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Conserved domains on  [gi|47212350|emb|CAF93268|]
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unnamed protein product, partial [Tetraodon nigroviridis]

Protein Classification

CTH1 family zinc finger protein( domain architecture ID 1004917)

CTH1 family zinc finger protein similar to Homo sapiens mRNA decay activator protein ZFP36 that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|11179890
SCOP:  4003893

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
128-200 8.51e-15

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 71.62  E-value: 8.51e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47212350 128 QVQPMVSTNRYKTELCRGFQETGTCKYGSKCQFAHGEAELRGLYRHP--KYKTEPCRTFYNFGYCPYGSRCHFIH 200
Cdd:COG5063 262 ELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSF 336
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
128-200 8.51e-15

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 71.62  E-value: 8.51e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47212350 128 QVQPMVSTNRYKTELCRGFQETGTCKYGSKCQFAHGEAELRGLYRHP--KYKTEPCRTFYNFGYCPYGSRCHFIH 200
Cdd:COG5063 262 ELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSF 336
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
138-164 3.77e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 50.27  E-value: 3.77e-09
                          10        20
                  ....*....|....*....|....*..
gi 47212350   138 YKTELCRGFQETGTCKYGSKCQFAHGE 164
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
137-164 8.94e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.08  E-value: 8.94e-06
                           10        20
                   ....*....|....*....|....*...
gi 47212350    137 RYKTELCRgFQETGTCKYGSKCQFAHGE 164
Cdd:smart00356   1 KYKTELCK-FFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
128-200 8.51e-15

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 71.62  E-value: 8.51e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47212350 128 QVQPMVSTNRYKTELCRGFQETGTCKYGSKCQFAHGEAELRGLYRHP--KYKTEPCRTFYNFGYCPYGSRCHFIH 200
Cdd:COG5063 262 ELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSF 336
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
138-200 1.10e-14

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 71.24  E-value: 1.10e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47212350 138 YKTELCRGFQETGTCKYGSKCQFAHGEAELRGLYRHPKYKTEPCRTFYNFGYCPYGSRCHFIH 200
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
127-200 4.30e-11

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 60.84  E-value: 4.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47212350 127 AQVQPMVSTNrykTELCRGFQETGTCKY---GSKCQFA---HGEAELRGLYRHPKYKTEPCRTFYNFGYCPYGSRCHFIH 200
Cdd:COG5063 220 EQNKPLYKTN---PELCESFTRKGTCPYwisGVKCQFAcrgHGLNELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKH 296
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
138-164 3.77e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 50.27  E-value: 3.77e-09
                          10        20
                  ....*....|....*....|....*..
gi 47212350   138 YKTELCRGFQETGTCKYGSKCQFAHGE 164
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
176-200 5.17e-08

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 47.19  E-value: 5.17e-08
                          10        20
                  ....*....|....*....|....*
gi 47212350   176 YKTEPCRTFYNFGYCPYGSRCHFIH 200
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAH 25
ZnF_C3H1 smart00356
zinc finger;
137-164 8.94e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.08  E-value: 8.94e-06
                           10        20
                   ....*....|....*....|....*...
gi 47212350    137 RYKTELCRgFQETGTCKYGSKCQFAHGE 164
Cdd:smart00356   1 KYKTELCK-FFKRGYCPRGDRCKFAHPL 27
ZnF_C3H1 smart00356
zinc finger;
175-200 1.53e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 40.31  E-value: 1.53e-05
                           10        20
                   ....*....|....*....|....*.
gi 47212350    175 KYKTEPCRtFYNFGYCPYGSRCHFIH 200
Cdd:smart00356   1 KYKTELCK-FFKRGYCPRGDRCKFAH 25
COG5152 COG5152
Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function ...
 127-162 1.12e-03

Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only];


Pssm-ID: 227481 [Multi-domain]  Cd Length: 259  Bit Score: 38.90  E-value: 1.12e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 47212350 127 AQVQP-MVSTNR---YKTELCRGFQETGTCKYGSKCQFAH 162
Cdd:COG5152 124 QINQPtMFRDGEvidTQPDVCKDYKETGYCGYGDSCKFLH 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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