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Conserved domains on  [gi|47117821|sp|O95935|]
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RecName: Full=T-box transcription factor TBX18; Short=T-box protein 18

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 137-330 2.82e-152

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


:

Pssm-ID: 410317  Cd Length: 194  Bit Score: 435.86  E-value: 2.82e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 137 QAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADS 216
Cdd:cd20191   1 KEIQVELQGSELWKRFHDIGTEMIITKAGRRMFPAIRVKVSGLDPHAQYIVAMDIVPVDNKRYRYVYHSSKWMVAGNADA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 217 PVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAF 296
Cdd:cd20191  81 PVPPRVYIHPDSPASGETWMRQVVSFDKLKLTNNEMDDQGHIILHSMHKYQPRVHVIRKDSSTDLSPKKPVPPGEGVKTF 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 47117821 297 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20191 161 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 194
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 32-139 3.95e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821    32 QQLQKKRRKLGAEEAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPPAGATSGPARSGADLERG-------AAGGCEDGF 104
Cdd:PHA03307  794 AAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSESSKSKpaaaggrARGKNGRRR 873

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 47117821   105 QQGASPLASPGGSPKGSPARSLARPGTPLPSPQAP 139
Cdd:PHA03307  874 PRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPA 908
 
Name Accession Description Interval E-value
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 137-330 2.82e-152

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 435.86  E-value: 2.82e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 137 QAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADS 216
Cdd:cd20191   1 KEIQVELQGSELWKRFHDIGTEMIITKAGRRMFPAIRVKVSGLDPHAQYIVAMDIVPVDNKRYRYVYHSSKWMVAGNADA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 217 PVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAF 296
Cdd:cd20191  81 PVPPRVYIHPDSPASGETWMRQVVSFDKLKLTNNEMDDQGHIILHSMHKYQPRVHVIRKDSSTDLSPKKPVPPGEGVKTF 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 47117821 297 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20191 161 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 194
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 141-330 9.39e-125

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 365.34  E-value: 9.39e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821   141 VDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVPP 220
Cdd:pfam00907   1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKF--HNGKWVVAGKAEPHSPP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821   221 RVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRkdCGDDlspiKPVPSGEGVKAFSFPE 300
Cdd:pfam00907  79 RVYIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVR--VGGD----EPSLPEENVKTFVFPE 152

                         170       180       190
                  ....*....|....*....|....*....|
gi 47117821   301 TVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:pfam00907 153 TEFIAVTAYQNEEITQLKIDNNPFAKGFRD 182
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
139-335 6.04e-111

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 330.00  E-value: 6.04e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821    139 PRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRyvYHSSKWMVAGNADSPV 218
Cdd:smart00425   1 IKVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYK--FNNGKWVVAGKAEPHM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821    219 PPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGH--IILHSMHKYQPRVHVIRkdcGDDLSPIKPvpsgEGVKAF 296
Cdd:smart00425  79 PSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGHlqIILNSMHKYQPRLHIVE---VDDISKEIL----SQFKTF 151

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 47117821    297 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNR 335
Cdd:smart00425 152 VFPETQFIAVTAYQNQKITKLKIDNNPFAKGFRDQGRRR 190
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 32-139 3.95e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821    32 QQLQKKRRKLGAEEAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPPAGATSGPARSGADLERG-------AAGGCEDGF 104
Cdd:PHA03307  794 AAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSESSKSKpaaaggrARGKNGRRR 873

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 47117821   105 QQGASPLASPGGSPKGSPARSLARPGTPLPSPQAP 139
Cdd:PHA03307  874 PRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPA 908
 
Name Accession Description Interval E-value
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 137-330 2.82e-152

