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Conserved domains on  [gi|485662414|ref|WP_001303944|]
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MULTISPECIES: T3SS effector E3 ubiquitin-protein ligase NleG [Enterobacteriaceae]

Protein Classification

DUF1076 domain-containing protein( domain architecture ID 10533987)

DUF1076 domain-containing protein similar to Escherichia coli Ecs2156

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T3SS_NleG pfam06416
Effector protein NleG; Many bacterial pathogens deliver effector proteins into host cells via ...
 94-206 1.19e-68

Effector protein NleG; Many bacterial pathogens deliver effector proteins into host cells via a type III secretion system. These effector proteins then alter the host cell's biology in ways that are advantageous to the pathogen. The NleG protein and its homologs form the largest family of effector proteins in the enterohemorrhagic Escherichia coli O157:H7, with 14 members identified in the Sakai strain alone.


:

Pssm-ID: 368893  Cd Length: 113  Bit Score: 205.67  E-value: 1.19e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485662414   94 MEQSRATPCTRQNVSSAIQNKINSHAFTVSHQDFSCHEQHLNCPITLCIPETGVFVRNAKNSEICSLYDHNALTELIRRN 173
Cdd:pfam06416   1 MLQVSSEPQSQEGARKALQDKINSCAFSVNPEEFSCPEEALTCPITLCIPETGVFVKNSENSNVCSLYDKDALSRLVREG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 485662414  174 APHPLSREPFVPEMIVSKDECHFNLIEQYFCIL 206
Cdd:pfam06416  81 APHPLSREPITPSMIVSRDECYFDTTKGNFVIK 113
 
Name Accession Description Interval E-value
T3SS_NleG pfam06416
Effector protein NleG; Many bacterial pathogens deliver effector proteins into host cells via ...
 94-206 1.19e-68

Effector protein NleG; Many bacterial pathogens deliver effector proteins into host cells via a type III secretion system. These effector proteins then alter the host cell's biology in ways that are advantageous to the pathogen. The NleG protein and its homologs form the largest family of effector proteins in the enterohemorrhagic Escherichia coli O157:H7, with 14 members identified in the Sakai strain alone.


Pssm-ID: 368893  Cd Length: 113  Bit Score: 205.67  E-value: 1.19e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485662414   94 MEQSRATPCTRQNVSSAIQNKINSHAFTVSHQDFSCHEQHLNCPITLCIPETGVFVRNAKNSEICSLYDHNALTELIRRN 173
Cdd:pfam06416   1 MLQVSSEPQSQEGARKALQDKINSCAFSVNPEEFSCPEEALTCPITLCIPETGVFVKNSENSNVCSLYDKDALSRLVREG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 485662414  174 APHPLSREPFVPEMIVSKDECHFNLIEQYFCIL 206
Cdd:pfam06416  81 APHPLSREPITPSMIVSRDECYFDTTKGNFVIK 113
 
Name Accession Description Interval E-value
T3SS_NleG pfam06416
Effector protein NleG; Many bacterial pathogens deliver effector proteins into host cells via ...
 94-206 1.19e-68

Effector protein NleG; Many bacterial pathogens deliver effector proteins into host cells via a type III secretion system. These effector proteins then alter the host cell's biology in ways that are advantageous to the pathogen. The NleG protein and its homologs form the largest family of effector proteins in the enterohemorrhagic Escherichia coli O157:H7, with 14 members identified in the Sakai strain alone.


Pssm-ID: 368893  Cd Length: 113  Bit Score: 205.67  E-value: 1.19e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485662414   94 MEQSRATPCTRQNVSSAIQNKINSHAFTVSHQDFSCHEQHLNCPITLCIPETGVFVRNAKNSEICSLYDHNALTELIRRN 173
Cdd:pfam06416   1 MLQVSSEPQSQEGARKALQDKINSCAFSVNPEEFSCPEEALTCPITLCIPETGVFVKNSENSNVCSLYDKDALSRLVREG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 485662414  174 APHPLSREPFVPEMIVSKDECHFNLIEQYFCIL 206
Cdd:pfam06416  81 APHPLSREPITPSMIVSRDECYFDTTKGNFVIK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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