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Conserved domains on  [gi|46397887|sp|Q9RUD2|]
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RecName: Full=Ribose-phosphate pyrophosphokinase; Short=RPPK; AltName: Full=5-phospho-D-ribosyl alpha-1-diphosphate synthase; AltName: Full=Phosphoribosyl diphosphate synthase; AltName: Full=Phosphoribosyl pyrophosphate synthase; Short=P-Rib-PP synthase; Short=PRPP synthase; Short=PRPPase

Protein Classification

ribose-phosphate diphosphokinase( domain architecture ID 11421473)

ribose-phosphate diphosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

CATH:  3.40.50.2020
EC:  2.7.6.1
Gene Ontology:  GO:0002189|GO:0000287|GO:0004749|GO:0005524|GO:0009156|GO:0016301|GO:0016310|GO:0006015|GO:0009165
PubMed:  11751055|7593598

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 5-319 1.84e-151

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


:

Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 427.17  E-value: 1.84e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   5 RSPLLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSA 84
Cdd:COG0462   1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  85 SAGRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCvp 164
Cdd:COG0462  81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887 165 DAHNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMG 244
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397887 245 AKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPQDKldrAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEK---RCDKIKVLSVAPLLAEAIRRIHEGESVSSLF 310
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 5-319 1.84e-151

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 427.17  E-value: 1.84e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   5 RSPLLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSA 84
Cdd:COG0462   1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  85 SAGRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCvp 164
Cdd:COG0462  81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887 165 DAHNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMG 244
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397887 245 AKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPQDKldrAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEK---RCDKIKVLSVAPLLAEAIRRIHEGESVSSLF 310
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 8-320 6.33e-147

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 415.52  E-value: 6.33e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887     8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIV-QTFSTPVSDAIMELMLMIDAAKSASA 86
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    87 GRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPDa 166
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   167 hNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLS-DTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGA 245
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRISaTNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397887   246 KDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVpqdklDRAGGKLAVLDVAPLFASAIANIHTGASVSTLFT 320
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPH-----EKHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
8-319 7.06e-120

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 347.11  E-value: 7.06e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAG 87
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   88 RVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPDah 167
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  168 NGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGAKD 247
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46397887  248 VYVAVTHGVYSGPAIERIAALDVTQVASCNTvlVPQDKLDRAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDS--IPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 8-124 1.34e-57

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 181.46  E-value: 1.34e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887     8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAG 87
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 46397887    88 RVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAG 124
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 170-269 6.57e-19

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 81.29  E-value: 6.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887 170 VVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRA------LIGDVDGKTVFIVDDEISTAGSLVETVSIARSM 243
Cdd:cd06223  18 VVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEPyglelpLGGDVKGKRVLLVDDVIATGGTLLAAIELLKEA 97

                        90       100
                ....*....|....*....|....*.
gi 46397887 244 GAKDVYVAVTHGVYSGPAIERIAALD 269
Cdd:cd06223  98 GAKVVGVAVLLDKPEGGARELASPGD 123
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 5-319 1.84e-151

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 427.17  E-value: 1.84e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   5 RSPLLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSA 84
Cdd:COG0462   1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  85 SAGRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCvp 164
Cdd:COG0462  81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887 165 DAHNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMG 244
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397887 245 AKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPQDKldrAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEK---RCDKIKVLSVAPLLAEAIRRIHEGESVSSLF 310
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 8-320 6.33e-147

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 415.52  E-value: 6.33e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887     8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIV-QTFSTPVSDAIMELMLMIDAAKSASA 86
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    87 GRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPDa 166
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   167 hNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLS-DTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGA 245
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRISaTNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397887   246 KDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVpqdklDRAGGKLAVLDVAPLFASAIANIHTGASVSTLFT 320
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPH-----EKHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
8-319 7.06e-120

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 347.11  E-value: 7.06e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAG 87
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   88 RVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPDah 167
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  168 NGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGAKD 247
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46397887  248 VYVAVTHGVYSGPAIERIAALDVTQVASCNTvlVPQDKLDRAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDS--IPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 17-319 5.68e-95

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 283.51  E-value: 5.68e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   17 RPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAGRVTAVIPYY 96
Cdd:PLN02369   1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   97 SYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPDAHNGVVLAPDA 176
Cdd:PLN02369  81 GYARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  177 GSIKRASQIARRL-DSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGAKDVYVAVTHG 255
Cdd:PLN02369 161 GGVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHA 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46397887  256 VYSGPAIERIAALDVTQVASCNTVLVPQdklDRAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PLN02369 241 VFSPPAIERLSSGLFQEVIVTNTIPVSE---KNYFPQLTVLSVANLLGETIWRVHDDCSVSSIF 301
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
19-319 7.49e-92