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 435.86  E-value: 2.82e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 137 QAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADS 216
Cdd:cd20191   1 KEIQVELQGSELWKRFHDIGTEMIITKAGRRMFPAIRVKVSGLDPHAQYIVAMDIVPVDNKRYRYVYHSSKWMVAGNADA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 217 PVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAF 296
Cdd:cd20191  81 PVPPRVYIHPDSPASGETWMRQVVSFDKLKLTNNEMDDQGHIILHSMHKYQPRVHVIRKDSSTDLSPKKPVPPGEGVKTF 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 47117821 297 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20191 161 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 194
T-box_TBX18_like cd20199
DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as ...
 136-330 5.33e-152

DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as a transcription repressor involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels. TBX18 is important for the development of the head portion of the sino atrial node (SAN); SAN is the pacemaker region of the heart that initiates each heartbeat. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410325  Cd Length: 195  Bit Score: 435.24  E-value: 5.33e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 136 PQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNAD 215
Cdd:cd20199   1 GEEVRVDLQGADLWKRFHEIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNAD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 216 SPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKA 295
Cdd:cd20199  81 SPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKECGEELSPVKPIPSGEGVKA 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 47117821 296 FSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20199 161 FSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 195
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 133-330 1.95e-134

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 390.63  E-value: 1.95e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 133 LPSPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAG 212
Cdd:cd20198   1 TSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 213 NADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEG 292
Cdd:cd20198  81 NADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPTGDG 160

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 47117821 293 VKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20198 161 VKTFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 198
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 140-330 1.25e-128

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 375.80  E-value: 1.25e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNAD-SPV 218
Cdd:cd20200   4 QVELQGSELWKRFHEIGTEMIITKAGRRMFPSVRVKVKGLDPLKQYYIAMDVVPVDSKRYRYVYHSSQWMVAGNTDhSCI 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 219 PPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSgEGVKAFSF 298
Cdd:cd20200  84 TPRLYVHPDSPCSGETWMRQIISFDRVKLTNNEMDDKGHIILQSMHKYKPRVHVILQDSRFDLSQIQSLPA-EGVKTFSF 162

                       170       180       190
                ....*....|....*....|....*....|..
gi 47117821 299 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20200 163 PETEFTTVTAYQNQQITKLKIDRNPFAKGFRD 194
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 141-330 9.39e-125

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 365.34  E-value: 9.39e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821   141 VDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVPP 220
Cdd:pfam00907   1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKF--HNGKWVVAGKAEPHSPP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821   221 RVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRkdCGDDlspiKPVPSGEGVKAFSFPE 300
Cdd:pfam00907  79 RVYIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVR--VGGD----EPSLPEENVKTFVFPE 152

                         170       180       190
                  ....*....|....*....|....*....|
gi 47117821   301 TVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:pfam00907 153 TEFIAVTAYQNEEITQLKIDNNPFAKGFRD 182
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 143-331 1.65e-115

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 341.72  E-value: 1.65e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 143 LQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRV 222
Cdd:cd20193   5 LETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 223 YIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKdcgDDLSPIKPVPSGEGVKAFSFPETV 302
Cdd:cd20193  85 YVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKK---KDHTASLVNLKSEEFRTFIFPETV 161

                       170       180
                ....*....|....*....|....*....
gi 47117821 303 FTTVTAYQNQQITRLKIDRNPFAKGFRDS 331
Cdd:cd20193 162 FTAVTAYQNQLITKLKIDSNPFAKGFRDS 190
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
139-335 6.04e-111

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 330.00  E-value: 6.04e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821    139 PRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRyvYHSSKWMVAGNADSPV 218
Cdd:smart00425   1 IKVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYK--FNNGKWVVAGKAEPHM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821    219 PPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGH--IILHSMHKYQPRVHVIRkdcGDDLSPIKPvpsgEGVKAF 296
Cdd:smart00425  79 PSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGHlqIILNSMHKYQPRLHIVE---VDDISKEIL----SQFKTF 151

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 47117821    297 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNR 335
Cdd:smart00425 152 VFPETQFIAVTAYQNQKITKLKIDNNPFAKGFRDQGRRR 190
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 140-330 2.08e-104

