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Conserved domains on  [gi|46242630|gb|AAS83447|]
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arylalkylamine N-acetyltransferase, partial [Psittacus erithacus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
23-175 1.06e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 62.03  E-value: 1.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  23 FRCLSPEDAVSVFEIEREAFisVSGDCPLHLDEIRHFLNLcpELSLGWFEEGRLVAFIIGSLWDQErlsqaalslhrPQG 102
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVDID-----------GEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46242630 103 SAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRALpAARRALLMCQGFLVPFYQKCGFRALGPCAVTVGDLAFV 175
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRAALEAARER-GARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEVF 137
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
23-175 1.06e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 62.03  E-value: 1.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  23 FRCLSPEDAVSVFEIEREAFisVSGDCPLHLDEIRHFLNLcpELSLGWFEEGRLVAFIIGSLWDQErlsqaalslhrPQG 102
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVDID-----------GEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46242630 103 SAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRALpAARRALLMCQGFLVPFYQKCGFRALGPCAVTVGDLAFV 175
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRAALEAARER-GARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEVF 137
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 33-159 1.46e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.99  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630    33 SVFEIEREAFISVSGDCPLhlDEIRHFLNLCPELSLGWFEEGRLVAFIIGSLWDQErlsqaalslhrpqGSAVHIHVLAV 112
Cdd:pfam00583   3 ALYELLSEEFPEPWPDEPL--DLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDE-------------PPVGEIEGLAV 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 46242630   113 HRGCRQQGKGSILMWRYLRYLRALPAARRAL--LMCQGFLVPFYQKCGF 159
Cdd:pfam00583  68 APEYRGKGIGTALLQALLEWARERGCERIFLevAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 67-140 9.13e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 33.40  E-value: 9.13e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46242630  67 SLGWFEEGRLVAFIIgslwdqerlsqaaLSLHRPQGSAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRALPAAR 140
Cdd:cd04301   1 FLVAEDDGEIVGFAS-------------LSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKR 61
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
23-175 1.06e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 62.03  E-value: 1.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  23 FRCLSPEDAVSVFEIEREAFisVSGDCPLHLDEIRHFLNLcpELSLGWFEEGRLVAFIIGSLWDQErlsqaalslhrPQG 102
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVDID-----------GEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46242630 103 SAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRALpAARRALLMCQGFLVPFYQKCGFRALGPCAVTVGDLAFV 175
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRAALEAARER-GARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEVF 137
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 33-159 1.46e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.99  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630    33 SVFEIEREAFISVSGDCPLhlDEIRHFLNLCPELSLGWFEEGRLVAFIIGSLWDQErlsqaalslhrpqGSAVHIHVLAV 112
Cdd:pfam00583   3 ALYELLSEEFPEPWPDEPL--DLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDE-------------PPVGEIEGLAV 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 46242630   113 HRGCRQQGKGSILMWRYLRYLRALPAARRAL--LMCQGFLVPFYQKCGF 159
Cdd:pfam00583  68 APEYRGKGIGTALLQALLEWARERGCERIFLevAADNLAAIALYEKLGF 116
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 106-178 1.06e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 45.72  E-value: 1.06e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46242630   106 HIHVLAVHRGCRQQGKGSILMWRYLRYLRALPAARRALLM-CQGFLVPFYQKCGFRALGPcaVTVGD-LAFVEME 178
Cdd:pfam13673  53 HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVnASPYAVPFYEKLGFRATGP--EQEFNgIRFVPME 125
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
68-164 1.33e-06

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 45.56  E-value: 1.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  68 LGWFEEGRLVAfiigslwdqerlsqaALSLHRPQGSAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRALPAaRRALLMCQ 147
Cdd:COG2153  37 LLAYDDGELVA---------------TARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGA-RRIVLSAQ 100

                        90
                ....*....|....*..
gi 46242630 148 GFLVPFYQKCGFRALGP 164
Cdd:COG2153 101 AHAVGFYEKLGFVPVGE 117
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 72-160 2.83e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 40.90  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630    72 EEGRLVAFIIGSLWDQERlsqaalslhrpqgsAVHIHVLAVHRGCRQQGKGSILMwRYLRYLRALPAARRALLMCQGFLV 151
Cdd:pfam13508  10 DDGKIVGFAALLPLDDEG--------------ALAELRLAVHPEYRGQGIGRALL-EAAEAAAKEGGIKLLELETTNRAA 74


                  ....*....
gi 46242630   152 PFYQKCGFR 160
Cdd:pfam13508  75 AFYEKLGFE 83
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 93-175 1.09e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 39.25  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  93 AALSLHRPQGSAvHIHVLAVHRGCRQQGKGSILMWRYLRYLRALpAARRALLMCQGF---LVPFYQKCGFRALGPCAVTV 169
Cdd:COG0456   3 ALLGLVDGGDEA-EIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDneaAIALYEKLGFEEVGERPNYY 80


                ....*.
gi 46242630 170 GDLAFV 175
Cdd:COG0456  81 GDDALV 86
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 72-183 5.47e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 38.50  E-value: 5.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  72 EEGRLVAFIIGSlwDQERLsQAALSLHRPQGSAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRALpAARRALLMC---QG 148
Cdd:COG0454  29 GSLAGAEFIAVD--DKGEP-IGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARER-GCTALELDTldgNP 104

                        90       100       110
                ....*....|....*....|....*....|....*
gi 46242630 149 FLVPFYQKCGFRALGpcavTVGDLAFVEMEHAVRG 183
Cdd:COG0454 105 AAIRFYERLGFKEIE----RYVAYVGGEFEKELSL 135
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 22-164 1.14e-03

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 37.28  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  22 EFRCLSPEDAVSVFEIEREAFIsvsgdcplhLDEIRHFLnlcpelslGWFEEGRLVAFIigslwdqerlsqaalSLHRPQ 101
Cdd:COG1246   2 TIRPATPDDVPAILELIRPYAL---------EEEIGEFW--------VAEEDGEIVGCA---------------ALHPLD 49

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46242630 102 GSAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRALpAARRALLMCQGFLVPFYQKCGFRALGP 164
Cdd:COG1246  50 EDLAELRSLAVHPDYRGRGIGRRLLEALLAEAREL-GLKRLFLLTTSAAIHFYEKLGFEEIDK 111
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
22-163 1.38e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 37.67  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  22 EFRCLSPEDAVSVFEIEREAFISVS---GDCPLHLDEIRHFLNLCPELSLGWF---EEGRLVAFIIGSLWDQerlsqaal 95
Cdd:COG1247   3 TIRPATPEDAPAIAAIYNEAIAEGTatfETEPPSEEEREAWFAAILAPGRPVLvaeEDGEVVGFASLGPFRP-------- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46242630  96 slhRPQGSAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRAL-------------PAARRallmcqgflvpFYQKCGFRAL 162
Cdd:COG1247  75 ---RPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARgyrrlvavvladnEASIA-----------LYEKLGFEEV 140


                .
gi 46242630 163 G 163
Cdd:COG1247 141 G 141
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 67-140 9.13e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 33.40  E-value: 9.13e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46242630  67 SLGWFEEGRLVAFIIgslwdqerlsqaaLSLHRPQGSAVHIHVLAVHRGCRQQGKGSILMWRYLRYLRALPAAR 140
Cdd:cd04301   1 FLVAEDDGEIVGFAS-------------LSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKR 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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