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Conserved domains on  [gi|46394123|gb|AAS91463|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Thoopterus nigrescens]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-336 3.98e-166

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 467.02  E-value: 3.98e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330
                 ....*....|....*.
gi 46394123  321 KSTALLSPLTILSTMI 336
Cdd:MTH00105 321 KPMTLLPTLIILSTML 336
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-336 3.98e-166

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 467.02  E-value: 3.98e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330
                 ....*....|....*.
gi 46394123  321 KSTALLSPLTILSTMI 336
Cdd:MTH00105 321 KPMTLLPTLIILSTML 336
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-276 1.11e-24

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 101.62  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    23 SSHWLTMWIGFEMNMLAIIP-ILMKKYNPRSMEASTKYFLTQATASMLLMLAVTI-----------NLVHSGQWSTTNPL 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    91 NPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILL-TWQKLAP-----MSVLYQISPMINLDLMFTMSILSIAI 164
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGyglirRSLLYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   165 GGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIIL---------TTTTFLTFMTNSTTTTLSLSHLWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLThglfsaglfLCAGSVIYRRVHTRNIRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 46394123   236 KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSI 276
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWI 281
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-298 6.96e-24

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 101.73  E-value: 6.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   6 FSIITFTMMLGtGIVMTSS-HWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------T 75
Cdd:COG1007 104 FYALLLFATLG-MMLMASAnDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGIsllygatgS 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  76 INLVHSGQWSTTNPLNP---AASIILTLA-MAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQI------ 145
Cdd:COG1007 183 LNLAGIAAALAAGGANSpllLLGLVLVLAgLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlveafp 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 146 SPMINLDLMFT-MSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNST 224
Cdd:COG1007 263 GLAADWQLLLAvLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMNLGAFAVIL 342

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 225 TTTLSLSHLWN---------KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMR 295
Cdd:COG1007 343 LLSRKGGEAEEiedlaglarRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLR 422


                ...
gi 46394123 296 LIY 298
Cdd:COG1007 423 VVK 425
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 15-297 8.61e-21

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 92.70  E-value: 8.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    15 LGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQWS 85
Cdd:TIGR01770 113 LGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgSLNFEDLLLFL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    86 TTNPLNP---AASIILTL-AMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMI-------NLDLM 154
Cdd:TIGR01770 193 SNGMLNIsllLLGIVLILvGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgfseaWQIFL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   155 FTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGW------------MTAILAYNPTMALLNLTIYIILTTTTFLTFMTN 222
Cdd:TIGR01770 273 AIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYiligllagtlegIKAVLFYIFIYALMSLGAFGVLSLLRSYKDEWI 352

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46394123   223 STTTTLSLSHLWNkePLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLI 297
Cdd:TIGR01770 353 EYISDFAGLFKTN--PILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVV 425
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-336 3.98e-166

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 467.02  E-value: 3.98e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330
                 ....*....|....*.
gi 46394123  321 KSTALLSPLTILSTMI 336
Cdd:MTH00105 321 KPMTLLPTLIILSTML 336
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-336 2.19e-115

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 337.95  E-value: 2.19e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00112  81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00112 161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00112 241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPK 320

                        330
                 ....*....|....*.
gi 46394123  321 KSTaLLSPLTILSTMI 336
Cdd:MTH00112 321 KNT-LTATLTTLSTLL 335
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-335 2.34e-115

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 337.93  E-value: 2.34e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMiNLDLMFTMSIL 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                        330
                 ....*....|....*
gi 46394123  321 KSTALLSPLTILSTM 335
Cdd:MTH00135 320 QLTLPLAISTTATLM 334
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-336 2.23e-108

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 320.33  E-value: 2.23e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00070 161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNqT 320
Cdd:MTH00070 241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFK-N 319

                        330
                 ....*....|....*.
gi 46394123  321 KSTALLSPLTILSTMI 336
Cdd:MTH00070 320 KTNNLLSLTIILSLML 335
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-336 6.42e-86

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 262.94  E-value: 6.42e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00041  81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00041 161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGN 320

                        330       340
                 ....*....|....*....|.
gi 46394123  321 KS-----TALLSPLTILSTMI 336
Cdd:MTH00041 321 ITvygviLSILSSISILGLLL 341
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-336 1.09e-82

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 254.89  E-value: 1.09e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00200  81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00200 161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00200 241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN 320

                        330
                 ....*....|....*.
gi 46394123  321 KSTaLLSPLTILSTMI 336
Cdd:MTH00200 321 SNL-LVGLLLLLSILG 335
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-336 6.77e-52

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 175.01  E-value: 6.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLvh 80
Cdd:MTH00160   2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNM-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 sgqwSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQispMINLDLMFTMSIL 160
Cdd:MTH00160  80 ----LNLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSY---LINNNFIIIIIIL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00160 153 SAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00160 233 KFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFS 312

                        330
                 ....*....|....*.
gi 46394123  321 KSTALLSPLTILSTMI 336
Cdd:MTH00160 313 LILNFLSFISLFGLIL 328
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 11-336 6.30e-49

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 166.99  E-value: 6.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   11 FTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVHSGQWSTtnpl 90
Cdd:MTH00144  11 FLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFS---- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   91 npaaSIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINL-DLMFTMSILSIAIGGWGG 169
Cdd:MTH00144  87 ----MSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaYLLCVISVLSALVGSIGG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  170 LNQTQLRKVMAYSSIAHMGWMTAILAYNPtMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTML 249
Cdd:MTH00144 163 LNQTQVRALLAYSSISHTGWMLVAILHGS-WLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  250 SLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQTKSTALLSPL 329
Cdd:MTH00144 242 SLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNLLGGL 321


                 ....*..
gi 46394123  330 TILSTMI 336
Cdd:MTH00144 322 LFLLLYL 328
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 12-300 4.62e-45

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 156.86  E-value: 4.62e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   12 TMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTInlvhsgQWSTTNPLN 91
Cdd:MTH00011  14 TMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTM------MWSFPSLLK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   92 PAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSILSIAIGGWGGLN 171
Cdd:MTH00011  88 NITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAGGLGGMN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  172 QTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSL 251
Cdd:MTH00011 168 QTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSL 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 46394123  252 GGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSS 300
Cdd:MTH00011 248 GGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNF 296
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 11-332 9.30e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 137.50  E-value: 9.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   11 FTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLvhsgqwsTTNPL 90
Cdd:MTH00197   5 FIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSF-------SNLYL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   91 NPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPmiNLDLMFTMSILSIAIGGWGGL 170
Cdd:MTH00197  78 SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSS--SFMGLLICSVLSSLIGGIGGM 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  171 NQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLS 250
Cdd:MTH00197 156 NQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  251 LGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQTKSTALLSPLT 330
Cdd:MTH00197 236 LGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFILLMMMLP 315


                 ..
gi 46394123  331 IL 332
Cdd:MTH00197 316 LL 317
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 15-314 4.38e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 103.96  E-value: 4.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   15 LGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAVT-------------INLVH 80
Cdd:MTH00196   4 LGILCLISSSNWLSVYLAIELQTLSLfILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCAllcgttgglhlsyINLVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTmsIL 160
Cdd:MTH00196  84 NSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGG--LF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMAL------LNLTIYIILTTTTFLTFMTNSTTTTLSLSHLW 234
Cdd:MTH00196 162 SLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSFESIqaslvyLFIYIIMSICVFSIILALNVYKNLIIEFSGLS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  235 NKEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRL---IYSSALTLFPSMNNT 311
Cdd:MTH00196 242 RRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRIvkiLFFQANSFLLISTKI 321


                 ...
gi 46394123  312 VMK 314
Cdd:MTH00196 322 LKK 324
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-276 1.11e-24

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 101.62  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    23 SSHWLTMWIGFEMNMLAIIP-ILMKKYNPRSMEASTKYFLTQATASMLLMLAVTI-----------NLVHSGQWSTTNPL 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    91 NPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILL-TWQKLAP-----MSVLYQISPMINLDLMFTMSILSIAI 164
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGyglirRSLLYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   165 GGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIIL---------TTTTFLTFMTNSTTTTLSLSHLWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLThglfsaglfLCAGSVIYRRVHTRNIRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 46394123   236 KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSI 276
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWI 281
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-298 6.96e-24

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 101.73  E-value: 6.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   6 FSIITFTMMLGtGIVMTSS-HWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------T 75
Cdd:COG1007 104 FYALLLFATLG-MMLMASAnDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGIsllygatgS 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  76 INLVHSGQWSTTNPLNP---AASIILTLA-MAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQI------ 145
Cdd:COG1007 183 LNLAGIAAALAAGGANSpllLLGLVLVLAgLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlveafp 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 146 SPMINLDLMFT-MSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNST 224
Cdd:COG1007 263 GLAADWQLLLAvLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMNLGAFAVIL 342

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 225 TTTLSLSHLWN---------KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMR 295
Cdd:COG1007 343 LLSRKGGEAEEiedlaglarRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLR 422


                ...
gi 46394123 296 LIY 298
Cdd:COG1007 423 VVK 425
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 15-297 8.61e-21

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 92.70  E-value: 8.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    15 LGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQWS 85
Cdd:TIGR01770 113 LGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgSLNFEDLLLFL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    86 TTNPLNP---AASIILTL-AMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMI-------NLDLM 154
Cdd:TIGR01770 193 SNGMLNIsllLLGIVLILvGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgfseaWQIFL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   155 FTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGW------------MTAILAYNPTMALLNLTIYIILTTTTFLTFMTN 222
Cdd:TIGR01770 273 AIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYiligllagtlegIKAVLFYIFIYALMSLGAFGVLSLLRSYKDEWI 352

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46394123   223 STTTTLSLSHLWNkePLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLI 297
Cdd:TIGR01770 353 EYISDFAGLFKTN--PILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVV 425
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 6-267 3.03e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 91.23  E-value: 3.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    6 FSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVHSGQW 84
Cdd:MTH00199  99 SPILILIVALGSLLLVSSINWLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGET 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   85 ST----TNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMftMSIL 160
Cdd:MTH00199 179 SIqginSILTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLI--CAVL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  161 SIAIGGWGGLNQTQLRKVMAYSSIAHMG---WMTAILAYNPTMALLNLTIYIILTTT---TFLTFMTNSTTTTLSLSHLW 234
Cdd:MTH00199 257 SIIYGAIGALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESIQASLIYMIIYVIMSIcsfSIILSLKLTKGLIVEVSGLS 336

                        250       260       270
                 ....*....|....*....|....*....|...
gi 46394123  235 NKEPLITTIILVTMLSLGGLPPLSGFLPKWMII 267
Cdd:MTH00199 337 RKNPVIALTLALTFLSIAGIPPLAGFLSKWLIL 369
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
13-297 5.55e-19

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 87.57  E-value: 5.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   13 MMLGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQ 83
Cdd:PRK05777 112 ALLGMMVMVSANDLLTLFLGLELLSLPLyALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMsllygatgSLSFAGIAK 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   84 WSTTNPLNP---AASIILTLA-MAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQI-------SPMINLD 152
Cdd:PRK05777 192 ALADGSGNSlllLFGLVFLLVgLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLlvvafggLSEDWQQ 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  153 LMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSH 232
Cdd:PRK05777 272 VLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMTLGAFGVISLLRRKGGE 351

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46394123  233 LWN---------KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLI 297
Cdd:PRK05777 352 AESisdfaglskRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRVI 425
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 13-298 2.14e-17

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 82.50  E-value: 2.14e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  13 MMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQW 84
Cdd:COG0651 116 LLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVgllygatgTLNMADLAAR 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  85 STT--NPLNPAASIILTLAMAMKLGLSPFHFWVPE-----------VTQGVHLPSGL--ILLTWQKLAPMSVLYQISPmi 149
Cdd:COG0651 196 LAEldPGLLLAAFALLLVGFGIKAALFPLHFWLPDaypaapspvsaLLSGLLTKVGVyaILRVLTLLFGADPALFLGT-- 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 150 nldLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALL--------NLTIYIILTTTTFLTFMT 221
Cdd:COG0651 274 ---LLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAgalfhllnHALAKALLFLAAGAIERA 350

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 46394123 222 NSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIY 298
Cdd:COG0651 351 TGTRDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIFG 427
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 15-267 3.52e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 67.19  E-value: 3.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   15 LGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSM---------EASTKYFLTQATASMLLMLAV----------- 74
Cdd:MTH00198 199 LGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCalyfgftgneg 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   75 TINLVHSGQWSTTNPLNPAASI---ILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLyqISPMINL 151
Cdd:MTH00198 279 MLGTILSATLETTNIELRQGSLgylFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILL--TSLVITS 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  152 DLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMG-----------------WMTAILAYNPTMALLNL--------T 206
Cdd:MTH00198 357 KLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGfiligvsagtyeslqasWTYAVTYLVSALASFTVictleefgT 436

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46394123  207 IYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLPPLSGFLPKWMII 267
Cdd:MTH00198 437 RTPTSRQRDGSFGNYNLVRRLVDLTILSRGQPYIAFSLAIVFLSLAGIPPLLGFLGKWFIL 497
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 50-298 1.61e-09

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 58.80  E-value: 1.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    50 PRSMEASTKYFLTQATASmLLMLAVTINLVHSGQWST------TNPLNPAASIILTL----AMAMKLGLSPFHFWVPEV- 118
Cdd:TIGR01972 152 PNRIYAAMKFFLYTLAGS-LLMLLAILGLYFLGGGTFdllellNLPLPFGVQTWLFLaffiAFAVKVPLFPLHTWLPDAh 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   119 ----TQGVHLPSGLILltwqKLAPMSVLYQISPM------INLDLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMG 188
Cdd:TIGR01972 231 veapTAGSVILAGVLL----KMGTYGFLRFNLPLfpdaslYFAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   189 WMT-AILAYNPT-------MALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLPPLSGF 260
Cdd:TIGR01972 307 FVLlGIFSFNELgisgavfQMISHGLITAALFLLVGVLYERAHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGF 386

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 46394123   261 LPKWMIIQELTKNN---SIIAPTTMAITALLNLFFYMRLIY 298
Cdd:TIGR01972 387 VGEFLILLGSFKVNpvvAFLAALGIVLAAAYMLTLYKRVFF 427
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 291-335 4.37e-09

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 51.87  E-value: 4.37e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 46394123   291 FFYMRLIYSSALTLFPSMNNTVMKWQLNQTKSTALLSPLTILSTM 335
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSIL 45
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 50-199 2.00e-08

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 55.47  E-value: 2.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  50 PRSMEASTKYFLTQATASMLLMLAVTINLVHSGQWS------TTNPLNPAASIILTLAM----AMKLGLSPFHFWVPEV- 118
Cdd:COG1008 157 ERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTfdiaelAAAPLPLTAQLLLFLAFfiafAVKVPMFPFHTWLPDAh 236

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 119 ----TQGVHLPSGLIL----------------LTWQKLAPmsvlyqispminldLMFTMSILSIAIGGWGGLNQTQLRKV 178
Cdd:COG1008 237 veapTAGSVLLAGVLLkmggygllrfalplfpEASAYFAP--------------LLAALGVIGIIYGALVALAQTDLKRL 302

                       170       180
                ....*....|....*....|..
gi 46394123 179 MAYSSIAHMGWMT-AILAYNPT 199
Cdd:COG1008 303 IAYSSVSHMGFVLlGIFALNPL 324
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
6-263 2.37e-08

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 55.44  E-value: 2.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    6 FSIITFTMMLGTGIVMTSSHWLTMWIGFEMnmLAIIPILMKKY---NPRSMEASTKYFLTQATASMLLMLAVTI------ 76
Cdd:PRK02504 112 FAAILLTATLGGMFLSGATELVMIFISLET--LSIASYLLTGYmkrDPRSNEAALKYLLIGAASSAIFLYGSSLlyglsg 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   77 ---NLVHSGQWSTTNPlNPAASIILTLAMA---MKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLA----PMSVLYQIS 146
Cdd:PRK02504 190 gstQLSAIALALITSP-SLGLALALVFVIAgiaFKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAF 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  147 PMINLD--LMFT-MSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWM------------TAILAYNPTMALLNltiyIIL 211
Cdd:PRK02504 269 PSFDEQwkLLFTaLAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVmiglvagteagyASMVFYLLAYLFMN----LGA 344

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 46394123  212 TTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLPPLSGFLPK 263
Cdd:PRK02504 345 FACVILFSLRTGTDQISDYAGLYQKDPLLTLGLSLCLLSLGGIPPLAGFFGK 396
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 49-298 2.67e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 52.19  E-value: 2.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   49 NPRSMEASTKYFLTQATASMLLMLAV--------TINL-VHSGQWSTTNPLNpAASIILTLAMAMKLGLSPFHFWVPE-- 117
Cdd:PRK08375 151 DRRALAAARKYLIVGLIGSTFLLIGVgllygvtgTLNMaDLAGALAENPTVV-TAFGFVLLALALKAAVFPLHTWLPRay 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  118 ---------------VTQGVHlpsGLILLtwqklapMSVLYQISPMINLDLMF---TMSILSIAIGGWGGLNQTQLRKVM 179
Cdd:PRK08375 230 paappvvtallsglvTKVAVY---ALIRI-------YFTVFGGDFRFALGLGWllaVLALLSMLVGSLAALGQDDVKRVL 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  180 AYSSIAHMGWMTAILAYN----PTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWN----KEPLITTIILVTMLSL 251
Cdd:PRK08375 300 AYSTVSQMGYILLGLALLtplaLAAGLLHLLHHALMKGALFLAAGAIEVTYGTRRLSELSglgrRMPLTAAAFAVASLSL 379

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 46394123  252 GGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIY 298
Cdd:PRK08375 380 IGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWY 426
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 47-299 3.27e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 51.90  E-value: 3.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   47 KYNPRSMEASTKYFLTQATASMLLMLAV--------TINL------VHSGQWSTTNPL--NPAASIILTLAMAM-----K 105
Cdd:PRK12667 157 RDRGDAVEAAIKYALIGAVGTTLYFLALaflyatfgTLNMadlsakIRGLSFPLTGGLagNPPLALGVALALALwaftiK 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  106 LGLSPFHFWVPEVTQGVHLP-----SGLILLTwQKLAPMSVLYQI--SPMINLDLMFTMSIL-------SIAIGGWGGLN 171
Cdd:PRK12667 237 AAIFPNHFWLPDAHPAAPSPvsamlSGLVVNV-GAYAIIRFLYTIfgISPSLIDFRAALSPIliilgavSAIIGALMMVV 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  172 QTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSH--------LWNKEPLITTI 243
Cdd:PRK12667 316 QKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASGVFIHAAGTrdidelagLGRKMPIASFA 395

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 46394123  244 ILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYS 299
Cdd:PRK12667 396 FLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYS 451
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
33-296 1.28e-06

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 49.95  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   33 FEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVH----SGQWSTTNPLnPAASIILTL 100
Cdd:PRK12663 137 FEVMLIASFVLITLGQEREQLRGAIKYVVLNLIGSWLFLLGIgllygtfgTLNMAHiamrLNDMGDTATL-TTIALLFLL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  101 AMAMKLGLSPFhFWVPevtQGVHLPSGLI------LLT----WQKLAPMSVLYQISPMINLDLMFTMSILSIAIGGWGGL 170
Cdd:PRK12663 216 AFGMKAALFPF-MWLP---AAYHTPNTEVaalfaaLLTkvgiYALIRVFTLLFPQERELLHPLLATMAAITMVIGALGAL 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  171 NQTQLRKVMAYSSIAHMGWMTAILAYNPTM--------ALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITT 242
Cdd:PRK12663 292 AYKDIRRIAGYQVISSIGFILLGLALGTPAgingaifyLVHDMVVKTALFLIAGSLVRLTGYRSLQYLGGLYRKEPLFGA 371

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 46394123  243 IILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRL 296
Cdd:PRK12663 372 LFLILIFAIGGLPPFSGFWGKVLLVQGALDNGAYILLALMLITSLITMYSLFRI 425
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 48-299 2.07e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 49.33  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   48 YNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQWSTTNP--LNPAASIILTLAMAMKLGLSPFHFWVPE 117
Cdd:PRK08376 166 DTWEAIEAGIKYMFVGSLASSMVLLGIallygqygTLNMAYLAVKMSENPtvVAKIALALFIAGLAMKSGAVPVHMWLPD 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  118 VTQGVhlPSGL-ILLTWQKLAPMSVLYQIS-----PMINLD----LMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHM 187
Cdd:PRK08376 246 AYPAA--PSSIsAMLLVIKQAGLYALARVLfsiygPAINLAtvgwVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQI 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  188 GWM-----TAILAYNPT------MALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWN---------KEPLITTIILVT 247
Cdd:PRK08376 324 GYMllglgVGLAALGDPamasygEIALAGGIYHIVNHALYKALLFLTAGAVIYETGTRNlnelgglarTMPKTTIAFLIG 403

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 46394123  248 MLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMaITALLNLFFYMRLIYS 299
Cdd:PRK08376 404 AAAIVGLPPFNGFASKWLIYESSALFNPILGVIAM-IGSVLTLASFVKVFHT 454
ndhB CHL00049
NADH dehydrogenase subunit 2
 51-297 3.26e-06

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 48.46  E-value: 3.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   51 RSMEASTKYFLTQATASMLLMLAVTINLVHSG----------QWSTTNPLNPAAS----IILTLAMAMKLGLSPFHFWVP 116
Cdd:CHL00049 159 RSNEATMKYLLMGGASSSILVYGFSWLYGLSGgeielqeivnGLINTQMYNSPGIsialIFITVGIGFKLSLAPFHQWTP 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  117 EVTQGVHLPSGLILLTWQKLAPMSVLYQIspminLDLMFT------------MSILSIAIGGWGGLNQTQLRKVMAYSSI 184
Cdd:CHL00049 239 DVYEGSPTPVVAFLSVTSKVAASALATRI-----FDIPFYfssnewhllleiLAILSMILGNLIAITQTSMKRMLAYSSI 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  185 AHMGW-MTAILAYNP--------TMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLP 255
Cdd:CHL00049 314 GQIGYvIIGIIVGDSndgyasmiTYMLFYIFMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGIP 393

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 46394123  256 PLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLI 297
Cdd:CHL00049 394 PLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVISIYYYLKII 435
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 50-191 1.69e-05

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 46.35  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   50 PRSMEASTKYFLTQATASMLLMLAV-TINLVHSGQWSTTN-------PLNPAASIILTLAM----AMKLGLSPFHFWVPE 117
Cdd:PRK05846 157 KNRIYAATKFFLYTLLGSLLMLVAIiYLVVVYYNATGTFDiadllnlPLPPGVQYWLFLAFfiafAVKMPMFPLHTWLPD 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  118 V-----TQGVHLPSGLILltwqKLAP---MSVLYQISPMINLD---LMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAH 186
Cdd:PRK05846 237 AhvqapTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEfapIIITLGVIAIIYGALVALAQTDIKKLIAYSSISH 312


                 ....*
gi 46394123  187 MGWMT 191
Cdd:PRK05846 313 MGFVT 317
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 6-291 3.31e-05

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 45.76  E-value: 3.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    6 FSIITFTMMLGtgiVMTSSHWLTMWIGFEMNMLA--IIPILMKKYNprsMEASTKYFLTQATASMLLMLAV--------T 75
Cdd:PRK08668 103 FALMSLAGVLG---VFLANDLLTLYIFWEIMTFSsfMMVPMGKKES---RKASLKYFVLSAIGAYAMLYAIfliyaktgT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   76 INLVHSGQWSTTNPLNPAASIILTLAMAM---KLGLSPFHFWVPE-----------VTQGVHLPSG-------LILLTWQ 134
Cdd:PRK08668 177 FDFADISQGLINDTSTGFALIVFLFLLAFgvaKAGIFPLHVWAPDayseapqsfsaVLSGQLSKLGaygfllvLYVLPGT 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  135 KLAPMSVLYQISPMINLDLMFtMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGW-------MTAILAYNPTMALLNLTI 207
Cdd:PRK08668 257 KLFSEFGTYRGVPLFNYILAW-LGNISIIVGTLMAILQEDIKKLIAYSSVANGGYilvglglGTSLGFAGGLFHVFNHAL 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  208 YIILTTTTFLTFMTNSTTTTLSLS-HLWNKEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNsiiapttMAITA 286
Cdd:PRK08668 336 FKGLFFLIFAAVIYRTGTTKISEMgGLIEKMPFTFAMYLVAIISLAGIPPMSGFASKWLIFEALISKG-------MPITA 408


                 ....*
gi 46394123  287 LLNLF 291
Cdd:PRK08668 409 FMAFF 413
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 110-298 3.40e-05

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 45.53  E-value: 3.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 110 PFHFWVPE-----------------VTQGVHLpsglilltwqkLAPMSVLYQISPMInLDLMFTMSILSIAIGGWGGLNQ 172
Cdd:COG1009 229 PLHFWLPDamegptpvsallhaatmVKAGVYL-----------LARLSPLFALSPVW-LTVVAIIGAITALFAALIALAQ 296

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 173 TQLRKVMAYSSIAHMGWMTAIL---AYNPTMALLnltiyiilttttfltfmtnsttttlslshL---------------- 233
Cdd:COG1009 297 TDIKRVLAYSTVSQLGYMFLALgvgAYVAALFHL-----------------------------Lthaffkallflgagsv 347

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123 234 ---------------WNKEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQEL--TKNNSIIAPTTMAITALLNLFFYMRL 296
Cdd:COG1009 348 ihatgtrdirkmgglRKKMPITAITFLIGALSLAGIPPFAGFFSKEAILEAAleAGGLGPLLLAVALLGAFLTAFYSFRL 427


                ..
gi 46394123 297 IY 298
Cdd:COG1009 428 FF 429
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 100-304 1.11e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 43.76  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  100 LAMAMKLGLSPFHFWVPEV-----TQGVHLPSGlILLTWQKLAPMSVLYQISPMINLDL---MFTMSILSIAIGGWGGLN 171
Cdd:MTH00226 238 LAMAVKIPIFPFHIWLPKAhveapVAGSVLLAG-ILLKLGGYGLVRLSWPILPLGAQNLapaVIAMGIVGIVYGSFATCR 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  172 QTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNK--------EPLITTI 243
Cdd:MTH00226 317 QIDVKRLVAYSSVAHMGLVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTRLIKyyrglsitMPIWGTI 396

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46394123  244 ILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAP---TTMAITALLNLFFYMRLIYSSALTL 304
Cdd:MTH00226 397 MIVTSLANVAVPPSGNFIGEYLSILSSFNWNPIIGVfvcSGVILSAVYSFYFANRVTFGAPGNL 460
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 100-191 2.12e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 43.12  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  100 LAMAMKLGLSPFHFWVPE-----------VTQGVHLP---SGLILLTWqKLAPMSVLYqISPMInldlmFTMSILSIAIG 165
Cdd:MTH00217 214 LSLAIKIPKIPFHIWLPQahveapvagsvILAGVLLKlggYGFIRFSW-PLLPEASEY-FSPLI-----QTLSLLAIIYG 286

                         90       100
                 ....*....|....*....|....*.
gi 46394123  166 GWGGLNQTQLRKVMAYSSIAHMGWMT 191
Cdd:MTH00217 287 SLTTCRQVDLKRIIAYSSVAHMGLVT 312
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 55-188 5.53e-04

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 41.56  E-value: 5.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   55 ASTKYFLTQATASMLLMLA----------VTINLVHSGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPE------- 117
Cdd:PRK12561 138 AATKFILYTALASIFILVAglalalsgdtFTFDLAELGAKSYPLALELLLYAGFLIAFGVKLPIFPLHTWLPDahgeasa 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46394123  118 ----VTQGVHLPSG---LILLTWQKLAPMSVlyQISPminldLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMG 188
Cdd:PRK12561 218 pvsmILAGVLLKMGgyaLIRFNVQMLPDAHV--YFAP-----ALAILGVVNIIYGALNAFAQDNVKRRLAYSSVSHMG 288
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 11-299 6.60e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 41.34  E-value: 6.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   11 FTMMLGTGIVMtSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTI---NLVHSGQWSTT 87
Cdd:PRK06589 124 LTILIGVLIAL-SSDLFTMFVCYELLTISTAFLIGHTRNNISLSGGYKYLKILMISALLLFLPAVIliyTKTGNLDFVSG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   88 NPLNPAASIILTLAMAMKLG---LSPFHFWVPEV----TQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMS-- 158
Cdd:PRK06589 203 GLFSKNQSIILLLMFIYGIAktaIFPVHSWLPAAmvahYPVSALLHAVIVVKTGLFCIYKILLYIFGLSYLQRIFAEFnw 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  159 -----ILSIAIGGWGGLNQTQLRKVMAYSSIAHMGW-------MTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTT 226
Cdd:PRK06589 283 lifipIVSIFYSSLKALKTDNIKKILAYSTISQLSLallsafiLTPKALGAAILHLVSHSFAKICLFYSMGSIYSLKKED 362

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46394123  227 TLSLSHLWNKE-PLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNN----SIIAPTTMAITALLNLFFYMRLIYS 299
Cdd:PRK06589 363 QVDKLHGTSKSfPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNqpwlSIIVMLVVIASSILSALYLLKILSS 440
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 6-191 1.71e-03

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 39.91  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123    6 FSIITFTMMLgtgiVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFL------TQATASMLLMLAVTINLV 79
Cdd:PRK06458 114 YQLFLFTMLL----ALTSNNLGLMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIicsvgvAFALFGTILVYANAATVM 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   80 HSGQ----WSTTNPLNPAA-SIILTLAMAM-------KLGLSPFHFWVPE-----------VTQGVHLPSGL-ILLTWQK 135
Cdd:PRK06458 190 GDGEmailWTELLKHASLLdPTLMKLAFVFlligfgtKVGLFPMHAWLPDahseapspvsaLLSGVLLNVALyAVLRYYI 269

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 46394123  136 LAPMSVLYQISPMinldLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMT 191
Cdd:PRK06458 270 LIDAAIGSDFPGR----LLLIFGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLIA 321
ND5 MTH00210
NADH dehydrogenase subunit 5; Provisional
 238-333 7.60e-03

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 177253 [Multi-domain]  Cd Length: 616  Bit Score: 38.07  E-value: 7.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  238 PLITTIILVTMLSLGGLPPLSGFLPKWMIIqELTKNNSIIAPTTM--AITALLNLFFYMRLIYssaLTLFPSMNNTVMKW 315
Cdd:MTH00210 368 PFTYVMILIGSLSLMGFPYLTGFYSKDLIL-ELTYDKYYIAFAYWlgSFSALLTAFYSIRLIY---LTFITNTNSKKEVF 443

                         90
                 ....*....|....*...
gi 46394123  316 QLNQTKSTALLSPLTILS 333
Cdd:MTH00210 444 IGVHESSWNITFPLLLLA 461
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 35-195 8.44e-03

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 37.82  E-value: 8.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123   35 MNMLAIIPILMKKYNP--RSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQWSTTnpLNPAASII----LTL 100
Cdd:PRK08377 137 MEITAITAYALTAYNKtgEAAEASMKYIVLGGIGSSFFLIGValiygatgTLNMAHIAQLAGT--IDPTVAQVglalLIF 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46394123  101 AMAMKLGLSPFHFWVPEVTQGVHLPsglILLTWQKLAPMSVLYQISPMIN-----------LDLMFTMSILSIAIGGWGG 169
Cdd:PRK08377 215 GLAVEAELFPLNAWAPDAYQAAPHP---ITVMFSAFVVKAGLYAMARILYlmqnangwssvLKLVIIMATLTVFFAELSA 291

                        170       180
                 ....*....|....*....|....*.
gi 46394123  170 LNQTQLRKVMAYSSIAHMGWMTAILA 195
Cdd:PRK08377 292 LRQKNVKRMIAYSSIGQVGMIALALA 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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