|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
1-398 |
0e+00 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 757.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 1 MSTKDEKF-----TNENDIEGNTEEIVDTFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTA 75
Cdd:PTZ00424 1 MATSEQKNqseqvASTGTIESNYDEIVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 76 TFVISSLQLINYDYVACQALILAPTRELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDM 155
Cdd:PTZ00424 81 TFVIAALQLIDYDLNACQALILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 156 IDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTILVKKDELTLEG 235
Cdd:PTZ00424 161 IDKRHLRVDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 236 IRQFYVAVEKEEWKLDTLCDLYETLTITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRV 315
Cdd:PTZ00424 241 IRQFYVAVEKEEWKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 316 LVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAINFVTNddKEKDKLKKIESYYSTQIEEMPLEVA 395
Cdd:PTZ00424 321 LITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTP--DDIEQLKEIERHYNTQIEEMPMEVA 398
|
...
gi 457874044 396 DYL 398
Cdd:PTZ00424 399 DYL 401
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
24-393 |
1.02e-153 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 440.35 E-value: 1.02e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYV-ACQALILAPTRE 102
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPrAPQALILAPTRE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 103 LAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGF 182
Cdd:COG0513 83 LALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 183 KAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTILVKKDELTLEGIRQFYVAVEKEEwKLDTLCDLYETLTI 262
Cdd:COG0513 163 IEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD-KLELLRRLLRDEDP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 263 TQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCS 342
Cdd:COG0513 242 ERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPED 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 457874044 343 PDTYIHRIGRSGRFGRKGVAINFVTNddKEKDKLKKIESYYSTQIEEMPLE 393
Cdd:COG0513 322 PEDYVHRIGRTGRAGAEGTAISLVTP--DERRLLRAIEKLIGQKIEEEELP 370
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
25-225 |
1.86e-128 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 367.93 E-value: 1.86e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 25 FDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELA 104
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 105 QQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKA 184
Cdd:cd18046 81 QQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRGFKD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 457874044 185 QIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTIL 225
Cdd:cd18046 161 QIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRIL 201
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
27-225 |
4.08e-116 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 336.22 E-value: 4.08e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 27 ALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELAQQ 106
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 107 IQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQI 186
Cdd:cd17939 81 IQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQI 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 457874044 187 YEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTIL 225
Cdd:cd17939 161 YDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRIL 199
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
25-390 |
5.10e-101 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 307.50 E-value: 5.10e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 25 FDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELA 104
Cdd:PRK11776 6 FSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTRELA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 105 QQIQKVVLALGDYL-KVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFK 183
Cdd:PRK11776 86 DQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDMGFQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 184 AQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTILV--KKDELTlegIRQFYVAVEKEEwKLDTLCDLYETLT 261
Cdd:PRK11776 166 DAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVesTHDLPA---IEQRFYEVSPDE-RLPALQRLLLHHQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 262 ITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPC 341
Cdd:PRK11776 242 PESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELAR 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 457874044 342 SPDTYIHRIGRSGRFGRKGVAINFVTNDdkekdklkkiESYYSTQIEEM 390
Cdd:PRK11776 322 DPEVHVHRIGRTGRAGSKGLALSLVAPE----------EMQRANAIEDY 360
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
25-225 |
8.10e-98 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 290.14 E-value: 8.10e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 25 FDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELA 104
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 105 QQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKA 184
Cdd:cd18045 81 VQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKGFKE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 457874044 185 QIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTIL 225
Cdd:cd18045 161 QIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRIL 201
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
34-224 |
2.93e-81 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 247.36 E-value: 2.93e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYD----YVACQALILAPTRELAQQIQK 109
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEpkkkGRGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 110 VVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEV 189
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEKI 160
|
170 180 190
....*....|....*....|....*....|....*
gi 457874044 190 FKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd00268 161 LSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
18-368 |
2.18e-80 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 259.01 E-value: 2.18e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 18 TEEIVDTFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALIL 97
Cdd:PRK11634 1 MAEFETTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 98 APTRELAQQIQKvvlALGDYLK----VKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDE 173
Cdd:PRK11634 81 APTRELAVQVAE---AMTDFSKhmrgVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 174 ADEMLSRGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTILVKKDELTLEGIRQFYVAVEKEEwKLDTL 253
Cdd:PRK11634 158 ADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMR-KNEAL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 254 CDLYETLTITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSL 333
Cdd:PRK11634 237 VRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISL 316
|
330 340 350
....*....|....*....|....*....|....*
gi 457874044 334 VINYDLPCSPDTYIHRIGRSGRFGRKGVAINFVTN 368
Cdd:PRK11634 317 VVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVEN 351
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
24-366 |
3.17e-79 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 250.63 E-value: 3.17e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQ-LINY---DYVACQALILAP 99
Cdd:PRK11192 2 TFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQhLLDFprrKSGPPRILILTP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 100 TRELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLS 179
Cdd:PRK11192 82 TRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEADRMLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 180 RGFKAQIYEVFKKLVPDIQVALFSATMPQE-ILELTTRFMRDPKTILVKKDELTLEGIRQFYVAVEKEEWKLDTLCDLYE 258
Cdd:PRK11192 162 MGFAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEVEAEPSRRERKKIHQWYYRADDLEHKTALLCHLLK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 259 TLTITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYD 338
Cdd:PRK11192 242 QPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFD 321
|
330 340
....*....|....*....|....*...
gi 457874044 339 LPCSPDTYIHRIGRSGRFGRKGVAINFV 366
Cdd:PRK11192 322 MPRSADTYLHRIGRTGRAGRKGTAISLV 349
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
1-367 |
7.45e-75 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 242.37 E-value: 7.45e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 1 MSTKD-EKFTNENDI---EG-NTEEIVDTFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTA 75
Cdd:PTZ00110 103 LSSKEvDEIRKEKEItiiAGeNVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTL 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 76 TFV------ISSLQLINY-DYVACqaLILAPTRELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGT 148
Cdd:PTZ00110 183 AFLlpaivhINAQPLLRYgDGPIV--LVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIAC 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 149 PGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRD-PKTILVK 227
Cdd:PTZ00110 261 PGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEePVHVNVG 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 228 KDELTL-EGIRQfYVAVEKEEWKLDTLCDLYETLTITQS--IIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLI 304
Cdd:PTZ00110 341 SLDLTAcHNIKQ-EVFVVEEHEKRGKLKMLLQRIMRDGDkiLIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWV 419
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 457874044 305 MREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAINFVT 367
Cdd:PTZ00110 420 LNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLT 482
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
24-366 |
2.45e-74 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 238.55 E-value: 2.45e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQ------ALIL 97
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKgrrpvrALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 98 APTRELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEM 177
Cdd:PRK10590 82 TPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 178 LSRGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTILVKKDELTLEGIRQFYVAVEKEEwKLDTLCDLY 257
Cdd:PRK10590 162 LDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKR-KRELLSQMI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 258 ETLTITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINY 337
Cdd:PRK10590 241 GKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNY 320
|
330 340
....*....|....*....|....*....
gi 457874044 338 DLPCSPDTYIHRIGRSGRFGRKGVAINFV 366
Cdd:PRK10590 321 ELPNVPEDYVHRIGRTGRAAATGEALSLV 349
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
4-390 |
4.66e-67 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 220.17 E-value: 4.66e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 4 KDEKFTNEnDIEGNTEeivdtFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSL- 82
Cdd:PRK01297 74 KLEDFVVE-PQEGKTR-----FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIIn 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 83 QLINYD-----YVA-CQALILAPTRELAQQIQKVVLALGDYLKVKCHACVGGTvvreDIDK-LKQ----GVHMVVGTPGR 151
Cdd:PRK01297 148 QLLQTPppkerYMGePRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGM----DFDKqLKQlearFCDILVATPGR 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 152 VYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKKLVP--DIQVALFSATMPQEILELTTRFMRDPKTILVKKD 229
Cdd:PRK01297 224 LLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPE 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 230 ELTLEGIRQFYVAVEKEEwKLDTLCDLYETLTITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFR 309
Cdd:PRK01297 304 NVASDTVEQHVYAVAGSD-KYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFR 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 310 SGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAINFVTNDdkekdklkkiESYYSTQIEE 389
Cdd:PRK01297 383 EGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGED----------DAFQLPEIEE 452
|
.
