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Conserved domains on  [gi|485662341|ref|WP_001303876|]
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MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Escherichia]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007814)

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0110001|GO:0090729
PubMed:  20143871|20487277|28279904|15718296

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-92 3.93e-21

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


:

Pssm-ID: 442885  Cd Length: 96  Bit Score: 79.55  E-value: 3.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485662341  4 ILWLPSARDDLRQIITYIAKE-NPPAARRLKIRIETSVLPLSEHPYLYPPSE--RVSGLREIVtHPNYIILYRVAASSIE 80
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDwGPEAAERYLDEIEEAIELLAEFPELGRPRPelRVPGLRELV-VGPYVIFYRVDDDTVE 81

                        90
                ....*....|..
gi 485662341 81 IVSVTHSRRQFP 92
Cdd:COG3668  82 ILRVLHGRRDLP 93
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-92 3.93e-21

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 79.55  E-value: 3.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485662341  4 ILWLPSARDDLRQIITYIAKE-NPPAARRLKIRIETSVLPLSEHPYLYPPSE--RVSGLREIVtHPNYIILYRVAASSIE 80
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDwGPEAAERYLDEIEEAIELLAEFPELGRPRPelRVPGLRELV-VGPYVIFYRVDDDTVE 81

                        90
                ....*....|..
gi 485662341 81 IVSVTHSRRQFP 92
Cdd:COG3668  82 ILRVLHGRRDLP 93
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 4-91 1.05e-14

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 63.22  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485662341   4 ILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTH-PNYIILYRVAASS--IE 80
Cdd:pfam05016  1 VILTPKALKDLKKIADYIAQDNPDAAERFLKALEEALELLAENPALGRPLPEGGLKGLRRIRiGDYRIIYRIDDDDlvIL 80

                         90
                 ....*....|.
gi 485662341  81 IVSVTHSRRQF 91
Cdd:pfam05016 81 ILRVGHRRRDY 91
RelE_StbE TIGR02385
addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial ...
 4-74 9.80e-05

addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 211740  Cd Length: 88  Bit Score: 37.67  E-value: 9.80e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485662341   4 ILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPlseHPYL-YPPSERVSGLREIVTHPNYIILYRV 74
Cdd:TIGR02385  2 IVYTEQFKKDLKKIKKYIRKDLPKLLEVIELLINGKPLE---RRYRdHPLTGSWKGTRECHIEPDYLLVYQV 70
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-92 3.93e-21

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 79.55  E-value: 3.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485662341  4 ILWLPSARDDLRQIITYIAKE-NPPAARRLKIRIETSVLPLSEHPYLYPPSE--RVSGLREIVtHPNYIILYRVAASSIE 80
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDwGPEAAERYLDEIEEAIELLAEFPELGRPRPelRVPGLRELV-VGPYVIFYRVDDDTVE 81

                        90
                ....*....|..
gi 485662341 81 IVSVTHSRRQFP 92
Cdd:COG3668  82 ILRVLHGRRDLP 93
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 4-91 1.05e-14

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 63.22  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485662341   4 ILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTH-PNYIILYRVAASS--IE 80
Cdd:pfam05016  1 VILTPKALKDLKKIADYIAQDNPDAAERFLKALEEALELLAENPALGRPLPEGGLKGLRRIRiGDYRIIYRIDDDDlvIL 80

                         90
                 ....*....|.
gi 485662341  81 IVSVTHSRRQF 91
Cdd:pfam05016 81 ILRVGHRRRDY 91
RelE_StbE TIGR02385
addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial ...
 4-74 9.80e-05

addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 211740  Cd Length: 88  Bit Score: 37.67  E-value: 9.80e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485662341   4 ILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPlseHPYL-YPPSERVSGLREIVTHPNYIILYRV 74
Cdd:TIGR02385  2 IVYTEQFKKDLKKIKKYIRKDLPKLLEVIELLINGKPLE---RRYRdHPLTGSWKGTRECHIEPDYLLVYQV 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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