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 275.67  E-value: 7.49e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   19 LAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAGRVTAVIPYYSY 98
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   99 ARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPDaHNGVVLAPDAGS 178
Cdd:PRK03092  81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVVSPDAGR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  179 IKRASQIARRLDSG-LAMIDKER--LSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGAKDVYVAVTHG 255
Cdd:PRK03092 160 VRVAEQWADRLGGApLAFIHKTRdpTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHG 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397887  256 VYSGPAIERIAALDVTQVASCNTVLVPQDK-LDraggKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PRK03092 240 VLSGPAAERLKNCGAREVVVTDTLPIPEEKrFD----KLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 8-319 9.14e-91

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 273.93  E-value: 9.14e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAG 87
Cdd:PRK02812  22 LRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASAR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   88 RVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFK-KCVPDA 166
Cdd:PRK02812 102 QITAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLAsKNLEDI 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  167 hngVVLAPDAGSIKRASQIARRL-DSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGA 245
Cdd:PRK02812 182 ---VVVSPDVGGVARARAFAKKLnDAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGA 258

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46397887  246 KDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPQdklDRAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PRK02812 259 KQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPVPE---ERRFPQLKVLSVANMLGEAIWRIHEESSVSSMF 329
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
6-319 4.40e-86

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 261.65  E-value: 4.40e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    6 SPLLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSAS 85
Cdd:PRK02269   4 SDLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRAS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   86 AGRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPD 165
Cdd:PRK02269  84 AESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  166 AHNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRA--LIGDVDGKTVFIVDDEISTAGSLVETVSIARSM 243
Cdd:PRK02269 164 GDDVVVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSVDKMNTSEVmnIIGNVKGKKCILIDDMIDTAGTICHAADALAEA 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46397887  244 GAKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPQDKLDRaggKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PRK02269 244 GATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIYLPEERLID---KIEQISIADLLGEAIIRIHEKRPLSPLF 316
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 9-319 4.40e-81

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 252.49  E-value: 4.40e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    9 LVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAGR 88
Cdd:PTZ00145 121 ILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRASAKK 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   89 VTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFF--KVPVDHLSADVVLSQHFKKcvPDA 166
Cdd:PTZ00145 201 ITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFgpRVPVDNLEAQLIGLDYFTK--KDL 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  167 HNGVVLAPDAGSIKRASQIARRL------DSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIA 240
Cdd:PTZ00145 279 YKPVIVSPDAGGVYRARKFQDGLnhrgisDCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQL 358

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46397887  241 RSMGAKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTvlVPQDKLDRAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PTZ00145 359 KKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDT--VKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
8-319 7.32e-78

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 240.60  E-value: 7.32e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAG 87
Cdd:PRK04923   7 LLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRASAA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   88 RVTAVIPYYSYARSDKK-DSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSAD-VVLSQHFKKCVPD 165
Cdd:PRK04923  87 SVTAVIPYFGYSRQDRRmRSSRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASpLLLADIWRAYGTD 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  166 ahNGVVLAPDAGSIKRASQIARRL-DSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMG 244
Cdd:PRK04923 167 --NLIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRG 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397887  245 AKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTvlVPQDKLDRAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PRK04923 245 ALKVVAYITHPVLSGPAVDNINNSQLDELVVTDT--IPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-319 3.34e-74

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 231.17  E-value: 3.34e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    1 MNSRRSPLLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDA 80
Cdd:PRK02458   3 ERYADKQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   81 AKSASAGRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFK 160
Cdd:PRK02458  83 CKRASANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYC 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  161 KCVPDAHNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERlSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIA 240
Cdd:PRK02458 163 KKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQ-DDSEREEGYIIGDVAGKKAILIDDILNTGKTFAEAAKIV 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46397887  241 RSMGAKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPqdklDRAGGKLAVLDVAPLFASAIANIHTGASVSTLF 319
Cdd:PRK02458 242 EREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATK----ERVPKNVTYLSASELIADAIIRIHERKPLSPLF 316
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 1-320 1.56e-69

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 219.40  E-value: 1.56e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    1 MNSRRSPLLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDA 80
Cdd:PRK00553   3 LSIDKSNHVIFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   81 AKSASAGRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFK 160
Cdd:PRK00553  83 LKRGSAKSITAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  161 KCVpDAHNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIA 240
Cdd:PRK00553 163 ELL-GKKDLVVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  241 RSMGAKDVYVAVTHGVYSGPAIERI-AALD---VTQVASCNTvlVPQDKLDRAgGKLAVLDVAPLFASAIANIHTGASVS 316
Cdd:PRK00553 242 KKQKAKKVCVMATHGLFNKNAIQLFdEAFKkklIDKLFVSNS--IPQTKFEKK-PQFKVVDLAHLYEEVLLCYANGGSIS 318


                 ....
gi 46397887  317 TLFT 320
Cdd:PRK00553 319 AIYT 322
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 12-308 1.08e-62

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 200.52  E-value: 1.08e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   12 SGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFStPVSDAIMELMLMIDAAKSASAGRVTA 91
Cdd:PRK00934   4 GGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTY-PQDENLVELLLLIDALRDEGAKSITL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   92 VIPYYSYARSDKKDSPRISIAGRLVADLLQEAGaDRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKcvpDAHNGVV 171
Cdd:PRK00934  83 VIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGD---KLDDPLV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  172 LAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGAKDVYVA 251
Cdd:PRK00934 159 LAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVA 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 46397887  252 VTHGVYSGPAIERIAALDVTQVASCNTVLVPQDKldraggklavLDVAPLFASAIAN 308
Cdd:PRK00934 239 CVHPVLVGDAILKLYNAGVDEIIVTDTLESEVSK----------ISVAPLIADLLKK 285
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 8-124 1.34e-57

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 181.46  E-value: 1.34e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887     8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAG 87
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 46397887    88 RVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAG 124
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 35-318 2.17e-35

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 131.61  E-value: 2.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   35 RTEKFTNDNLIVHYEESLREGDVFIVQ-------TFST-------PVSDAIMELMLMIDAAkSASAGRVTAVIPYYSYAR 100
Cdd:PRK06827  58 KFIRFSNGEAKGEILESVRGKDIYILQdvgnysvTYNMfgeknhmSPDDHFQDLKRTIDAI-RGKARRITVIMPFLYESR 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  101 SDKKDSpRISIAGRLVADLLQEAGADRVLTMTLHSPQVH------GFFKVpvdHLSADVV--LSQHFKKCVPDAHNGVVL 172
Cdd:PRK06827 137 QHKRKG-RESLDCALALQELEELGVDNIITFDAHDPRIEnaiplmGFENL---YPSYQIIkaLLKNEKDLEIDKDHLMVI 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  173 APDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALI-------GDVDGKTVFIVDDEISTAGSLVETVSIARSMGA 245
Cdd:PRK06827 213 SPDTGAMDRAKYYASVLGVDLGLFYKRRDYSRVVNGRNPIvaheflgRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGA 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  246 KDVYVAVTHGVYSgpaiERIAALD-------VTQVASCNTVLVPQDKLDRAGGKLAvlDVAPLFASAIANIHTGASVSTL 318
Cdd:PRK06827 293 KKIIVAATFGFFT----NGLEKFDkayeegyFDRIIGTNLVYHPEELLSKPWYIEV--DMSKLIARIIDALNHDVSLSKL 366
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
6-306 1.97e-32

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 121.97  E-value: 1.97e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887    6 SPLLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPvSDAIMELMLMIDAAKSAS 85
Cdd:PRK07199   1 MQPLLLALPGNEAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLDRP-DEKLLPLLFAAEAARELG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   86 AGRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQeAGADRVLTMTLHSPQVHGF---FKVPVDHLSADVVLSQHFKKC 162
Cdd:PRK07199  80 ARRVGLVAPYLAYMRQDIAFHPGEAISQRHFARLLS-GSFDRLVTVDPHLHRYPSLsevYPIPAVVLSAAPAIAAWIRAH 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  163 VPDAhngVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRAL-IGDVDGKTVFIVDDEISTAGSLVETVSIAR 241
Cdd:PRK07199 159 VPRP---LLIGPDEESEQWVAAVAERAGAPHAVLRKTRHGDRDVEISLPdAAPWAGRTPVLVDDIVSTGRTLIEAARQLR 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46397887  242 SMGAKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPQDKldraggklavLDVAPLFASAI 306
Cdd:PRK07199 236 AAGAASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVPHPSNA----------ISLAPLLAEAL 290
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 165-319 1.80e-21

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 89.88  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   165 DAHNGVVLAPDAGSIKRASQIARRLDSGLAMIDKE-----------RLSDTEVR-------------------PRALIGD 214
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEqkeaesdevdgRQSPPPYRsrtvsrslglpeiipkekpPMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   215 VDGKTVFIVDDEISTAGSLVETVSIARSMGAKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTvlVPQDKLDRAGGKLA 294
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNT--IPHEIQKMQCHKIK 158

                         170       180
                  ....*....|....*....|....*
gi 46397887   295 VLDVAPLFASAIANIHTGASVSTLF 319
Cdd:pfam14572 159 TIDISQLIAEAIRRIHNGESMSYLF 183
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 170-269 6.57e-19

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 81.29  E-value: 6.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887 170 VVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRA------LIGDVDGKTVFIVDDEISTAGSLVETVSIARSM 243
Cdd:cd06223  18 VVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEPyglelpLGGDVKGKRVLLVDDVIATGGTLLAAIELLKEA 97

                        90       100
                ....*....|....*....|....*.
gi 46397887 244 GAKDVYVAVTHGVYSGPAIERIAALD 269
Cdd:cd06223  98 GAKVVGVAVLLDKPEGGARELASPGD 123
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 170-254 3.42e-10

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 57.76  E-value: 3.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887   170 VVLAPDAGSIKRASQIARRLDSGLAMIDKERLSD---TEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGAK 246
Cdd:pfam00156  32 VVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPdtsEVMKTSSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPK 111


                  ....*...
gi 46397887   247 DVYVAVTH 254
Cdd:pfam00156 112 EVKIAVLI 119
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 164-264 4.25e-08

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 53.92  E-value: 4.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  164 PDAHNGVVLAPDAGSIKRASqiarRLDSGLAMIDKERLSDTEVR-PRALIGDVDGKTVFIVDDEISTAGSLVETVSIARS 242
Cdd:PLN02297 180 PDSDNIVIAFPDDGAWKRFH----KQFEHFPMVVCTKVREGDKRiVRIKEGNPAGRHVVIVDDLVQSGGTLIECQKVLAA 255

                         90       100
                 ....*....|....*....|..
gi 46397887  243 MGAKDVYVAVTHGVYSGPAIER 264
Cdd:PLN02297 256 HGAAKVSAYVTHGVFPNESWER 277
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 213-274 6.07e-06

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 46.30  E-value: 6.07e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46397887 213 GDVDGKTVFIVDDEISTAGSLVETVSIARSMGAK--DVYVAVThgvYSGPAIERIAALDVTQVA 274
Cdd:COG0461 108 GLLPGERVLVVEDVITTGGSVLEAVEALREAGAEvvGVAVIVD---REEGAAENLEEAGVPLHS 168
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 114-274 2.55e-04

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 41.30  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  114 RLVADLLQEAGADR----VLTMTLHSPqvhgFF----KVPVDHLSADVV---LSQHFKKCVPDAhnGVVLAPDAGSIKRA 182
Cdd:PRK00455   6 REFIEFLLEIGALLfghfTLSSGRKSP----YYfdcrKLLSYPEALALLgrfLAEAIKDSGIEF--DVVAGPATGGIPLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397887  183 SQIARRLDsgLAMIDKERLSDTEVRPRALIG-DVDGKTVFIVDDEISTAGSLVETVSIARSMGAK--DVYVAVThgvYSG 259
Cdd:PRK00455  80 AAVARALD--LPAIFVRKEAKDHGEGGQIEGrRLFGKRVLVVEDVITTGGSVLEAVEAIRAAGAEvvGVAVIVD---RQS 154

                        170
                 ....*....|....*
gi 46397887  260 PAIERIAALDVTQVA 274
Cdd:PRK00455 155 AAQEVFADAGVPLIS 169
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 182-252 2.79e-04

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 41.39  E-value: 2.79e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46397887  182 ASQIARRLDSGLAM-IDKERLSDTEVRPRALI----GDVDGKTVFIVDDEISTAGSLVETVSIARSMGAKDVYVAV 252
Cdd:PRK02277 100 ATLVADELGKDLAIyHPKKWDHGEGEKKTGSFsrnfASVEGKRCVIVDDVITSGTTMKETIEYLKEHGGKPVAVVV 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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