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Conserved domains on  [gi|4827048|ref|NP_005139|]
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protein unc-119 homolog A isoform a [Homo sapiens]

Protein Classification

PDE6D/unc-119 family protein( domain architecture ID 10526547)

PDE6D/unc-119 family protein similar to mammalian retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) that promotes the release of prenylated target proteins from cellular membranes

Gene Ontology:  GO:0050953

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GMP_PDE_delta pfam05351
GMP-PDE, delta subunit; GMP-PDE delta subunit was originally identified as a fourth subunit of ...
 81-236 3.17e-101

GMP-PDE, delta subunit; GMP-PDE delta subunit was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase (PDE)(EC:3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.


:

Pssm-ID: 428436  Cd Length: 153  Bit Score: 290.63  E-value: 3.17e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827048     81 ENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSerlPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFR 160
Cdd:pfam05351   1 ANIYGIEFTRFKIRDADTGKVLFEIAKDPSD---PEDDDLEDENAGREVRYQFPPKFLKLKTVGATLEFSVGDEPVKNFR 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4827048    161 MIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSY 236
Cdd:pfam05351  78 MIERHYFRDQLLKSFDFEFGFCIPNSTNTWEHIYEAPPLSEQMIPEMILSPNETKSDSFYFVDNKLIMHNKARYAY 153
 
Name Accession Description Interval E-value
GMP_PDE_delta pfam05351
GMP-PDE, delta subunit; GMP-PDE delta subunit was originally identified as a fourth subunit of ...
 81-236 3.17e-101

GMP-PDE, delta subunit; GMP-PDE delta subunit was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase (PDE)(EC:3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.


Pssm-ID: 428436  Cd Length: 153  Bit Score: 290.63  E-value: 3.17e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827048     81 ENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSerlPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFR 160
Cdd:pfam05351   1 ANIYGIEFTRFKIRDADTGKVLFEIAKDPSD---PEDDDLEDENAGREVRYQFPPKFLKLKTVGATLEFSVGDEPVKNFR 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4827048    161 MIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSY 236
Cdd:pfam05351  78 MIERHYFRDQLLKSFDFEFGFCIPNSTNTWEHIYEAPPLSEQMIPEMILSPNETKSDSFYFVDNKLIMHNKARYAY 153
 
Name Accession Description Interval E-value
GMP_PDE_delta pfam05351
GMP-PDE, delta subunit; GMP-PDE delta subunit was originally identified as a fourth subunit of ...
 81-236 3.17e-101

GMP-PDE, delta subunit; GMP-PDE delta subunit was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase (PDE)(EC:3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.


Pssm-ID: 428436  Cd Length: 153  Bit Score: 290.63  E-value: 3.17e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827048     81 ENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSerlPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFR 160
Cdd:pfam05351   1 ANIYGIEFTRFKIRDADTGKVLFEIAKDPSD---PEDDDLEDENAGREVRYQFPPKFLKLKTVGATLEFSVGDEPVKNFR 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4827048    161 MIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSY 236
Cdd:pfam05351  78 MIERHYFRDQLLKSFDFEFGFCIPNSTNTWEHIYEAPPLSEQMIPEMILSPNETKSDSFYFVDNKLIMHNKARYAY 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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