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Conserved domains on  [gi|48425317]
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Chain D, bone morphogenetic protein receptor type IA

Protein Classification

Activin_recp domain-containing protein( domain architecture ID 10471049)

Activin_recp domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_BMPR1A cd23612
extracellular domain (ECD) found in bone morphogenetic protein receptor type-1A (BMPR-1A) and ...
 40-123 1.63e-55

extracellular domain (ECD) found in bone morphogenetic protein receptor type-1A (BMPR-1A) and similar proteins; BMPR-1A (EC 2.7.11.30, also called BMP type-1A receptor, or activin receptor-like kinase 3 (ALK-3), or serine/threonine-protein kinase receptor R5 (SKR5), or CD292) on ligand binding, forms a receptor complex consisting of two type II, and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR-1A is the receptor for BMP2, BMP4, GDF5, and GDF6. It positively regulates chondrocyte differentiation through GDF5 interaction and mediates induction of adipogenesis by GDF6. This model corresponds to extracellular domain (ECD) of BMPR-1A, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467132  Cd Length: 84  Bit Score: 168.08  E-value: 1.63e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48425317  40 PFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQP 119
Cdd:cd23612   1 PFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQP 80


                ....
gi 48425317 120 TLPP 123
Cdd:cd23612  81 TLPP 84
 
Name Accession Description Interval E-value
TFP_LU_ECD_BMPR1A cd23612
extracellular domain (ECD) found in bone morphogenetic protein receptor type-1A (BMPR-1A) and ...
 40-123 1.63e-55

extracellular domain (ECD) found in bone morphogenetic protein receptor type-1A (BMPR-1A) and similar proteins; BMPR-1A (EC 2.7.11.30, also called BMP type-1A receptor, or activin receptor-like kinase 3 (ALK-3), or serine/threonine-protein kinase receptor R5 (SKR5), or CD292) on ligand binding, forms a receptor complex consisting of two type II, and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR-1A is the receptor for BMP2, BMP4, GDF5, and GDF6. It positively regulates chondrocyte differentiation through GDF5 interaction and mediates induction of adipogenesis by GDF6. This model corresponds to extracellular domain (ECD) of BMPR-1A, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467132  Cd Length: 84  Bit Score: 168.08  E-value: 1.63e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48425317  40 PFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQP 119
Cdd:cd23612   1 PFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQP 80


                ....
gi 48425317 120 TLPP 123
Cdd:cd23612  81 TLPP 84
Activin_recp pfam01064
Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor ...
 42-114 2.78e-15

Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.


Pssm-ID: 460048  Cd Length: 78  Bit Score: 65.98  E-value: 2.78e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48425317    42 LKCYCSGH-CPDDAINNTCITNGHCFAIIEEDDQGETTL-ASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCN 114
Cdd:pfam01064   1 LKCYCNPLkCNDDNVNFTCETDGQCFSSWELDTDGFIECvKKGCLSPEDDPFECKTSNKPHSLYRIECCKTDFCN 75
 
Name Accession Description Interval E-value
TFP_LU_ECD_BMPR1A cd23612
extracellular domain (ECD) found in bone morphogenetic protein receptor type-1A (BMPR-1A) and ...
 40-123 1.63e-55

extracellular domain (ECD) found in bone morphogenetic protein receptor type-1A (BMPR-1A) and similar proteins; BMPR-1A (EC 2.7.11.30, also called BMP type-1A receptor, or activin receptor-like kinase 3 (ALK-3), or serine/threonine-protein kinase receptor R5 (SKR5), or CD292) on ligand binding, forms a receptor complex consisting of two type II, and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR-1A is the receptor for BMP2, BMP4, GDF5, and GDF6. It positively regulates chondrocyte differentiation through GDF5 interaction and mediates induction of adipogenesis by GDF6. This model corresponds to extracellular domain (ECD) of BMPR-1A, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467132  Cd Length: 84  Bit Score: 168.08  E-value: 1.63e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48425317  40 PFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQP 119
Cdd:cd23612   1 PFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQP 80


                ....
gi 48425317 120 TLPP 123
Cdd:cd23612  81 TLPP 84
TFP_LU_ECD_BMPR1B cd23613
extracellular domain (ECD) found in bone morphogenetic protein receptor type-1B (BMPR-1B) and ...
 42-124 1.67e-32

extracellular domain (ECD) found in bone morphogenetic protein receptor type-1B (BMPR-1B) and similar proteins; BMPR-1B (EC 2.7.11.30, also called BMP type-1B receptor, or CDw293, or activin receptor-like kinase 6 (ALK-6)) on ligand binding forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR-1B is the receptor for BMP7/OP-1 and GDF5. It positively regulates chondrocyte differentiation through GDF5 interaction. This model corresponds to extracellular domain (ECD) of BMPR-1B, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467133  Cd Length: 86  Bit Score: 109.92  E-value: 1.67e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48425317  42 LKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCR-TNLCNQYLQPT 120
Cdd:cd23613   3 LRCHCHHHCPEDSVNNTCRTDGYCFTMIEEDESGVPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTdQDYCNKDLHPT 82


                ....
gi 48425317 121 LPPV 124
Cdd:cd23613  83 LPPL 86
TFP_LU_ECD_BMPR1 cd23532
extracellular domain (ECD) found in the family of bone morphogenetic protein receptor type-1 ...
 42-123 4.47e-26

extracellular domain (ECD) found in the family of bone morphogenetic protein receptor type-1 (BMPR1); The BMPR1 family includes BMPR-1A (also known as activin receptor-like kinase 3/ALK-3, or serine/threonine-protein kinase receptor R5/SKR5, or CD292) and BMPR-1B (also known as activin receptor-like kinase 6/ALK-6, or CDw293). They form a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR-1A is the receptor for BMP2, BMP4, GDF5, and GDF6. It positively regulates chondrocyte differentiation through GDF5 interaction and mediates induction of adipogenesis by GDF6. BMPR-1B is the receptor for BMP7/OP-1 and GDF5. It positively regulates chondrocyte differentiation through GDF5 interaction. Members in this family contain an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467062  Cd Length: 90  Bit Score: 93.56  E-value: 4.47e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48425317  42 LKCYCSGHCPDDAINNTCIT--NGHCFAIIEEDDQG---ETTLASGCMKY-EGSDFQCKDSPKA-QLRRTIECCR-TNLC 113
Cdd:cd23532   1 LRCYCNPHCPDGAVNNTCTTkpGGKCFAAIEEVEDGgekEEEVTYGCLPPeESGILQCKGHLVPhLIPKSIECCNdSDLC 80

                        90
                ....*....|
gi 48425317 114 NQYLQPTLPP 123
Cdd:cd23532  81 NDDLNPTLPE 90
Activin_recp pfam01064
Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor ...
 42-114 2.78e-15

Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.


Pssm-ID: 460048  Cd Length: 78  Bit Score: 65.98  E-value: 2.78e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48425317    42 LKCYCSGH-CPDDAINNTCITNGHCFAIIEEDDQGETTL-ASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCN 114
Cdd:pfam01064   1 LKCYCNPLkCNDDNVNFTCETDGQCFSSWELDTDGFIECvKKGCLSPEDDPFECKTSNKPHSLYRIECCKTDFCN 75
TFP_LU_ECD_Tkv cd23596
extracellular domain (ECD) found in Drosophila melanogaster receptor protein serine/threonine ...
 42-119 1.54e-14

extracellular domain (ECD) found in Drosophila melanogaster receptor protein serine/threonine kinase Thickveins and similar proteins; Thickveins (Tkv) is a decapentaplegic (dpp) type I receptor encoded by the thick veins (tkv) gene that is expressed in a highly localized and dynamic pattern during development. Thickveins is the ortholog of the human activin receptor-like kinase (ALK)-3/6. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467125  Cd Length: 88  Bit Score: 64.28  E-value: 1.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48425317  42 LKCYCSGHCPDDAINNTCITN--GHCFAIIEEDDQGET-----TLASGCM-KYEGSDFQCKD--SPKAQlRRTIECCR-T 110
Cdd:cd23596   1 LTCYCEGHCPEGVSNGTCEVKpgGKCFTAVEEVYNEETgeyepERTYGCLpPEEGGLMQCKGylVPHAI-PKSIECCNdT 79


                ....*....
gi 48425317 111 NLCNQYLQP 119
Cdd:cd23596  80 DFCNKDLFP 88
TFP_LU_ECD_Babo cd23598
extracellular domain (ECD) found in Drosophila melanogaster Baboon and similar proteins; ...
 42-115 7.28e-09

extracellular domain (ECD) found in Drosophila melanogaster Baboon and similar proteins; Baboon (Babo) is the Drosophila transforming growth factor-beta (TGF-beta)/activin-specific type I receptor that transmits signals through dSmad2. Baboon/dSmad2-mediated TGF-beta signaling is required during late larval stage for development of adult-specific neurons. In addition to dSmad2, it can Mad and bone morphogenetic protein (BMP)-specific R-Smad. Baboon is the ortholog of the human activin receptor-like kinase (ALK)-4/5/7. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467127  Cd Length: 78  Bit Score: 49.27  E-value: 7.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48425317  42 LKCYCSGhCPDDaiNNTCITNGHCFAIIEEDDQGETTLASGCMKYE-----GSDFQCKDSPKAQLRRTIECCR-TNLCNQ 115
Cdd:cd23598   1 LKCYCDI-CKKT--NYTCETDGVCFTSTSLVKNGVIEYSYRCLDKKrlfppENPLICHSSKPRNDTFVIKCCKdYDFCNR 77
TFP_LU_ECD_ALK5 cd23537
extracellular domain (ECD) found in activin receptor-like kinase 5 (ALK-5) and similar ...
 42-114 2.06e-05

