NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|48474650|sp|Q9HDZ2|]
View 

RecName: Full=Protein cwh43

Protein Classification

Frag1/DRAM/Sfk1 family protein( domain architecture ID 10563211)

Frag1/DRAM/Sfk1 family membrane protein such as Sfk1, which may be involved in the regulation of phospholipid asymmetry across the plasma membrane

PubMed:  29540528|10585768|25929859

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Frag1 pfam10277
Frag1/DRAM/Sfk1 family; This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF ...
 14-220 5.82e-40

Frag1/DRAM/Sfk1 family; This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumour-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localization of Stt4p to the actin cytoskeleton.


:

Pssm-ID: 431193  Cd Length: 220  Bit Score: 147.40  E-value: 5.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48474650    14 YVALVHTICSFAAFFIPLALALYTHYYQVVKNEFygypEEWFPSVSAtIGDWYPERSVFQWLIALTATPRLLVLLLWFTL 93
Cdd:pfam10277   4 LLPLIAAILPLGGFIIVLIIAVVLGHVDPTFTHY----GYNFPYISD-IGAYPPESCFFSIAINIGAFLRLAVAFLRYLR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48474650    94 SGISRPS-------VIITTALGVLRTALCGGWVYVTSTDDHDWHDIFMIGYLISNAPWFILVSKCS--------PVNSMA 158
Cdd:pfam10277  79 LRPLARRservlrlNILALVFGLLGALGLSLVSNFQSTEDHSVHDIGAILFFVFGFIYMLLQTALSyrlgphytPKSRKS 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48474650   159 SRIRNIGSALFVLTIFPLIYWYIQHKFKHIPGAYTVYAFFEWSLILWDILFDSALYWDFKPL 220
Cdd:pfam10277 159 FRLKLVLLILAFVSAVAFIVFFIRHKKHCGYGAYSLSAIFEWLLALSFIFFFGTFAVDFKPI 220
ElsH COG3568
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ...
 783-858 1.25e-10

Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only];


:

Pssm-ID: 442789 [Multi-domain]  Cd Length: 167  Bit Score: 61.08  E-value: 1.25e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48474650 783 ALLSKFPIVNSTHHLLPSPQGELAPAIHATLDVYGELIDVVVSHNGqYESQLDRRLQSTELARIMRESP--RPLVFLG 858
Cdd:COG3568  48 AILSRYPIVSSGTFDLPDPGGEPRGALWADVDVPGKPLRVVNTHLD-LRSAAARRRQARALAELLAELPagAPVILAG 124
 
Name Accession Description Interval E-value
Frag1 pfam10277
Frag1/DRAM/Sfk1 family; This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF ...
 14-220 5.82e-40

Frag1/DRAM/Sfk1 family; This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumour-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localization of Stt4p to the actin cytoskeleton.


Pssm-ID: 431193  Cd Length: 220  Bit Score: 147.40  E-value: 5.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48474650    14 YVALVHTICSFAAFFIPLALALYTHYYQVVKNEFygypEEWFPSVSAtIGDWYPERSVFQWLIALTATPRLLVLLLWFTL 93
Cdd:pfam10277   4 LLPLIAAILPLGGFIIVLIIAVVLGHVDPTFTHY----GYNFPYISD-IGAYPPESCFFSIAINIGAFLRLAVAFLRYLR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48474650    94 SGISRPS-------VIITTALGVLRTALCGGWVYVTSTDDHDWHDIFMIGYLISNAPWFILVSKCS--------PVNSMA 158
Cdd:pfam10277  79 LRPLARRservlrlNILALVFGLLGALGLSLVSNFQSTEDHSVHDIGAILFFVFGFIYMLLQTALSyrlgphytPKSRKS 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48474650   159 SRIRNIGSALFVLTIFPLIYWYIQHKFKHIPGAYTVYAFFEWSLILWDILFDSALYWDFKPL 220
Cdd:pfam10277 159 FRLKLVLLILAFVSAVAFIVFFIRHKKHCGYGAYSLSAIFEWLLALSFIFFFGTFAVDFKPI 220
ElsH COG3568
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ...
 783-858 1.25e-10

Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only];


Pssm-ID: 442789 [Multi-domain]  Cd Length: 167  Bit Score: 61.08  E-value: 1.25e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48474650 783 ALLSKFPIVNSTHHLLPSPQGELAPAIHATLDVYGELIDVVVSHNGqYESQLDRRLQSTELARIMRESP--RPLVFLG 858
Cdd:COG3568  48 AILSRYPIVSSGTFDLPDPGGEPRGALWADVDVPGKPLRVVNTHLD-LRSAAARRRQARALAELLAELPagAPVILAG 124
Exo_endo_phos pfam03372
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ...
 721-858 6.95e-05

Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.


Pssm-ID: 460902 [Multi-domain]  Cd Length: 183  Bit Score: 44.52  E-value: 6.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48474650   721 MYASENRIRDAVRDMELDVFGLLESDTQRLimgfRDLTQVLAHDLGMYADYGPGPDKHTWGAALLSKFPIVNSTHHLLPS 800
Cdd:pfam03372  15 DDRKLDALAALIRAYDPDVVALQETDDDDA----SRLLLALLAYGGFLSYGGPGGGGGGGGVAILSRYPLSSVILVDLGE 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 48474650   801 ---PQGELAPAIHATLDVYGELIDVVVSHNGQYESQLDRRLQSTELARIMRESPRPLVFLG 858
Cdd:pfam03372  91 fgdPALRGAIAPFAGVLVVPLVLTLAPHASPRLARDEQRADLLLLLLALLAPRSEPVILAG 151
 
Name Accession Description Interval E-value
Frag1 pfam10277
Frag1/DRAM/Sfk1 family; This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF ...
 14-220 5.82e-40

Frag1/DRAM/Sfk1 family; This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumour-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localization of Stt4p to the actin cytoskeleton.


Pssm-ID: 431193  Cd Length: 220  Bit Score: 147.40  E-value: 5.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48474650    14 YVALVHTICSFAAFFIPLALALYTHYYQVVKNEFygypEEWFPSVSAtIGDWYPERSVFQWLIALTATPRLLVLLLWFTL 93
Cdd:pfam10277   4 LLPLIAAILPLGGFIIVLIIAVVLGHVDPTFTHY----GYNFPYISD-IGAYPPESCFFSIAINIGAFLRLAVAFLRYLR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48474650    94 SGISRPS-------VIITTALGVLRTALCGGWVYVTSTDDHDWHDIFMIGYLISNAPWFILVSKCS--------PVNSMA 158
Cdd:pfam10277  79 LRPLARRservlrlNILALVFGLLGALGLSLVSNFQSTEDHSVHDIGAILFFVFGFIYMLLQTALSyrlgphytPKSRKS 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48474650   159 SRIRNIGSALFVLTIFPLIYWYIQHKFKHIPGAYTVYAFFEWSLILWDILFDSALYWDFKPL 220
Cdd:pfam10277 159 FRLKLVLLILAFVSAVAFIVFFIRHKKHCGYGAYSLSAIFEWLLALSFIFFFGTFAVDFKPI 220
ElsH COG3568
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ...
 783-858 1.25e-10

Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only];


Pssm-ID: 442789 [Multi-domain]  Cd Length: 167  Bit Score: 61.08  E-value: 1.25e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48474650 783 ALLSKFPIVNSTHHLLPSPQGELAPAIHATLDVYGELIDVVVSHNGqYESQLDRRLQSTELARIMRESP--RPLVFLG 858
Cdd:COG3568  48 AILSRYPIVSSGTFDLPDPGGEPRGALWADVDVPGKPLRVVNTHLD-LRSAAARRRQARALAELLAELPagAPVILAG 124
Exo_endo_phos pfam03372
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ...
 721-858 6.95e-05

Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.


Pssm-ID: 460902 [Multi-domain]  Cd Length: 183  Bit Score: 44.52  E-value: 6.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48474650   721 MYASENRIRDAVRDMELDVFGLLESDTQRLimgfRDLTQVLAHDLGMYADYGPGPDKHTWGAALLSKFPIVNSTHHLLPS 800
Cdd:pfam03372  15 DDRKLDALAALIRAYDPDVVALQETDDDDA----SRLLLALLAYGGFLSYGGPGGGGGGGGVAILSRYPLSSVILVDLGE 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 48474650   801 ---PQGELAPAIHATLDVYGELIDVVVSHNGQYESQLDRRLQSTELARIMRESPRPLVFLG 858
Cdd:pfam03372  91 fgdPALRGAIAPFAGVLVVPLVLTLAPHASPRLARDEQRADLLLLLLALLAPRSEPVILAG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH