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Conserved domains on  [gi|47458048|ref|NP_998818|]
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hemojuvelin isoform a precursor [Homo sapiens]

Protein Classification

repulsive guidance molecule family protein( domain architecture ID 10534812)

repulsive guidance molecule (RGM) family protein may have several functions in the developing and adult nervous system, including regulation of cephalic neural tube closure, inhibition of neurite outgrowth and cortical neuron branching, and the formation of mature synapses

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGM_C pfam06534
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ...
 230-389 3.64e-80

Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


:

Pssm-ID: 461939  Cd Length: 171  Bit Score: 244.84  E-value: 3.64e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   230 CIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFS 309
Cdd:pfam06534   1 CTDQKVYQAETDDLPAAFVDGTTNGGDRDGGNSLRILEKEPGRHVEIHARYIGTTIIVRQVGRYLTFAIRMPEEVANALE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   310 AEQDLQLCVGGCPPSQR------LSRSERN-----RRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQ 378
Cdd:pfam06534  81 EDQDLQLCVNGCPRSERidyrtlLAEPVKRtacyqPRVAFTLESATAKCRESLPVEDVYFQSCVFDLLTTGDANFTLAAY 160

                         170
                  ....*....|.
gi 47458048   379 AALEDARAFLP 389
Cdd:pfam06534 161 SALEDVKRLHP 171
RGM_N pfam06535
Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of ...
 37-225 1.07e-78

Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


:

Pssm-ID: 461940  Cd Length: 165  Bit Score: 240.72  E-value: 1.07e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048    37 CKILRCNAEYVSSTLSLRGGGSSGALRggggggrgggvgsgglCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQ 116
Cdd:pfam06535   1 CKILKCNSEYVAATSALGGGPEPNEAY----------------CSALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMKQ 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   117 HNCSRQGPTAPPPPRGPalpgagSGLPAPDPCDYEGRFSRlhGRPPGFLHCASFGDPHVRSFHHHFHTCRVQGAWPLLDN 196
Cdd:pfam06535  65 HNCSKVGPTSPPRPRSP------PASPSPDICTYEGRFSK--GKPPEYRHCGLFGDPHLRTFNDEFQTCKVEGAWPLIDN 136

                         170       180
                  ....*....|....*....|....*....
gi 47458048   197 DFLFVQATSSPMALGANATATRKLTIIFK 225
Cdd:pfam06535 137 PYLSVQVTNSPVVPGSLATATTKLTVIFK 165
 
Name Accession Description Interval E-value
RGM_C pfam06534
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ...
 230-389 3.64e-80

Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


Pssm-ID: 461939  Cd Length: 171  Bit Score: 244.84  E-value: 3.64e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   230 CIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFS 309
Cdd:pfam06534   1 CTDQKVYQAETDDLPAAFVDGTTNGGDRDGGNSLRILEKEPGRHVEIHARYIGTTIIVRQVGRYLTFAIRMPEEVANALE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   310 AEQDLQLCVGGCPPSQR------LSRSERN-----RRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQ 378
Cdd:pfam06534  81 EDQDLQLCVNGCPRSERidyrtlLAEPVKRtacyqPRVAFTLESATAKCRESLPVEDVYFQSCVFDLLTTGDANFTLAAY 160

                         170
                  ....*....|.
gi 47458048   379 AALEDARAFLP 389
Cdd:pfam06534 161 SALEDVKRLHP 171
RGM_N pfam06535
Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of ...
 37-225 1.07e-78

Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


Pssm-ID: 461940  Cd Length: 165  Bit Score: 240.72  E-value: 1.07e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048    37 CKILRCNAEYVSSTLSLRGGGSSGALRggggggrgggvgsgglCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQ 116
Cdd:pfam06535   1 CKILKCNSEYVAATSALGGGPEPNEAY----------------CSALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMKQ 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   117 HNCSRQGPTAPPPPRGPalpgagSGLPAPDPCDYEGRFSRlhGRPPGFLHCASFGDPHVRSFHHHFHTCRVQGAWPLLDN 196
Cdd:pfam06535  65 HNCSKVGPTSPPRPRSP------PASPSPDICTYEGRFSK--GKPPEYRHCGLFGDPHLRTFNDEFQTCKVEGAWPLIDN 136

                         170       180
                  ....*....|....*....|....*....
gi 47458048   197 DFLFVQATSSPMALGANATATRKLTIIFK 225
Cdd:pfam06535 137 PYLSVQVTNSPVVPGSLATATTKLTVIFK 165
 
Name Accession Description Interval E-value
RGM_C pfam06534
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ...
 230-389 3.64e-80

Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


Pssm-ID: 461939  Cd Length: 171  Bit Score: 244.84  E-value: 3.64e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   230 CIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFS 309
Cdd:pfam06534   1 CTDQKVYQAETDDLPAAFVDGTTNGGDRDGGNSLRILEKEPGRHVEIHARYIGTTIIVRQVGRYLTFAIRMPEEVANALE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   310 AEQDLQLCVGGCPPSQR------LSRSERN-----RRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQ 378
Cdd:pfam06534  81 EDQDLQLCVNGCPRSERidyrtlLAEPVKRtacyqPRVAFTLESATAKCRESLPVEDVYFQSCVFDLLTTGDANFTLAAY 160

                         170
                  ....*....|.
gi 47458048   379 AALEDARAFLP 389
Cdd:pfam06534 161 SALEDVKRLHP 171
RGM_N pfam06535
Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of ...
 37-225 1.07e-78

Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.


Pssm-ID: 461940  Cd Length: 165  Bit Score: 240.72  E-value: 1.07e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048    37 CKILRCNAEYVSSTLSLRGGGSSGALRggggggrgggvgsgglCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQ 116
Cdd:pfam06535   1 CKILKCNSEYVAATSALGGGPEPNEAY----------------CSALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMKQ 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458048   117 HNCSRQGPTAPPPPRGPalpgagSGLPAPDPCDYEGRFSRlhGRPPGFLHCASFGDPHVRSFHHHFHTCRVQGAWPLLDN 196
Cdd:pfam06535  65 HNCSKVGPTSPPRPRSP------PASPSPDICTYEGRFSK--GKPPEYRHCGLFGDPHLRTFNDEFQTCKVEGAWPLIDN 136

                         170       180
                  ....*....|....*....|....*....
gi 47458048   197 DFLFVQATSSPMALGANATATRKLTIIFK 225
Cdd:pfam06535 137 PYLSVQVTNSPVVPGSLATATTKLTVIFK 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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