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Conserved domains on  [gi|487750873|ref|WP_001832666|]
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MULTISPECIES: multidrug-binding transcriptional regulator QacR [Terrabacteria group]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 10451972)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance; similar to Staphylococcus aureus HTH-type transcriptional regulator QacR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_5 pfam08360
QacR-like protein, C-terminal region; This family features the C-terminal region of a number ...
 57-188 2.08e-55

QacR-like protein, C-terminal region; This family features the C-terminal region of a number of proteins that bear similarity to the QacR protein, a transcriptional regulator of the TetR family. QacR is able to bind various environmental agents, which include a number of cationic lipophilic compounds, and thus regulate the transcription of QacA, a multidrug efflux pump. The C-terminal region contains the multifaceted, expansive drug-binding pocket, which is composed of several separate, but linked, binding sites.


:

Pssm-ID: 400592  Cd Length: 131  Bit Score: 171.64  E-value: 2.08e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750873   57 EESKWQEQWKKEQIKCKTNREKFYLYNELSLTtEYYYPLQNAIIEFCTEYYKTNSINEKMNKLENKYIDAYHVIFKEGNL 136
Cdd:pfam08360   1 EESKWQEKWKKEEKKYKTNTEKLYLYAELSLT-EYYYPLQNAIIEFYTEYYKTNSINEKMNKLENKYIDAYHVIFKEGIQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 487750873  137 NGEWCINDVNAVSKIAANAVNGIVTFTHEQNINERIKLMNKFSQIFLNGLSK 188
Cdd:pfam08360  80 SGEFRINNVNDVSKIAANALNGLVTFTHEQNINELIKLMNKAIQIFLNGLSK 131
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-67 1.52e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 64.92  E-value: 1.52e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487750873   4 KDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQEQWKK 67
Cdd:COG1309    8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEE 71
 
Name Accession Description Interval E-value
TetR_C_5 pfam08360
QacR-like protein, C-terminal region; This family features the C-terminal region of a number ...
 57-188 2.08e-55

QacR-like protein, C-terminal region; This family features the C-terminal region of a number of proteins that bear similarity to the QacR protein, a transcriptional regulator of the TetR family. QacR is able to bind various environmental agents, which include a number of cationic lipophilic compounds, and thus regulate the transcription of QacA, a multidrug efflux pump. The C-terminal region contains the multifaceted, expansive drug-binding pocket, which is composed of several separate, but linked, binding sites.


Pssm-ID: 400592  Cd Length: 131  Bit Score: 171.64  E-value: 2.08e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750873   57 EESKWQEQWKKEQIKCKTNREKFYLYNELSLTtEYYYPLQNAIIEFCTEYYKTNSINEKMNKLENKYIDAYHVIFKEGNL 136
Cdd:pfam08360   1 EESKWQEKWKKEEKKYKTNTEKLYLYAELSLT-EYYYPLQNAIIEFYTEYYKTNSINEKMNKLENKYIDAYHVIFKEGIQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 487750873  137 NGEWCINDVNAVSKIAANAVNGIVTFTHEQNINERIKLMNKFSQIFLNGLSK 188
Cdd:pfam08360  80 SGEFRINNVNDVSKIAANALNGLVTFTHEQNINELIKLMNKAIQIFLNGLSK 131
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-67 1.52e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 64.92  E-value: 1.52e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487750873   4 KDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQEQWKK 67
Cdd:COG1309    8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEE 71
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
7-53 4.68e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 60.50  E-value: 4.68e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 487750873    7 ILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEI 53
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-63 2.41e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 48.74  E-value: 2.41e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 487750873   7 ILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQE 63
Cdd:NF041196  11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLRE 67
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 7-63 5.12e-07

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 48.08  E-value: 5.12e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 487750873   7 ILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQE 63
Cdd:PRK10668  16 ILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGE 72
 
Name Accession Description Interval E-value
TetR_C_5 pfam08360
QacR-like protein, C-terminal region; This family features the C-terminal region of a number ...
 57-188 2.08e-55

QacR-like protein, C-terminal region; This family features the C-terminal region of a number of proteins that bear similarity to the QacR protein, a transcriptional regulator of the TetR family. QacR is able to bind various environmental agents, which include a number of cationic lipophilic compounds, and thus regulate the transcription of QacA, a multidrug efflux pump. The C-terminal region contains the multifaceted, expansive drug-binding pocket, which is composed of several separate, but linked, binding sites.


Pssm-ID: 400592  Cd Length: 131  Bit Score: 171.64  E-value: 2.08e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487750873   57 EESKWQEQWKKEQIKCKTNREKFYLYNELSLTtEYYYPLQNAIIEFCTEYYKTNSINEKMNKLENKYIDAYHVIFKEGNL 136
Cdd:pfam08360   1 EESKWQEKWKKEEKKYKTNTEKLYLYAELSLT-EYYYPLQNAIIEFYTEYYKTNSINEKMNKLENKYIDAYHVIFKEGIQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 487750873  137 NGEWCINDVNAVSKIAANAVNGIVTFTHEQNINERIKLMNKFSQIFLNGLSK 188
Cdd:pfam08360  80 SGEFRINNVNDVSKIAANALNGLVTFTHEQNINELIKLMNKAIQIFLNGLSK 131
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-67 1.52e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 64.92  E-value: 1.52e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487750873   4 KDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQEQWKK 67
Cdd:COG1309    8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEE 71
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
7-53 4.68e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 60.50  E-value: 4.68e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 487750873    7 ILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEI 53
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-63 2.41e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 48.74  E-value: 2.41e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 487750873   7 ILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQE 63
Cdd:NF041196  11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLRE 67
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 7-63 5.12e-07

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 48.08  E-value: 5.12e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 487750873   7 ILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQE 63
Cdd:PRK10668  16 ILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGE 72
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 4-54 2.97e-03

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 37.22  E-value: 2.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 487750873   4 KDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEIL 54
Cdd:PRK15008  20 KKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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