NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|459541374|gb|EMH32351|]
View 

hypothetical protein HMPREF1423_00002, partial [Helicobacter pylori GAM270ASi]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FucT_N super family cl39443
Alpha-(1,3)-fucosyltransferase FucT N-terminal domain; This is the N-terminal domain of the ...
 2-77 7.77e-18

Alpha-(1,3)-fucosyltransferase FucT N-terminal domain; This is the N-terminal domain of the alpha chain found in Helicobacter pylori Fucosyltransferase protein which is involved in the production of Lewis x trisaccharide, a major component of lipopolysaccharide. The N-terminal domain contains the catalyst base, Glu-95 which is equivalent to the Asp-100 of other members of the glycosyltransferases-B family. The domain contains the pocket where LacNAc binds. The domain is composed of 2-10 heptad repeats and a conserved N-terminal alpha-beta-alpha motif which has little sequence similarity to the conserved N-terminal motif in other glycosyltransferases.


The actual alignment was detected with superfamily member pfam18025:

Pssm-ID: 436218  Cd Length: 92  Bit Score: 76.92  E-value: 7.77e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459541374    2 ILSQRYKITLHQNPnkpsDLVFGSPIGSarKILSYQNTKRVFYTGENEVPNFNLFDYAIGFDELDFRDRYLRMPLY 77
Cdd:pfam18025  20 ILSQHYEIELDDDP----DYLFYSVFGT--EHLKYRKCVRIFFTGENITPDFNICDYAIGFDHLDFGDRYLRLPLY 89
Glyco_transf_10 super family cl02988
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 129-257 5.54e-15

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


The actual alignment was detected with superfamily member pfam00852:

Pssm-ID: 459962  Cd Length: 176  Bit Score: 71.43  E-value: 5.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459541374  129 PLKRGFASFVASNPNAP-KRNAFYDALNSIEPVTGGGSVKNTLGYNVKNKSEFLSQYKFNLCFENTQGYGYVTEKIIDAY 207
Cdd:pfam00852   2 PKKTKLVAWVVSNCNTSsARVKYYNELQKHIEVDVYGRCGNLKPLSPGCYLMLISSYKFYLAFENSICKDYITEKLWNAL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 459541374  208 FSHTIPIYWGSPsvAKDFN----PKSFVNVCDFKNFDEAIDYVRYLHTHPNAYL 257
Cdd:pfam00852  82 LRGAVPVVLGPP--RANYErfapPDSFIHVDDFPSPKELAEYLLYLDKNDTLYL 133
 
Name Accession Description Interval E-value
FucT_N pfam18025
Alpha-(1,3)-fucosyltransferase FucT N-terminal domain; This is the N-terminal domain of the ...
 2-77 7.77e-18

Alpha-(1,3)-fucosyltransferase FucT N-terminal domain; This is the N-terminal domain of the alpha chain found in Helicobacter pylori Fucosyltransferase protein which is involved in the production of Lewis x trisaccharide, a major component of lipopolysaccharide. The N-terminal domain contains the catalyst base, Glu-95 which is equivalent to the Asp-100 of other members of the glycosyltransferases-B family. The domain contains the pocket where LacNAc binds. The domain is composed of 2-10 heptad repeats and a conserved N-terminal alpha-beta-alpha motif which has little sequence similarity to the conserved N-terminal motif in other glycosyltransferases.


Pssm-ID: 436218  Cd Length: 92  Bit Score: 76.92  E-value: 7.77e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459541374    2 ILSQRYKITLHQNPnkpsDLVFGSPIGSarKILSYQNTKRVFYTGENEVPNFNLFDYAIGFDELDFRDRYLRMPLY 77
Cdd:pfam18025  20 ILSQHYEIELDDDP----DYLFYSVFGT--EHLKYRKCVRIFFTGENITPDFNICDYAIGFDHLDFGDRYLRLPLY 89
Glyco_transf_10 pfam00852
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 129-257 5.54e-15

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


Pssm-ID: 459962  Cd Length: 176  Bit Score: 71.43  E-value: 5.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459541374  129 PLKRGFASFVASNPNAP-KRNAFYDALNSIEPVTGGGSVKNTLGYNVKNKSEFLSQYKFNLCFENTQGYGYVTEKIIDAY 207
Cdd:pfam00852   2 PKKTKLVAWVVSNCNTSsARVKYYNELQKHIEVDVYGRCGNLKPLSPGCYLMLISSYKFYLAFENSICKDYITEKLWNAL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 459541374  208 FSHTIPIYWGSPsvAKDFN----PKSFVNVCDFKNFDEAIDYVRYLHTHPNAYL 257
Cdd:pfam00852  82 LRGAVPVVLGPP--RANYErfapPDSFIHVDDFPSPKELAEYLLYLDKNDTLYL 133
 
Name Accession Description Interval E-value
FucT_N pfam18025
Alpha-(1,3)-fucosyltransferase FucT N-terminal domain; This is the N-terminal domain of the ...
 2-77 7.77e-18

Alpha-(1,3)-fucosyltransferase FucT N-terminal domain; This is the N-terminal domain of the alpha chain found in Helicobacter pylori Fucosyltransferase protein which is involved in the production of Lewis x trisaccharide, a major component of lipopolysaccharide. The N-terminal domain contains the catalyst base, Glu-95 which is equivalent to the Asp-100 of other members of the glycosyltransferases-B family. The domain contains the pocket where LacNAc binds. The domain is composed of 2-10 heptad repeats and a conserved N-terminal alpha-beta-alpha motif which has little sequence similarity to the conserved N-terminal motif in other glycosyltransferases.


Pssm-ID: 436218  Cd Length: 92  Bit Score: 76.92  E-value: 7.77e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459541374    2 ILSQRYKITLHQNPnkpsDLVFGSPIGSarKILSYQNTKRVFYTGENEVPNFNLFDYAIGFDELDFRDRYLRMPLY 77
Cdd:pfam18025  20 ILSQHYEIELDDDP----DYLFYSVFGT--EHLKYRKCVRIFFTGENITPDFNICDYAIGFDHLDFGDRYLRLPLY 89
Glyco_transf_10 pfam00852
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 129-257 5.54e-15

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


Pssm-ID: 459962  Cd Length: 176  Bit Score: 71.43  E-value: 5.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459541374  129 PLKRGFASFVASNPNAP-KRNAFYDALNSIEPVTGGGSVKNTLGYNVKNKSEFLSQYKFNLCFENTQGYGYVTEKIIDAY 207
Cdd:pfam00852   2 PKKTKLVAWVVSNCNTSsARVKYYNELQKHIEVDVYGRCGNLKPLSPGCYLMLISSYKFYLAFENSICKDYITEKLWNAL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 459541374  208 FSHTIPIYWGSPsvAKDFN----PKSFVNVCDFKNFDEAIDYVRYLHTHPNAYL 257
Cdd:pfam00852  82 LRGAVPVVLGPP--RANYErfapPDSFIHVDDFPSPKELAEYLLYLDKNDTLYL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH