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Conserved domains on  [gi|487859046|ref|WP_001932512|]
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MULTISPECIES: Tol-Pal system beta propeller repeat protein TolB [Vibrio]

Protein Classification

Tol-Pal system beta propeller repeat protein TolB( domain architecture ID 11495503)

Tol-Pal system beta propeller repeat protein TolB is part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Gene Ontology:  GO:0042597|GO:0007049|GO:0017038|GO:0051301
PubMed:  32152098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 7-438 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 590.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046    7 FSNIANAALELVITDGIDSARPIAIVPFKWEGATKLP----EDVSAVIASDLQRSGKFSPVPTSKMPQTPYSEEQVNFGK 82
Cdd:TIGR02800   3 VSTPAAADLTIEITKGGASALPIAVAPFSNDGGGSPDanlgESIAEVIANDLKRSGLFSPVDKAGLPSNPIAESQVNPAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046   83 WTSMGVDSLLTGTITQNAEGSYVISYQLVDIVRGQLtqgqskalsqdgqlvlskdhVLFNKVATVPASRMREYAHRIADL 162
Cdd:TIGR02800  83 WQALGADALVVGSVTPNGNGRYTVRFRLYDVVSGQL--------------------QLLGKQYTVTASQLRRVAHRIADA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  163 VYEELTGERGAFLTRIAYVVVNDKdPYPYQLRIADYDGYNERLVLRSKQPLMSPAWSPDGQTLAYVSFQNGQAEIYMMNI 242
Cdd:TIGR02800 143 IYEKLTGERGAFSTRIAYVSKSGK-SRRYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDL 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  243 YSGKREKLTSFPRHNGAPRFSPDGKTLALVLSKTGNLQVYTMDLATRRLTEVTSGRSNNTEPFWHPDGKSLIFTSDRGGK 322
Cdd:TIGR02800 222 ATGQREKVASFPGMNGAPAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGS 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  323 PQIYQVNLSGGETKRLTWQGSQNLGGQITPDGKFLVMVNRSDSGFNLAKQDLETGAMQILTKTLLDESPSIAPNGGMVIY 402
Cdd:TIGR02800 302 PQIYMMDADGGEVRRLTFRGGYNASPSWSPDGDLIAFVHREGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILY 381

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 487859046  403 SSIYNKANVLSMVSIDGRFKARLPATNGRVRAPAWS 438
Cdd:TIGR02800 382 ATTRGGRGVLGLVSTDGRFRARLPLGNGDVREPAWS 417
 
Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 7-438 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 590.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046    7 FSNIANAALELVITDGIDSARPIAIVPFKWEGATKLP----EDVSAVIASDLQRSGKFSPVPTSKMPQTPYSEEQVNFGK 82
Cdd:TIGR02800   3 VSTPAAADLTIEITKGGASALPIAVAPFSNDGGGSPDanlgESIAEVIANDLKRSGLFSPVDKAGLPSNPIAESQVNPAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046   83 WTSMGVDSLLTGTITQNAEGSYVISYQLVDIVRGQLtqgqskalsqdgqlvlskdhVLFNKVATVPASRMREYAHRIADL 162
Cdd:TIGR02800  83 WQALGADALVVGSVTPNGNGRYTVRFRLYDVVSGQL--------------------QLLGKQYTVTASQLRRVAHRIADA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  163 VYEELTGERGAFLTRIAYVVVNDKdPYPYQLRIADYDGYNERLVLRSKQPLMSPAWSPDGQTLAYVSFQNGQAEIYMMNI 242
Cdd:TIGR02800 143 IYEKLTGERGAFSTRIAYVSKSGK-SRRYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDL 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  243 YSGKREKLTSFPRHNGAPRFSPDGKTLALVLSKTGNLQVYTMDLATRRLTEVTSGRSNNTEPFWHPDGKSLIFTSDRGGK 322
Cdd:TIGR02800 222 ATGQREKVASFPGMNGAPAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGS 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  323 PQIYQVNLSGGETKRLTWQGSQNLGGQITPDGKFLVMVNRSDSGFNLAKQDLETGAMQILTKTLLDESPSIAPNGGMVIY 402
Cdd:TIGR02800 302 PQIYMMDADGGEVRRLTFRGGYNASPSWSPDGDLIAFVHREGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILY 381

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 487859046  403 SSIYNKANVLSMVSIDGRFKARLPATNGRVRAPAWS 438
Cdd:TIGR02800 382 ATTRGGRGVLGLVSTDGRFRARLPLGNGDVREPAWS 417
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 269-429 3.62e-50

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 167.16  E-value: 3.62e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 269 LALVLSKTGNLQVYTMDLATRRLTEVTSGRSNNTEPFWHPDGKSLIFTSDRGGKPQIYQVNLSGGETKRLTWQGSQNLGG 348
Cdd:COG0823    1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 349 QITPDGKFLVMVNRSDSGFNLAKQDLETGAMQILTKTLLdeSPSIAPNGGMVIYSSIYNKANVLSMVSIDGRfKARLPAT 428
Cdd:COG0823   81 SWSPDGKRLAFVSRSDGRFDIYVLDLDGGAPRRLTDGPG--SPSWSPDGRRIVFSSDRGGRPDLYVVDLDGR-KRRLTPA 157


                 .
gi 487859046 429 N 429
Cdd:COG0823  158 S 158
TolB_N pfam04052
TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent ...
 15-119 1.18e-42

TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.


Pssm-ID: 461148  Cd Length: 105  Bit Score: 145.84  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046   15 LELVITDGIDSARPIAIVPFKWEGATKLPEDVSAVIASDLQRSGKFSPVPTSKMPQTPYSEEQVNFGKWTSMGVDSLLTG 94
Cdd:pfam04052   1 LRIEITGGGDTALPIAVVPFQGEGGADLPQDISEVIAADLERSGLFRPIDPAAFPQRPTSDSEVDFADWRALGADALVTG 80

                          90       100
                  ....*....|....*....|....*
gi 487859046   95 TITQNAEGSYVISYQLVDIVRGQLT 119
Cdd:pfam04052  81 SVTRGGDGRYKVEFRLYDVVKGKQL 105
tolB PRK01029
Tol-Pal system protein TolB;
103-440 2.66e-25

Tol-Pal system protein TolB;


Pssm-ID: 234889 [Multi-domain]  Cd Length: 428  Bit Score: 107.15  E-value: 2.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 103 SYVISYQLVDIVRGQLTQGQSkaLSQDGQLVLSKDhvlfnkvatvpASRMREYAHRIADLVYEELTGERGAFLTRIAYVV 182
Cdd:PRK01029  87 FIFIEAHYPELVFSLKKEGKN--PQKLFSLELSGD-----------LSKDRQKIHEAADTIHYALTGVPGISSGKIIFSL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 183 --VNDKDPYPY-QLRIADYDGYNERLVLRSKQPLMSPAWSPDGQTLA--YVSFQNGQAEIYMMNIYSGKREKLTSFPRHN 257
Cdd:PRK01029 154 stTNSDTELKQgELWSVDYDGQNLRPLTQEHSLSITPTWMHIGSGFPylYVSYKLGVPKIFLGSLENPAGKKILALQGNQ 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 258 GAPRFSPDGKTLALVLSKTGN--LQVYTMDLAT------RRLTEVTSGRSNNtePFWHPDGKSLIFTSDRGGKPQIYQVN 329
Cdd:PRK01029 234 LMPTFSPRKKLLAFISDRYGNpdLFIQSFSLETgaigkpRRLLNEAFGTQGN--PSFSPDGTRLVFVSNKDGRPRIYIMQ 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 330 LS-GGETKRL-TWQGSQNLGGQITPDGKFLVMVNRSDSGFNLAKQDLETGAMQILTKTLLD-ESPSIAPNGGMVIYSSIY 406
Cdd:PRK01029 312 IDpEGQSPRLlTKKYRNSSCPAWSPDGKKIAFCSVIKGVRQICVYDLATGRDYQLTTSPENkESPSWAIDSLHLVYSAGN 391

                        330       340       350
                 ....*....|....*....|....*....|....
gi 487859046 407 NKANVLSMVSIDGRFKARLPATNGRVRAPAWSPF 440
Cdd:PRK01029 392 SNESELYLISLITKKTRKIVIGSGEKRFPSWGAF 425
 
Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 7-438 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 590.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046    7 FSNIANAALELVITDGIDSARPIAIVPFKWEGATKLP----EDVSAVIASDLQRSGKFSPVPTSKMPQTPYSEEQVNFGK 82
Cdd:TIGR02800   3 VSTPAAADLTIEITKGGASALPIAVAPFSNDGGGSPDanlgESIAEVIANDLKRSGLFSPVDKAGLPSNPIAESQVNPAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046   83 WTSMGVDSLLTGTITQNAEGSYVISYQLVDIVRGQLtqgqskalsqdgqlvlskdhVLFNKVATVPASRMREYAHRIADL 162
Cdd:TIGR02800  83 WQALGADALVVGSVTPNGNGRYTVRFRLYDVVSGQL--------------------QLLGKQYTVTASQLRRVAHRIADA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  163 VYEELTGERGAFLTRIAYVVVNDKdPYPYQLRIADYDGYNERLVLRSKQPLMSPAWSPDGQTLAYVSFQNGQAEIYMMNI 242
Cdd:TIGR02800 143 IYEKLTGERGAFSTRIAYVSKSGK-SRRYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDL 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  243 YSGKREKLTSFPRHNGAPRFSPDGKTLALVLSKTGNLQVYTMDLATRRLTEVTSGRSNNTEPFWHPDGKSLIFTSDRGGK 322
Cdd:TIGR02800 222 ATGQREKVASFPGMNGAPAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGS 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  323 PQIYQVNLSGGETKRLTWQGSQNLGGQITPDGKFLVMVNRSDSGFNLAKQDLETGAMQILTKTLLDESPSIAPNGGMVIY 402
Cdd:TIGR02800 302 PQIYMMDADGGEVRRLTFRGGYNASPSWSPDGDLIAFVHREGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILY 381

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 487859046  403 SSIYNKANVLSMVSIDGRFKARLPATNGRVRAPAWS 438
Cdd:TIGR02800 382 ATTRGGRGVLGLVSTDGRFRARLPLGNGDVREPAWS 417
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 269-429 3.62e-50

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 167.16  E-value: 3.62e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 269 LALVLSKTGNLQVYTMDLATRRLTEVTSGRSNNTEPFWHPDGKSLIFTSDRGGKPQIYQVNLSGGETKRLTWQGSQNLGG 348
Cdd:COG0823    1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 349 QITPDGKFLVMVNRSDSGFNLAKQDLETGAMQILTKTLLdeSPSIAPNGGMVIYSSIYNKANVLSMVSIDGRfKARLPAT 428
Cdd:COG0823   81 SWSPDGKRLAFVSRSDGRFDIYVLDLDGGAPRRLTDGPG--SPSWSPDGRRIVFSSDRGGRPDLYVVDLDGR-KRRLTPA 157


                 .
gi 487859046 429 N 429
Cdd:COG0823  158 S 158
TolB_N pfam04052
TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent ...
 15-119 1.18e-42

TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.


Pssm-ID: 461148  Cd Length: 105  Bit Score: 145.84  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046   15 LELVITDGIDSARPIAIVPFKWEGATKLPEDVSAVIASDLQRSGKFSPVPTSKMPQTPYSEEQVNFGKWTSMGVDSLLTG 94
Cdd:pfam04052   1 LRIEITGGGDTALPIAVVPFQGEGGADLPQDISEVIAADLERSGLFRPIDPAAFPQRPTSDSEVDFADWRALGADALVTG 80

                          90       100
                  ....*....|....*....|....*
gi 487859046   95 TITQNAEGSYVISYQLVDIVRGQLT 119
Cdd:pfam04052  81 SVTRGGDGRYKVEFRLYDVVKGKQL 105
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 178-336 3.16e-41

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 144.04  E-value: 3.16e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 178 IAYVVVNDKDPypyQLRIADYDGYNERLVLRSKQPLMSPAWSPDGQTLAYVSFQNGQAEIYMMNIYSGKREKLTSFPRHN 257
Cdd:COG0823    1 LAFTLSRDGNS---DIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYN 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487859046 258 GAPRFSPDGKTLALVLSKTGNLQVYTMDLATRRLTEVTSGRSNntePFWHPDGKSLIFTSDRGGKPQIYQVNLSGGETK 336
Cdd:COG0823   78 ASPSWSPDGKRLAFVSRSDGRFDIYVLDLDGGAPRRLTDGPGS---PSWSPDGRRIVFSSDRGGRPDLYVVDLDGRKRR 153
tolB PRK01029
Tol-Pal system protein TolB;
103-440 2.66e-25

Tol-Pal system protein TolB;


Pssm-ID: 234889 [Multi-domain]  Cd Length: 428  Bit Score: 107.15  E-value: 2.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 103 SYVISYQLVDIVRGQLTQGQSkaLSQDGQLVLSKDhvlfnkvatvpASRMREYAHRIADLVYEELTGERGAFLTRIAYVV 182
Cdd:PRK01029  87 FIFIEAHYPELVFSLKKEGKN--PQKLFSLELSGD-----------LSKDRQKIHEAADTIHYALTGVPGISSGKIIFSL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 183 --VNDKDPYPY-QLRIADYDGYNERLVLRSKQPLMSPAWSPDGQTLA--YVSFQNGQAEIYMMNIYSGKREKLTSFPRHN 257
Cdd:PRK01029 154 stTNSDTELKQgELWSVDYDGQNLRPLTQEHSLSITPTWMHIGSGFPylYVSYKLGVPKIFLGSLENPAGKKILALQGNQ 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 258 GAPRFSPDGKTLALVLSKTGN--LQVYTMDLAT------RRLTEVTSGRSNNtePFWHPDGKSLIFTSDRGGKPQIYQVN 329
Cdd:PRK01029 234 LMPTFSPRKKLLAFISDRYGNpdLFIQSFSLETgaigkpRRLLNEAFGTQGN--PSFSPDGTRLVFVSNKDGRPRIYIMQ 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 330 LS-GGETKRL-TWQGSQNLGGQITPDGKFLVMVNRSDSGFNLAKQDLETGAMQILTKTLLD-ESPSIAPNGGMVIYSSIY 406
Cdd:PRK01029 312 IDpEGQSPRLlTKKYRNSSCPAWSPDGKKIAFCSVIKGVRQICVYDLATGRDYQLTTSPENkESPSWAIDSLHLVYSAGN 391

                        330       340       350
                 ....*....|....*....|....*....|....
gi 487859046 407 NKANVLSMVSIDGRFKARLPATNGRVRAPAWSPF 440
Cdd:PRK01029 392 SNESELYLISLITKKTRKIVIGSGEKRFPSWGAF 425
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 168-375 5.91e-24

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 105.12  E-value: 5.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  168 TGERGAFLTR--IAYVVVNDKDPYpyqlRIADYDGYNERlvlrskqplmSPAWSPDGQTLAYVSFQNGQAEIYMMNIY-S 244
Cdd:COG4946   312 DGKRVAFEARgeVFTVPAEKGPTR----NLTNTPGVRER----------LPAWSPDGKSIAYFSDASGEYELYIAPADgS 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  245 GKREKLTSF-PRHNGAPRFSPDGKTLALVlSKTGNLQVYtmDLATRRLTEVTSGRSN--NTEPFWHPDGKSLIFT-SDRG 320
Cdd:COG4946   378 GEPKQLTLGdLGRVFNPVWSPDGKKIAFT-DNRGRLWVV--DLASGKVRKVDTDGYGdgISDLAWSPDSKWLAYSkPGPN 454

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 487859046  321 GKPQIYQVNLSGGETKRLTWQGSQNLGGQITPDGKFLVMVnrSDSGFNLAKQDLE 375
Cdd:COG4946   455 QLSQIFLYDVETGKTVQLTDGRYDDGSPAFSPDGKYLYFL--SSRDFNPTYGDLD 507
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 177-337 4.43e-22

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 99.34  E-value: 4.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  177 RIAYVvvNDKDPYpYQLRIADYDGYNERLVLRSKQPL--MSPAWSPDGQTLAYVSfqNGQaEIYMMNIYSGKREKLTS-- 252
Cdd:COG4946   356 SIAYF--SDASGE-YELYIAPADGSGEPKQLTLGDLGrvFNPVWSPDGKKIAFTD--NRG-RLWVVDLASGKVRKVDTdg 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  253 FPRHNGAPRFSPDGKTLALVLSKTGNL-QVYTMDLATRRLTEVTSGRSNNTEPFWHPDGKSLIFTSDRGGKPQIYQVNLS 331
Cdd:COG4946   430 YGDGISDLAWSPDSKWLAYSKPGPNQLsQIFLYDVETGKTVQLTDGRYDDGSPAFSPDGKYLYFLSSRDFNPTYGDLDFD 509


                  ....*.
gi 487859046  332 GGETKR 337
Cdd:COG4946   510 LAFPRT 515
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 250-371 3.48e-19

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 90.48  E-value: 3.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  250 LTSFPRHNGAPRFSPDGKTLALVLSKTGNLQVYTMDLAT---RRLT-----EVTSGrsnntepfWHPDGKSLIFTSDRGG 321
Cdd:COG4946    56 LTSHPGYESFPRFSPDGKWIAFTSDYDGNTDVYVMPAEGgepKRLTyhpanDRVVG--------WTPDGKSVLFASNRGS 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 487859046  322 KP----QIYQVNLSGGETKRLTW-QGSQnlgGQITPDGKFLVmVNRSDSGFNLAK 371
Cdd:COG4946   128 PPsrsnQLYTVPVDGGLPERLPLpPAGD---GSFSPDGKKLA-YTRIGREFRTWK 178
tolB PRK04043
Tol-Pal system protein TolB;
216-437 1.55e-15

Tol-Pal system protein TolB;


Pssm-ID: 235212 [Multi-domain]  Cd Length: 419  Bit Score: 78.11  E-value: 1.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 216 PAWSPDGQT-LAYVSFQNGQAEIYMMNIYSGKREKLTSfprHNG---APRFSPDGKTLALVLSKTGNLQVYTMDLATRRL 291
Cdd:PRK04043 193 PKWANKEQTaFYYTSYGERKPTLYKYNLYTGKKEKIAS---SQGmlvVSDVSKDGSKLLLTMAPKGQPDIYLYDTNTKTL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 292 TEVTSGR----SNNtepFWHpDGKSLIFTSDRGGKPQIYQVNLSGGETKRLTWQGSQNLGgqITPDGKFLVMVNR----- 362
Cdd:PRK04043 270 TQITNYPgidvNGN---FVE-DDKRIVFVSDRLGYPNIFMKKLNSGSVEQVVFHGKNNSS--VSTYKNYIVYSSRetnne 343

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487859046 363 -SDSGFNLAKQDLETGAMQILTKTLLDESPSIAPNGGMVIYSSIYNKANVLSMVSIDGRFKARLPATNGRVRAPAW 437
Cdd:PRK04043 344 fGKNTFNLYLISTNSDYIRRLTANGVNQFPRFSSDGGSIMFIKYLGNQSALGIIRLNYNKSFLFPLKVGKIQSIDW 419
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 221-439 1.33e-14

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 76.23  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  221 DGQTLAYvsfQNGqAEIYMMNIYSGKREKLT---SFPRHNGAPRF------------SPDGKTLALVLSktGnlQVYTM- 284
Cdd:COG4946   257 DGGRIVY---EQG-GDLYLLDLASGEPRKLNitlAGDFPQRRPRWvdvsgyltsfalSPDGKRVAFEAR--G--EVFTVp 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  285 --DLATRRLTEvTSGrSNNTEPFWHPDGKSLIFTSDRGGKPQIYQVNLSG-GETKRLTWQGS-QNLGGQITPDGKFLVMV 360
Cdd:COG4946   329 aeKGPTRNLTN-TPG-VRERLPAWSPDGKSIAYFSDASGEYELYIAPADGsGEPKQLTLGDLgRVFNPVWSPDGKKIAFT 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  361 NRsdsGFNLAKQDLETGAM-QILTKTLLDESPSIA--PNGGMVIYS-SIYNKANVLSMVSIDGrfKARLPATNGRVRA-- 434
Cdd:COG4946   407 DN---RGRLWVVDLASGKVrKVDTDGYGDGISDLAwsPDSKWLAYSkPGPNQLSQIFLYDVET--GKTVQLTDGRYDDgs 481


                  ....*
gi 487859046  435 PAWSP 439
Cdd:COG4946   482 PAFSP 486
WD40 COG2319
WD40 repeat [General function prediction only];
217-439 1.34e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 1.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 217 AWSPDGQTLAYVSfQNGQAEIYmmNIYSGKRekLTSFPRHNGAPR---FSPDGKTLAlVLSKTGNLQVYtmDLATRRLTE 293
Cdd:COG2319  169 AFSPDGKLLASGS-DDGTVRLW--DLATGKL--LRTLTGHTGAVRsvaFSPDGKLLA-SGSADGTVRLW--DLATGKLLR 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 294 VTSGRSNN-TEPFWHPDGKsLIFTSDRGGKPQIYQVNlSGGETKRLTWQGSQNLGGQITPDGKFLVMVNRSDSgfnlAKQ 372
Cdd:COG2319  241 TLTGHSGSvRSVAFSPDGR-LLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT----VRL 314

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487859046 373 -DLETGAmqiLTKTLLDESP---SIA--PNGGMVIYSSIYNKANVLSMVSidGRFKARLPATNGRVRAPAWSP 439
Cdd:COG2319  315 wDLATGK---LLRTLTGHTGavrSVAfsPDGKTLASGSDDGTVRLWDLAT--GELLRTLTGHTGAVTSVAFSP 382
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 214-439 1.88e-14