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 313.56  E-value: 2.08e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVP 219
Cdd:cd20682   2 QVELCSRELWLQFHNLGNEMIITKAGRRMFPALKVKLTGLDPDKLYIVWVDIVPVDSNRYRYVYHSSKWVVAGSGDVLPP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 PRVYIHPDSPASGETWMRQVISFDKLKLTNN-ELDDQGHIILHSMHKYQPRVHVIRKDcgDDLSPIKPVPSGEGVKAFSF 298
Cdd:cd20682  82 ANRYIHPDSPASGKYWMSQIVSFDKLKLTNNkEPKQKGQISLHSMHKYQPRIHIQPVE--DDGRNVEKAINSSKALSFEF 159

                       170       180       190
                ....*....|....*....|....*....|..
gi 47117821 299 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20682 160 PETSFITVTAYQNQQITKLKIASNPFAKGFRD 191
T-box_TBX1_10-like cd20187
DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; ...
 140-330 2.76e-104

DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; This subfamily includes TBX1 and TBX10. TBX1 is a T-box transcription factor which plays an important role in heart development and has been implicated in DiGeorge or 22q11.2 deletion syndrome. This syndrome is associated with various types of cardiac outflow tract (OFT) and vascular defects. Wnt5a is regulated by TBX1 in the second heart field (SHF). TBX1 is required to maintain the integrity of extracellular matrix-cell interactions in the SHF and this interaction is critical for cardiac (OFT) development. TBX10 is a putative T-box transcription factor. Diseases associated with TBX10 include Isolated Cleft Lip and Cleft Lip/cleft lip with or without cleft palate. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410313  Cd Length: 189  Bit Score: 313.21  E-value: 2.76e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVP 219
Cdd:cd20187   3 TVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLMMDFVPVDDKRYRYAFHSSSWLVAGKADPAMP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 PRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVI----RKDCGDDLSpikpvpsgEGVKA 295
Cdd:cd20187  83 GRIHVHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVyvdpRKDSENSAE--------ENFKT 154

                       170       180       190
                ....*....|....*....|....*....|....*
gi 47117821 296 FSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20187 155 FIFPETKFTAVTAYQNHRITQLKIASNPFAKGFRD 189
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 140-330 1.40e-102

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 308.59  E-value: 1.40e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVP 219
Cdd:cd20189   2 KVFLENRELWQKFHEVGTEMIITKAGRRMFPSIKVKVTGLNPKTKYILLMDIVPADDHRYKF--HDSEWVVAGKAEPAMP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 PRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSpikpvPSGEGVKAFSFP 299
Cdd:cd20189  80 GRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDQFGHIILNSMHKYQPRIHIVQADDNNAFG-----SKNTAFSTHVFP 154

                       170       180       190
                ....*....|....*....|....*....|.
gi 47117821 300 ETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20189 155 ETAFIAVTAYQNHQITQLKIENNPFAKGFRG 185
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 139-330 2.05e-97

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 295.11  E-value: 2.05e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 139 PRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNkrYRYVYHSSKWMVAGNADSPV 218
Cdd:cd20188   3 PKVELEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADD--CRYKFHNSRWMVAGKADPEM 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 219 PPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRkdCGDdlspIKPVPSGEgVKAFSF 298
Cdd:cd20188  81 PKRMYIHPDSPSTGEQWMQKVVSFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVR--AND----ILKLPYST-FRTYVF 153

                       170       180       190
                ....*....|....*....|....*....|..
gi 47117821 299 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20188 154 KETEFIAVTAYQNEKITQLKIDNNPFAKGFRD 185
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 141-330 4.47e-92

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 281.53  E-value: 4.47e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 141 VDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVyHSSKWMVAGNAD--SPV 218
Cdd:cd20681   3 VTLKNRDLWQQFHREGTEMIITKSGRRMFPSLRLSVSGLEPDARYCVLLEMVLASDCRFKYS-GNGGWVPAGGAEpqPPL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 219 PPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRkdcGDDLSPIKPVPSgegvKAFSF 298
Cdd:cd20681  82 PRRIYIHPDSPATGDHWMSQPISFSKVKLTNNTLDPQGNIVLTSMHKYQPRIHIVR---CSDTLALPWAPT----ASFTF 154

                       170       180       190
                ....*....|....*....|....*....|..
gi 47117821 299 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20681 155 PETEFIAVTAYQNERITKLKIDNNPFAKGFRE 186
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 139-322 2.01e-91

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 279.48  E-value: 2.01e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 139 PRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRyvYHSSKWMVAGNADSPV 218
Cdd:cd00182   1 ITVSLRNEELWKKFHELGTEMIVTKSGRRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYK--FNNGKWVPSGKAEPPP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 219 -PPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQ-GHIILHSMHKYQPRVHVIRKDCGDDLSPIkpvpsgegVKAF 296
Cdd:cd00182  79 ePSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKEDKKeGHILLHSMHKYIPVLTIYEVDDNGLLSKL--------VKEF 150

                       170       180
                ....*....|....*....|....*.
gi 47117821 297 SFPETVFTTVTAYQNQQITRLKIDRN 322
Cdd:cd00182 151 RFPETEFIAVTAYQNDEITQLKIDNN 176
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 140-330 2.84e-91

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 279.42  E-value: 2.84e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVP 219
Cdd:cd20197   2 RASLEDQDLWKKFHQIGTEMIITKSGRRMFPQCKIRVSGLLPYAKYVMLVDFVPVDNFRYKW--NKDQWEVAGKAEPQPP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 PRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRkdcGDDLSPIKPvpsgEGVKAFSFP 299
Cdd:cd20197  80 CRTYVHPDSPAPGSHWMKQPISFQKLKLTNNTLDQHGHIILHSMHRYQPRFHIVQ---ADDLFNVRW----SLFQVFSFP 152

                       170       180       190
                ....*....|....*....|....*....|.
gi 47117821 300 ETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20197 153 ETVFTAVTAYQNEKITKLKIDNNPFAKGFRE 183
T-box_TBX6 cd20196
DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a ...
 140-330 5.56e-88

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410322  Cd Length: 182  Bit Score: 270.97  E-value: 5.56e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVP 219
Cdd:cd20196   2 RMSLENAELWKQFSSVGTEMIITKAGRRMFPQLRVSVSGLDPEARYLLLLDVVPVDGSRYRW--QGNSWEASGKAEPRLP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 PRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRkdCGDDLSpikpvpSGEGVKAFSFP 299
Cdd:cd20196  80 DRVYIHPDSPATGAHWMRQPISFHRAKLTNNTLDPHGHIILHSMHRYQPRVHVVR--ARDVLS------WGGGCASFTFP 151

                       170       180       190
                ....*....|....*....|....*....|.
gi 47117821 300 ETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20196 152 ETQFITVTAYQNPKITQLKINSNPFAKGFRE 182
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 141-330 2.14e-86

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 266.75  E-value: 2.14e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 141 VDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVPP 220
Cdd:cd20190   3 LSLEDRELWKEFSSVGTEMIITKSGRRMFPACKVSVTGLDPEAKYLFLLDVVPVDNARYKW--NKRRWEPSGKAEPHLPD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 221 RVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRkdcGDDLSPIKPvpsgEGVKAFSFPE 300
Cdd:cd20190  81 RVYIHPDSPAPGAHWMRQPISFHKLKLTNNTLDPHGHLILHSMHKYQPRIHLVQ---SADLCSQHW----GGMASFRFPE 153

                       170       180       190
                ....*....|....*....|....*....|
gi 47117821 301 TVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20190 154 TTFIAVTAYQNPQITKLKIAANPFAKGFRE 183
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 139-330 3.84e-86

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 266.05  E-value: 3.84e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 139 PRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVyhSSKWMVAGNADSPV 218
Cdd:cd20192   1 IRVTLEDRELWKKFHSLTNEMIVTKSGRRMFPVLKVSVSGLDPNAMYSVLLDFVQVDNHRWKYV--NGEWVPGGKAEPPP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 219 PPRVYIHPDSPASGETWMRQVISFDKLKLTNNeLDDQGHIILHSMHKYQPRVHVIRKDcgddlspikPVPSGEGVKAFSF 298
Cdd:cd20192  79 PSSVYVHPDSPNFGAHWMKGPVSFSKVKLTNK-PNGEGQIMLNSLHKYEPRVHIVRVG---------SNNHERLVSTFSF 148

                       170       180       190
                ....*....|....*....|....*....|..
gi 47117821 299 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20192 149 PETQFIAVTAYQNEEITALKIKYNPFAKAFLD 180
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 140-330 7.06e-84

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 260.44  E-value: 7.06e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVP 219
Cdd:cd20195   2 TVTLENNSMWNEFYRCGTEMILTKQGRRMFPYCRFRISGLDPDRNYILVMDISPVDNFRYRW--NGRWWEPSGKAEPHVL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 PRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIkpvpSGEGVKAFSFP 299
Cdd:cd20195  80 GRVFIHPESPATGRHWMDQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHVVPADKEVDVIQL----NGPDVHTFTFP 155

                       170       180       190
                ....*....|....*....|....*....|.
gi 47117821 300 ETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20195 156 QTEFFAVTAYQNKQITQLKIDYNPFAKGFRE 186
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 140-330 7.03e-75

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 236.99  E-value: 7.03e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADsPVP 219
Cdd:cd20194   3 SVYLCNRDLWLKFHQHQTEMIITKQGRRMFPTLSFNLSGLDPTAHYNVFVDMVLADPNHWKF--QSGKWVPCGKAE-GLP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 P--RVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIrkdcgdDLSPIKPvPSGEGVKAFS 297
Cdd:cd20194  80 QgnRVYVHPDSPNTGAHWMKQEISFSKLKLTNNKGADQGMIVLNSMHKYQPRIHVI------EVGGNGP-NEQRNLQTHS 152

                       170       180       190
                ....*....|....*....|....*....|...
gi 47117821 298 FPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20194 153 FPETQFIAVTAYQNTDITQLKIDHNPFAKGFRD 185
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 140-330 2.02e-65

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 212.51  E-value: 2.02e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRyvYHSSKWMVAGNADSPVP 219
Cdd:cd20203   3 QVLLNNHPLWSKFHKHQTEMIITKQGRRMFPFLSFNLTGLDPTAHYNVYVDVVLADQHHWR--YQGGKWVQCGKAEGNMP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 -PRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQG---HIILHSMHKYQPRVHVIRKDCGDdlsPIKPVPSGEgVKA 295
Cdd:cd20203  81 gNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNvtqMIVLQSLHKYQPRLHIVEVKEGE---TEEAYSSSK-THT 156

                       170       180       190
                ....*....|....*....|....*....|....*
gi 47117821 296 FSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20203 157 FTFPETQFIAVTAYQNAEITQLKIDHNPFAKGFRD 191
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 140-330 6.31e-63

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 205.66  E-value: 6.31e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 140 RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVyhSSKWMVAGNADSPVP 219
Cdd:cd20202   3 KVSLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYV--NGEWVPGGKPEPQAP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 220 PRVYIHPDSPASGETWMRQVISFDKLKLTnNELDDQGHIILHSMHKYQPRVHVIRkdCGDdlsPIKPVPSgegvkaFSFP 299
Cdd:cd20202  81 SCVYIHPDSPNFGAHWMKAPVSFSKVKLT-NKLNGGGQIMLNSLHKYEPRIHIVR--VGG---PQRMITS------HSFP 148

                       170       180       190
                ....*....|....*....|....*....|.
gi 47117821 300 ETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20202 149 ETQFIAVTAYQNEEITALKIKYNPFAKAFLD 179
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 134-330 2.81e-62

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 204.11  E-value: 2.81e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 134 PSPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVyhSSKWMVAGN 213
Cdd:cd20201   1 PTEKQLQVSLEDAELWQRFKEVTNEMIVTKNGRRMFPVLKISVSGLDPNAMYSFLLDFAPADGHRWKYV--NGEWVPAGK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 214 ADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTnNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLspikpvpsgegV 293
Cdd:cd20201  79 PEPHSHSCVYIHPDSPNFGAHWMKAPISFSKVKLT-NKLNGGGQIMLNSLHKYEPQIHIVRVGGPHRM-----------V 146

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 47117821 294 KAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20201 147 TNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLD 183
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 139-331 1.55e-61

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 203.01  E-value: 1.55e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 139 PRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVyhSSKWMV-------- 210
Cdd:cd20683   1 PQLLLEDADLWAQFHSVQNEMIITKSGRCLFPLLRFRAVNLDPKALYSIALDIEQVSPNRFRFR--NGRWNPidkdqrgd 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 211 -----AGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTN-------------NELDD-----QGHIILHSMHKYQ 267
Cdd:cd20683  79 dafssGTADKSVLLPESYIHPDGPQTGAFWMANGISFAKIKLSNrqpnssdrdgpkeNITNSisalpDGHFFLTSFHKYQ 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47117821 268 PRVHVIRKDCGDDlspikpvpSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDS 331
Cdd:cd20683 159 PRLHLIQHSAGDH--------DDILSTTFTFEETEFIAVTHYQNEKVNILKKDYNPHAKGFKDD 214
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 148-330 1.10e-57

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 192.26  E-value: 1.10e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 148 LWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVP-PRVYIHP 226
Cdd:cd20204  11 LWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRF--QGGKWVPCGKADTNVQgNRVYMHP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 227 DSPASGETWMRQVISFDKLKLTNNE--LDDQGH-IILHSMHKYQPRVHVIR--KDCGDDLSpiKPvpsgEGVKAFSFPET 301
Cdd:cd20204  89 DSPNTGAHWMRQEISFGKLKLTNNKgaSNNNGQmVVLQSLHKYQPRLHVVEvnEDGTEDTS--QP----GRVQTFTFPET 162

                       170       180
                ....*....|....*....|....*....
gi 47117821 302 VFTTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20204 163 QFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 148-330 3.23e-56

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 188.35  E-value: 3.23e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 148 LWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVP-PRVYIHP 226
Cdd:cd20205  11 LWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRF--QGGKWVTCGKADNNMQgNKVYVHP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821 227 DSPASGETWMRQVISFDKLKLTNNE---LDDQGHIILHSMHKYQPRVHVIrkDCGDDLSPIKPVPSGEgvKAFSFPETVF 303
Cdd:cd20205  89 ESPNTGAHWMRQEISFGKLKLTNNKganNNNTQMIVLQSLHKYQPRLHIV--EVSEDGVEDLNDSSKT--QTFTFPENQF 164

                       170       180
                ....*....|....*....|....*..
gi 47117821 304 TTVTAYQNQQITRLKIDRNPFAKGFRD 330
Cdd:cd20205 165 IAVTAYQNTDITQLKIDHNPFAKGFRD 191
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 32-139 3.95e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821    32 QQLQKKRRKLGAEEAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPPAGATSGPARSGADLERG-------AAGGCEDGF 104
Cdd:PHA03307  794 AAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSESSKSKpaaaggrARGKNGRRR 873

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 47117821   105 QQGASPLASPGGSPKGSPARSLARPGTPLPSPQAP 139
Cdd:PHA03307  874 PRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPA 908
PHA03169 PHA03169
hypothetical protein; Provisional
 44-140 8.93e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 38.80  E-value: 8.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117821   44 EEAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPPAGATSGPARSGADLERGAAGGCEDGFQQGASPLASPGGSPK--GS 121
Cdd:PHA03169 153 ESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQqaVE 232

                         90
                 ....*....|....*....
gi 47117821  122 PARSLARPGTPLPSPQAPR 140
Cdd:PHA03169 233 HEDEPTEPEREGPPFPGHR 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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