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Conserved domains on  [gi|459838|gb|AAA61247|]
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UDP-glucuronosyltransferase, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 1-73 9.38e-50

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member pfam00201:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 499  Bit Score: 164.50  E-value: 9.38e-50
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 459838       1 EFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL 73
Cdd:pfam00201 264 EMEAFVQSSGEHGVVVFSLGSMVSNIPEEKANAIASALAQIPQKVLWRFDGTKPSTLGNNTRLVKWLPQNDLL 336
 
Name Accession Description Interval E-value
UDPGT pfam00201
UDP-glucoronosyl and UDP-glucosyl transferase;
1-73 9.38e-50

UDP-glucoronosyl and UDP-glucosyl transferase;


Pssm-ID: 278624 [Multi-domain]  Cd Length: 499  Bit Score: 164.50  E-value: 9.38e-50
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 459838       1 EFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL 73
Cdd:pfam00201 264 EMEAFVQSSGEHGVVVFSLGSMVSNIPEEKANAIASALAQIPQKVLWRFDGTKPSTLGNNTRLVKWLPQNDLL 336
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
 1-73 1.74e-15

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 70.66  E-value: 1.74e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459838     1 EFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPS---NLANNTILVKWLPQNDLL 73
Cdd:cd03784 228 ELWEWLDKQPPRSVVYVSFGSMVRDLPEELLELIAEALASLGQRFLWVVGPDPLGgleRLPDNVLVVKWVPQDELL 303
egt PHA03392
ecdysteroid UDP-glucosyltransferase; Provisional
 3-73 5.49e-06

ecdysteroid UDP-glucosyltransferase; Provisional


Pssm-ID: 223071 [Multi-domain]  Cd Length: 507  Bit Score: 43.79  E-value: 5.49e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 459838      3 EAYINASGEhGIVVFSLGSMVseipEKKAMA------IADALGKIPQTVLWRYTGT-RPSNLANNTILVKWLPQNDLL 73
Cdd:PHA03392 288 EEFLNNSTN-GVVYVSFGSSI----DTNDMDneflqmLLRTFKKLPYNVLWKYDGEvEAINLPANVLTQKWFPQRAVL 360
 
Name Accession Description Interval E-value
UDPGT pfam00201
UDP-glucoronosyl and UDP-glucosyl transferase;
1-73 9.38e-50

UDP-glucoronosyl and UDP-glucosyl transferase;


Pssm-ID: 278624 [Multi-domain]  Cd Length: 499  Bit Score: 164.50  E-value: 9.38e-50
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 459838       1 EFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL 73
Cdd:pfam00201 264 EMEAFVQSSGEHGVVVFSLGSMVSNIPEEKANAIASALAQIPQKVLWRFDGTKPSTLGNNTRLVKWLPQNDLL 336
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
 1-73 1.74e-15

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 70.66  E-value: 1.74e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459838     1 EFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPS---NLANNTILVKWLPQNDLL 73
Cdd:cd03784 228 ELWEWLDKQPPRSVVYVSFGSMVRDLPEELLELIAEALASLGQRFLWVVGPDPLGgleRLPDNVLVVKWVPQDELL 303
egt PHA03392
ecdysteroid UDP-glucosyltransferase; Provisional
 3-73 5.49e-06

ecdysteroid UDP-glucosyltransferase; Provisional


Pssm-ID: 223071 [Multi-domain]  Cd Length: 507  Bit Score: 43.79  E-value: 5.49e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 459838      3 EAYINASGEhGIVVFSLGSMVseipEKKAMA------IADALGKIPQTVLWRYTGT-RPSNLANNTILVKWLPQNDLL 73
Cdd:PHA03392 288 EEFLNNSTN-GVVYVSFGSSI----DTNDMDneflqmLLRTFKKLPYNVLWKYDGEvEAINLPANVLTQKWFPQRAVL 360
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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