELIQAAKMAVVgQTMTSLAHELNQPLNAMSMYLFSAKKALeqeNYAQLPTSLDKIEGLIERMDKIIKSLRQ 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 188 PQRPGQHITQ--SIHQVAERVCQLVSLE-KPDNVTLIRDYDPSLPElahDPDQIEQVLLNITRNALQAlgetggtitlrT 264
Cdd:COG4192 494 FSRKSDTPLQpvDLRQVIEQAWELVESRaKPQQITLHIPDDLMVQG---DQVLLEQVLVNLLVNALDA-----------V 559
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488141943 265 RTAFQVTLHGMRYRLAARIDIEDDGPGVPtqLQDTVFYPMVSGREGGTGLGLSIARNLIDQHSGKI 330
Cdd:COG4192 560 ATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDL 623
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
4.55e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 58.88 E-value: 4.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLLNITRNALQALGETggtitlrtrtafqVTLHGMRYRLAARIDIEDDGPGVPTQLQDTVFYPMV---SGRE---GG 311
Cdd:cd16949 1 LARALENVLRNALRYSPSK-------------ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdSARDresGG 67
|
90 100 110
....*....|....*....|....*....|....*.
gi 488141943 312 TGLGLSIARNLIDQHSGKIEF-NSWPGHTEFSVYLP 346
Cdd:cd16949 68 TGLGLAIAERAIEQHGGKIKAsNRKPGGLRVRIWLP 103
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-336 |
4.58e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 59.01 E-value: 4.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALQaLGETGGTITLRTRTAFQvtlhgmryrlAARIDIEDDGPGVPTQLQDTV---FYPMVSGRE- 309
Cdd:cd16946 1 DRDRLQQLFVNLLENSLR-YTDTGGKLRIRAAQTPQ----------EVRLDVEDSAPGVSDDQLARLferFYRVESSRNr 69
|
90 100
....*....|....*....|....*....
gi 488141943 310 --GGTGLGLSIARNLIDQHSGKIEFNSWP 336
Cdd:cd16946 70 asGGSGLGLAICHNIALAHGGTISAEHSP 98
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
131-186 |
5.33e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 57.58 E-value: 5.33e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 488141943 131 RDLVRGLAHEIKNPLGGLRGAAQLLAKALPDPALLEYTQVIIEQADRLRNLVDRLL 186
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLL 58
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
113-330 |
7.15e-11 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 63.03 E-value: 7.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 113 NQRRLSQEQLQHAQQVaardLVRGLAHEIKNPLGGLRGAAQLLAKALPDPALLEYtqviIE-QADRLRNLVDRLLGPQRp 191
Cdd:PRK09470 230 NQMVTALERMMTSQQR----LLSDISHELRTPLTRLQLATALLRRRQGESKELER----IEtEAQRLDSMINDLLVLSR- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 192 GQHI------TQSIHQVAERVCQLVSLE-KPDNVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQAlgeTGGTITLrt 264
Cdd:PRK09470 301 NQQKnhlereTFKANSLWSEVLEDAKFEaEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRY---SHTKIEV-- 375
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488141943 265 rtAFQVTLHGMRyrlaarIDIEDDGPGVPTQLQDTVFYPM--VS---GRE-GGTGLGLSIARNLIDQHSGKI 330
Cdd:PRK09470 376 --AFSVDKDGLT------ITVDDDGPGVPEEEREQIFRPFyrVDearDREsGGTGLGLAIVENAIQQHRGWV 439
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
131-186 |
9.28e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 56.84 E-value: 9.28e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 488141943 131 RDLVRGLAHEIKNPLGGLRGAAQLLA-KALPDPALLEYTQVIIEQADRLRNLVDRLL 186
Cdd:cd00082 5 GEFLANVSHELRTPLTAIRGALELLEeELLDDEEQREYLERIREEAERLLRLINDLL 61
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
123-347 |
1.32e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 62.74 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 123 QHAQQVAAR--DLVRGLAHEIKNPLGGLRGAAQLLakalpdpallEYTQVIIEQAD----------RLRNLVDRLLGPQR 190
Cdd:PRK15347 389 QRAEQANKRksEHLTTISHEIRTPLNGVLGALELL----------QNTPLTAEQMDladtarqctlSLLAIINNLLDFSR 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 191 --PGQhITQSIHQV--------AERVCQLVSLEKPdnVTLIRDYDPSLPELAH-DPDQIEQVLLNITRNALQaLGETGGt 259
Cdd:PRK15347 459 ieSGQ-MTLSLEETallplldqAMLTIQGPAQSKS--LTLRTFVGAHVPLYLHlDSLRLRQILVNLLGNAVK-FTETGG- 533
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 260 itlrtrtafqVTLHGMRYRLAARIDIEDDGPGVPTQLQDTVFYPM--VSGREGGTGLGLSIARNLIDQHSGKIEFNSWPG 337
Cdd:PRK15347 534 ----------IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFyqADTHSQGTGLGLTIASSLAKMMGGELTLFSTPG 603
|
250
....*....|.
