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Conserved domains on  [gi|477688395|gb|ENJ04230|]
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fibrinogen-binding protein [Staphylococcus aureus M0177]

Protein Classification

fibrinogen-binding protein( domain architecture ID 10573553)

fibrinogen-binding protein plays an important role in virulence and interacts with the alpha chain of fibrinogen and its derivative fibrin, which enhances a non-functional interaction between fibrinogen and platelets and is responsible for repression of fibrinogen-dependent platelet aggregation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
efb-c pfam12199
Extracellular fibrinogen binding protein C terminal; This domain family is found in bacteria, ...
 101-165 3.52e-28

Extracellular fibrinogen binding protein C terminal; This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.


:

Pssm-ID: 289007  Cd Length: 65  Bit Score: 99.35  E-value: 3.52e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 477688395  101 TDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVR 165
Cdd:pfam12199   1 TNFKKQVNKKVVDAQKAVREFKRTRTVATHRKAQRAVNLIHFQHSYEKKKLQRQIDLVLKYNTLK 65
staph_coagu super family cl41543
staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino ...
 56-98 2.18e-10

staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino acid tandem repeats (see PF04022). This HMM omits coverage of a portion of the repetitive C-terminal region.


The actual alignment was detected with superfamily member NF035921:

Pssm-ID: 468263 [Multi-domain]  Cd Length: 520  Bit Score: 57.91  E-value: 2.18e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 477688395  56 KYQSRPKFNSTPKYIKFKH-DYNILEFNDGTFEYGARPQFNKPA 98
Cdd:NF035921 465 QYGPRPQFNKTPKYVKYRDaGTGIREYNDGTFGYEARPRFNKPS 508
 
Name Accession Description Interval E-value
efb-c pfam12199
Extracellular fibrinogen binding protein C terminal; This domain family is found in bacteria, ...
 101-165 3.52e-28

Extracellular fibrinogen binding protein C terminal; This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.


Pssm-ID: 289007  Cd Length: 65  Bit Score: 99.35  E-value: 3.52e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 477688395  101 TDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVR 165
Cdd:pfam12199   1 TNFKKQVNKKVVDAQKAVREFKRTRTVATHRKAQRAVNLIHFQHSYEKKKLQRQIDLVLKYNTLK 65
staph_coagu NF035921
staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino ...
 56-98 2.18e-10

staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino acid tandem repeats (see PF04022). This HMM omits coverage of a portion of the repetitive C-terminal region.


Pssm-ID: 468263 [Multi-domain]  Cd Length: 520  Bit Score: 57.91  E-value: 2.18e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 477688395  56 KYQSRPKFNSTPKYIKFKH-DYNILEFNDGTFEYGARPQFNKPA 98
Cdd:NF035921 465 QYGPRPQFNKTPKYVKYRDaGTGIREYNDGTFGYEARPRFNKPS 508
 
Name Accession Description Interval E-value
efb-c pfam12199
Extracellular fibrinogen binding protein C terminal; This domain family is found in bacteria, ...
 101-165 3.52e-28

Extracellular fibrinogen binding protein C terminal; This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.


Pssm-ID: 289007  Cd Length: 65  Bit Score: 99.35  E-value: 3.52e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 477688395  101 TDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVR 165
Cdd:pfam12199   1 TNFKKQVNKKVVDAQKAVREFKRTRTVATHRKAQRAVNLIHFQHSYEKKKLQRQIDLVLKYNTLK 65
staph_coagu NF035921
staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino ...
 56-98 2.18e-10

staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino acid tandem repeats (see PF04022). This HMM omits coverage of a portion of the repetitive C-terminal region.


Pssm-ID: 468263 [Multi-domain]  Cd Length: 520  Bit Score: 57.91  E-value: 2.18e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 477688395  56 KYQSRPKFNSTPKYIKFKH-DYNILEFNDGTFEYGARPQFNKPA 98
Cdd:NF035921 465 QYGPRPQFNKTPKYVKYRDaGTGIREYNDGTFGYEARPRFNKPS 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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