extracellular domain (ECD) found in activin receptor-like kinase 5 (ALK-5) and similar proteins; ALK-5 (EC 2.7.11.30, also called TGF-beta receptor type-1 (TGFR-1), or activin A receptor type II-like protein kinase of 53kD, or serine/threonine-protein kinase receptor R4 (SKR4), or TGF-beta type I receptor, or transforming growth factor-beta receptor type I (TGFBR1), or TGF-beta receptor type I (TbetaR-I)) is the transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2, and TGFB3. It transduces the TGFB1, TGFB2, and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. This model corresponds to the extracellular domain (ECD) of ALK-5, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467067  Cd Length: 74  Bit Score: 40.09  E-value: 2.06e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48425317  42 LKCYCSgHCPDdaiNNTCITNGHCFAIIEEDDqGETTLASGCMKYE-----GSDFQCKDSPKAQLRRTIECCRTNLCN 114
Cdd:cd23537   1 LQCYCH-LCTK---NFTCVTDGLCFVSVTRST-DKVIHNSMCIAEIdliprDRPFVCAPSSKDGSSTHPYCCNTDHCN 73
TFP_LU_ECD_sma6 cd23586
extracellular domain (ECD) found in Caenorhabditis elegans serine/threonine-protein kinase ...
 42-115 9.23e-05

extracellular domain (ECD) found in Caenorhabditis elegans serine/threonine-protein kinase receptor sma-6 and similar proteins; Sma-6 (EC 2.7.11.30) is serine/threonine-protein kinase receptor that binds transforming growth factor-beta (TGF-beta)-like ligands dbl-1 and perhaps daf-7. Upon ligand binding, it probably activates a TGF-beta-like signaling pathway. Sma-6 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467116  Cd Length: 78  Bit Score: 38.54  E-value: 9.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48425317  42 LKCYC--SGHCPddAINNTCITNGHCFAIIEEDD--QGETTLASGCMKYE--GSDFQCKDspKAQLRRTIECC-RTNLCN 114
Cdd:cd23586   1 LICYCtpSDHCP--NGNKTCTTTAGCFHSIEIDGnkRMETLEQFGCFSNDrgGSHLTCNA--KRPTPSSIKCCyNGDFCN 76


                .
gi 48425317 115 Q 115
Cdd:cd23586  77 R 77
TFP_LU_ECD_ALK2 cd23535
extracellular domain (ECD) found in activin receptor-like kinase 2 (ALK-2) and similar ...
 42-115 3.85e-04

extracellular domain (ECD) found in activin receptor-like kinase 2 (ALK-2) and similar proteins; ALK-2 (EC 2.7.11.30, also called ACVRLK2, or activin receptor type-1 (ACVR1), or activin receptor type I (ACTR-I), or serine/threonine-protein kinase receptor R1 (SKR1), or TGF-B superfamily receptor type I (TSR-I)) is bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, ALK-2 forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A, or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, ALK-2 suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, it can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs. This model corresponds to the extracellular domain (ECD) of ALK-2, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467065  Cd Length: 71  Bit Score: 36.59  E-value: 3.85e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48425317  42 LKCYCSG-HCPDDainNTCitNGH-CFAIIEEDDQGETtLASGCMK-YEGSDFQCKDSPkaQLRRTIECCRTNLCNQ 115
Cdd:cd23535   1 FECVCEGsSCPGG---DRC--EGQqCFSSLSVEDGGAV-VQKGCLEgEEQGRMTCKTPP--SPDLAVECCSGHLCNA 69
TFP_LU_ECD_ALK4 cd23536
extracellular domain (ECD) found in activin receptor-like kinase 4 (ALK-4) and similar ...
 42-114 8.22e-03

extracellular domain (ECD) found in activin receptor-like kinase 4 (ALK-4) and similar proteins; ALK-4 (EC 2.7.11.30, also called ACVRLK4, or activin receptor type-1B (ACVR1B), or activin receptor type IB (ACTR-IB), or serine/threonine-protein kinase receptor R2 (SKR2)) is the transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). It transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. This model corresponds to the extracellular domain (ECD) of ALK-4, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467066  Cd Length: 77  Bit Score: 33.12  E-value: 8.22e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48425317  42 LKCYCSgHCPDdaiNNTCITNGHCFAIIEEDDQGETTLASGCMKYE-----GSDFQCKDSPKAQLRRTIECCR-TNLCN 114
Cdd:cd23536   3 LKCVCS-DCTN---NGTCETDGYCLVSITIDKDGEIKIRRTCIDKDklfppGRPFFCLSSEDLLHNSNVHCCNdEDFCN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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