|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
1-377 |
0e+00 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 750.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 1 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF 80
Cdd:PRK06176 3 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 81 SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKD 160
Cdd:PRK06176 83 SLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 161 HNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGI 240
Cdd:PRK06176 163 HGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 241 KTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAALFVESLKLFILGES 320
Cdd:PRK06176 243 KTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILGES 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 321 LGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK06176 323 LGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 379
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
2-377 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 642.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAI--------GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGL 73
Cdd:COG0626 4 ATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAealaarfaGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 74 AGIHAV-FSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLA 152
Cdd:COG0626 84 AAISAVlLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVDIA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 153 QCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQD 232
Cdd:COG0626 164 AIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPFD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 233 SWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-FVES 311
Cdd:COG0626 244 AWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARrFLDA 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459495034 312 LKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:COG0626 324 LKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
2-375 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 632.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH-AVF 80
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITaAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 81 SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKD 160
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 161 HNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGI 240
Cdd:pfam01053 161 HGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 241 KTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-FVESLKLFILGE 319
Cdd:pfam01053 241 KTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKkFLDNLKLFSLAV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 459495034 320 SLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 375
Cdd:pfam01053 321 SLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
2-375 |
0e+00 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 609.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFS 81
Cdd:PRK07671 4 KTKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 82 LLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDH 161
Cdd:PRK07671 84 LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 162 NLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIK 241
Cdd:PRK07671 164 GLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 242 TLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAALFVESLKLFILGESL 321
Cdd:PRK07671 244 TLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDVGSEETANKVLERLQYFTLAESL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 459495034 322 GGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 375
Cdd:PRK07671 324 GAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
17-375 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 568.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 17 GAVSVPIYQTSTYRQDA--------IGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF-SLLQSGD 87
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSpaeaadlfALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLlALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 88 HVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIV 167
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 168 DNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRM 247
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 248 EAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-FVESLKLFILGESLGGVES 326
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKkFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 459495034 327 LVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 375
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
3-376 |
0e+00 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 545.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGR-HKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF- 80
Cdd:PRK07811 15 TRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATDCLLr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 81 SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKD 160
Cdd:PRK07811 95 AVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELAHD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 161 HNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGI 240
Cdd:PRK07811 175 AGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLRGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 241 KTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-FVESLKLFILGE 319
Cdd:PRK07811 255 KTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARdFCARTKVFTLAE 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 320 SLGGVESLVGIPAFMTHACIPKEQREaagIRDGLVRLSVGIEHEQDLLEDLEQAFAK 376
Cdd:PRK07811 335 SLGGVESLIEHPSAMTHASTAGSQLE---VPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
1-378 |
4.05e-174 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 490.05 E-value: 4.05e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 1 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF 80
Cdd:PRK08064 7 IDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 81 SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKD 160
Cdd:PRK08064 87 LLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 161 HNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGI 240
Cdd:PRK08064 167 IGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 241 KTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAALFVESLKLFILGES 320
Cdd:PRK08064 247 KTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQSEEAVRQFVSHVKLPVFAVS 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 459495034 321 LGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIS 378
Cdd:PRK08064 327 LGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYVE 384
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
1-377 |
2.26e-169 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 477.27 E-value: 2.26e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 1 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF 80
Cdd:PRK08247 5 IETKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLVM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 81 SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKD 160
Cdd:PRK08247 85 SLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 161 HNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGI 240
Cdd:PRK08247 165 HGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 241 KTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGlpthpnhelakaqmRGfsGMLSFTLKNDSEAALFVESLKLFILGES 320
Cdd:PRK08247 245 KTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPG--------------RG--GMLSFRLQDEEWVNPFLKSLKLITFAES 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 321 LGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK08247 309 LGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
3-377 |
2.59e-147 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 423.29 E-value: 2.59e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYR----QDAIGR----HKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLA 74
Cdd:COG2873 10 TLALHAGQEPDPTTGARAVPIYQTTSYVfddaEHAADLfalkEPGNIYTRIMNPTTDVLEKRIAALEGGVAALATASGQA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 75 GIH-AVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQ 153
Cdd:COG2873 90 AITlAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDVLDIEA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 154 CASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLV-----------------TTNNEAL--- 213
Cdd:COG2873 170 IAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwaangkfpelTEPDPSYhgl 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 214 -----AQEIAFFQNA-------IGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNH 281
Cdd:COG2873 250 vyteaFGNAAFITKArvqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPSHPYH 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 282 ELAKAQM-RGFSGMLSFTLKNDSEAAL-FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVG 359
Cdd:COG2873 330 ELAQKYLpKGAGGVLTFGLKGGREAGKkFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLIRLSVG 409
|
410
....*....|....*...
gi 459495034 360 IEHEQDLLEDLEQAFAKI 377
Cdd:COG2873 410 IEDIDDIIADLDQALAAA 427
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
3-377 |
1.33e-143 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 413.07 E-value: 1.33e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYRQDAI--------GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLA 74
Cdd:PRK06234 11 TKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAeqggrrfaGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 75 GI-HAVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQ 153
Cdd:PRK06234 91 AIsSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIKA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 154 CASVAKDHN--LLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEaLAQEIAFF--QNAIGGVLG 229
Cdd:PRK06234 171 ISNIAHENNkeCLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEE-FINQVKLFgiKDMTGSVIG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 230 PQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAA-LF 308
Cdd:PRK06234 250 PFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEGkVV 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 459495034 309 VESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK06234 330 MNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALDLI 398
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
9-377 |
8.40e-139 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 400.33 E-value: 8.40e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 9 GISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAV-FSLLQSGD 87
Cdd:TIGR02080 12 GLNSDTQYGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVtTALLGPDD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 88 HVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIV 167
Cdd:TIGR02080 92 LLVAPHDCYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVGAVVVV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 168 DNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRM 247
Cdd:TIGR02080 172 DNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARM 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 248 EAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEA-ALFVESLKLFILGESLGGVES 326
Cdd:TIGR02080 252 RLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTvRRFLGGLSLFTLAESLGGVES 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 459495034 327 LVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:TIGR02080 332 LIAHPATMTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRAA 382
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
17-375 |
2.49e-138 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 398.82 E-value: 2.49e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 17 GAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVY 96
Cdd:TIGR01329 16 DASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITRLLNNGDEIIAGDDLY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 97 GGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIVDNTFATPYC 176
Cdd:TIGR01329 96 GGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVVDNTMMSPLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 177 QNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALC 256
Cdd:TIGR01329 176 CNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 257 VAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAALFVESLKLFILGESLGGVESLVGIPAFMTH 336
Cdd:TIGR01329 256 IAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFETGSVALSKRLVEATKLFSITVSFGSVNSLISMPCFMSH 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 459495034 337 ACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 375
Cdd:TIGR01329 336 ASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFV 374
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
3-377 |
4.27e-136 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 394.11 E-value: 4.27e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYRQD--------AIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLA 74
Cdd:PRK08249 11 TKAVWAGEKEYLPYGATQVPVVLSVAYGYDdidewydvALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 75 GIHAV-FSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQ 153
Cdd:PRK08249 91 AISNTlYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIER 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 154 CASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVtTNNEALAQEIAFFQNAIGGVLGPQDS 233
Cdd:PRK08249 171 LAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVV-CGSKELMEQVYHYREINGATMDPMSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 234 WLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEA-ALFVESL 312
Cdd:PRK08249 250 YLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTvKRLLPKL 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 459495034 313 KLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK08249 330 RYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
2-373 |
2.41e-130 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 379.23 E-value: 2.41e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAI--------GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGL 73
Cdd:TIGR01328 5 ATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCeqggnrfaGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 74 AGIHA-VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLA 152
Cdd:TIGR01328 85 GAIAAtLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDME 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 153 QCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGG-VLGPQ 231
Cdd:TIGR01328 165 RVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQIRMVGIKDMTGsVISPF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 232 DSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-FVE 310
Cdd:TIGR01328 245 DAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGAKkLLN 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 459495034 311 SLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQA 373
Cdd:TIGR01328 325 NLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQA 387
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
1-377 |
3.64e-130 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 378.41 E-value: 3.64e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 1 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAI--------GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 72
Cdd:PRK06767 6 METALIHHGYTSEEHKGSLTPPLFQTSTFTFETAqqgeasfaGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 73 LAGIHAV-FSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDL 151
Cdd:PRK06767 86 MAAISATlIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 152 AQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQ 231
Cdd:PRK06767 166 KQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 232 DSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYpglpthPNHELAKAQMRGFSGMLSFTLK-NDSEAALFVE 310
Cdd:PRK06767 246 DAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKgGKEETQAFIN 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 311 SLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK06767 320 DLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
18-374 |
4.92e-127 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 373.21 E-value: 4.92e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 18 AVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYG 97
Cdd:PLN02509 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 98 GTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIVDNTFATPYCQ 177
Cdd:PLN02509 183 GSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLS 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 178 NPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCV 257
Cdd:PLN02509 263 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 258 AEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAALFVESLKLFILGESLGGVESLVGIPAFMTHA 337
Cdd:PLN02509 343 AMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHA 422
|
330 340 350
....*....|....*....|....*....|....*..
gi 459495034 338 CIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 374
Cdd:PLN02509 423 SIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
3-376 |
5.58e-127 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 371.24 E-value: 5.58e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF-S 81
Cdd:PRK08776 15 TAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLnA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 82 LLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDH 161
Cdd:PRK08776 95 LLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 162 NLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIK 241
Cdd:PRK08776 175 GALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 242 TLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLkNDSEAAL--FVESLKLFILGE 319
Cdd:PRK08776 255 TLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFEL-EGGEAAVraFVDGLRYFTLAE 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 320 SLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 376
Cdd:PRK08776 334 SLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLAR 390
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
2-375 |
4.05e-123 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 361.68 E-value: 4.05e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIG--------RHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGL 73
Cdd:TIGR01326 3 ETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEhaaalfglQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVASGQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 74 AGI-HAVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLA 152
Cdd:TIGR01326 83 AAItYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDIE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 153 QCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTT------NNEALAQ----------- 215
Cdd:TIGR01326 163 AIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDggkfdwNNGRFPLfttpdpsyhgl 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 216 -------EIAFFQNAI-------GGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNH 281
Cdd:TIGR01326 243 vftetlgNPAFILKARvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPHH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 282 ELAKAQM-RGFSGMLSFTLKNDSEAAL-FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVG 359
Cdd:TIGR01326 323 ALAKKYLpKGFGAVLSFEIKGGREAGKkFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLSVG 402
|
410
....*....|....*.
gi 459495034 360 IEHEQDLLEDLEQAFA 375
Cdd:TIGR01326 403 IENIDDIIADLEQALE 418
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
20-375 |
5.22e-122 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 357.77 E-value: 5.22e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 20 SVPIYQTSTYRQDA--------IGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA-VFSLLQSGDHVL 90
Cdd:PRK08133 25 SEALFLTSSFVFESaaeaaarfAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATASGMAAILAvVMALLQAGDHVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 91 LGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIVDNT 170
Cdd:PRK08133 105 SSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNC 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 171 FATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAiGGVLGPQDSWLLQRGIKTLGLRMEAH 250
Cdd:PRK08133 185 FCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVFGFLRTA-GPTLSPFNAWVFLKGLETLSLRMEAH 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 251 QKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-FVESLKLFILGESLGGVESLVG 329
Cdd:PRK08133 264 SANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWrVIDATRLISITANLGDTKTTIT 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 459495034 330 IPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 375
Cdd:PRK08133 344 HPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLA 389
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
3-376 |
1.22e-121 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 357.19 E-value: 1.22e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYRQDAI--------GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLA 74
Cdd:PRK07503 12 TRAIHHGYDPLDHGGALVPPVYLTATFAFPTAeygaecfaGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 75 GIHAVF-SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQ 153
Cdd:PRK07503 92 AITATLwTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 154 CASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTnNEALAQEIAFF--QNAIGGVLGPQ 231
Cdd:PRK07503 172 VAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVG-GKALADRIRLEglKDMTGAVMSPF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 232 DSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-FVE 310
Cdd:PRK07503 251 DAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGRrFMN 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459495034 311 SLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 376
Cdd:PRK07503 331 ALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDA 396
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
2-373 |
7.69e-121 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 354.54 E-value: 7.69e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGIsEDTTTGAVSVPIYQTSTYRQDAI--------GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGL 73
Cdd:TIGR01325 1 ATLAVRGGM-LRSGFEETAEALYLTSGYVYDSAavaakrfaGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 74 AGIHA-VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLA 152
Cdd:TIGR01325 80 AAIFAaLMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 153 QCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQD 232
Cdd:TIGR01325 160 AVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 233 SWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAALFVESL 312
Cdd:TIGR01325 240 AWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCRQAAFKVLDAM 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459495034 313 KLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQA 373
Cdd:TIGR01325 320 RLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRA 380
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
2-373 |
9.94e-119 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 349.36 E-value: 9.94e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTtGAVSVPIYQTSTYRQ--DAIGRHKGYE--YSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH 77
Cdd:PRK08574 4 GTDAVRGYRGSDPY-GSLQPPIYLTALFRQegEAYPSDRGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 78 AVF-SLLQSGDHVLLGDDVYGGTFRLFnKVLVKNGLSCTII--DTSDIsqIKKAIKPNTKALYLETPSNPLLKITDLAQC 154
Cdd:PRK08574 83 TLFfSLLKAGDRVVLPMEAYGTTLRLL-KSLEKFGVKVVLAypSTEDI--IEAIKEGRTKLVFIETMTNPTLKVIDVPEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 155 ASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSW 234
Cdd:PRK08574 160 AKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 235 LLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRG--FSGMLSFTLKNDSEAAL-FVES 311
Cdd:PRK08574 240 LVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKdlYGGVVSFRVKGGRDAVLkFLRS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 459495034 312 LKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQA 373
Cdd:PRK08574 320 LKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQA 381
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
3-374 |
3.68e-118 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 348.04 E-value: 3.68e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSL 82
Cdd:PRK08045 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 83 -LQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDH 161
Cdd:PRK08045 87 fLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 162 NLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIK 241
Cdd:PRK08045 167 GAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 242 TLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDsEAAL--FVESLKLFILGE 319
Cdd:PRK08045 247 TLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGD-EQTLrrFLGGLSLFTLAE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 459495034 320 SLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 374
Cdd:PRK08045 326 SLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGF 380
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
9-376 |
8.91e-117 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 344.57 E-value: 8.91e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 9 GISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDH 88
Cdd:PRK08861 14 GIESDSQYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 89 VLLG-DDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIV 167
Cdd:PRK08861 94 LIVApHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 168 DNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRM 247
Cdd:PRK08861 174 DNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARM 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 248 EAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEA-ALFVESLKLFILGESLGGVES 326
Cdd:PRK08861 254 RVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQlKVFVKALALFSLAESLGGVES 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 459495034 327 LVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 376
Cdd:PRK08861 334 LICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAK 383
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
1-373 |
7.26e-112 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 331.01 E-value: 7.26e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 1 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF 80
Cdd:PRK07269 7 INTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 81 SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDisQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKD 160
Cdd:PRK07269 87 SVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYANTEE--ELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 161 HNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGI 240
Cdd:PRK07269 165 KGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 241 KTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLpthpnhelakaqmrgfSGMLSFTLKNDSEAALFVESLKLFILGES 320
Cdd:PRK07269 245 KTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVADETRIPHILNSLKVFTFAES 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 459495034 321 LGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQA 373
Cdd:PRK07269 309 LGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQA 361
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
3-377 |
2.09e-111 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 330.26 E-value: 2.09e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGIseDTTTGAVSVPIYQTSTYRqdaIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAV-FS 81
Cdd:PRK06460 5 TRTVREDI--DEATGAITTPIYQTTAYH---YPEGEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTaLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 82 LLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDH 161
Cdd:PRK06460 80 LLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 162 NLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEaLAQEIAFFQNAIGGVLGPQDSWLLQRGIK 241
Cdd:PRK06460 160 GSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGK-LLNVIDQMRRTLGTSLDPHAAYLTLRGIK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 242 TLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAALFV-ESLKLFILGES 320
Cdd:PRK06460 239 TLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVmKSLKLIIPAQT 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 321 LGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK06460 319 LGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALSTL 375
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
3-376 |
3.28e-109 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 324.93 E-value: 3.28e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTY-----RQDAI---GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLA 74
Cdd:PRK06434 11 TRAVQSGELRDPRFGNVTTPIFETSTFvypnsEKEAYmdsTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 75 GI-HAVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKkaIKP-NTKALYLETPSNPLLKITDLA 152
Cdd:PRK06434 91 AItSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLD--FDPsNYDLIYAESITNPTLKVPDIK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 153 QCASVAKDHnlLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQD 232
Cdd:PRK06434 169 NVSSFCHEN--DVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQ 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 233 SWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLpthpnhELAKAQMRGFSGMLSFTLKNDSEAALFVESL 312
Cdd:PRK06434 247 AYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSMEDVHKFIRNL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 459495034 313 KLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 376
Cdd:PRK06434 321 EIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
2-375 |
1.89e-107 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 322.47 E-value: 1.89e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIgRHK---------GYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 72
Cdd:PRK07812 15 ETKQIHAGQTPDPATNARALPIYQTTSYTFDDT-DHAaalfglaepGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 73 LAGI-HAVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTII-DTSDISQIKKAIKPNTKALYLETPSNPLLKITD 150
Cdd:PRK07812 94 QAAEtFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 151 LAQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLV----------------TTNNE--- 211
Cdd:PRK07812 174 IPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpgfTTPDPsyh 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 212 ------------ALAQEIAFFQNaIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHP 279
Cdd:PRK07812 254 gvvfaelgppayALKARVQLLRD-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSP 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 280 NHELAKAQM-RGFSGMLSFTLKNDSEAA-LFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLS 357
Cdd:PRK07812 333 WYERAKRLApKGTGAVLSFELAGGVEAGkAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLA 412
|
410
....*....|....*...
gi 459495034 358 VGIEHEQDLLEDLEQAFA 375
Cdd:PRK07812 413 VGIEGIDDILADLEAGFA 430
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
17-378 |
2.50e-102 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 307.39 E-value: 2.50e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 17 GAVSVPIYQTSTYRQDAI--------GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA-VFSLLQSGD 87
Cdd:PRK05968 24 DAVVPPIFQTSLFTFDSYdemedvyaGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISStVLSFVEPGD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 88 HVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIkPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIV 167
Cdd:PRK05968 104 RIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAALAKRHGVVTMI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 168 DNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRM 247
Cdd:PRK05968 183 DNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYPYLGAKLSPFEAWLLLRGLRTLPLRM 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 248 EAHQKNALCVAEFLEKHPKVERVYYPGLPTHPnhelaKAQMRGFSGMLSFTLKNDSEAALFVESLKLFILGESLGGVESL 327
Cdd:PRK05968 263 KAHEASALEIARRLKAHPVVERVCHPALANHP-----PAGLSGTSGLFSFIFREGIDVRAFADALKLFRLGVSWGGHESL 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 459495034 328 VgIPAFMTHACIPKEQREAA-GIRDGLVRLSVGIEHEQDLLEDLEQAFAKIS 378
Cdd:PRK05968 338 V-VPAEVVLQQKAQPNSAARfGVSPRSVRLHVGLEGTEALWADLEQALAAAS 388
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
3-377 |
1.78e-100 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 304.33 E-value: 1.78e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYR-QDAigRHK---------GYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 72
Cdd:PRK05994 10 TLAVHAGAQPDPTTGARATPIYQTTSFVfNDA--DHAaslfglqafGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 73 LAGIHAVF-SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDL 151
Cdd:PRK05994 88 HAAQFLVFhTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 152 AQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTT----------------------N 209
Cdd:PRK05994 168 AAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDggtfdwsksgkypmlseprpeyH 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 210 NEALAQEIAFFQNAIGG-VLG---------PQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHP 279
Cdd:PRK05994 248 GLVLHETFGNFAFAIAArVLGlrdlgpaisPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDP 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 280 NHELAKAQM-RGFSGMLSFTLKNDSEAAL-FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLS 357
Cdd:PRK05994 328 YHALAQKYSpKGAGAVFTFGLKGGYEAGVkLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLS 407
|
410 420
....*....|....*....|
gi 459495034 358 VGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK05994 408 IGIEDVDDIIADLEQALAKA 427
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
3-373 |
2.22e-99 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 299.22 E-value: 2.22e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGvKGFAFASGLAGIHAV-FS 81
Cdd:PRK07582 6 TRSVHAGGPEAVPGEPVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAITAVlRA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 82 LLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQikkAIKPNTKALYLETPSNPLLKITDLAQCASVAKDH 161
Cdd:PRK07582 85 LLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGMAE---AALAGADLVLAETPSNPGLDVCDLAALAAAAHAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 162 NLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIK 241
Cdd:PRK07582 162 GALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 242 TLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAALFVESLKLFILGESL 321
Cdd:PRK07582 242 TLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFELADAAAAERFVAASRLVVAATSF 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 459495034 322 GGVESLVgipafmthacipkEQREAAG--IRDGLVRLSVGIEHEQDLLEDLEQA 373
Cdd:PRK07582 322 GGVHTSA-------------DRRARWGdaVPEGFVRLSCGIEDTDDLVADLERA 362
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
3-373 |
1.46e-98 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 299.35 E-value: 1.46e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTSTYR-QDAigRHK---------GYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 72
Cdd:PRK08134 11 TLALHAGAAPDPATGARAVPIHLTTSFVfRDS--DHAaalfnleraGHVYSRISNPTVAVLEERVAALEGGVGAIATASG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 73 LAGIH-AVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDL 151
Cdd:PRK08134 89 QAALHlAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 152 AQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNE----------ALAQEIAFFQ 221
Cdd:PRK08134 169 PTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRfdweasgkfpELTEPYAGFH 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 222 NAI----------------------GGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHP 279
Cdd:PRK08134 249 GMVfaeestvaafllrarreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHP 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 280 NHELAKAQM-RGFSGMLSFTLKNDSEAA-LFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLS 357
Cdd:PRK08134 329 DHALAKRLLpRGAGSVFSFDLKGGRAAGrKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLS 408
|
410
....*....|....*.
gi 459495034 358 VGIEHEQDLLEDLEQA 373
Cdd:PRK08134 409 IGLEDADDLIDDLKRA 424
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
2-378 |
2.68e-98 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 297.44 E-value: 2.68e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGiSEDTTTGAVSVPIYQTSTYRQDAI--------GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGL 73
Cdd:PRK07504 12 ATRLVHSG-TLRSQFGETSEALFLTQGFVYDTAeaaearfkGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 74 AGIH-AVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLA 152
Cdd:PRK07504 91 AAVTaAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 153 QCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQD 232
Cdd:PRK07504 171 AVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEHLQDYFRHTGPSLSPFN 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 233 SWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-FVES 311
Cdd:PRK07504 251 AWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAFrFLNA 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 312 LKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIS 378
Cdd:PRK07504 331 LKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKKVR 397
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
17-375 |
3.33e-97 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 294.67 E-value: 3.33e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 17 GAVSVPIYQTSTY----RQDAI----GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF-SLLQSGD 87
Cdd:PRK05939 8 GAVHKPIHTSVTYgyedARDLIdvfqGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFlTLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 88 HVLLGDDVYGGTFRLFNkVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIV 167
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFG-TLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 168 DNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVT---------------------TNNEALAQEIAFFQNAIGG 226
Cdd:PRK05939 167 DNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsaypnifpayrkgdPQQWGLTQIRKKGLRDMGA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 227 VLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAA 306
Cdd:PRK05939 247 TLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGIDCF 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459495034 307 LFVESLKLFILGESLGGVESLVgIPAFMT--HACIPkEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 375
Cdd:PRK05939 327 DFLNRLKLVIKATHLGDTRTLV-IPVAPTiyYEMGA-ERRASMGIADSLIRVSVGIEDEADLIADFEQALD 395
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
1-376 |
4.83e-97 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 295.60 E-value: 4.83e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 1 MQTKLIHGGISEDTTTGAVSVPIYQTSTY--RQDAIG------RHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 72
Cdd:PRK08248 9 LETLAIHAGQEIDPTTGSRAVPIYQTTSYgfRDSEHAanlfslKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 73 LAGI-HAVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDL 151
Cdd:PRK08248 89 QAAItYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 152 AQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVT------------------------ 207
Cdd:PRK08248 169 EAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpgltepdpsyh 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 208 --TNNEALAqEIAFFQNA-------IGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTH 278
Cdd:PRK08248 249 glVYTDAVG-EAAYITKArvqllrdLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSH 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 279 PNHELAKAQM-RGFSGMLSFTLKNDSEAAL-FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRL 356
Cdd:PRK08248 328 PSYELAKKYLpKGQGAILTFGIKGGVEAGKkLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRL 407
|
410 420
....*....|....*....|
gi 459495034 357 SVGIEHEQDLLEDLEQAFAK 376
Cdd:PRK08248 408 SVGTEAIDDILDDLRQAIRQ 427
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
1-375 |
9.27e-91 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 279.09 E-value: 9.27e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 1 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIgRH---------KGYEYSRSGNPTRFALEELIADLEGGVKGFAFAS 71
Cdd:PRK06084 3 LETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDT-QHgadlfdlkvPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 72 GLAGI-HAVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITD 150
Cdd:PRK06084 82 GMAAItYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIID 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 151 LAQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVT----------------------- 207
Cdd:PRK06084 162 IQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVdsgkfpwaehkerfallntpdps 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 208 ----TNNEALAQEiAFFQN-------AIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLP 276
Cdd:PRK06084 242 yhgvTYTEAFGPA-AFIGRcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 277 THPNHELAKAQMRGF-SGMLSFTLKNDSEA-ALFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLV 354
Cdd:PRK06084 321 DHPEHELARRYMGGKpASILSFGIKGGQAAgARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMV 400
|
410 420
....*....|....*....|.
gi 459495034 355 RLSVGIEHEQDLLEDLEQAFA 375
Cdd:PRK06084 401 RLSIGIEHIDDIIADLAQALD 421
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
20-375 |
7.59e-87 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 268.53 E-value: 7.59e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 20 SVPIYQTSTYRQDA--------IGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAgihAVF----SLLQSGD 87
Cdd:PRK07810 34 AEALYLTSGYVYESaaaaeaafTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMS---AVFtalgALLGAGD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 88 HVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIV 167
Cdd:PRK07810 111 RLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 168 DNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRM 247
Cdd:PRK07810 191 DNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 248 EAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAA-----LFVESLKLFILGESLG 322
Cdd:PRK07810 271 RHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEDAAkkrafEVLDKLRVIDISNNLG 350
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 459495034 323 GVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 375
Cdd:PRK07810 351 DAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
17-377 |
4.92e-84 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 261.92 E-value: 4.92e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 17 GAVSVPIYQTSTY------------------RQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA 78
Cdd:PRK07049 34 GAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 79 V-FSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTII-DTSDISQIKKAI-----KPNTKALYLETPSNPLLKITDL 151
Cdd:PRK07049 114 TlLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFaDGLSEAAIGAAAeaaaaKGRVSLILIETPANPTNSLVDV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 152 AQCASVA------KDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNeALAQEIAFFQNAIG 225
Cdd:PRK07049 194 AAVRRVAdaiearQGHRPIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVLGRK-ALIRQVRALRSAIG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 226 GVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGL--PTHPNHELAKAQMRGFSGMLSFTLKNDS 303
Cdd:PRK07049 273 TQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVYKRQCTGAGSTFSFDIKGGQ 352
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 459495034 304 EAAL-FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK07049 353 AAAFrFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
3-377 |
5.91e-82 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 255.19 E-value: 5.91e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTST--YRQDA--IGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGI-H 77
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTvlFDSHAaqRRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVtN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 78 AVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASV 157
Cdd:TIGR01324 81 SILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 158 AKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNaIGGVLGPQDSWLLQ 237
Cdd:TIGR01324 161 ARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANARTWDQLREHSYL-MGQMVDADDAYTTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 238 RGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL--FVESLKLF 315
Cdd:TIGR01324 240 RGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQVhaFLDHLQLF 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 459495034 316 ILGESLGGVESLVgIPAFMTHACIPKEQREAAGirdGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:TIGR01324 320 GLGYSWGGYESLA-LCNQPELGHRPNIKRNLEG---PLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
2-376 |
1.54e-80 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 251.96 E-value: 1.54e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTTGAVSVPIYQTSTY--------RQDAIGRHKG-YEYSRSGNPTRFALEELIADLEGGVKGFAFASG 72
Cdd:PRK09028 6 ATKIVSAGRDKKWTKGVINPPVFRASTVvfdtvaemRHAAKNRANGeMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 73 LAGI-HAVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDL 151
Cdd:PRK09028 86 AAAIsNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQDV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 152 AQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQ--EIAFFqnaIGGVLG 229
Cdd:PRK09028 166 PTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQlrEHSYL---MGQCTS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 230 PQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAAL-- 307
Cdd:PRK09028 243 PDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKQGDPKAVta 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 308 FVESLKLFILGESLGGVESLV-GIPAFMTHACIPKEQREAAgirdgLVRLSVGIEHEQDLLEDLEQAFAK 376
Cdd:PRK09028 323 LVEGMQHFKMGFSWGGFESLIlGVFGINKLRTATNWDFSKP-----LIRLHIGLEDVDDLIADLEAGFER 387
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
3-378 |
1.28e-79 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 249.73 E-value: 1.28e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 3 TKLIHGGISEDTTTGAVSVPIYQTST--YRQDAI--GRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA 78
Cdd:PRK05967 15 TRLAHDGNDPGDYHGFVNPPVVHASTvlFPDAETmaTRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 79 VF-SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASV 157
Cdd:PRK05967 95 PFlGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 158 AKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFqNAIGGVLGPQDSWLLQ 237
Cdd:PRK05967 175 AHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCWPQLLEAH-GTLGLCAGPDDTYQIL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 238 RGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDS-----EAALFVESL 312
Cdd:PRK05967 254 RGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPekgkaKAHAFLDAL 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 313 KLFILGESLGGVESLVgipafmTHACIpKEQREAAGIRDG-LVRLSVGIEHEQDLLEDLEQAFAKIS 378
Cdd:PRK05967 334 EIFGLGYSWGGYESLA------LHVKL-GDRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGFAAAS 393
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
2-377 |
1.12e-78 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 248.63 E-value: 1.12e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHK--------GYEYSRSGNPTRFALEELIADLEGGVKGFAFASGL 73
Cdd:PRK05613 15 ETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKqrfaledlGPIYSRLTNPTVEALENRIASLEGGVHAVAFASGQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 74 AGIHAVF-SLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQI-KKAIKPNTKALYLETPSNPLLKITDL 151
Cdd:PRK05613 95 AAETAAIlNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENPDDPESwQAAVQPNTKAFFGETFANPQADVLDI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 152 AQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGL----------VTTNNEAL-------- 213
Cdd:PRK05613 175 PAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVlidggkfdwtVERDGKPVfpyfvtpd 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 214 ----------AQEIAFFQNA-------IGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLP 276
Cdd:PRK05613 255 payhglkyadLGAPAFGLKAragllrdTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLK 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 277 THPNHELAKAQMRGFSG-MLSFTLKNDSEAAL-FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLV 354
Cdd:PRK05613 335 DSPWYATKEKLGLKYTGsVLSFDIKGGKDEAWaFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQATV 414
|
410 420
....*....|....*....|...
gi 459495034 355 RLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK05613 415 RLSVGIEDIDDIIADLEGGFAAI 437
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
1-378 |
2.57e-73 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 233.44 E-value: 2.57e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 1 MQTKLIHGGISEDTTTGAVSVPIYQTSTY--------RQDAIGRHKG-YEYSRSGNPTRFALEELIADLEGGVKGFAFAS 71
Cdd:PRK08114 6 LDTQLVNAGRSKKYTQGSVNSVIQRASSLvfdsveakKHATRNRANGeLFYGRRGTLTHFSLQEAMCELEGGAGCALYPC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 72 GLAGI-HAVFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITD 150
Cdd:PRK08114 86 GAAAVaNAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSITMEVHD 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 151 L-AQCASV-AKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQ--EIAFFqnaIGG 226
Cdd:PRK08114 166 VpAIVAAVrSVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARCWEQlrENSYL---MGQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 227 VLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLK---NDS 303
Cdd:PRK08114 243 MVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKkklTDE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 304 EAALFVESLKLFILGESLGGVESLVgipafmthacIPKEQREAAGIRDG--------LVRLSVGIEHEQDLLEDLEQAFA 375
Cdd:PRK08114 323 QLANYLDNFSLFSMAYSWGGFESLI----------LANQPEEIAAIRPAgevdftgtLIRLHIGLEDVDDLIADLAAGFA 392
|
...
gi 459495034 376 KIS 378
Cdd:PRK08114 393 RIV 395
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
2-377 |
9.62e-73 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 231.92 E-value: 9.62e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 2 QTKLIHGgiSEDTTTG--AVSVPIYQTST--------YRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFAS 71
Cdd:PRK07050 11 QTRIVQP--DDQIPPGfrSFVTPVARASTvvfpdlatMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 72 GLAGIHAV-FSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITD 150
Cdd:PRK07050 89 GLAAISLVyFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 151 LAQCASVAKDHNLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGP 230
Cdd:PRK07050 169 VPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 231 QDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMLSFTLKNDSEAA---L 307
Cdd:PRK07050 249 DDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDERYSPAqvdA 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 308 FVESLKLFILGESLGGVESLvgipAFMTHacIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 377
Cdd:PRK07050 329 FVEALELFAIGWSWGGACSL----AMPYD--VASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQALEAA 392
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
21-374 |
5.74e-65 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 212.99 E-value: 5.74e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 21 VPIYQTSTYRQDAIG--------RHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH-AVFSLLQSGDHVLL 91
Cdd:PRK06702 26 LPLYQSTTYKYDTSDdlaalfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMlAVLNICSSGDHLLC 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 92 GDDVYGGTFRLFNKVLVKNGLSCTIIDTS-DISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIVDNT 170
Cdd:PRK06702 106 SSTVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 171 FATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVT-------TNN--------EALAQEIAFFQN------------- 222
Cdd:PRK06702 186 LATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwTNGkypelvepDPSYHGVSYVQNfgaaayivkarvq 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 223 ---AIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQM-RGFSGMLSFT 298
Cdd:PRK06702 266 llrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLkKGASGVLTFG 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 459495034 299 LKNDSEAAL-FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 374
Cdd:PRK06702 346 IKGGLEAAKeFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
7-360 |
1.54e-64 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 211.16 E-value: 1.54e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 7 HGGIS---EDTTTGAVSVPiyqtSTYRQ---DAIGRHKG-YEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAV 79
Cdd:PLN02242 32 HGGVNmsiEASATFTVMEP----DTMRRmfsGELGPDRDfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 80 F-SLLQSGDHVLLGDDVYGGTFRLFNKVL-VKNGLSCTIIDTSDISQIKKAIKPN-TKALYLETPSNPLLKITDLAQCAS 156
Cdd:PLN02242 108 LlQLCSSGGHVVASNTLYGGTHALLAHFLpRKCNITTTFVDITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 157 VAKDHNLLTIVDNTFAtPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAI---GGVLGPQDS 233
Cdd:PLN02242 188 IAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFISGGADIIAGAVCGPAELVNSMMDLHHGALmllGPTMNPKVA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 234 WLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKveRVYYPGLPTHPNHELAKAQMR---GFSGMLSFTLKNDSEAALFVE 310
Cdd:PLN02242 267 FELSERLPHLSLRMKEHCRRAMEYAKRMKELGL--KVIYPGLEDHPQHALLKSMANkgyGFGGLLCLDMDTEERANRLMR 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 459495034 311 SLKLF----ILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGI 360
Cdd:PLN02242 345 YLQNStqfgFMAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVGY 398
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
30-274 |
1.56e-11 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 65.06 E-value: 1.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 30 RQDAIGRHKGYEYSRSGNPtrfALEELIADLEGGVKGFA--------FASGLAGIHAVFS-LLQSGDHVLLGD---DVYG 97
Cdd:cd00609 21 AAAALRAGLLGYYPDPGLP---ELREAIAEWLGRRGGVDvppeeivvTNGAQEALSLLLRaLLNPGDEVLVPDptyPGYE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 98 GTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNP---LLKITDLAQCASVAKDHNLLTIVDNTFA-- 172
Cdd:cd00609 98 AAARLAGAEVVPVPLDEEGGFLLDLELLEAAKTPKTKLLYLNNPNNPtgaVLSEEELEELAELAKKHGILIISDEAYAel 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 173 --TPYCQNPLLLGAD----IVVHSGTKYLGghsdvVAGL----VTTNNEALAQEIAFFQNAIGGVLGPQD----SWLLQR 238
Cdd:cd00609 178 vyDGEPPPALALLDAyervIVLRSFSKTFG-----LPGLrigyLIAPPEELLERLKKLLPYTTSGPSTLSqaaaAAALDD 252
|
250 260 270
....*....|....*....|....*....|....*.
gi 459495034 239 GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPG 274
Cdd:cd00609 253 GEEHLEELRERYRRRRDALLEALKELGPLVVVKPSG 288
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
52-209 |
4.68e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 60.86 E-value: 4.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 52 ALEELIADL--EGGVKGFAFASGLAGIHAVF-SLLQSGDHVLLGDDVYGGTFrlfNKVLVKNGLSCTIIDTSD------- 121
Cdd:cd01494 4 ELEEKLARLlqPGNDKAVFVPSGTGANEAALlALLGPGDEVIVDANGHGSRY---WVAAELAGAKPVPVPVDDagyggld 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 122 -ISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHNLLTIVDNTFATPYCQNPLLL----GADIVVHSGTKYLG 196
Cdd:cd01494 81 vAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLipegGADVVTFSLHKNLG 160
|
170
....*....|...
gi 459495034 197 GhsdVVAGLVTTN 209
Cdd:cd01494 161 G---EGGGVVIVK 170
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
77-238 |
1.43e-08 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 55.91 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 77 HAVFSLLQSGDHVLLGD---DVYGGTFRLFNKVLVknglsctIIDTS-------DISQIKKAIKPNTKALYLETPSNP-- 144
Cdd:COG0436 105 LALLALLNPGDEVLVPDpgyPSYRAAVRLAGGKPV-------PVPLDeengflpDPEALEAAITPRTKAIVLNSPNNPtg 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 145 -LLKITDLAQCASVAKDHNLLTIVDN-----TFATPYCQNPLLLGAD----IVVHSGTK----------YLGGHSDVVAG 204
Cdd:COG0436 178 aVYSREELEALAELAREHDLLVISDEiyeelVYDGAEHVSILSLPGLkdrtIVINSFSKsyamtgwrigYAVGPPELIAA 257
|
170 180 190
....*....|....*....|....*....|....*....
gi 459495034 205 LvttnnEALAQEI-----AFFQNAIGGVLGPQDSWLLQR 238
Cdd:COG0436 258 L-----LKLQSNLtscapTPAQYAAAAALEGPQDYVEEM 291
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
124-172 |
8.67e-05 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 8.67e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 459495034 124 QIKKAIKPNTKALYLETPSNP---LLKITDLAQCASVAKDHNLLTIVDNTFA 172
Cdd:PRK07682 146 QIEAAITAKTKAILLCSPNNPtgaVLNKSELEEIAVIVEKHDLIVLSDEIYA 197
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
121-168 |
1.74e-04 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 43.19 E-value: 1.74e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 459495034 121 DISQIKKAIKPNTKALYLETPSNP---LLKITDLAQCASVAKDHNLLTIVD 168
Cdd:PRK05764 153 TVEQLEAAITPKTKALILNSPSNPtgaVYSPEELEAIADVAVEHDIWVLSD 203
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
118-188 |
3.84e-04 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 42.43 E-value: 3.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 118 DTSDISQIKKAIKPNTKALYLETPsNPLLKITDLAQCASVAKDHNLLTIVdntfatpyCQNPLLL---------GADIVV 188
Cdd:PRK00451 190 GVTDLEALEAAVDDDTAAVVVQYP-NFFGVIEDLEEIAEIAHAGGALFIV--------GVDPVSLgllkppgeyGADIVV 260
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
121-168 |
6.13e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 41.38 E-value: 6.13e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 459495034 121 DISQIKKAIKPNTKALYLETPSNP---LLKITDLAQCASVAKDHNLLTIVD 168
Cdd:PRK07568 151 SKEEIEKLITPKTKAILISNPGNPtgvVYTKEELEMLAEIAKKHDLFLISD 201
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
52-172 |
1.00e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 40.75 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 52 ALEELIADLEGGVKGFA--------FASGLAGI--HAVFSLLQSGDHVLLGDDVY----------GGTFRLFNKVLVKNG 111
Cdd:pfam00155 43 ELREALAKFLGRSPVLKldreaavvFGSGAGANieALIFLLANPGDAILVPAPTYasyiriarlaGGEVVRYPLYDSNDF 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 459495034 112 lsctiidTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQ---CASVAKDHNLLTIVDNTFA 172
Cdd:pfam00155 123 -------HLDFDALEAALKEKPKVVLHTSPHNPTGTVATLEElekLLDLAKEHNILLLVDEAYA 179
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
46-271 |
1.41e-03 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 40.28 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 46 GNPTRFALEELIADLEGGVKGFAFASGLAGIH-AVFSLLQSGDHVLLGDD--VY---GGTFRLFNKVLVKNglsctiIDT 119
Cdd:pfam01212 30 GDPTVNRLEDRVAELFGKEAALFVPSGTAANQlALMAHCQRGDEVICGEPahIHfdeTGGHAELGGVQPRP------LDG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 120 S-----DISQIKKAIK-------PNTKALYLETPSNPL----LKITDLAQCASVAKDHNLLTIVDntfATPYCQNPLLLG 183
Cdd:pfam01212 104 DeagnmDLEDLEAAIRevgadifPPTGLISLENTHNSAggqvVSLENLREIAALAREHGIPVHLD---GARFANAAVALG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 184 ---------ADIVVHSGTKYLGGHsdvVAGLVTTNNEALAQEIAfFQNAIGGVLgPQDSWLLQRGIKTLGL---RMEAHQ 251
Cdd:pfam01212 181 vivkeitsyADSVTMCLSKGLGAP---VGSVLAGSDDFIAKAIR-QRKYLGGGL-RQAGVLAAAGLRALEEgvaRLARDH 255
|
250 260
....*....|....*....|..
gi 459495034 252 KNALCVAEFLEKHP--KVERVY 271
Cdd:pfam01212 256 ATARRLAEGLELLRlaIPRRVY 277
|
|
| PRK06348 |
PRK06348 |
pyridoxal phosphate-dependent aminotransferase; |
121-176 |
2.03e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180537 Cd Length: 384 Bit Score: 39.70 E-value: 2.03e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 459495034 121 DISQIKKAIKPNTKALYLETPSNP---LLKITDLAQCASVAKDHNLLTIVDN-----TFATPYC 176
Cdd:PRK06348 151 NVKKLEALITSKTKAIILNSPNNPtgaVFSKETLEEIAKIAIEYDLFIISDEvydgfSFYEDFV 214
|
|
| SelA |
COG1921 |
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis]; |
122-197 |
2.13e-03 |
|
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441524 Cd Length: 399 Bit Score: 39.72 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 122 ISQIKKAIKPNTKALYLETPSN----PLLKITDLAQCASVAKDHNLLTIVD---------NTFATPYCQNP---LLLGAD 185
Cdd:COG1921 144 LRDYEAAITENTAALLKVHTSNyrivGFTEEVSLAELAELAHEHGLPVIVDlgsgslvdlSKYGLPHEPTVqeyLAAGAD 223
|
90
....*....|..
gi 459495034 186 IVVHSGTKYLGG 197
Cdd:COG1921 224 LVTFSGDKLLGG 235
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
121-222 |
2.54e-03 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 39.45 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 121 DISQIKKAIKPNTKA-----LYletpSNPllkiTDLAQCASVAKDHNLLTIVDNtfatpyCQNpllLGAdivVHSGtKYL 195
Cdd:cd00616 95 DPELIEAAITPRTKAiipvhLY----GNP----ADMDAIMAIAKRHGLPVIEDA------AQA---LGA---TYKG-RKV 153
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 459495034 196 GGHSDVVA--------------GLVTTNNEALAQEIAFFQN 222
Cdd:cd00616 154 GTFGDAGAfsfhptknlttgegGAVVTNDEELAERARLLRN 194
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
52-222 |
3.99e-03 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 38.90 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 52 ALEELIADLEGGVKGFAFASGLAGIHAVFSLL--QSGDHVLLGD--------------------DVYGGTFRLfnkvlvk 109
Cdd:COG0399 34 EFEEEFAAYLGVKHAVAVSSGTAALHLALRALgiGPGDEVITPAftfvatanailyvgatpvfvDIDPDTYNI------- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 110 nglsctiidtsDISQIKKAIKPNTKA-----LYletpSNPllkiTDLAQCASVAKDHNLLTIVDNTFAtpycqnpllLGA 184
Cdd:COG0399 107 -----------DPEALEAAITPRTKAiipvhLY----GQP----ADMDAIMAIAKKHGLKVIEDAAQA---------LGA 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 459495034 185 divVHSGtKYLGGHSDVVA--------------GLVTTNNEALAQEIAFFQN 222
Cdd:COG0399 159 ---TYKG-KKVGTFGDAGCfsfyptknlttgegGAVVTNDEELAERARSLRN 206
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
39-208 |
4.85e-03 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 38.55 E-value: 4.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 39 GYEYSRSGnptRFALEELIADLEGGVKGF---AFASGlagIHAV----FSLLQSGDHVL---------LgDDVYG----- 97
Cdd:COG4100 51 GYGYDDIG---RDTLERVYADVFGAEDALvrpQIVSG---THAIalalFGVLRPGDELLsitgkpydtL-EEVIGirgeg 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459495034 98 -GTFR----LFNKV-LVKNGlsctiidTSDISQIKKAIKPNTKAL-------YLETPSnplLKITDLAQCASVAKDHNLL 164
Cdd:COG4100 124 qGSLKefgiSYRQVpLTEDG-------KIDLEAIKKAINEKTKMVliqrsrgYSWRPS---LTIEEIGEIIKFVKSINPD 193
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 459495034 165 TI--VDNtfatpyC-------QNPLLLGADIVVHSGTKYLGGhsdvvaGLVTT 208
Cdd:COG4100 194 VIcfVDN------CygefvetREPTEVGADLMAGSLIKNPGG------GLAPT 234
|
|
| |
