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Conserved domains on  [gi|47085759|ref|NP_998214|]
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POC1 centriolar protein homolog A [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-300 5.96e-97

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 295.67  E-value: 5.96e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   5 LDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTV 84
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  85 RLWVPSVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVSD 164
Cdd:COG2319 187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 165 DRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHLL 244
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47085759 245 TASSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWRTN 300
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-300 5.96e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 295.67  E-value: 5.96e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   5 LDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTV 84
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  85 RLWVPSVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVSD 164
Cdd:COG2319 187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 165 DRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHLL 244
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47085759 245 TASSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWRTN 300
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 1.37e-85

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 262.66  E-value: 1.37e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  10 LERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTVRLWVP 89
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  90 SVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVSDDRTVK 169
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 170 LWDASSRQLIHTFcepGGYSSYV---DFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHLLTA 246
Cdd:cd00200 161 LWDLRTGKCVATL---TGHTGEVnsvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47085759 247 SSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWR 298
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 32-258 7.18e-15

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 76.66  E-value: 7.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   32 QIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPS-AHLLASSSRDKTVRLWVPSvKGESVLFRAHTGSVRSVCF 110
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdPTLLASGSDDGSVKLWSIN-QGVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  111 SAD-GQSLLTASDDQSIKLWSVHRQKI-ICTLREHNNWVRCARFSpDGQLMVSVSDDRTVKLWDAS------SRQLIHTF 182
Cdd:PLN00181 626 PSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSF 704

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  183 CEPGGYSSYVDFHPSSTCIATASSDNTVRVWD-----------IRTHTLLQHYQVHSAA--VNALSFHPSGNHLLTASSD 249
Cdd:PLN00181 705 MGHTNVKNFVGLSVSDGYIATGSETNEVFVYHkafpmpvlsykFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANST 784


                 ....*....
gi 47085759  250 STLKILDLL 258
Cdd:PLN00181 785 GNIKILEMV 793
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-172 1.39e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.39e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47085759    135 KIICTLREHNNWVRCARFSPDGQLMVSVSDDRTVKLWD 172
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-172 1.28e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.28e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47085759   135 KIICTLREHNNWVRCARFSPDGQLMVSVSDDRTVKLWD 172
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 152-226 6.66e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.10  E-value: 6.66e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085759   152 FSPDGQ-LMVSVSDDRTVKLWDASSRQLIHTFcePGGYS-SYVDFHPSSTCIATAS-SDNTVRVWDIRTHTLLQHYQV 226
Cdd:TIGR03866  48 FSKDGKlLYVCASDSDTIQVIDPATGEVLHTL--PSGPDpEQFALHPNGKILYIANeDDALVTVIDIETRKVLAQIDV 123
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-300 5.96e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 295.67  E-value: 5.96e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   5 LDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTV 84
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  85 RLWVPSVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVSD 164
Cdd:COG2319 187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 165 DRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHLL 244
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47085759 245 TASSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWRTN 300
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
4-300 3.20e-93

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 286.04  E-value: 3.20e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   4 ALDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKT 83
Cdd:COG2319  64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  84 VRLWVPSVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVS 163
Cdd:COG2319 144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 164 DDRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHL 243
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47085759 244 LTASSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWRTN 300
Cdd:COG2319 304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 1.37e-85

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 262.66  E-value: 1.37e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  10 LERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTVRLWVP 89
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  90 SVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVSDDRTVK 169
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 170 LWDASSRQLIHTFcepGGYSSYV---DFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHLLTA 246
Cdd:cd00200 161 LWDLRTGKCVATL---TGHTGEVnsvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47085759 247 SSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWR 298
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-300 6.08e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.15  E-value: 6.08e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   4 ALDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKT 83
Cdd:COG2319  22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  84 VRLWVPSVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVS 163
Cdd:COG2319 102 VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 164 DDRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHL 243
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47085759 244 LTASSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWRTN 300
Cdd:COG2319 262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-254 2.18e-71

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.06  E-value: 2.18e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   5 LDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTV 84
Cdd:cd00200  38 LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  85 RLW-VPSVKGESVlFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVS 163
Cdd:cd00200 118 KVWdVETGKCLTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 164 DDRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHL 243
Cdd:cd00200 197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                       250
                ....*....|.
gi 47085759 244 LTASSDSTLKI 254
Cdd:cd00200 277 ASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-311 1.40e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 224.14  E-value: 1.40e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  56 FTGHKDAVTCVQFSPSAHLLASSSRDKTVRLWvpSVKGESVLFR--AHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHR 133
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW--DLETGELLRTlkGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 134 QKIICTLREHNNWVRCARFSPDGQLMVSVSDDRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVW 213
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 214 DIRTHTLLQHYQVHSAAVNALSFHPSGNHLLTASSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQ 293
Cdd:cd00200 163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                       250
                ....*....|....*...
gi 47085759 294 VMVWRTnfDSVDYSRVLQ 311
Cdd:cd00200 243 IRVWDL--RTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
25-300 1.09e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.17  E-value: 1.09e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  25 DFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTVRLWVPSVKGESVLFRAHTGS 104
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 105 VRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVSDDRTVKLWDASSRQLIHTFCE 184
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 185 PGGYSSYVDFHPSSTCIATASSDNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHLLTASSDSTLKILDLLEGRLLY 264
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47085759 265 TLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWRTN 300
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
5-217 1.55e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.47  E-value: 1.55e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   5 LDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTV 84
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  85 RLWVPSVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVSD 164
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 47085759 165 DRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWDIRT 217
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-172 4.12e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.89  E-value: 4.12e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   5 LDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPSAHLLASSSRDKTV 84
Cdd:cd00200 122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  85 RLWVPSVKGESVLFRAHTGSVRSVCFSADGQSLLTASDDQSIKLWSVHRQKIICTLREHNNWVRCARFSPDGQLMVSVSD 164
Cdd:cd00200 202 KLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                ....*...
gi 47085759 165 DRTVKLWD 172
Cdd:cd00200 282 DGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-300 5.08e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 5.08e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 137 ICTLREHNNWVRCARFSPDGQLMVSVSDDRTVKLWDASSRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWDIR 216
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 217 THTLLQHYQVHSAAVNALSFHPSGNHLLTASSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMV 296
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161


                ....
gi 47085759 297 WRTN 300
Cdd:cd00200 162 WDLR 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 220-300 2.23e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 2.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 220 LLQHYQVHSAAVNALSFHPSGNHLLTASSDSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWRT 299
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80


                .
gi 47085759 300 N 300
Cdd:cd00200  81 E 81
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 32-258 7.18e-15

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 76.66  E-value: 7.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   32 QIASGSVDASVMVWNMKPQSRAYRFTGHKDAVTCVQFSPS-AHLLASSSRDKTVRLWVPSvKGESVLFRAHTGSVRSVCF 110
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdPTLLASGSDDGSVKLWSIN-QGVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  111 SAD-GQSLLTASDDQSIKLWSVHRQKI-ICTLREHNNWVRCARFSpDGQLMVSVSDDRTVKLWDAS------SRQLIHTF 182
Cdd:PLN00181 626 PSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSF 704

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  183 CEPGGYSSYVDFHPSSTCIATASSDNTVRVWD-----------IRTHTLLQHYQVHSAA--VNALSFHPSGNHLLTASSD 249
Cdd:PLN00181 705 MGHTNVKNFVGLSVSDGYIATGSETNEVFVYHkafpmpvlsykFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANST 784


                 ....*....
gi 47085759  250 STLKILDLL 258
Cdd:PLN00181 785 GNIKILEMV 793
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-172 1.39e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.39e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47085759    135 KIICTLREHNNWVRCARFSPDGQLMVSVSDDRTVKLWD 172
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-172 1.28e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.28e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47085759   135 KIICTLREHNNWVRCARFSPDGQLMVSVSDDRTVKLWD 172
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-87 2.37e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.37e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 47085759     54 YRFTGHKDAVTCVQFSPSAHLLASSSRDKTVRLW 87
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 151-299 3.53e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.28  E-value: 3.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  151 RFSP-DGQLMVSVSDDRTVKLWDASSRQLIHTFCEP----GGYSSYV---DFHPSST-CIATASSDNTVRVWDIRTHTLL 221
Cdd:PTZ00421  82 AFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDPivhlQGHTKKVgivSFHPSAMnVLASAGADMVVNVWDVERGKAV 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  222 QHYQVHSAAVNALSFHPSGNHLLTASSDSTLKILDLLEGRLLYTLHGHQGSAS--CVsFSRSGDQFASAGSD----QQVM 295
Cdd:PTZ00421 162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCL-WAKRKDLIITLGCSksqqRQIM 240


                 ....
gi 47085759  296 VWRT 299
Cdd:PTZ00421 241 LWDT 244
WD40 pfam00400
WD domain, G-beta repeat;
54-87 4.65e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 4.65e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 47085759    54 YRFTGHKDAVTCVQFSPSAHLLASSSRDKTVRLW 87
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-46 6.84e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 6.84e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47085759      7 DPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWN 46
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
9-46 1.69e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.69e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47085759     9 TLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWN 46
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-130 5.85e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.85e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 47085759     98 FRAHTGSVRSVCFSADGQSLLTASDDQSIKLWS 130
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 4-164 9.70e-07

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 50.46  E-value: 9.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759     4 ALDDPTLERNFKGHRDAITSLDFSPSGKQIASGSVDASVMVWNM---KPQSRAYRFT--------------------GHK 60
Cdd:pfam20426 110 SLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgRSSEKRSRNTqtefprkdhviaetpfhilcGHD 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759    61 DAVTCVQFSPSAHLLASSSRDKT-----------VR-LWVPSVKGESVLFRAHTGSVrsvcfsadgqsLLTASDDQSIKL 128
Cdd:pfam20426 190 DIITCLYVSVELDIVISGSKDGTcifhtlregryVRsIRHPSGCPLSKLVASRHGRI-----------VLYADDDLSLHL 258

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 47085759   129 WSVHRQKIICTlrEHNNWVRCARFSPDGQLMVSVSD 164
Cdd:pfam20426 259 YSINGKHIASS--ESNGRLNCIELSSCGEFLVCAGD 292
WD40 pfam00400
WD domain, G-beta repeat;
98-130 1.16e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.16e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 47085759    98 FRAHTGSVRSVCFSADGQSLLTASDDQSIKLWS 130
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 260-297 1.37e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.37e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47085759    260 GRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVW 297
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 217-256 2.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47085759    217 THTLLQHYQVHSAAVNALSFHPSGNHLLTASSDSTLKILD 256
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 201-279 1.57e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.04  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   201 IATASSDNTV--------RVWDIRThtllqhyQVHSAAVNALSFHPSGNHLLTASSDSTLKILDLLEGRLLYTLHGHQGS 272
Cdd:pfam12894  10 IALATEDGELllhrlnwqRVWTLSP-------DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDL 82


                  ....*..
gi 47085759   273 ASCVSFS 279
Cdd:pfam12894  83 ITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-214 1.69e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.69e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47085759    175 SRQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWD 214
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
260-297 2.54e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.54e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47085759   260 GRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVW 297
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
219-256 4.00e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47085759   219 TLLQHYQVHSAAVNALSFHPSGNHLLTASSDSTLKILD 256
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 14-87 5.25e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 5.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   14 FKGHRDAITSLDFSPSGKQI-ASGSVDASVMVWNMKPQSRAYR--------FTGHKDAVTCVQFSP-SAHLLASSSRDKT 83
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEIlASGSEDLTIRVWEIPHNDESVKeikdpqciLKGHKKKISIIDWNPmNYYIMCSSGFDSF 149


                 ....
gi 47085759   84 VRLW 87
Cdd:PTZ00420 150 VNIW 153
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 140-294 4.80e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  140 LREHNNWVRCARFSPDGQLMVSVSDDRTVKLWDASS-----RQLIHTFCEPGGYSSYvdfhpSSTC--------IATASS 206
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVVELASRSKL-----SGICwnsyiksqVASSNF 553

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  207 DNTVRVWDIRTHTLLQHYQVHSAAVNALSFHPSGNHLL-TASSDSTLKILDLLEGRLLYTLHGhQGSASCVSF-SRSGDQ 284
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRS 632

                        170
                 ....*....|
gi 47085759  285 FASAGSDQQV 294
Cdd:PLN00181 633 LAFGSADHKV 642
WD40 pfam00400
WD domain, G-beta repeat;
176-214 8.02e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47085759   176 RQLIHTFCEPGGYSSYVDFHPSSTCIATASSDNTVRVWD 214
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 120-182 8.89e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 8.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47085759   120 ASDDQSIKLWSVHRQKIICT-LREHNNWVRCARFSPDGQLMVSVSDDRTVKLWDASSRQLIHTF 182
Cdd:pfam12894  13 ATEDGELLLHRLNWQRVWTLsPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 27-126 9.83e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 9.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   27 SPSGKQIASGSVDASVMVWNMK-PQSRAYRFTGHKDAVTCVQFSPSAHLLaSSSRDKTVRLWVPSVK----GESVL--FR 99
Cdd:PLN00181 627 SESGRSLAFGSADHKVYYYDLRnPKLPLCTMIGHSKTVSYVRFVDSSTLV-SSSTDNTLKLWDLSMSisgiNETPLhsFM 705

