NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|45946632|gb|AAH53533|]
View 

MTERF domain containing 2 [Homo sapiens]

Protein Classification

mTERF domain-containing protein( domain architecture ID 139977)

mTERF (mitochondrial transcription termination factor) domain-containing protein may function as a transcription termination factor that binds promoter DNA and regulates mitochondrial replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
mTERF super family cl47744
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 91-302 2.75e-04

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


The actual alignment was detected with superfamily member pfam02536:

Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 42.59  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45946632    91 ELERVMSSLLDMGFSNAHINELLSvRR----GASLQQLLDIISEFIL-LGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSY 165
Cdd:pfam02536 145 TFEEKVEFLKELGFSVEDVWKIIK-KCpeilGLSIEKKLKKKIEFLKkCGLSEEELPRVIKKYPQILSLSERTILNRVEF 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45946632   166 LQKLGLGEGKLKRVLYCCPEIFTMRqqdindtVRLLKEKCLFTVQQVTKILHSCpsvlredlgqleykfqyayfrmgIKH 245
Cdd:pfam02536 224 LLGLGFSKEEVAKMVKRFPQLLGLS-------IEVLKPKLEFLVKEMKWPLKEV-----------------------VEY 273

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45946632   246 PdivksEYLQYSLTK-IKQRHIYLERLGRyqtpdkkgqtqipNPLLKDILRVSEAEFL 302
Cdd:pfam02536 274 P-----RVFGYSLEKrIKPRIKALVSKGL-------------ECSLSWMLACSDERFL 313
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 91-302 2.75e-04

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 42.59  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45946632    91 ELERVMSSLLDMGFSNAHINELLSvRR----GASLQQLLDIISEFIL-LGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSY 165
Cdd:pfam02536 145 TFEEKVEFLKELGFSVEDVWKIIK-KCpeilGLSIEKKLKKKIEFLKkCGLSEEELPRVIKKYPQILSLSERTILNRVEF 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45946632   166 LQKLGLGEGKLKRVLYCCPEIFTMRqqdindtVRLLKEKCLFTVQQVTKILHSCpsvlredlgqleykfqyayfrmgIKH 245
Cdd:pfam02536 224 LLGLGFSKEEVAKMVKRFPQLLGLS-------IEVLKPKLEFLVKEMKWPLKEV-----------------------VEY 273

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45946632   246 PdivksEYLQYSLTK-IKQRHIYLERLGRyqtpdkkgqtqipNPLLKDILRVSEAEFL 302
Cdd:pfam02536 274 P-----RVFGYSLEKrIKPRIKALVSKGL-------------ECSLSWMLACSDERFL 313
PLN03196 PLN03196
MOC1-like protein; Provisional
 134-272 4.08e-03

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 38.92  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45946632  134 LGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSYLQKLGlgegklkrvlyccpeiftmrqqdindtvrllkekclFTVQQVT 213
Cdd:PLN03196 315 LKIDPEDFGRVIEKLPQIVSLNRNVALKHVEFLRGRG------------------------------------FSAQDVA 358

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45946632  214 KILHSCPSVLREDLGQLeyKFQYAYFRMGIKHP--DIVK-SEYLQYSL-TKIKQRHIYLERLG 272
Cdd:PLN03196 359 KMVVRCPQILALNLEIM--KPSLEFFKKEMKRPlkELVEfPAYFTYGLeSRIKPRYERVAKKG 419
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 91-302 2.75e-04

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 42.59  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45946632    91 ELERVMSSLLDMGFSNAHINELLSvRR----GASLQQLLDIISEFIL-LGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSY 165
Cdd:pfam02536 145 TFEEKVEFLKELGFSVEDVWKIIK-KCpeilGLSIEKKLKKKIEFLKkCGLSEEELPRVIKKYPQILSLSERTILNRVEF 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45946632   166 LQKLGLGEGKLKRVLYCCPEIFTMRqqdindtVRLLKEKCLFTVQQVTKILHSCpsvlredlgqleykfqyayfrmgIKH 245
Cdd:pfam02536 224 LLGLGFSKEEVAKMVKRFPQLLGLS-------IEVLKPKLEFLVKEMKWPLKEV-----------------------VEY 273

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45946632   246 PdivksEYLQYSLTK-IKQRHIYLERLGRyqtpdkkgqtqipNPLLKDILRVSEAEFL 302
Cdd:pfam02536 274 P-----RVFGYSLEKrIKPRIKALVSKGL-------------ECSLSWMLACSDERFL 313
PLN03196 PLN03196
MOC1-like protein; Provisional
 134-272 4.08e-03

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 38.92  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45946632  134 LGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSYLQKLGlgegklkrvlyccpeiftmrqqdindtvrllkekclFTVQQVT 213
Cdd:PLN03196 315 LKIDPEDFGRVIEKLPQIVSLNRNVALKHVEFLRGRG------------------------------------FSAQDVA 358

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45946632  214 KILHSCPSVLREDLGQLeyKFQYAYFRMGIKHP--DIVK-SEYLQYSL-TKIKQRHIYLERLG 272
Cdd:PLN03196 359 KMVVRCPQILALNLEIM--KPSLEFFKKEMKRPlkELVEfPAYFTYGLeSRIKPRYERVAKKG 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH