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Conserved domains on  [gi|46241311|gb|AAS82875|]
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FREB-2 [Mus musculus]

Protein Classification

Ig and Ig2_FcgammaR_like domain-containing protein( domain architecture ID 10309102)

Ig and Ig2_FcgammaR_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 104-190 2.30e-38

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


:

Pssm-ID: 409411  Cd Length: 83  Bit Score: 133.58  E-value: 2.30e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311 104 WLILQVPYAAVFEGEPLVMRCRGWYDKVVYKLHYYHDGQAVRYFHSSTNYTVLQARASDSGHYQCSGTMRIpvesAPMFS 183
Cdd:cd05753   1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGTVRI----KRRSS 76


                ....*..
gi 46241311 184 SKVAVTV 190
Cdd:cd05753  77 ESVNITV 83
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 23-100 2.26e-31

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05752:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 79  Bit Score: 114.77  E-value: 2.26e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311  23 PILTLHPPWTTIFKGERVTLRCDGYHPllleLRPISTLWYLGHVLLPSHKKSIEVQA-----PGVYRCQTRGAPVSDPIH 97
Cdd:cd05752   1 AVVSLDPPWTTVFQGEKVTLTCQGFYS----PEQNSTQWYHNGTLISSTSSSYRIVAatvndSGEYRCQTQGSSLSDPVH 76


                ...
gi 46241311  98 LSV 100
Cdd:cd05752  77 LEV 79
 
Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 104-190 2.30e-38

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 133.58  E-value: 2.30e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311 104 WLILQVPYAAVFEGEPLVMRCRGWYDKVVYKLHYYHDGQAVRYFHSSTNYTVLQARASDSGHYQCSGTMRIpvesAPMFS 183
Cdd:cd05753   1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGTVRI----KRRSS 76


                ....*..
gi 46241311 184 SKVAVTV 190
Cdd:cd05753  77 ESVNITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 23-100 2.26e-31

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 114.77  E-value: 2.26e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311  23 PILTLHPPWTTIFKGERVTLRCDGYHPllleLRPISTLWYLGHVLLPSHKKSIEVQA-----PGVYRCQTRGAPVSDPIH 97
Cdd:cd05752   1 AVVSLDPPWTTVFQGEKVTLTCQGFYS----PEQNSTQWYHNGTLISSTSSSYRIVAatvndSGEYRCQTQGSSLSDPVH 76


                ...
gi 46241311  98 LSV 100
Cdd:cd05752  77 LEV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 104-190 2.10e-12

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 62.41  E-value: 2.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311   104 WLILQVPYAAVFEGEPLVMRCRGWyDKVVYKLHYYHDGQAVRyfhSSTNYTVLQARASDSGHYQCSGTMripvESAPMFS 183
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAP-GNPPPSYTWYKDGSAIS---SSPNFFTLSVSAEDSGTYTCVARN----GRGGKVS 72


                  ....*..
gi 46241311   184 SKVAVTV 190
Cdd:pfam13895  73 NPVELTV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 22-100 8.16e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 49.32  E-value: 8.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311    22 KPILTLHPpwTTIFKGERVTLRCDGYHPLllelrPISTLWYLGHVLLPSHK----KSIEVQAPGVYRCQ---TRGAPVSD 94
Cdd:pfam13895   1 KPVLTPSP--TVVTEGEPVTLTCSAPGNP-----PPSYTWYKDGSAISSSPnfftLSVSAEDSGTYTCVarnGRGGKVSN 73


                  ....*.
gi 46241311    95 PIHLSV 100
Cdd:pfam13895  74 PVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 114-190 5.39e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 5.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311    114 VFEGEPLVMRCRGWYDKVVYkLHYYHDGQA---------VRYFHSSTNYTVLQARASDSGHYQCSGTmripvESAPMFSS 184
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPE-VTWYKQGGKllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAAT-----NSSGSASS 79


                   ....*.
gi 46241311    185 KVAVTV 190
Cdd:smart00410  80 GTTLTV 85
 
Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 104-190 2.30e-38

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 133.58  E-value: 2.30e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311 104 WLILQVPYAAVFEGEPLVMRCRGWYDKVVYKLHYYHDGQAVRYFHSSTNYTVLQARASDSGHYQCSGTMRIpvesAPMFS 183
Cdd:cd05753   1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGTVRI----KRRSS 76


                ....*..
gi 46241311 184 SKVAVTV 190
Cdd:cd05753  77 ESVNITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 23-100 2.26e-31

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 114.77  E-value: 2.26e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311  23 PILTLHPPWTTIFKGERVTLRCDGYHPllleLRPISTLWYLGHVLLPSHKKSIEVQA-----PGVYRCQTRGAPVSDPIH 97
Cdd:cd05752   1 AVVSLDPPWTTVFQGEKVTLTCQGFYS----PEQNSTQWYHNGTLISSTSSSYRIVAatvndSGEYRCQTQGSSLSDPVH 76


                ...
gi 46241311  98 LSV 100
Cdd:cd05752  77 LEV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 104-190 2.10e-12

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 62.41  E-value: 2.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311   104 WLILQVPYAAVFEGEPLVMRCRGWyDKVVYKLHYYHDGQAVRyfhSSTNYTVLQARASDSGHYQCSGTMripvESAPMFS 183
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAP-GNPPPSYTWYKDGSAIS---SSPNFFTLSVSAEDSGTYTCVARN----GRGGKVS 72


                  ....*..
gi 46241311   184 SKVAVTV 190
Cdd:pfam13895  73 NPVELTV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 22-100 8.16e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 49.32  E-value: 8.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311    22 KPILTLHPpwTTIFKGERVTLRCDGYHPLllelrPISTLWYLGHVLLPSHK----KSIEVQAPGVYRCQ---TRGAPVSD 94
Cdd:pfam13895   1 KPVLTPSP--TVVTEGEPVTLTCSAPGNP-----PPSYTWYKDGSAISSSPnfftLSVSAEDSGTYTCVarnGRGGKVSN 73


                  ....*.
gi 46241311    95 PIHLSV 100
Cdd:pfam13895  74 PVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 114-190 5.39e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 5.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46241311    114 VFEGEPLVMRCRGWYDKVVYkLHYYHDGQA---------VRYFHSSTNYTVLQARASDSGHYQCSGTmripvESAPMFSS 184
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPE-VTWYKQGGKllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAAT-----NSSGSASS 79


                   ....*.
gi 46241311    185 KVAVTV 190
Cdd:smart00410  80 GTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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