NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|460367880|ref|XP_004229798|]
View 

methionine aminopeptidase 1A [Solanum lycopersicum]

Protein Classification

methionyl aminopeptidase( domain architecture ID 11477535)

methionyl aminopeptidase catalyzes the hydrolytic removal of N-terminal methionine residues

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 9-402 0e+00

methionine aminopeptidase; Provisional


:

Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 837.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880   9 EAALSCAKCGKPAHLQCPKCVELKLPREGAAFCTQDCFKASWSSHKSVHLKAKLSSLateslgEQNAASPSDGWLYCLRK 88
Cdd:PLN03158   7 TSPLACARCSKPAHLQCPKCLELKLPREGASFCSQDCFKAAWSSHKSVHTKAKLSSI------GQNSDAPAEGWLYCLKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  89 GQARTPKIPHFDWTGTLRPYPISEKRVVPAHIDLPDWANDGIPKIEPSSDLQHVVEIKTPELIERMRETCRIGREVLDAA 168
Cdd:PLN03158  81 GQARTSKLPDFDWTGPLRPYPISPRRVVPDHIPKPDWALDGTPKIEPNSDLQHSVEIKTPEQIQRMRETCRIAREVLDAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 169 ARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGVHGDLN 248
Cdd:PLN03158 161 ARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 249 ETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSVVKSYCGHGIGELFHCAPNIPHYSRNK 328
Cdd:PLN03158 241 ETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYARNK 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 460367880 329 AVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTGRLPTSPKVFPWLSS 402
Cdd:PLN03158 321 AVGVMKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTARLPSSPDVFPWLKP 394
 
Name Accession Description Interval E-value
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 9-402 0e+00

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 837.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880   9 EAALSCAKCGKPAHLQCPKCVELKLPREGAAFCTQDCFKASWSSHKSVHLKAKLSSLateslgEQNAASPSDGWLYCLRK 88
Cdd:PLN03158   7 TSPLACARCSKPAHLQCPKCLELKLPREGASFCSQDCFKAAWSSHKSVHTKAKLSSI------GQNSDAPAEGWLYCLKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  89 GQARTPKIPHFDWTGTLRPYPISEKRVVPAHIDLPDWANDGIPKIEPSSDLQHVVEIKTPELIERMRETCRIGREVLDAA 168
Cdd:PLN03158  81 GQARTSKLPDFDWTGPLRPYPISPRRVVPDHIPKPDWALDGTPKIEPNSDLQHSVEIKTPEQIQRMRETCRIAREVLDAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 169 ARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGVHGDLN 248
Cdd:PLN03158 161 ARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 249 ETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSVVKSYCGHGIGELFHCAPNIPHYSRNK 328
Cdd:PLN03158 241 ETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYARNK 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 460367880 329 AVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTGRLPTSPKVFPWLSS 402
Cdd:PLN03158 321 AVGVMKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTARLPSSPDVFPWLKP 394
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 151-387 5.06e-146

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 413.81  E-value: 5.06e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 151 IERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGD 230
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 231 IVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSVVKSYCGHG 310
Cdd:cd01086   81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 460367880 311 IGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLT 387
Cdd:cd01086  161 IGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
143-387 1.80e-138

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 395.14  E-value: 1.80e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 143 VEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPD 222
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 223 ARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSV 302
Cdd:COG0024   81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 303 VKSYCGHGIGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETG 382
Cdd:COG0024  161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240


                 ....*
gi 460367880 383 VEVLT 387
Cdd:COG0024  241 PEILT 245
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 143-389 4.87e-112

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 328.15  E-value: 4.87e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  143 VEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPD 222
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  223 ARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSV 302
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  303 VKSYCGHGIGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETG 382
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 460367880  383 VEVLTGR 389
Cdd:TIGR00500 241 PEILTER 247
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 152-380 1.22e-64

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 205.55  E-value: 1.22e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  152 ERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYpsplNYHFFPKSCCTSVNEVICHGIPDARKLEDGDI 231
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  232 VNVDVTVYYKGV-HGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLS-VVKSYCGH 309
Cdd:pfam00557  77 VLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 460367880  310 GIGELFHCAPNIPHYSRNkavGVMKAGQTFTIEPMInagvwrdrmwpdgwtaVTADGKRSAQFEHTLLVTE 380
Cdd:pfam00557 157 GIGLEVHEGPYISRGGDD---RVLEPGMVFTIEPGI----------------YFIPGWGGVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 9-402 0e+00

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 837.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880   9 EAALSCAKCGKPAHLQCPKCVELKLPREGAAFCTQDCFKASWSSHKSVHLKAKLSSLateslgEQNAASPSDGWLYCLRK 88
Cdd:PLN03158   7 TSPLACARCSKPAHLQCPKCLELKLPREGASFCSQDCFKAAWSSHKSVHTKAKLSSI------GQNSDAPAEGWLYCLKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  89 GQARTPKIPHFDWTGTLRPYPISEKRVVPAHIDLPDWANDGIPKIEPSSDLQHVVEIKTPELIERMRETCRIGREVLDAA 168
Cdd:PLN03158  81 GQARTSKLPDFDWTGPLRPYPISPRRVVPDHIPKPDWALDGTPKIEPNSDLQHSVEIKTPEQIQRMRETCRIAREVLDAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 169 ARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGVHGDLN 248
Cdd:PLN03158 161 ARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 249 ETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSVVKSYCGHGIGELFHCAPNIPHYSRNK 328
Cdd:PLN03158 241 ETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYARNK 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 460367880 329 AVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTGRLPTSPKVFPWLSS 402
Cdd:PLN03158 321 AVGVMKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTARLPSSPDVFPWLKP 394
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 151-387 5.06e-146

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 413.81  E-value: 5.06e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 151 IERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGD 230
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 231 IVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSVVKSYCGHG 310
Cdd:cd01086   81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 460367880 311 IGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLT 387
Cdd:cd01086  161 IGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
143-387 1.80e-138

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 395.14  E-value: 1.80e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 143 VEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPD 222
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 223 ARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSV 302
Cdd:COG0024   81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 303 VKSYCGHGIGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETG 382
Cdd:COG0024  161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240


                 ....*
gi 460367880 383 VEVLT 387
Cdd:COG0024  241 PEILT 245
PRK05716 PRK05716
methionine aminopeptidase; Validated
 142-389 2.04e-138

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 395.27  E-value: 2.04e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 142 VVEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIP 221
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 222 DARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLS 301
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 302 VVKSYCGHGIGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTET 381
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241


                 ....*...
gi 460367880 382 GVEVLTGR 389
Cdd:PRK05716 242 GPEILTLR 249
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 143-389 4.87e-112

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 328.15  E-value: 4.87e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  143 VEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPD 222
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  223 ARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSV 302
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  303 VKSYCGHGIGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETG 382
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 460367880  383 VEVLTGR 389
Cdd:TIGR00500 241 PEILTER 247
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 143-389 1.27e-108

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 319.47  E-value: 1.27e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 143 VEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPD 222
Cdd:PRK12896   8 MEIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHGIPG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 223 ARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSV 302
Cdd:PRK12896  88 PRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 303 VKSYCGHGIGELFHCAPN-IPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTET 381
Cdd:PRK12896 168 VRDLTGHGVGRSLHEEPSvILTYTDPLPNRLLRPGMTLAVEPFLNLGAKDAETLDDGWTVVTPDKSLSAQFEHTVVVTRD 247


                 ....*...
gi 460367880 382 GVEVLTGR 389
Cdd:PRK12896 248 GPEILTDR 255
PRK12318 PRK12318
methionyl aminopeptidase;
140-387 4.56e-85

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 260.91  E-value: 4.56e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 140 QHVVEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHF--FPKSCCTSVNEVIC 217
Cdd:PRK12318  38 QYDIIIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVIC 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 218 HGIPDARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASM 297
Cdd:PRK12318 118 HGIPNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADK 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 298 SGLSVVKSYCGHGIGELFHCAPNIPHYsRNKAVGVMKAGQTFTIEPMINAGVWRDRMWP-DGWTAVTADGKRSAQFEHTL 376
Cdd:PRK12318 198 YGFSVVDQFVGHGVGIKFHENPYVPHH-RNSSKIPLAPGMIFTIEPMINVGKKEGVIDPiNHWEARTCDNQPSAQWEHTI 276

                        250
                 ....*....|.
gi 460367880 377 LVTETGVEVLT 387
Cdd:PRK12318 277 LITETGYEILT 287
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 152-380 1.22e-64

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 205.55  E-value: 1.22e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  152 ERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYpsplNYHFFPKSCCTSVNEVICHGIPDARKLEDGDI 231
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  232 VNVDVTVYYKGV-HGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLS-VVKSYCGH 309
Cdd:pfam00557  77 VLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 460367880  310 GIGELFHCAPNIPHYSRNkavGVMKAGQTFTIEPMInagvwrdrmwpdgwtaVTADGKRSAQFEHTLLVTE 380
Cdd:pfam00557 157 GIGLEVHEGPYISRGGDD---RVLEPGMVFTIEPGI----------------YFIPGWGGVRIEDTVLVTE 208
PRK12897 PRK12897
type I methionyl aminopeptidase;
142-387 1.55e-48

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 165.21  E-value: 1.55e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 142 VVEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPLNYHFFPKSCCTSVNEVICHGIP 221
Cdd:PRK12897   1 MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 222 DARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLS 301
Cdd:PRK12897  81 ADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 302 VVKSYCGHGIGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTET 381
Cdd:PRK12897 161 VARDFTGHGIGKEIHEEPAIFHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKD 240


                 ....*.
gi 460367880 382 GVEVLT 387
Cdd:PRK12897 241 GPIILT 246
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 151-382 1.09e-45

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 156.46  E-value: 1.09e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 151 IERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPlnyhffpkSCCTSVNEV--ICHGIPDARKLED 228
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPAG--------PTIVGSGARtaLPHYRPDDRRLQE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 229 GDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSVVK-SYC 307
Cdd:cd01066   73 GDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFgHRT 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 460367880 308 GHGIGELFHCAPNIPHYSRnkavGVMKAGQTFTIEPMINagvwrdrmwpdgwtavtADGKRSAQFEHTLLVTETG 382
Cdd:cd01066  153 GHGIGLEIHEPPVLKAGDD----TVLEPGMVFAVEPGLY-----------------LPGGGGVRIEDTVLVTEDG 206
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
138-391 1.16e-40

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 145.73  E-value: 1.16e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 138 DLQHVVE----IKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGG-YPSplnyhfFPKSCCTSV 212
Cdd:COG0006   62 DASDLLEelraIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAeGPS------FDTIVASGE 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 213 NEVICHGIPDARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVIN 292
Cdd:COG0006  136 NAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAAR 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 293 RHASMSGLsvvKSY----CGHGIGELFHCAPNIphYSRNKavGVMKAGQTFTIEPMInagvwrdrmWPDGWTAVtadgkR 368
Cdd:COG0006  216 DVLAEAGY---GEYfphgTGHGVGLDVHEGPQI--SPGND--RPLEPGMVFTIEPGI---------YIPGIGGV-----R 274

                        250       260
                 ....*....|....*....|...
gi 460367880 369 SaqfEHTLLVTETGVEVLTgRLP 391
Cdd:COG0006  275 I---EDTVLVTEDGAEVLT-RLP 293
PRK07281 PRK07281
methionyl aminopeptidase;
142-387 3.06e-32

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 123.03  E-value: 3.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 142 VVEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSPL----NYHFFPKSCCTSVNEVIC 217
Cdd:PRK07281   1 MITLKSAREIEAMDRAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENVLPLQIgvdgAMMDYPYATCCGLNDEVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 218 HGIPDARKLEDGDIVNVDV---------------------------TVYYKGVHGDLNETFFVGNVDEASQRLVQCTYEC 270
Cdd:PRK07281  81 HAFPRHYILKEGDLLKVDMvlsepldksivdvsklnfdnveqmkkyTESYRGGLADSCWAYAVGTPSDEVKNLMDVTKEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 271 LEKAIAIVKPGVRFREIGEVINRHASMSGLSVVKSYCGHGIGELFHCAPNIPHYSRNKAVGVMKAGQTFTIEPMINAGVW 350
Cdd:PRK07281 161 MYRGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLREGMVLTIEPMINTGTW 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 460367880 351 R-DRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLT 387
Cdd:PRK07281 241 EiDTDMKTGWAHKTLDGGLSCQYEHQFVITKDGPVILT 278
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 151-345 5.32e-29

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 112.22  E-value: 5.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 151 IERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGY-PSplnyhfFPKSCCTSVNEVICHGIPDARKLEDG 229
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEgPS------FDTIVASGPNSALPHGVPSDRKIEEG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 230 DIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIG----EVINRHasmsGLsvvKS 305
Cdd:cd01092   75 DLVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDkaarDVIEEA----GY---GE 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 460367880 306 Y----CGHGIGELFHCAPNIPHYSRnkavGVMKAGQTFTIEPMI 345
Cdd:cd01092  148 YfihrTGHGVGLEVHEAPYISPGSD----DVLEEGMVFTIEPGI 187
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 151-387 2.89e-28

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 112.34  E-value: 2.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 151 IERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAAGGYPSplnyhfFPKSCctSVNEVICHGIP---DARKLE 227
Cdd:cd01088    1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPA------FPVNL--SINECAAHYTPnagDDTVLK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 228 DGDIVNVDVtvyykGVH--GDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSVVKS 305
Cdd:cd01088   73 EGDVVKLDF-----GAHvdGYIADSAFTVDFDPKYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRN 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 306 YCGHGIGE-LFHCAPNIPHYsRNKAVGVMKAGQTFTIEP------------------MINAGV----------------- 349
Cdd:cd01088  148 LTGHSIERyRLHAGKSIPNV-KGGEGTRLEEGDVYAIEPfattgkgyvhdgpecsiyMLNRDKplrlprarklldviyen 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 460367880 350 ---------WRDRMWPDGW-----------------TAVTADGKRSAQFEHTLLVTETGVEVLT 387
Cdd:cd01088  227 fgtlpfarrWLDRLGETKLlmalknlckagivypypVLKEISGGYVAQFEHTIIVREDGKEVTT 290
zf-C6H2 pfam15801
zf-MYND-like zinc finger, mRNA-binding; zf-C6H2 is an unusual zinc-finger similar to zf-MYND, ...
 17-57 2.18e-16

zf-MYND-like zinc finger, mRNA-binding; zf-C6H2 is an unusual zinc-finger similar to zf-MYND, pfam01753.This zinc-finger is found at the N-terminus of Pfam families Exo_endo_phos pfam03372 and Peptidase_M24 pfam00557. The domain is missing in prokaryotic methionine aminopeptidases, and is a unique type of zinc-finger domain. It consists of a C2-C2 zinc-finger motif similar to the RING finger family followed by a C2H2 motif similar to zinc-fingers involved in RNA-binding. In yeast the domain chelates zinc in a 2:1 ratio. The domain is found in yeast, plants and mammals. The domain is necessary for the association of the methionine aminopeptidase with the ribosome and the normal processing of the peptidase.


Pssm-ID: 464880 [Multi-domain]  Cd Length: 46  Bit Score: 72.26  E-value: 2.18e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 460367880   17 CGKPAH-LQCPKCVELKLPreGAAFCTQDCFKASWSSHKSVH 57
Cdd:pfam15801   6 CGKEASsLQCPTCLKLGIK--GSFFCSQDCFKKNWKSHKAIH 45
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 151-388 2.53e-16

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 78.00  E-value: 2.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 151 IERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVhEATVAAGGYPSPLNYHffpksCCTSVNEVICHGIPDARKLEDGD 230
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEF-EYEFRSRGARLAYSYI-----VAAGSNAAILHYVHNDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 231 IVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVqctYECLEKA----IAIVKPGVRFREI----GEVINRH-------- 294
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQREL---YEAVLAAqkaaIAACKPGVSYEDIhllaHRVLAEGlkelgilk 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 295 ---ASMSGLSVVKSYCGHGIGELF----H-CAPNIPHYSRNKavgVMKAGQTFTIEP---MINAGVWRDRMWPDGwtavt 363
Cdd:cd01087  152 gdvDEIVESGAYAKFFPHGLGHYLgldvHdVGGYLRYLRRAR---PLEPGMVITIEPgiyFIPDLLDVPEYFRGG----- 223

                        250       260
                 ....*....|....*....|....*
gi 460367880 364 adGKRsaqFEHTLLVTETGVEVLTG 388
Cdd:cd01087  224 --GIR---IEDDVLVTEDGPENLTR 243
PRK09795 PRK09795
aminopeptidase; Provisional
 136-386 1.00e-13

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 71.89  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 136 SSDLQHVVEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDA----VVHEA--------TVAAGGYPSPLNyhf 203
Cdd:PRK09795 118 SATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAelewFMRQQgaekasfdTIVASGWRGALP--- 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 204 fpkscctsvnevicHGIPDARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQR-----LVQCTYECLEKAIAIV 278
Cdd:PRK09795 195 --------------HGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfnVYQIVLQAQLAAISAI 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 279 KPGVRFREIGEVINRHASMSGLSVVKSY-CGHGIGELFHCApniPHYSRNKAVgVMKAGQTFTIEPminagvwrdrmwpd 357
Cdd:PRK09795 261 RPGVRCQQVDDAARRVITEAGYGDYFGHnTGHAIGIEVHED---PRFSPRDTT-TLQPGMLLTVEP-------------- 322

                        250       260
                 ....*....|....*....|....*....
gi 460367880 358 gwtAVTADGKRSAQFEHTLLVTETGVEVL 386
Cdd:PRK09795 323 ---GIYLPGQGGVRIEDVVLVTPQGAEVL 348
PRK15173 PRK15173
peptidase; Provisional
 133-312 2.16e-10

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 61.27  E-value: 2.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 133 IEPSSDLQHVVEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVaaggypSPLNYHFFPKSCCTSV 212
Cdd:PRK15173  83 VDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVM------SKSETHFSRFHLISVG 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 213 NEVICHGIPDARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVIN 292
Cdd:PRK15173 157 ADFSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTM 236

                        170       180
                 ....*....|....*....|.
gi 460367880 293 RHASMSGL-SVVKSYCGHGIG 312
Cdd:PRK15173 237 EVIKKSGLpNYNRGHLGHGNG 257
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 145-387 2.67e-10

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 61.66  E-value: 2.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 145 IKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDA-VVHEATVAAGGYPSplnYHFFPKScctSVNEVICHGIPDA 223
Cdd:PRK10879 173 FKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGeIHHEFNRHGARYPS---YNTIVGS---GENGCILHYTENE 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 224 RKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLV-QCTYECLEKAIAIVKPGVRFREI-GEVI---------- 291
Cdd:PRK10879 247 SEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIyDIVLESLETSLRLYRPGTSIREVtGEVVrimvsglvkl 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 292 ---------------NRHASMSGLSvvksycgHGIGELFHcapNIPHYSRNKAvGVMKAGQTFTIEPMI----NAGVwrd 352
Cdd:PRK10879 327 gilkgdvdqliaenaHRPFFMHGLS-------HWLGLDVH---DVGVYGQDRS-RILEPGMVLTVEPGLyiapDADV--- 392

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 460367880 353 rmwPDGWTAVtadGKRsaqFEHTLLVTETGVEVLT 387
Cdd:PRK10879 393 ---PEQYRGI---GIR---IEDDIVITETGNENLT 418
PRK14575 PRK14575
putative peptidase; Provisional
 133-312 4.22e-10

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 60.88  E-value: 4.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 133 IEPSSDLQHVVEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVaaggypSPLNYHFFPKSCCTSV 212
Cdd:PRK14575 166 VDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVM------SKSETHFSRFHLISVG 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 213 NEVICHGIPDARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVIN 292
Cdd:PRK14575 240 ADFSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTM 319

                        170       180
                 ....*....|....*....|.
gi 460367880 293 RHASMSGL-SVVKSYCGHGIG 312
Cdd:PRK14575 320 EVIKKSGLpNYNRGHLGHGNG 340
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 224-388 9.88e-10

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 58.32  E-value: 9.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 224 RKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINRHASMSGLSVV 303
Cdd:cd01090   75 RKVQRGDILSLNCFPMIAGYYTALERTLFLDEVSDAHLKIWEANVAVHERGLELIKPGARCKDIAAELNEMYREHDLLRY 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 304 KSY-CGHGIGELFHcapnipHYSRNKAV-------GVMKAGQTFTIEPMInagvwrdrMWPDGWTAvtADGKRsaqfEHT 375
Cdd:cd01090  155 RTFgYGHSFGVLSH------YYGREAGLelredidTVLEPGMVVSMEPMI--------MLPEGQPG--AGGYR----EHD 214

                        170
                 ....*....|....
gi 460367880 376 LLV-TETGVEVLTG 388
Cdd:cd01090  215 ILViNENGAENITG 228
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 151-388 7.54e-09

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 55.80  E-value: 7.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 151 IERMRETCRIGREVLDAAARMIRPGVTTDEI----DAVVHEATvaAGGYPSPLNYH---FFPKscCTSVNEVICHGIP-- 221
Cdd:cd01089    1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLcekgDKLILEEL--GKVYKKEKKLEkgiAFPT--CISVNNCVCHFSPlk 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 222 --DARKLEDGDIVNVDVtvyykGVHGD-----LNETFFVGNVDEASQR-----LVQCTYECLEKAIAIVKPGVRFREIGE 289
Cdd:cd01089   77 sdATYTLKDGDVVKIDL-----GCHIDgyiavVAHTIVVGAEAETPVTgkkadVIAAAHYALEAALRLLRPGNQNSDITE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 290 VINRHASMSGLSVVKSYCGHGIGELFHCAPNiphysRNKAVGVMKAGQTFTIEPMInagvwrdrmwpdgwtavTADGKRS 369
Cdd:cd01089  152 AIQKVIVDYGCTPVEGVLSHQLKRVVSSGEG-----KAKLVECVKHGLLFPYPVLY-----------------EKEGEVV 209

                        250
                 ....*....|....*....
gi 460367880 370 AQFEHTLLVTETGVEVLTG 388
Cdd:cd01089  210 AQFKLTVLLTPNGVTVLTG 228
PRK14576 PRK14576
putative endopeptidase; Provisional
 129-387 8.41e-09

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 56.95  E-value: 8.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 129 GIPKIEPSSDLQHVVEIKTPELIERMRETCRIGREVLDAAARMIRPGVTTDEIDAVVHEATVAaggypsplnyhfFPKSC 208
Cdd:PRK14576 161 GLKLVDSTALFNEIRMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMS------------FPETN 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 209 CTSVNeVICHG-------IPDARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPG 281
Cdd:PRK14576 229 FSRFN-LISVGdnfspkiIADTTPAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPG 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 282 VRFREIGEVINRHASMSGLS-VVKSYCGHGIGeLFHCAPNIPHYSrNKAVGVMKAGQTFTIEpminagvwrdrmwpdgwT 360
Cdd:PRK14576 308 VKLKAVFDSTMAVIKTSGLPhYNRGHLGHGDG-VFLGLEEVPFVS-TQATETFCPGMVLSLE-----------------T 368

                        250       260
                 ....*....|....*....|....*..
gi 460367880 361 AVTADGKRSAQFEHTLLVTETGVEVLT 387
Cdd:PRK14576 369 PYYGIGVGSIMLEDMILITDSGFEFLS 395
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 204-309 1.89e-07

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 52.58  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880  204 FPKscCTSVNEVICHGIP----DARKLEDGDIVNVDVTVYYKGVHGDLNETFFVGNVDEAS-----QRLVQCTYECLEKA 274
Cdd:TIGR00495  78 FPT--CISVNNCVGHFSPlksdQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPvtgrkADVIAAAHLAAEAA 155

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 460367880  275 IAIVKPGVRFREIGEVINRHASMSGLSVVKSYCGH 309
Cdd:TIGR00495 156 LRLVKPGNTNTQVTEAINKVAHSYGCTPVEGMLSH 190
PLN03144 PLN03144
Carbon catabolite repressor protein 4 homolog; Provisional
 9-75 9.14e-06

Carbon catabolite repressor protein 4 homolog; Provisional


Pssm-ID: 178689 [Multi-domain]  Cd Length: 606  Bit Score: 47.80  E-value: 9.14e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 460367880   9 EAALSCAKCGKPAHLQCPKCVELKLPREGAAFCTQDCFKASWSSHKSVHlkaklsSLATESLGEQNA 75
Cdd:PLN03144  61 KVAVCSVHPSEPATLQCVGCVKAKLPVSKSYHCSPKCFSDAWRHHRVLH------ERAASAVRENGN 121
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 151-342 9.88e-05

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 44.32  E-value: 9.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 151 IERMRETCRIGREVLDAAARMIRPGVT----TDEIDAVVHEaTVAAGGYPSPLNyhfFPKSCctSVNEVICHGIP---DA 223
Cdd:PTZ00053 158 YQDLRRAAEVHRQVRRYAQSVIKPGVKlidiCERIESKSRE-LIEADGLKCGWA---FPTGC--SLNHCAAHYTPntgDK 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460367880 224 RKLEDGDIVNVDVtvyykGVH--GDLNETFFVGNVDEASQRLVQCTYECLEKAIAIVKPGVRFREIGEVINrhasmsglS 301
Cdd:PTZ00053 232 TVLTYDDVCKLDF-----GTHvnGRIIDCAFTVAFNPKYDPLLQATKDATNTGIKEAGIDVRLSDIGAAIQ--------E 298

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 460367880 302 VVKSY-----------------CGHGIGE-LFHCAPNIPHYSRNKAVgVMKAGQTFTIE 342
Cdd:PTZ00053 299 VIESYeveikgktypiksirnlNGHSIGPyIIHGGKSVPIVKGGENT-RMEEGELFAIE 356
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH