|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
6-388 |
8.33e-110 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 327.14 E-value: 8.33e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 6 VEEARKIINNTNFEVKKREkdVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDYLKYG-KLRVVGKLYPNTLNI 84
Cdd:cd00887 1 VEAARELLLALAPPLGTET--VPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASvTLRVVGEIPAGEPPD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 85 PELKEGETYYVTTGSPLPTNADSVVPIENSKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGILLQQ 164
Cdd:cd00887 79 GPLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 165 QIFHINV-SDLRFTIFANGDEITSF-ENPEKNKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEISDVI 241
Cdd:cd00887 159 GIAEVPVyRRPRVAIISTGDELVEPgEPLAPGQIYDSNSYMLAALLRELGaEVVDLGIVPDDPEALREALEEALEEADVV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 242 ISIGGSSVGEKDYVKRAINKL-GEILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHEFGLSVLSNIL--SANL 318
Cdd:cd00887 239 ITSGGVSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQgaPEPE 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 478754216 319 KRFVKSALVEDIYVNHSMD-----SIYLFDVKGNSAFPLRWGVGLYSELSKANGFAILKRSVT-YKKGEEVELQLF 388
Cdd:cd00887 319 PPRVKARLAEDLKSKPGRReflrvRLERDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEgLEAGEEVEVLLL 394
|
|
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
3-388 |
3.69e-99 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 300.08 E-value: 3.69e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 3 LIPVEEARKIINNtNFEVKKREKdVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDYLKYG--KLRVVGKLYPN 80
Cdd:COG0303 1 MISVEEALALILA-AVRPLGTET-VPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANpvTLRVVGEIAAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 81 TLNIPELKEGETYYVTTGSPLPTNADSVVPIENSKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGI 160
Cdd:COG0303 79 SPPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 161 LLQQQIFHINVSD-LRFTIFANGDEITSF-ENPEKNKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEI 237
Cdd:COG0303 159 LASLGIAEVPVYRrPRVAILSTGDELVEPgEPLGPGQIYDSNSYMLAALLREAGaEVVDLGIVPDDPEALRAALREALAE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 238 SDVIISIGGSSVGEKDYVKRAINKLG-EILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHEFGLSVLSNI--L 314
Cdd:COG0303 239 ADLVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLagL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 315 SANLKRFVKSALVEDIYVNHSMDSI---YLFDVKGN-SAFPLRW-GVGLYSELSKANGFAILKRSVT-YKKGEEVELQLF 388
Cdd:COG0303 319 PPPPPPRVRARLAEDLPKKPGRTEFlrvRLERDDGElVVEPLGGqGSGLLSSLAEADGLIVLPEGVEgVEAGEEVEVLLL 398
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
2-388 |
9.79e-71 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 233.18 E-value: 9.79e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 2 TLIPVEEARKIINNTNFEVKKREKDVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDylKYG-------KLRVV 74
Cdd:PRK14498 8 TLVSLEEAREILESLLSELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAAD--TFGaseanpvRLKLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 75 GKLYPNTLNIPELKEGETYYVTTGSPLPTNADSVVPIENSKLEGEYVIfkgEIKK----GRNIRGEGEDIYAGQTIIRKG 150
Cdd:PRK14498 86 GEVHAGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEEVDDDTV---EIYRpvapGENVRPAGEDIVAGELILPKG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 151 TEVTPYHLGILLQQQIFHINVSD-LRFTIFANGDEITSF-ENPEKNKVIDSISPILI-KILEKFGSVKYMGVAKDDLNDV 227
Cdd:PRK14498 163 TRLTPRDIGALAAGGVAEVPVYKkPRVGIISTGDELVEPgEPLKPGKIYDVNSYTLAaAVEEAGGEPVRYGIVPDDEEEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 228 IGKIERSLEISDVIISIGGSSVGEKDYVKRAINKLGEILFDGVTvniIKRGS---IGRIQGKPILVLPGQVVSAITAFHE 304
Cdd:PRK14498 243 EAALRKALKECDLVLLSGGTSAGAGDVTYRVIEELGEVLVHGVA---IKPGKptiLGVIGGKPVVGLPGYPVSALTIFEE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 305 FGLSVLSNIL----------SANLKRFVKSALVEDIYVNHSMdsiyLFDVKGNSAFPLRWGVGLYSELSKANGFAILKRS 374
Cdd:PRK14498 320 FVAPLLRKLAglppperatvKARLARRVRSELGREEFVPVSL----GRVGDGYVAYPLSRGSGAITSLVRADGFIEIPAN 395
|
410
....*....|....*
gi 478754216 375 VTY-KKGEEVELQLF 388
Cdd:PRK14498 396 TEGlEAGEEVEVELF 410
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
20-161 |
2.27e-35 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 126.91 E-value: 2.27e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 20 VKKREKDVDI--FQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDYLKYGKLRVVGKLYPNTlniPELKEGETYYVTT 97
Cdd:pfam03453 2 LLGTEETVPLeaLDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGASEVNPIAAGEPPG---PLLPGGEAVRIMT 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 478754216 98 GSPLPTNADSVVPIEN-SKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGIL 161
Cdd:pfam03453 79 GAPLPEGADAVVMVEDtEEGGGRTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLL 143
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
174-307 |
1.64e-21 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 89.68 E-value: 1.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 174 LRFTIFANGDEITS-FENPEKNKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEISDVIISIGGSSVGE 251
Cdd:TIGR00177 1 PRVAVISVGDELVEgGQPLEPGQIYDSNGPLLAALLQEAGfNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 478754216 252 KDYVKRAINKLGEILFDGVTVNIIKRGS-----------IGRIQGKPILVLPGQVVSAITAFHEFGL 307
Cdd:TIGR00177 81 RDVTPEALEELGEKEIPGFGEFRMLSSLpvlsrpgkpatAGVRGGTLIFNLPGNPVSALVTFEVLIL 147
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
178-305 |
9.22e-18 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 79.17 E-value: 9.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 178 IFANGDEITSFEnpeknKVIDSISPILIKILEKFG-SVKYMGVA--KDDLNDVIGKIERSLEISDVIISIGGSSVGEKDY 254
Cdd:smart00852 2 IISTGDELLSGG-----QIRDSNGPMLAALLRELGiEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPDDL 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 478754216 255 VKRAINKLG--EILFDGV--------TVNIIKRGSIGRIQGK-PILVLPGQVVSAITAFHEF 305
Cdd:smart00852 77 TPEALAELGgrELLGHGVamrpggppGPLANLSGTAPGVRGKkPVFGLPGNPVAALVMFEEL 138
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
6-388 |
8.33e-110 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 327.14 E-value: 8.33e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 6 VEEARKIINNTNFEVKKREkdVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDYLKYG-KLRVVGKLYPNTLNI 84
Cdd:cd00887 1 VEAARELLLALAPPLGTET--VPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASvTLRVVGEIPAGEPPD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 85 PELKEGETYYVTTGSPLPTNADSVVPIENSKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGILLQQ 164
Cdd:cd00887 79 GPLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 165 QIFHINV-SDLRFTIFANGDEITSF-ENPEKNKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEISDVI 241
Cdd:cd00887 159 GIAEVPVyRRPRVAIISTGDELVEPgEPLAPGQIYDSNSYMLAALLRELGaEVVDLGIVPDDPEALREALEEALEEADVV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 242 ISIGGSSVGEKDYVKRAINKL-GEILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHEFGLSVLSNIL--SANL 318
Cdd:cd00887 239 ITSGGVSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQgaPEPE 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 478754216 319 KRFVKSALVEDIYVNHSMD-----SIYLFDVKGNSAFPLRWGVGLYSELSKANGFAILKRSVT-YKKGEEVELQLF 388
Cdd:cd00887 319 PPRVKARLAEDLKSKPGRReflrvRLERDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEgLEAGEEVEVLLL 394
|
|
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
3-388 |
3.69e-99 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 300.08 E-value: 3.69e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 3 LIPVEEARKIINNtNFEVKKREKdVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDYLKYG--KLRVVGKLYPN 80
Cdd:COG0303 1 MISVEEALALILA-AVRPLGTET-VPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANpvTLRVVGEIAAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 81 TLNIPELKEGETYYVTTGSPLPTNADSVVPIENSKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGI 160
Cdd:COG0303 79 SPPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 161 LLQQQIFHINVSD-LRFTIFANGDEITSF-ENPEKNKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEI 237
Cdd:COG0303 159 LASLGIAEVPVYRrPRVAILSTGDELVEPgEPLGPGQIYDSNSYMLAALLREAGaEVVDLGIVPDDPEALRAALREALAE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 238 SDVIISIGGSSVGEKDYVKRAINKLG-EILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHEFGLSVLSNI--L 314
Cdd:COG0303 239 ADLVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLagL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 315 SANLKRFVKSALVEDIYVNHSMDSI---YLFDVKGN-SAFPLRW-GVGLYSELSKANGFAILKRSVT-YKKGEEVELQLF 388
Cdd:COG0303 319 PPPPPPRVRARLAEDLPKKPGRTEFlrvRLERDDGElVVEPLGGqGSGLLSSLAEADGLIVLPEGVEgVEAGEEVEVLLL 398
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
2-388 |
9.79e-71 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 233.18 E-value: 9.79e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 2 TLIPVEEARKIINNTNFEVKKREKDVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDylKYG-------KLRVV 74
Cdd:PRK14498 8 TLVSLEEAREILESLLSELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAAD--TFGaseanpvRLKLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 75 GKLYPNTLNIPELKEGETYYVTTGSPLPTNADSVVPIENSKLEGEYVIfkgEIKK----GRNIRGEGEDIYAGQTIIRKG 150
Cdd:PRK14498 86 GEVHAGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEEVDDDTV---EIYRpvapGENVRPAGEDIVAGELILPKG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 151 TEVTPYHLGILLQQQIFHINVSD-LRFTIFANGDEITSF-ENPEKNKVIDSISPILI-KILEKFGSVKYMGVAKDDLNDV 227
Cdd:PRK14498 163 TRLTPRDIGALAAGGVAEVPVYKkPRVGIISTGDELVEPgEPLKPGKIYDVNSYTLAaAVEEAGGEPVRYGIVPDDEEEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 228 IGKIERSLEISDVIISIGGSSVGEKDYVKRAINKLGEILFDGVTvniIKRGS---IGRIQGKPILVLPGQVVSAITAFHE 304
Cdd:PRK14498 243 EAALRKALKECDLVLLSGGTSAGAGDVTYRVIEELGEVLVHGVA---IKPGKptiLGVIGGKPVVGLPGYPVSALTIFEE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 305 FGLSVLSNIL----------SANLKRFVKSALVEDIYVNHSMdsiyLFDVKGNSAFPLRWGVGLYSELSKANGFAILKRS 374
Cdd:PRK14498 320 FVAPLLRKLAglppperatvKARLARRVRSELGREEFVPVSL----GRVGDGYVAYPLSRGSGAITSLVRADGFIEIPAN 395
|
410
....*....|....*
gi 478754216 375 VTY-KKGEEVELQLF 388
Cdd:PRK14498 396 TEGlEAGEEVEVELF 410
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
3-387 |
7.75e-48 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 170.37 E-value: 7.75e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 3 LIPVEEARKIINNTNFevKKREKDVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKyeDYLKYGKLRVVGKLYPNTL 82
Cdd:PRK14497 11 YSIDEAIKVFLSSLNF--KPKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALK--SSCTPGEFKVIDKIGIGEF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 83 NIPELKEGETYYVTTGSPLPTNADSVVPIENSK-LEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGIL 161
Cdd:PRK14497 87 KEIHIKECEAVEVDTGSMIPMGADAVIKVENTKvINGNFIKIDKKINFGQNIGWIGSDIPKGSIILRKGEVISHEKIGLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 162 LQQQIFHINVSD-LRFTIFANGDEITSFENP-EKNKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEIS 238
Cdd:PRK14497 167 ASLGISSVKVYEkPKIYLIATGDELVEPGNSlSPGKIYESNLHYLYSKLKSEGyKIVGLSLLSDDKESIKNEIKRAISVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 239 DVIISIGGSSVGEKDYVKRAINKLGEILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHEFGLSVLSnILSANL 318
Cdd:PRK14497 247 DVLILTGGTSAGEKDFVHQAIRELGNIIVHGLKIKPGKPTILGIVDGKPVIGLPGNIVSTMVVLNMVILEYLK-SLYPSR 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 478754216 319 KRF-----VKSALVEDI---YVNHSMDSIYLFDVKGNS-AFPLRWGVGLYSELSKANGFAILKRSVTYKKGEEVELQL 387
Cdd:PRK14497 326 KEIlglgkIKARLALRVkadEHRNTLIPVYLFKSDNSYyALPVPFDSYMVGTFSLTDGYIMLGPNEEIEEGKEVEVDL 403
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
25-305 |
9.73e-48 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 170.95 E-value: 9.73e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 25 KDVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDyLKYGKLRVVGKL-----YPNTLnipelKEGETYYVTTGS 99
Cdd:PRK14491 219 EDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSDD-LEPESYTLVGEVlaghqYDGTL-----QAGEAVRIMTGA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 100 PLPTNADSVVPIENSKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGILLQQQIFHINV-SDLRFTI 178
Cdd:PRK14491 293 PVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLASLGFAEVPVfRRPKVAV 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 179 FANGDEITSFENPEK-NKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEISDVIISIGGSSVGEKDYVK 256
Cdd:PRK14491 373 FSTGDEVQAPGETLKpNCIYDSNRFTIKAMAKKLGcEVIDLGIIEDSEAALEATLEQAAAQADVVISSGGVSVGDADYIK 452
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 478754216 257 RAINKLGEILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHEF 305
Cdd:PRK14491 453 TALAKLGQIDFWRINMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQF 501
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
20-161 |
2.27e-35 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 126.91 E-value: 2.27e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 20 VKKREKDVDI--FQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDYLKYGKLRVVGKLYPNTlniPELKEGETYYVTT 97
Cdd:pfam03453 2 LLGTEETVPLeaLDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGASEVNPIAAGEPPG---PLLPGGEAVRIMT 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 478754216 98 GSPLPTNADSVVPIEN-SKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGIL 161
Cdd:pfam03453 79 GAPLPEGADAVVMVEDtEEGGGRTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLL 143
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
3-304 |
3.28e-35 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 133.68 E-value: 3.28e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 3 LIPVEEA-----RKIINNTNFEVkkrekdVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDYLKYGKLRVVGKL 77
Cdd:PRK10680 7 LMSLETAltemlSRVTPLTATET------LPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLADLASGQPLPVAGKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 78 YPNTLNIPELKEGETYYVTTGSPLPTNADSVVPIENSKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYH 157
Cdd:PRK10680 81 FAGQPFHGEWPAGTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGTRLTTAE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 158 LGILLQQQIFHINV-SDLRFTIFANGDEITSFENPEKNKVIDSISPILIKI-LEKFG-SVKYMGVAKDDLNDVIGKIERS 234
Cdd:PRK10680 161 LPVLASLGIAEVPVvRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLmLEQLGcEVINLGIIRDDPHALRAAFIEA 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 235 LEISDVIISIGGSSVGEKDYVKRAINKLGEILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHE 304
Cdd:PRK10680 241 DSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQ 310
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
25-311 |
2.09e-31 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 123.49 E-value: 2.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 25 KDVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDY-------LKYGKlRVVGKLYPNTLnipelKEGETYYVTT 97
Cdd:PRK14690 43 KELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGFAGAAPegaqvlpLIEGR-AAAGVPFSGRV-----PEGMALRILT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 98 GSPLPTNADSVVPIENSKLEGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGTEVTPYHLGILLQQQIFHINV-SDLRF 176
Cdd:PRK14690 117 GAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLALLSAVGLTRVSVrRPLRV 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 177 TIFANGDEITS-FENPEKNKVIDSISPILIKILEKFGSVKY-MGVAKDDLNDVIGKIERSLEISDVIISIGGSSVGEKDY 254
Cdd:PRK14690 197 AVLSTGDELVEpGALAEVGQIYDANRPMLLALARRWGHAPVdLGRVGDDRAALAARLDRAAAEADVILTSGGASAGDEDH 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 478754216 255 VKRAINKLGEILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHEFGLSVLS 311
Cdd:PRK14690 277 VSALLREAGAMQSWRIALKPGRPLALGLWQGVPVFGLPGNPVAALVCTLVFARPAMS 333
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
2-310 |
3.12e-27 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 113.37 E-value: 3.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 2 TLIPVEEARKIInntnFEVKKREK--DVDIFQALGKIVTEDVIAIKSIPERSLSAMDGYAIKYEDylKYGKLRVVGKLYP 79
Cdd:PLN02699 6 EMISVEEALSIV----LSVAARLSpvIVPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVASD--GPGEYPVITESRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 80 --NTLNIpELKEGETYYVTTGSPLPTNADSVVPIENSKL------EGEYVIFKGEIKKGRNIRGEGEDIYAGQTIIRKGT 151
Cdd:PLN02699 80 gnDGLGV-TLTPGTVAYVTTGGPIPDGADAVVQVEDTEVvedpldGSKRVRILSQASKGQDIRPVGCDIEKDAKVLKAGE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 152 EVTPYHLGILLQQQIFHINVSDL-RFTIFANGDEIT--SFENPEKNKVIDSISPILI-KILEKFGSVKYMGVAKDDLNDV 227
Cdd:PLN02699 159 RLGASEIGLLATVGVTMVKVYPRpTVAILSTGDELVepTTGTLGRGQIRDSNRAMLLaAAIQQQCKVVDLGIARDDEEEL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 228 IGKIERSLEIS-DVIISIGGSSVGEKDYVKRAINKLGEILFDGVTVNIIKRGSIGRIQGKP-------ILV--LPGQVVS 297
Cdd:PLN02699 239 ERILDEAISSGvDILLTSGGVSMGDRDFVKPLLEKRGTVYFSKVLMKPGKPLTFAEIDAKSapsnskkMLAfgLPGNPVS 318
|
330
....*....|...
gi 478754216 298 AITAFHEFGLSVL 310
Cdd:PLN02699 319 CLVCFNLFVVPAI 331
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
174-307 |
1.64e-21 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 89.68 E-value: 1.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 174 LRFTIFANGDEITS-FENPEKNKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEISDVIISIGGSSVGE 251
Cdd:TIGR00177 1 PRVAVISVGDELVEgGQPLEPGQIYDSNGPLLAALLQEAGfNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 478754216 252 KDYVKRAINKLGEILFDGVTVNIIKRGS-----------IGRIQGKPILVLPGQVVSAITAFHEFGL 307
Cdd:TIGR00177 81 RDVTPEALEELGEKEIPGFGEFRMLSSLpvlsrpgkpatAGVRGGTLIFNLPGNPVSALVTFEVLIL 147
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
178-310 |
1.40e-18 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 81.53 E-value: 1.40e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 178 IFANGDEITSfenpekNKVIDSISPILIKILEKFG-SVKYMGVAKDDLNDVIGKIERSLEISDVIISIGGSSVGEKDYVK 256
Cdd:pfam00994 2 IITTGDELLP------GQIRDTNGPLLAALLREAGaEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDVTP 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 478754216 257 RAINKLGE-------ILFDGVTVNIIK-----RGSIGRIQGKPILVLPGQVVSAITAFHEFGLSVL 310
Cdd:pfam00994 76 EALAELGGrelpgfeELFRGVSLKPGKpvgtaPGAILSRAGKTVFGLPGSPVAAKVMFELLLLPLL 141
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
178-310 |
1.63e-18 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 80.85 E-value: 1.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 178 IFANGDEITSfenpekNKVIDSISPILIKILEK-FGSVKYMGVAKDDLNDVIGKIERSLEISDVIISIGGSSVGEKDYVK 256
Cdd:cd00758 4 IVTVSDELSQ------GQIEDTNGPALEALLEDlGCEVIYAGVVPDDADSIRAALIEASREADLVLTTGGTGVGRRDVTP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 478754216 257 RAINKLG--EILFDGVTVNIIKRGSIGRIQGKPILVLPGQVVSAITAFHEFGLSVL 310
Cdd:cd00758 78 EALAELGerEAHGKGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
178-305 |
9.22e-18 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 79.17 E-value: 9.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 478754216 178 IFANGDEITSFEnpeknKVIDSISPILIKILEKFG-SVKYMGVA--KDDLNDVIGKIERSLEISDVIISIGGSSVGEKDY 254
Cdd:smart00852 2 IISTGDELLSGG-----QIRDSNGPMLAALLRELGiEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPDDL 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 478754216 255 VKRAINKLG--EILFDGV--------TVNIIKRGSIGRIQGK-PILVLPGQVVSAITAFHEF 305
Cdd:smart00852 77 TPEALAELGgrELLGHGVamrpggppGPLANLSGTAPGVRGKkPVFGLPGNPVAALVMFEEL 138
|
|
| |