                         90       100
                 ....*....|....*....|....*..
gi 47085759  100 AHTGSVRSVCFSADGQSLLTASDDQSI 126
Cdd:PLN00181 706 GHTNVKNFVGLSVSDGYIATGSETNEV 732
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 238-299 3.99e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 3.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085759   238 PSGNHLLTASS-DSTLKILDLLEGRLLYTLHGHQGSASCVSFSRSGDQFASAGSDQQVMVWRT 299
Cdd:pfam20426  91 PSENFLISCGNwENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 74-208 5.20e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.34  E-value: 5.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  74 LLASSSRDKTVRLWVPSVK-GESVLFRAHTGSVRSVCFSADGQSLLTASD-DQSIKLWSVHR-----QKIicTLREHNNW 146
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDLDgGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDrGGGPQIYVVDAdggepRRL--TFGGGYNA 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085759 147 vrCARFSPDGQLMVSVSDD------RTVKLWDASSRQLIHTFCEPggyssyvDFHPSSTCIATASSDN 208
Cdd:COG0823  79 --SPSWSPDGKRLAFVSRSdgrfdiYVLDLDGGAPRRLTDGPGSP-------SWSPDGRRIVFSSDRG 137
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 22-131 5.40e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.34  E-value: 5.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759  22 TSLDFSPSGKQIA-SGSVDASVMVWNMKPQ-SRAYRFTGHKDAVTCVQFSPSAHLLA-SSSRDKTVRLWVPSVKGESVlf 98
Cdd:COG0823  34 TSPAWSPDGRRIAfTSDRGGGPQIYVVDADgGEPRRLTFGGGYNASPSWSPDGKRLAfVSRSDGRFDIYVLDLDGGAP-- 111

                        90       100       110
                ....*....|....*....|....*....|....
gi 47085759  99 RAHTGSVRSVCFSADGQSLLTASDDQ-SIKLWSV 131
Cdd:COG0823 112 RRLTDGPGSPSWSPDGRRIVFSSDRGgRPDLYVV 145
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 196-300 5.50e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 38.75  E-value: 5.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759 196 PSSTCIATASSDNTVRVWDIRThtllQHYQVHS-----AAVNALSFHPSGNHLLTASSDSTLKILDLLEGRLLYTLHGHQ 270
Cdd:cd22857 190 DDHRKIVTGTGYHQVRLYDTRA----QRRPVVSvdfgeTPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKC 265

                        90       100       110
                ....*....|....*....|....*....|.
gi 47085759 271 GSA-SCVSFSRSGDQFASAGSDQQVMVWRTN 300
Cdd:cd22857 266 GGSiRSIARHPELPLIASCGLDRYLRIWDTE 296
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 152-226 6.66e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.10  E-value: 6.66e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085759   152 FSPDGQ-LMVSVSDDRTVKLWDASSRQLIHTFcePGGYS-SYVDFHPSSTCIATAS-SDNTVRVWDIRTHTLLQHYQV 226
Cdd:TIGR03866  48 FSKDGKlLYVCASDSDTIQVIDPATGEVLHTL--PSGPDpEQFALHPNGKILYIANeDDALVTVIDIETRKVLAQIDV 123
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 132-213 8.63e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 37.25  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085759   132 HRQKIICTLREHN-NwvrCARFSPDGQLMV-----SVSDDrtVKLWDASSRQLIHTFCEPGgySSYVDFHPSSTCIATAS 205
Cdd:pfam08662  90 LKGNVIHSFGEQPrN---TIFWSPFGRLVLlagfgNLAGD--IEFWDVVNKKKIATAEASN--ATLCEWSPDGRYFLTAT 162

                          90
                  ....*....|....
gi 47085759   206 S------DNTVRVW 213
Cdd:pfam08662 163 TaprlrvDNGFKIW 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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