gi 488141943 338 H-TEFSVYLPI 347
Cdd:PRK15347 604 VgSCFSLVLPL 614
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-346 |
1.42e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 57.68 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 244 NITRNALQALGETGG-----TITLRTRTAFQVtlhgmryrlaarIDIEDDGPGVPTQLQDTVFYPMVSGRE-GGTGLGLS 317
Cdd:cd16915 7 NLIDNALDALAATGApnkqvEVFLRDEGDDLV------------IEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLA 74
|
90 100 110
....*....|....*....|....*....|
gi 488141943 318 IARNLIDQHSGKIEF-NSWPGHTEFSVYLP 346
Cdd:cd16915 75 LVRQSVERLGGSITVeSEPGGGTTFSIRIP 104
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-345 |
1.55e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 57.47 E-value: 1.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLLNITRNALQALGEtggtitlRTRTAFQVTLHgmryRLAAR--IDIEDDGPGVPTQLQDTVFYPMVSGRE--GGTG 313
Cdd:cd16976 1 IQQVLMNLLQNALDAMGK-------VENPRIRIAAR----RLGGRlvLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTG 69
|
90 100 110
....*....|....*....|....*....|...
gi 488141943 314 LGLSIARNLIDQHSGKIEF-NSWPGHTEFSVYL 345
Cdd:cd16976 70 LGLSISYGIVEEHGGRLSVaNEEGAGARFTFDL 102
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
1.83e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 57.07 E-value: 1.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLLNITRNALQalgETGGTITLRTRTAFQVTlhgmryrlaaRIDIEDDGPGVPTQLQDTVFYPMVSGRE----GGTG 313
Cdd:cd16950 1 LKRVLSNLVDNALR---YGGGWVEVSSDGEGNRT----------RIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTG 67
|
90 100 110
....*....|....*....|....*....|....
gi 488141943 314 LGLSIARNLIDQHSGKIEF-NSWPGHTEFSVYLP 346
Cdd:cd16950 68 LGLAIVQRISDAHGGSLTLaNRAGGGLCARIELP 101
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
217-346 |
2.44e-10 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 61.47 E-value: 2.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 217 NVTLIRDYDPSLPElAHDPDQIEQ---VLLNITRNALQALGET-GGTITlrtrtafqVTLHGMRYRLAarIDIEDDGPGV 292
Cdd:PRK11086 411 GITLIISEDSQLPD-SGDEDQVHElitILGNLIENALEAVGGEeGGEIS--------VSLHYRNGWLH--CEVSDDGPGI 479
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 488141943 293 PTQLQDTVFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFNSWPG-HTEFSVYLP 346
Cdd:PRK11086 480 APDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGvGTQFFVQIP 534
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
234-346 |
4.50e-10 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 56.35 E-value: 4.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALQALGEtGGTITLRtrtafqVTLHGMRYRLaarIDIEDDGPGVPTQLQDTVFYPMVSGRE---- 309
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPD-GGRIRCI------LEKFRLNRFL---LTVSDSGPGIPPNLREEIFERFRQGDGsstr 70
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488141943 310 --GGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLP 346
Cdd:cd16925 71 ahGGTGLGLSIVKEFVELHGGTVTVSDAPGGgALFQVELP 110
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
133-349 |
6.80e-10 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 59.92 E-value: 6.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 133 LVRGLAHEIKNPLGGLRGAAQLLAKAlpDPALLEYtqvIIEQADRLRNLVDRLLGPQRPGQHITQSIHQVAERVCQLVSL 212
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIRLATEMMSEE--DGYLAES---INKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALLGEVIAA 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 213 EKPDNVTLIRDYDPSLPELAHDPDQIEQVLLNITRNALQAlgeTGGTITLRTRTAFQvtlhgmryrlAARIDIEDDGPGV 292
Cdd:PRK09467 307 ESGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAARY---GNGWIKVSSGTEGK----------RAWFQVEDDGPGI 373
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488141943 293 PTQLQDTVFYPMVSGREG----GTGLGLSIARNLIDQHSGKIEF-NSWPGHTEFSVYLPIRQ 349
Cdd:PRK09467 374 PPEQLKHLFQPFTRGDSArgssGTGLGLAIVKRIVDQHNGKVELgNSEEGGLSARAWLPLTT 435
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
2.00e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 54.26 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLLNITRNALQalgetggtiTLRTRTAFQVTLHGMRYRLAARIDIEDDGPGVPTQLQDTVF--YPMVSGRE--GGTG 313
Cdd:cd16921 1 LGQVLTNLLGNAIK---------FRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFgiFQRLHSREeyEGTG 71
|
90 100 110
....*....|....*....|....*....|....
gi 488141943 314 LGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLP 346
Cdd:cd16921 72 VGLAIVRKIIERHGGRIWLESEPGEgTTFYFTLP 105
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
2.05e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 54.36 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLLNITRNALQalgetggtiTLRTRTAFQVTLHGMRyrlaARIDIEDDGPGVPTQLQDTVFYPMV---SGRE---GG 311
Cdd:cd16939 1 MARALDNLLRNALR---------YAHRTVRIALLVSGGR----LTLIVEDDGPGIPAAARERVFEPFVrldPSRDratGG 67
|
90 100 110
....*....|....*....|....*....|....*.
gi 488141943 312 TGLGLSIARNLIDQHSGKIEFNSWP-GHTEFSVYLP 346
Cdd:cd16939 68 FGLGLAIVHRVALWHGGHVECDDSElGGACFRLTWP 103
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
129-348 |
2.97e-09 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 58.10 E-value: 2.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 129 AARDLVRGLAHEIKNPLGGLRG-----AAQLLAKALPDPALleytQVIIEQADRLRNLVDRLLGPQRpgqhITQS-IHQV 202
Cdd:PRK11006 203 ARRNFFANVSHELRTPLTVLQGylemmQDQPLEGALREKAL----HTMREQTQRMEGLVKQLLTLSK----IEAApTIDL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 203 AERV---CQLVSLEKP------DNVTLIRDYDPSLPELAHDpDQIEQVLLNITRNALQALGEtGGTITLRtrtaFQVTLH 273
Cdd:PRK11006 275 NEKVdvpMMLRVLEREaqtlsqGKHTITFEVDNSLKVFGNE-DQLRSAISNLVYNAVNHTPE-GTHITVR----WQRVPQ 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 274 GmryrlaARIDIEDDGPGVPTQ----LQDTvFYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYL 345
Cdd:PRK11006 349 G------AEFSVEDNGPGIAPEhiprLTER-FYRVDKARSrqtGGSGLGLAIVKHALSHHDSRLEIESEVGKgTRFSFVL 421
|
...
gi 488141943 346 PIR 348
Cdd:PRK11006 422 PER 424
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
220-348 |
3.17e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 58.32 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 220 LIRDYDPSLPE-LAHDPDQIEQVLLNITRNALQaLGETGG---TITLRTRTAFQVTLhgmryrlaaRIDIEDDGPGVPTQ 295
Cdd:PRK11107 390 LTLNIDPDVPDnVIGDPLRLQQIITNLVGNAIK-FTESGNidiLVELRALSNTKVQL---------EVQIRDTGIGISER 459
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 296 LQDTVFYPM------VSGREGGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIR 348
Cdd:PRK11107 460 QQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRgSTFWFHLPLD 519
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
97-346 |
6.85e-09 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 57.35 E-value: 6.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 97 QSLAEGFILL--------ELAPMDNQRRLS--QEQLQHAqqvaardLVRGLAHEIKNPLGGLRGAAQLLAKALPD----- 161
Cdd:PRK10490 628 QRLLETFTLLianalerlTLTASEEQARLAseREQLRNA-------LLAALSHDLRTPLTVLFGQAEILTLDLASegsph 700
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 162 -PALLEYTQVIIEQADRLRNLVD--RLlgpQRPGQHIT---QSIHQVAERVCQL---------VSLEKPDNVTLIrDYDP 226
Cdd:PRK10490 701 aRQASEIRQQVLNTTRLVNNLLDmaRI---QSGGFNLRkewLTLEEVVGSALQMlepglsghpINLSLPEPLTLI-HVDG 776
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 227 SLpelahdpdqIEQVLLNITRNALQALGEtGGTITLRTRTAFQvTLHgmryrlaarIDIEDDGPGVPTQLQDTVFYPMVS 306
Cdd:PRK10490 777 PL---------FERVLINLLENAVKYAGA-QAEIGIDAHVEGE-RLQ---------LDVWDNGPGIPPGQEQLIFDKFAR 836
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 488141943 307 GREG----GTGLGLSIARNLIDQHSGKI-EFNSWPGHTEFSVYLP 346
Cdd:PRK10490 837 GNKEsaipGVGLGLAICRAIVEVHGGTIwAENRPEGGACFRVTLP 881
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
1.37e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 52.20 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 244 NITRNALQALGEtGGTITLRtrtaFQVTLHGmryrlaARIDIEDDGPGVPTQ----LQDTvFYPMVSGR---EGGTGLGL 316
Cdd:cd16952 7 NLVSNAVKYTPP-SDTITVR----WSQEESG------ARLSVEDTGPGIPPEhiprLTER-FYRVDIERcrnTGGTGLGL 74
|
90 100 110
....*....|....*....|....*....|....
gi 488141943 317 SIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIRQ 349
Cdd:cd16952 75 AIVKHVMSRHDARLLIASELGKgSRFTCLFPSSR 108
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
92-348 |
2.83e-08 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 54.99 E-value: 2.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 92 LSLTAQSLAEGFI--LLELAPMDNQRRLSQEQLQHAQQVAA-----RDLVRGLAHEIKNPLGGLRGAAQLLaKALPDPAl 164
Cdd:PRK10604 167 LEAAAQRLGDGHLaeRIHFDEGSSLERLGVAFNQMADNINAliaskKQLIDGIAHELRTPLVRLRYRLEMS-DNLSAAE- 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 165 leyTQVIIEQADRLRNLVDRLLG------PQRPGQhiTQSI---HQVAERVCQLVSLEKPDNVTLIRDYDPSLpeLAHDP 235
Cdd:PRK10604 245 ---SQALNRDIGQLEALIEELLTyarldrPQNELH--LSEPdlpAWLSTHLADIQAVTPEKTVRLDTPHQGDY--GALDM 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 236 DQIEQVLLNITRNALQALGetggtitlrTRTAFQVTLHGMRYRLaariDIEDDGPGVPTQLQDTVFYPMV---SGRE--- 309
Cdd:PRK10604 318 RLMERVLDNLLNNALRYAH---------SRVRVSLLLDGNQACL----IVEDDGPGIPPEERERVFEPFVrldPSRDrat 384
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 488141943 310 GGTGLGLSIARNLIDQHSGKIEFNSWP-GHTEFSVYLPIR 348
Cdd:PRK10604 385 GGCGLGLAIVHSIALAMGGSVNCDESElGGARFSFSWPVW 424
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-330 |
1.53e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 49.11 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 240 QVLLNITRNALQALGETGGTITLRTRTAfqvtlhGMRYRLAaridIEDDGPGVPTQLQDTVFYPMVSGREGG------TG 313
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTGRITVSAMPT------GKMVTIS----VEDEGPGIPQEKLESIFDRFYTERPANeafgqhSG 72
|
90
....*....|....*..
gi 488141943 314 LGLSIARNLIDQHSGKI 330
Cdd:cd16953 73 LGLSISRQIIEAHGGIS 89
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-337 |
3.41e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 48.17 E-value: 3.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALQALGEtGGTITLRtrtafqvtlhgMRYRLAARIDIEDDGPGVPTQLQDTV---FYPMVSGREG 310
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQ-GSRVEIK-----------LSADDGAVIRVEDNGPGIDEEELEALferFYRSDGQNYG 77
|
90 100
....*....|....*....|....*..
gi 488141943 311 GTGLGLSIARNLIDQHSGKIEFNSWPG 337
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQG 104
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
225-347 |
4.36e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 51.51 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 225 DPSLPE-LAHDPDQIEQVLLNITRNALQaLGETGGTItlrtrtaFQVTLHGmrYRLAarIDIEDDGPGVPTQLQDTVFYP 303
Cdd:PRK10841 549 EPDVPVaLNGDPMRLQQVISNLLSNAIK-FTDTGCIV-------LHVRVDG--DYLS--FRVRDTGVGIPAKEVVRLFDP 616
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 488141943 304 MVSGREG------GTGLGLSIARNLIDQHSGKIEFNSWPG-HTEFSVYLPI 347
Cdd:PRK10841 617 FFQVGTGvqrnfqGTGLGLAICEKLINMMDGDISVDSEPGmGSQFTIRIPL 667
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
225-346 |
1.03e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 50.32 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 225 DPSLPELAH-DPDQIEQVLLNITRNALQALGEtgGTITLRTRTAFQVTLHgmryrlaarIDIEDDGPGVPTQLQDTVF-- 301
Cdd:PRK11091 385 LLPLPHKVItDGTRLRQILWNLISNAVKFTQQ--GGVTVRVRYEEGDMLT---------FEVEDSGIGIPEDELDKIFam 453
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 488141943 302 YPMVSGREG-----GTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLP 346
Cdd:PRK11091 454 YYQVKDSHGgkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKgSCFTLTIH 504
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
128-347 |
1.69e-06 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 50.12 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 128 VAARDLVRGLAHEIKNPLGGLRGAAQLLA-KALPDPALLEYTQVIIEQADRLRNLVDRLLGPQR--PGQHITQ----SIH 200
Cdd:PRK09959 710 VAKSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKieSGNYQLQpqwvDIP 789
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 201 QVAERVCQ-LVSLEKPDNVTLirDYDPSLPE---LAHDPDQIEQVLLNITRNALQALGEtgGTITLRTRTAFQVTLHGMr 276
Cdd:PRK09959 790 TLVQNTCHsFGAIAASKSIAL--SCSSTFPDhylVKIDPQAFKQVLSNLLSNALKFTTE--GAVKITTSLGHIDDNHAV- 864
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488141943 277 yrlaARIDIEDDGPGVPTQLQDTVF--YPMVSG--REGGTGLGLSIARNLIDQHSGKIEFNSWPG-HTEFSVYLPI 347
Cdd:PRK09959 865 ----IKMTIMDSGSGLSQEEQQQLFkrYSQTSAgrQQTGSGLGLMICKELIKNMQGDLSLESHPGiGTTFTITIPV 936
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-345 |
2.56e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 45.97 E-value: 2.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALQaLGETGGTItlrtrtafqvtlhGMRYRLAAR---IDIEDDGPGVPTQLQDTVF---YPMVSG 307
Cdd:cd16947 17 NTEALQRILKNLISNAIK-YGSDGKFL-------------GMTLREDEKhvyIDIWDKGKGISETEKDHVFerlYTLEDS 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 488141943 308 REG---GTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYL 345
Cdd:cd16947 83 RNSakqGNGLGLTITKRLAESMGGSIYVNSKPYEkTVFTVTL 124
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
131-330 |
3.06e-06 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 48.86 E-value: 3.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 131 RDLVRGLAHEIKNPLGGLRGAAQLLAKAL--PDPALLEYTQVIIEQadrLRNLVDRL----------LGPQRPGQHITQS 198
Cdd:PRK10549 241 RDFMADISHELRTPLAVLRGELEAIQDGVrkFTPESVASLQAEVGT---LTKLVDDLhqlslsdegaLAYRKTPVDLVPL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 199 IHQVA----ERVCQlvsleKPDNVTLirdydpSLPELAH---DPDQIEQVLLNITRNALQALGETGGtitlrtrtaFQVT 271
Cdd:PRK10549 318 LEVAGgafrERFAS-----RGLTLQL------SLPDSATvfgDPDRLMQLFNNLLENSLRYTDSGGS---------LHIS 377
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488141943 272 LHGMRYRLAarIDIEDDGPGV-PTQLQDTV--FYPMVSGR---EGGTGLGLSIARNLIDQHSGKI 330
Cdd:PRK10549 378 AEQRDKTLR--LTFADSAPGVsDEQLQKLFerFYRTEGSRnraSGGSGLGLAICLNIVEAHNGRI 440
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
81-349 |
3.23e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 47.69 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 81 VTLVVDGRAHILSLTAQSLAEGFILLELAPMDNQRRLSQEQLQHAQQVA-------ARDLVRGLAHEiknpLGGLRGAAQ 153
Cdd:COG4585 2 LALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAReeerrriARELHDGVGQS----LSAIKLQLE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 154 LLAKALP--DPALLEYTQVIIEQADR----LRNLVDRLLGPQRPGQHITQSIHQVAERVCQLVSLEkpdnVTLirDYDPS 227
Cdd:COG4585 78 AARRLLDadPEAAREELEEIRELAREalaeLRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIR----VEL--DVDGD 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 228 LPELahdPDQIEQVLLNITRNALqalgetggTITLR--TRTAFQVTLHGMRYRLaaRIDIEDDGPGVPTQlqdtvfypmv 305
Cdd:COG4585 152 PDRL---PPEVELALYRIVQEAL--------TNALKhaGATRVTVTLEVDDGEL--TLTVRDDGVGFDPE---------- 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 488141943 306 sgREGGTGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLPIRQ 349
Cdd:COG4585 209 --AAPGGGLGLRGMRERAEALGGTLTIGSAPGGgTRVRATLPLAA 251
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
282-345 |
4.63e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 45.70 E-value: 4.63e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488141943 282 RIDIEDDGPGVPTQLQDTVFYPMVSGREG--GTGLGLSIARNLIDQHSGKIEFNSWP-GHTEFSVYL 345
Cdd:cd16954 69 HLIVDDDGPGVPESQRSKIFQRGQRLDEQrpGQGLGLAIAKEIVEQYGGELSLSDSPlGGARFEVVF 135
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
310-346 |
4.66e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 44.68 E-value: 4.66e-06
10 20 30
....*....|....*....|....*....|....*..
gi 488141943 310 GGTGLGLSIARNLIDQHSGKIEFNSWPGHTEFSVYLP 346
Cdd:cd16923 66 EGAGLGLSIAKAIIELHGGSASAEYDDNHDLFKVRLP 102
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
282-336 |
5.76e-06 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 47.71 E-value: 5.76e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 282 RIDIEDDGPGVPTQLQDTVFypmVSGREG-----GTGLGLSIARNLIDQHSGKIEFNSWP 336
Cdd:PRK10815 410 HIVVEDDGPGIPESKRELIF---DRGQRAdtlrpGQGLGLSVAREITEQYEGKISAGDSP 466
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-337 |
1.98e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 43.22 E-value: 1.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 234 DPDQIEQVLLNITRNALqALGETGGTITLRTRTAFQvtlhgmryrlAARIDIEDDGPGVPTQLQDTVF-----YPMVSGR 308
Cdd:cd16945 1 DPFLLRQAINNLLDNAI-DFSPEGGLIALQLEADTE----------GIELLVFDEGSGIPDYALNRVFerfysLPRPHSG 69
|
90 100
....*....|....*....|....*....
gi 488141943 309 EGGTGLGLSIARNLIDQHSGKIEFNSWPG 337
Cdd:cd16945 70 QKSTGLGLAFVQEVAQLHGGRITLRNRPD 98
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
8-349 |
2.18e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 46.05 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 8 DAGQILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVLMRESLQAGQGFTDNEVTLVVDG 87
Cdd:COG3920 173 AAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGR 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 88 RAHILSLTAQSLAEGFILLELAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLAKALPDPALLEY 167
Cdd:COG3920 253 LLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHHRVKNNLQVVSSLLRLQARRADDPEAREA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 168 TQVIIeqaDRLR--NLVDRLLGPQRPGQHItqSIHQVAERVCQ-LVSLEKPDNVTLIRDydpsLPELAHDPDQIEQV--L 242
Cdd:COG3920 333 LEESQ---NRIQalALVHELLYQSEDWEGV--DLRDYLRELLEpLRDSYGGRGIRIELD----GPDVELPADAAVPLglI 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 243 LN--ITrNALQ--ALGETGGTITLRtrtafqVTLHGMRYRLaariDIEDDGPGVPTQLQdtvfypmvsgREGGTGLGLSI 318
Cdd:COG3920 404 LNelVT-NALKhaFLSGEGGRIRVS------WRREDGRLRL----TVSDNGVGLPEDVD----------PPARKGLGLRL 462
|
330 340 350
....*....|....*....|....*....|.
gi 488141943 319 ARNLIDQHSGKIEFNSWPGhTEFSVYLPIRQ 349
Cdd:COG3920 463 IRALVRQLGGTLELDRPEG-TRVRITFPLAE 492
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
11-56 |
3.33e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 41.23 E-value: 3.33e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 488141943 11 QILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLL 56
Cdd:smart00091 5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI 50
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
11-96 |
2.25e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 40.09 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 11 QILNTLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLL--GYFSLNIVLMRESLQAGQGFTDNEVTLVV-DG 87
Cdd:pfam00989 5 AILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIpeEDDAEVAELLRQALLQGEESRGFEVSFRVpDG 84
|
....*....
gi 488141943 88 RAHILSLTA 96
Cdd:pfam00989 85 RPRHVEVRA 93
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
16-102 |
2.94e-04 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 39.54 E-value: 2.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 16 LINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPDLLGYFSLNIVL--MRESLQAGQGFTDNEVTLVVDGRAHILS 93
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRerLENLLSGGEPVTLEVRLRRKDGSVIWVL 80
|
....*....
gi 488141943 94 LTAQSLAEG 102
Cdd:cd00130 81 VSLTPIRDE 89
|
|
| Phage_TAC_11 |
pfam11836 |
Phage tail tube protein, GTA-gp10; This is a family of phage tail tube proteins. |
80-173 |
3.48e-03 |
|
Phage tail tube protein, GTA-gp10; This is a family of phage tail tube proteins.
Pssm-ID: 432115 Cd Length: 97 Bit Score: 36.40 E-value: 3.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 80 EVTLVVDGRAHILSLTAQSLAEGFILLELAPMDNQRRLSQEQLqhaqqvAARDLVRGLAHeiknplgGLRGA------AQ 153
Cdd:pfam11836 3 EVTLFFGGRERTLRLTLGALAELEEALGAGLGALVERFAAGRL------SARDLLELIRA-------GLIGGgmtpseAD 69
|
90 100
....*....|....*....|
gi 488141943 154 LLAKALPDPALLEYTQVIIE 173
Cdd:pfam11836 70 VLVAAYAGGPLAEVAPIAAA 89
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
7.96e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 35.72 E-value: 7.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488141943 238 IEQVLlnitRNALQALGEtGGTITLRT-RTAFQVTLHgmryrlaaridIEDDGPGVPTQLQDTVFYPMVSGREG-----G 311
Cdd:cd16948 10 IGQIV----SNALKYSKQ-GGKIEIYSeTNEQGVVLS-----------IKDFGIGIPEEDLPRVFDKGFTGENGrnfqeS 73
|
90 100 110
....*....|....*....|....*....|....*.
gi 488141943 312 TGLGLSIARNLIDQHSGKIEFNSWPGH-TEFSVYLP 346
Cdd:cd16948 74 TGMGLYLVKKLCDKLGHKIDVESEVGEgTTFTITFP 109
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
11-68 |
9.49e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 34.45 E-value: 9.49e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 488141943 11 QILNTLINSILLLDDDLAIHYANPAAQQLL-AQSSRKLFGTPLPDLLGYFSLNIVLMRE 68
Cdd:pfam13188 5 ALFESSPDGILVLDEGGRIIYVNPAALELLgYELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| |