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 75.85  E-value: 1.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  214 MSPAWSPDGQTLAYVSFQNGQAEIYMMNIYSG--KRekLT--------------------------SFPRHN-------- 257
Cdd:COG4946    64 SFPRFSPDGKWIAFTSDYDGNTDVYVMPAEGGepKR--LTyhpandrvvgwtpdgksvlfasnrgsPPSRSNqlytvpvd 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  258 -GAPR-----------FSPDGKTLALVLSKTG-----------NLQVYTMDLATRRLTEVTSGRSNNTEPFWHPDgkSLI 314
Cdd:COG4946   142 gGLPErlplppagdgsFSPDGKKLAYTRIGREfrtwkryrggtAGDIWIYDLGTGEFTRLTDFGGNDRNPMWIGD--RIY 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  315 FTSDRGGKPQIYQVNLSGGETKRLTW-------------------QGSQ------------------------------N 345
Cdd:COG4946   220 FLSDRDGTFNLYSYDPDGKDLRQLTHfkdfdvrfpstdggrivyeQGGDlylldlasgeprklnitlagdfpqrrprwvD 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  346 LGGQIT-----PDGKFLVMVNRSDSgFNLAKQDLETGAmqiLTKT--LLDESPSIAPNGGMVIYSS-------IYnkanv 411
Cdd:COG4946   300 VSGYLTsfalsPDGKRVAFEARGEV-FTVPAEKGPTRN---LTNTpgVRERLPAWSPDGKSIAYFSdasgeyeLY----- 370

                         330       340       350
                  ....*....|....*....|....*....|
gi 487859046  412 lsMVSIDGRFKAR-LPATN-GRVRAPAWSP 439
Cdd:COG4946   371 --IAPADGSGEPKqLTLGDlGRVFNPVWSP 398
WD40 COG2319
WD40 repeat [General function prediction only];
217-439 2.63e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 2.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 217 AWSPDGQTLAYVSFQNgqaEIYMMNIYSGKRekLTSFPRHNGAPR---FSPDGKTLAlVLSKTGNLQVYtmDLATRRLTE 293
Cdd:COG2319  127 AFSPDGKTLASGSADG---TVRLWDLATGKL--LRTLTGHSGAVTsvaFSPDGKLLA-SGSDDGTVRLW--DLATGKLLR 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 294 VTSGRSNNTEPF-WHPDGKsLIFTSDRGGKPQIYQVNlSGGETKRLTWQGSQNLGGQITPDGKFLVmvnrSDSGFNLAKQ 372
Cdd:COG2319  199 TLTGHTGAVRSVaFSPDGK-LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLA----SGSADGTVRL 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 373 -DLETGAMQILTKTLLDESPSIA--PNGGMVIYSSIYNKANVLSMVSidGRFKARLPATNGRVRAPAWSP 439
Cdd:COG2319  273 wDLATGELLRTLTGHSGGVNSVAfsPDGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSP 340
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 289-438 4.94e-13

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 71.22  E-value: 4.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  289 RRLTevtSGRSNNTEPFWHPDGKSLIFTSDRGGKPQIYQVNLSGGETKRLTWQGSQN--LGgqITPDGKFLVMVNRSDSG 366
Cdd:COG4946    54 RRLT---SHPGYESFPRFSPDGKWIAFTSDYDGNTDVYVMPAEGGEPKRLTYHPANDrvVG--WTPDGKSVLFASNRGSP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  367 FNLAKQ----DLETGamqiLTKTLLD---ESPSIAPNGGMVIYSS--------------------IYNKANvlsmvsidG 419
Cdd:COG4946   129 PSRSNQlytvPVDGG----LPERLPLppaGDGSFSPDGKKLAYTRigrefrtwkryrggtagdiwIYDLGT--------G 196

                         170
                  ....*....|....*....
gi 487859046  420 RFKaRLPATNGRVRAPAWS 438
Cdd:COG4946   197 EFT-RLTDFGGNDRNPMWI 214
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 291-327 1.13e-11

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 59.07  E-value: 1.13e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 487859046  291 LTEVTSGRSNNTEPFWHPDGKSLIFTSDRGGKPQIYQ 327
Cdd:pfam07676   1 LGRLTNTPGNETAPSWSPDGKRLAFSSDRDGKPDIYV 37
WD40 COG2319
WD40 repeat [General function prediction only];
192-358 1.17e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 192 QLRIADYDGYNERLVLR-SKQPLMSPAWSPDGQTLAYVSFqNGQAEIYmmNIYSGKRekLTSFPRHNGAPR---FSPDGK 267
Cdd:COG2319  185 TVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSA-DGTVRLW--DLATGKL--LRTLTGHSGSVRsvaFSPDGR 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 268 TLALVlSKTGNLQVYtmDLATRRLTEVTSGRSNNTEPF-WHPDGKsLIFTSDRGGKPQIYqvNLSGGETKRlTWQGSQNL 346
Cdd:COG2319  260 LLASG-SADGTVRLW--DLATGELLRTLTGHSGGVNSVaFSPDGK-LLASGSDDGTVRLW--DLATGKLLR-TLTGHTGA 332

                        170
                 ....*....|....
gi 487859046 347 GGQIT--PDGKFLV 358
Cdd:COG2319  333 VRSVAfsPDGKTLA 346
WD40 COG2319
WD40 repeat [General function prediction only];
215-358 9.83e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 9.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 215 SPAWSPDGQTLAYVSFqNGQAEIYmmNIYSGKRekLTSFPRHNGAPR---FSPDGKTLAlVLSKTGNLQVYtmDLATRRL 291
Cdd:COG2319  251 SVAFSPDGRLLASGSA-DGTVRLW--DLATGEL--LRTLTGHSGGVNsvaFSPDGKLLA-SGSDDGTVRLW--DLATGKL 322

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487859046 292 TEVTSGRSNNTEPF-WHPDGKSLIFTSDrGGKPQIYQVNlSGGETKRLTWQGSQNLGGQITPDGKFLV 358
Cdd:COG2319  323 LRTLTGHTGAVRSVaFSPDGKTLASGSD-DGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPDGRTLA 388
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
217-365 1.56e-10

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 62.23  E-value: 1.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 217 AWSPDGQTLAYVSFQNGQAEIYMMNIYSGKREKLTSFPRHNGA-PR---FSPDGKTLALVLSKTGNLQVYTMDLATRRLT 292
Cdd:COG2706  156 VFDPDGRFLYVPDLGTDRIYVYRLDPATGKLPEPPEVSLPPGSgPRhlaFHPNGRFAYVINELDSTVSVYAYDAATGTLT 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 293 E---VTSGRSNNTEPFW------HPDGKsLIFTSDRG-GKPQIYQVNLSGGetkRLTWQGSQNLGGQ------ITPDGKF 356
Cdd:COG2706  236 LiqtVSTLPEDFTGENWaadihiSPDGR-FLYVSNRGhNSIAVFAIDADGG---KLTLVGHVPTGGKwprdfaIDPDGRF 311

                        170
                 ....*....|
gi 487859046 357 LVMVN-RSDS 365
Cdd:COG2706  312 LLVANqKSDN 321
WD40 COG2319
WD40 repeat [General function prediction only];
193-439 3.33e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 3.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 193 LRIADYDGYNERLVLRSKQPLMSPAWSPDGQTLAYVSFQnGQAEIYmmNIYSGKRekLTSFPRHNGAPR---FSPDGKTL 269
Cdd:COG2319   61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD-GTVRLW--DLATGLL--LRTLTGHTGAVRsvaFSPDGKTL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 270 ALVlSKTGNLQVYtmDLATRRLTEVTSGRSNNTEPF-WHPDGKSLIfTSDRGGKPQIYQVnLSGGETKRLTWQGSQNLGG 348
Cdd:COG2319  136 ASG-SADGTVRLW--DLATGKLLRTLTGHSGAVTSVaFSPDGKLLA-SGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSV 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 349 QITPDGKFLVmvnrSDSGFNLAKQ-DLETGAmqiLTKTLLDESPSI-----APNGGMVIYSSIYNKANVLSMVSidGRFK 422
Cdd:COG2319  211 AFSPDGKLLA----SGSADGTVRLwDLATGK---LLRTLTGHSGSVrsvafSPDGRLLASGSADGTVRLWDLAT--GELL 281

                        250
                 ....*....|....*..
gi 487859046 423 ARLPATNGRVRAPAWSP 439
Cdd:COG2319  282 RTLTGHSGGVNSVAFSP 298
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 217-339 1.21e-08

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 56.56  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  217 AWSPDGQTLAYVSF--------------------------------QNGQAEIYMMNIYSGKREKLTSFPRHNGAPR--- 261
Cdd:pfam00930 107 WWSPDGSRLAFLRFdesevpiitlpyytdegpgpevreikypkagaPNPTVELFVYDLASGKTVEVVPPDDLSDADYyit 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  262 ---FSPDGKTLALVLSKTGN-LQVYTMDLATRR----LTEVTSG--RSNNTEPFWHPDGKSLIFTSDRGGKPQIYQVNLS 331
Cdd:pfam00930 187 rvkWVPDGKLLVQWLNRDQNrLKVVLCDAETGRtvviLEETSDGwvELHQDPHFIKRDGSGFLWISERDGYNHLYLYDLD 266


                  ....*...
gi 487859046  332 GGETKRLT 339
Cdd:pfam00930 267 GKSPIQLT 274
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 204-239 6.81e-07

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 45.59  E-value: 6.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 487859046  204 RLVLRSKQPLMSPAWSPDGQTLAYVSFQNGQAEIYM 239
Cdd:pfam07676   2 GRLTNTPGNETAPSWSPDGKRLAFSSDRDGKPDIYV 37
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 247-282 1.13e-06

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 44.81  E-value: 1.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 487859046  247 REKLTSFPRHNGAPRFSPDGKTLALVLSKTGNLQVY 282
Cdd:pfam07676   1 LGRLTNTPGNETAPSWSPDGKRLAFSSDRDGKPDIY 36
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
 254-385 4.20e-06

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 48.37  E-value: 4.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  254 PRHnGAprFSPDGKTLALVLSKTGNLQVYTMDLATRRLTEVT---------SGRSNNTEPFWHPDGKSLiFTSDRGGKP- 323
Cdd:pfam10282 193 PRH-LA--FHPNGKYAYVVNELSSTVTVFEYDPATGTFEELQtvstlpegfTGTNGAAAIRVSPDGKFL-YVSNRGHDSi 268

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487859046  324 QIYQVNLSGGetkRLTWQGSQNLGGQ------ITPDGKFLVMVNRSDSGFNLAKQDLETGAmqiLTKT 385
Cdd:pfam10282 269 AVFAVDEAGG---TLTLVERVSTEGDfprdfnIDPDGKFLVVANQDSDNVTVFRRDPETGK---LTLL 330
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
217-382 9.27e-04

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 41.05  E-value: 9.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 217 AWSPDGQTLaYVSFQNGQAEIYMMNIY--SGKREKLTSFPRHNGAPRF---SPDGKTLALVLSKTGNLQVYTMDlATRRL 291
Cdd:COG2706   51 ALSPDGRFL-YAVNEVDDGGVSAFRIDpaDGTLTLLNTVSSGGASPCHlsvDPDGRFLFVANYGGGSVSVFPID-ADGSL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 292 TEVTS-----GRSNNTEP---------FWHPDGKSLiFTSDRGGkPQIYQVNLSGgETKRLTWQGSQNL-GGQ------I 350
Cdd:COG2706  129 GEPVQviqheGSGPNPERqegphahsvVFDPDGRFL-YVPDLGT-DRIYVYRLDP-ATGKLPEPPEVSLpPGSgprhlaF 205

                        170       180       190
                 ....*....|....*....|....*....|..
gi 487859046 351 TPDGKFLVMVNRSDSGFNLAKQDLETGAMQIL 382
Cdd:COG2706  206 HPNGRFAYVINELDSTVSVYAYDAATGTLTLI 237
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
 176-365 4.13e-03

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 39.13  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  176 TRIAYVVVNDKDPYpyqlRIADY--DGYNERLVLRSKQPL--MSPAW---SPDGQTLAYVSFQNGQAEIYMMNIySGKRE 248
Cdd:pfam10282  48 GRTLYAVNEEGDQG----GVAAFriDPDSGALTLLNQVPTggASPCHlsvDPDGRFLFVANYHGGSVSVFPLDA-DGSLG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046  249 KLTSFPRHNGAP--------------RFSPDGKTLALVLSKTGNLQVYTMDLATRRLTEVTSGrsnNTEP-------FWH 307
Cdd:pfam10282 123 ELSQVVQHEGSGppperqesphphsvDLTPDGKFLVVPDLGTDRVRVYKLDAGGGKLTPPASV---QTPPgsgprhlAFH 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487859046  308 PDGKSLIFTSDRGGKPQIYQVNLSGGETKRL--------TWQGsQNLGGQI--TPDGKFLVMVNR-SDS 365
Cdd:pfam10282 200 PNGKYAYVVNELSSTVTVFEYDPATGTFEELqtvstlpeGFTG-TNGAAAIrvSPDGKFLYVSNRgHDS 267
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
147-364 4.51e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.52  E-value: 4.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 147 VPASRMREYAHRIADLVYEELTGERGAFLTRIAYVVVNDKDPYPYQLRIADYDGYNERLVLRSKQPLMSPA---WSPDGQ 223
Cdd:COG3391    1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADgadAGADGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859046 224 TLaYVSfQNGQAEIYMMNIYSGKREKLTSFPRHNGAPRFSPDGKTLALVLSKTGNLQVYtmDLATRR-LTEVTSGRSnnt 302
Cdd:COG3391   81 RL-YVA-NSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVI--DTATGKvVATIPVGAG--- 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487859046 303 ePFW---HPDGKSLIFTSDRGGKPQ--IYQVNLSGGETKRLTWQGSQNLGGQITPDGKFLVMVNRSD 364
Cdd:COG3391  154 -PHGiavDPDGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGS 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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