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Conserved domains on  [gi|47589045|gb|AAT36044|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Lepilemur seali]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.12e-38

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 124.27  E-value: 1.12e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 47589045  81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.12e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 124.27  E-value: 1.12e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 47589045  81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 3.44e-12

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 56.80  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045    3 SISTNIILAFTIALTGMLvFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 47589045   83 NTYGLDHVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 9.73e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 35.04  E-value: 9.73e-04
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045 12 FTIALTGMLVfRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLDHVQ 91
Cdd:COG0713 14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


               ....*
gi 47589045 92 NLNLL 96
Cdd:COG0713 93 DLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.12e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 124.27  E-value: 1.12e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 47589045  81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 4.84e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 84.63  E-value: 4.84e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045  11 AFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLDHV 90
Cdd:MTH00126 11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                ....*...
gi 47589045  91 QNLNLLQC 98
Cdd:MTH00126 91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.91e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 83.36  E-value: 1.91e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 47589045  81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 8-98 4.18e-19

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 74.64  E-value: 4.18e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   8 IILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGL 87
Cdd:MTH00067  8 FYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVATTRTHGT 87

                        90
                ....*....|.
gi 47589045  88 DHVQNLNLLQC 98
Cdd:MTH00067 88 DHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 2.74e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 57.26  E-value: 2.74e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   9 ILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLD 88
Cdd:MTH00181  6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                ....*...
gi 47589045  89 HVQNLNLL 96
Cdd:MTH00181 86 HLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 3.44e-12

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 56.80  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045    3 SISTNIILAFTIALTGMLvFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 47589045   83 NTYGLDHVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 8.83e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 51.07  E-value: 8.83e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 47589045  81 VSNTYGLDHVQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 4.61e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 43.81  E-value: 4.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   8 IILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILgtLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGL 87
Cdd:MTH00188  9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWF--LLVGLSYMEKELYLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                        90
                ....*....|.
gi 47589045  88 DHVQNLNLLQC 98
Cdd:MTH00188 87 DYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 9.60e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 40.60  E-value: 9.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   9 ILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILgtLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLD 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 47589045  89 HVQNLNLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 5.15e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 38.58  E-value: 5.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHyTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFAN-QVNGMLAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 47589045  81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 8-92 7.40e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 37.83  E-value: 7.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   8 IILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILgtLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGL 87
Cdd:MTH00162  7 FLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSHGN 84


                ....*
gi 47589045  88 DHVQN 92
Cdd:MTH00162 85 DYFSS 89
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 9.73e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 35.04  E-value: 9.73e-04
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045 12 FTIALTGMLVfRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLDHVQ 91
Cdd:COG0713 14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


               ....*
gi 47589045 92 NLNLL 96
Cdd:COG0713 93 DLNEL 97
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 9-97 1.21e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 35.01  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   9 ILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLD 88
Cdd:MTH00180 10 IILFILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTI 89


                ....*....
gi 47589045  89 HVQNLNLLQ 97
Cdd:MTH00180 90 AVKSLNLLR 98
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
12-96 1.63e-03

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 34.77  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47589045   12 FTIALTGMLVFRSHLMSsLLCLEGMMLSMFILGTLLIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLDHVQ 91
Cdd:PRK05715  15 FCIGLVGLLLRRNAIVV-LMSIELMLNAVNLNFVAFSSYLGDLDGQVFAFFVITVAAAEAAIGLAILLQLYRNRGTIDVD 93


                 ....*
gi 47589045   92 NLNLL 96
Cdd:PRK05715  94 DLNEL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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