gi 457874044 390 M 390
Cdd:PRK01297 453 L 453
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
25-224 |
7.61e-67 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 210.62 E-value: 7.61e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 25 FDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELA 104
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 105 QQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKA 184
Cdd:cd17940 81 LQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQP 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 457874044 185 QIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17940 161 IIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
24-368 |
9.94e-65 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 215.04 E-value: 9.94e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATF---VISSLQLINYDYVACQ----ALI 96
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFlvpIISRCCTIRSGHPSEQrnplAMV 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 97 LAPTRELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADE 176
Cdd:PLN00206 202 LTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDC 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 177 MLSRGFKAQIYEVFKKLvPDIQVALFSATMPQEILELTTRFMRDPKTILVKKDELTLEGIRQFYVAVEKEEWKLdtlcDL 256
Cdd:PLN00206 282 MLERGFRDQVMQIFQAL-SQPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQ----KL 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 257 YETLTITQ-----SIIYCNTRKKVDILTQEMH--NRLFTVScMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQ 329
Cdd:PLN00206 357 FDILKSKQhfkppAVVFVSSRLGADLLANAITvvTGLKALS-IHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLL 435
|
330 340 350
....*....|....*....|....*....|....*....
gi 457874044 330 QVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAINFVTN 368
Cdd:PLN00206 436 RVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNE 474
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
24-365 |
8.21e-62 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 208.65 E-value: 8.21e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSL-QLINYDYVA------CQALI 96
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMnRLLSRPALAdrkpedPRALI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 97 LAPTRELAQQIQKVVLALGDYLKVKCHACVGGTvvreDIDK----LKQGVHMVVGTPGRVYDMIdKRH--LGVDRLKLFI 170
Cdd:PRK04537 90 LAPTRELAIQIHKDAVKFGADLGLRFALVYGGV----DYDKqrelLQQGVDVIIATPGRLIDYV-KQHkvVSLHACEICV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 171 LDEADEMLSRGFKAQIYEVFKKLvPDI---QVALFSATMPQEILELTTRFMRDPKTILVKKDELTLEGIRQ-FYVAVEKE 246
Cdd:PRK04537 165 LDEADRMFDLGFIKDIRFLLRRM-PERgtrQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQrIYFPADEE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 247 ewKLDTLCDLYETLTITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGI 326
Cdd:PRK04537 244 --KQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGL 321
|
330 340 350
....*....|....*....|....*....|....*....
gi 457874044 327 DVQQVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAINF 365
Cdd:PRK04537 322 HIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
30-224 |
8.98e-60 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 192.41 E-value: 8.98e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 30 LNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDT--IGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELAQQI 107
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDPPEnlIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 108 QKVVLALGDYLKVKCHACVGGTVV--REDIDKlkqgvHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEML-SRGFKA 184
Cdd:cd17963 81 GEVVEKMGKFTGVKVALAVPGNDVprGKKITA-----QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLdTQGHGD 155
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 457874044 185 QIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17963 156 QSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
34-221 |
9.12e-60 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 192.09 E-value: 9.12e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELAQQIQKVVLA 113
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 114 LGDYLK-VKCHACVGGTVVREDIDKLKqGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKK 192
Cdd:cd17943 81 IGKKLEgLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFSS 159
|
170 180
....*....|....*....|....*....
gi 457874044 193 LVPDIQVALFSATMPQEILELTTRFMRDP 221
Cdd:cd17943 160 LPKNKQVIAFSATYPKNLDNLLARYMRKP 188
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
236-366 |
7.99e-59 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 187.71 E-value: 7.99e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 236 IRQFYVAVEKEEWKLDTLCDLYETLTITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRV 315
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 457874044 316 LVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAINFV 366
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
25-365 |
3.99e-57 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 192.49 E-value: 3.99e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 25 FDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLqliNY--------DYVACQ--A 94
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATF---HYllshpapeDRKVNQprA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 95 LILAPTRELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEA 174
Cdd:PRK04837 87 LIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 175 DEMLSRGFKAQIYEVFKKLvPDIQV---ALFSATMPQEILELTTRFMRDPKTILVKKDELTLEGIRQ--FYVAVEKeewK 249
Cdd:PRK04837 167 DRMFDLGFIKDIRWLFRRM-PPANQrlnMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEelFYPSNEE---K 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 250 LDTLCDLYETLTITQSIIYCNTRKKV-DI---LTQEMHNrlftVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARG 325
Cdd:PRK04837 243 MRLLQTLIEEEWPDRAIIFANTKHRCeEIwghLAADGHR----VGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARG 318
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 457874044 326 IDVQQVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAINF 365
Cdd:PRK04837 319 LHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
47-213 |
2.28e-56 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 182.44 E-value: 2.28e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 47 SAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELAQQIQKVVLALGDYLKVKCHACV 126
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 127 GGTVVREDIDKLKqGVHMVVGTPGRVYDMIDKRHLgVDRLKLFILDEADEMLSRGFKAQIYEVFKKLVPDIQVALFSATM 206
Cdd:pfam00270 81 GGDSRKEQLEKLK-GPDILVGTPGRLLDLLQERKL-LKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATL 158
|
....*..
gi 457874044 207 PQEILEL 213
Cdd:pfam00270 159 PRNLEDL 165
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
25-226 |
4.98e-56 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 183.32 E-value: 4.98e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 25 FDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELA 104
Cdd:cd17950 4 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRELA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 105 QQIQKVVLALGDYLK-VKCHACVGGTVVREDIDKLKQGV-HMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEML-SRG 181
Cdd:cd17950 84 FQISNEYERFSKYMPnVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLeQLD 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 457874044 182 FKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTILV 226
Cdd:cd17950 164 MRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
38-239 |
2.98e-53 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 175.76 E-value: 2.98e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 38 IYSYGFEKPSAIQQRGIKPILNGY-DTIGQAQSGTGKTATFVISSLQLInYDYVACQALILAPTRELAQQIQKVVLALGD 116
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL-KRGKGGRVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 117 YLKVKCHACVGGTVVREDIDKLKQGV-HMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKKLVP 195
Cdd:smart00487 80 SLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 457874044 196 DIQVALFSATMPQEILELTTRFMRDPKTILVKkdELTLEGIRQF 239
Cdd:smart00487 160 NVQLLLLSATPPEEIENLLELFLNDPVFIDVG--FTPLEPIEQF 201
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
25-221 |
8.22e-51 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 169.33 E-value: 8.22e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 25 FDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELA 104
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 105 QQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMI---DKRHLGVDRLKLFILDEADEMLSRG 181
Cdd:cd17955 81 YQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLrssDDTTKVLSRVKFLVLDEADRLLTGS 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 457874044 182 FKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDP 221
Cdd:cd17955 161 FEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKP 200
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
24-220 |
1.12e-47 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 161.89 E-value: 1.12e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLI---------NYDYVAC-Q 93
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLledgppsvgRGRRKAYpS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 94 ALILAPTRELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDE 173
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 457874044 174 ADEMLSRGFKAQIyevfKKLV--PDI------QVALFSATMPQEILELTTRFMRD 220
Cdd:cd17967 161 ADRMLDMGFEPQI----RKIVehPDMppkgerQTLMFSATFPREIQRLAADFLKN 211
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
24-221 |
2.78e-46 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 157.48 E-value: 2.78e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTREL 103
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 104 AQQIQKVVLALGDYLKVKCHACVGGtvvredIDKLKQGV------HMVVGTPGRVYDMIDK-RHLGVDRLKLFILDEADE 176
Cdd:cd17954 81 AQQISEQFEALGSSIGLKSAVLVGG------MDMMAQAIalakkpHVIVATPGRLVDHLENtKGFSLKSLKFLVMDEADR 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 457874044 177 MLSRGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDP 221
Cdd:cd17954 155 LLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNP 199
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
28-224 |
3.18e-46 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 158.31 E-value: 3.18e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 28 LGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINyDYVACQ------ALILAPTR 101
Cdd:cd17953 17 CGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIK-DQRPVKpgegpiGLIMAPTR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 102 ELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMI---DKRHLGVDRLKLFILDEADEML 178
Cdd:cd17953 96 ELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILtanNGRVTNLRRVTYVVLDEADRMF 175
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 457874044 179 SRGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17953 176 DMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
24-224 |
6.67e-45 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 154.00 E-value: 6.67e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLIN--YDYVACQALILAPTR 101
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKahSPTVGARALILSPTR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 102 ELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRG 181
Cdd:cd17959 82 ELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLFEMG 161
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 457874044 182 FKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17959 162 FAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
34-221 |
1.05e-44 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 153.29 E-value: 1.05e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQ-----ALILAPTRELAQQIQ 108
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERgdgpiVLVLAPTRELAQQIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 109 KVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYE 188
Cdd:cd17966 81 QEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIRK 160
|
170 180 190
....*....|....*....|....*....|...
gi 457874044 189 VFKKLVPDIQVALFSATMPQEILELTTRFMRDP 221
Cdd:cd17966 161 IVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDY 193
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
24-219 |
4.27e-44 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 153.97 E-value: 4.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQ-LINYDYVAC--------QA 94
Cdd:cd18052 44 TFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTgMMKEGLTASsfsevqepQA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 95 LILAPTRELAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEA 174
Cdd:cd18052 124 LIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYLILDEA 203
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 457874044 175 DEMLSRGFKAQIyevfKKLVPDI--------QVALFSATMPQEILELTTRFMR 219
Cdd:cd18052 204 DRMLDMGFGPEI----RKLVSEPgmpskedrQTLMFSATFPEEIQRLAAEFLK 252
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
34-221 |
1.43e-43 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 150.26 E-value: 1.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSL-QLINYDYVACQ----ALILAPTRELAQQIQ 108
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLvHIMDQRELEKGegpiAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 109 KVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYE 188
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVRS 160
|
170 180 190
....*....|....*....|....*....|...
gi 457874044 189 VFKKLVPDIQVALFSATMPQEILELTTRFMRDP 221
Cdd:cd17952 161 IVGHVRPDRQTLLFSATFKKKIEQLARDILSDP 193
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
34-224 |
3.56e-43 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 149.33 E-value: 3.56e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQ-LINYDYV--ACQALILAPTRELAQQIQKV 110
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILErLLYRPKKkaATRVLVLVPTRELAMQCFSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 111 VLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMI-DKRHLGVDRLKLFILDEADEMLSRGFKAQIYEV 189
Cdd:cd17947 81 LQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLrNSPSFDLDSIEILVLDEADRMLEEGFADELKEI 160
|
170 180 190
....*....|....*....|....*....|....*
gi 457874044 190 FKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17947 161 LRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
30-213 |
1.11e-42 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 148.50 E-value: 1.11e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 30 LNEKLLRGIYSYGFEKPSAIQQRGIKPIL-NGYDTIGQAQSGTGKTATFVISSLQ-----LINYDYVACQALILAPTREL 103
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQsllntKPAGRRSGVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 104 AQQIQKVVLALGDYL-KVKCHACVGGTVVREDIDKL-KQGVHMVVGTPGRVYDMIDKRHLGVD--RLKLFILDEADEMLS 179
Cdd:cd17964 81 ALQIAAEAKKLLQGLrKLRVQSAVGGTSRRAELNRLrRGRPDILVATPGRLIDHLENPGVAKAftDLDYLVLDEADRLLD 160
|
170 180 190
....*....|....*....|....*....|....*...
gi 457874044 180 RGFKAQIYEVFKKLVP----DIQVALFSATMPQEILEL 213
Cdd:cd17964 161 MGFRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQI 198
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
34-224 |
1.47e-41 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 145.93 E-value: 1.47e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISslqLINY-------DYVACQ----ALILAPTRE 102
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIP---LLVYisrlpplDEETKDdgpyALILAPTRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 103 LAQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGF 182
Cdd:cd17945 78 LAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGF 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 457874044 183 KAQIYEVFKKLVPDI--------------------QVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17945 158 EPQVTKILDAMPVSNkkpdteeaeklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
34-224 |
2.33e-41 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 144.64 E-value: 2.33e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQ-----ALILAPTRELAQQIQ 108
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKkgqvgALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 109 KVVLALGDY--LKVKCHACVGGTVVREDIDKLK-QGVHMVVGTPGRVYDMIDKRHLGVD--RLKLFILDEADEMLSRGFK 183
Cdd:cd17960 81 EVLQSFLEHhlPKLKCQLLIGGTNVEEDVKKFKrNGPNILVGTPGRLEELLSRKADKVKvkSLEVLVLDEADRLLDLGFE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 457874044 184 AQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17960 161 ADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
34-226 |
9.89e-40 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 140.42 E-value: 9.89e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVAC--QALILAPTRELAQQIQKVV 111
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKKKglRALILAPTRELASQIYREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 112 LALGDYLKVKCHACVGGTVVR-EDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVF 190
Cdd:cd17957 81 LKLSKGTGLRIVLLSKSLEAKaKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDEIL 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 457874044 191 KKLV-PDIQVALFSATMPQEILELTTRFMRDPKTILV 226
Cdd:cd17957 161 AACTnPNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
34-224 |
1.78e-39 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 139.78 E-value: 1.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSL-----QLINYDYVACQ---ALILAPTRELAQ 105
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLImfaleQEKKLPFIKGEgpyGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 106 QIQKVV------LALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLS 179
Cdd:cd17951 81 QTHEVIeyyckaLQEGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMID 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 457874044 180 RGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17951 161 MGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
25-221 |
2.41e-39 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 139.38 E-value: 2.41e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 25 FDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLInydyvacQALILAPTRELA 104
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV-------VALILEPSRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 105 QQIQKVVLALGDYL---KVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRG 181
Cdd:cd17938 74 EQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQG 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 457874044 182 FKAQIYEVFKKLvPDI-------QVALFSATMPQ-EILELTTRFMRDP 221
Cdd:cd17938 154 NLETINRIYNRI-PKItsdgkrlQVIVCSATLHSfEVKKLADKIMHFP 200
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
34-224 |
4.83e-39 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 138.45 E-value: 4.83e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTRELAQQIQKVVLA 113
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 114 LGD-YLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKK 192
Cdd:cd17962 81 LMKgLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDILEN 160
|
170 180 190
....*....|....*....|....*....|..
gi 457874044 193 LVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17962 161 ISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
22-232 |
6.37e-38 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 136.69 E-value: 6.37e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 22 VDTFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNG--YDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAP 99
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 100 TRELAQQIQKVVLALGDY-LKVKCHACVGGTVVREDIDKLKQgvhMVVGTPGRVYDMIDK-RHLGVDRLKLFILDEADEM 177
Cdd:cd18048 97 TFELALQTGKVVEEMGKFcVGIQVIYAIRGNRPGKGTDIEAQ---IVIGTPGTVLDWCFKlRLIDVTNISVFVLDEADVM 173
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 457874044 178 LS-RGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTILVKKDELT 232
Cdd:cd18048 174 INvQGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEELT 229
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
43-220 |
1.56e-37 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 135.91 E-value: 1.56e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 43 FEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINY-------DYVACqaLILAPTRELAQQIQKVVLALG 115
Cdd:cd18049 44 FTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHqpflergDGPIC--LVLAPTRELAQQVQQVAAEYG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 116 DYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKKLVP 195
Cdd:cd18049 122 RACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRP 201
|
170 180
....*....|....*....|....*
gi 457874044 196 DIQVALFSATMPQEILELTTRFMRD 220
Cdd:cd18049 202 DRQTLMWSATWPKEVRQLAEDFLKD 226
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
43-220 |
4.03e-37 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 135.91 E-value: 4.03e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 43 FEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINY-------DYVACqaLILAPTRELAQQIQKVVLALG 115
Cdd:cd18050 82 FKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHqpylergDGPIC--LVLAPTRELAQQVQQVADDYG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 116 DYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKKLVP 195
Cdd:cd18050 160 KSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRP 239
|
170 180
....*....|....*....|....*
gi 457874044 196 DIQVALFSATMPQEILELTTRFMRD 220
Cdd:cd18050 240 DRQTLMWSATWPKEVRQLAEDFLRD 264
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
30-224 |
1.25e-36 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 132.32 E-value: 1.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 30 LNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLI------NYDYVACQALILAPTREL 103
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkakaeSGEEQGTRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 104 AQQIQKVVLALGDYL--KVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMID-KRHLGVDRLKLFILDEADEMLSR 180
Cdd:cd17961 81 AQQVSKVLEQLTAYCrkDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLEsGSLLLLSTLKYLVIDEADLVLSY 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 457874044 181 GFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17961 161 GYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
248-357 |
2.71e-36 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 128.10 E-value: 2.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 248 WKLDTLCDLYETLTITQSIIYCNTRKKVDIltQEMHNRL-FTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGI 326
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLEA--ELLLEKEgIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 457874044 327 DVQQVSLVINYDLPCSPDTYIHRIGRSGRFG 357
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
35-205 |
3.82e-35 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 128.25 E-value: 3.82e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 35 LRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLI------NYDYVACqaLILAPTRELAQQIQ 108
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLyklkfkPRNGTGV--IIISPTRELALQIY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 109 KVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYD-MIDKRHLGVDRLKLFILDEADEMLSRGFKAQIY 187
Cdd:cd17942 80 GVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDhLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMR 159
|
170
....*....|....*...
gi 457874044 188 EVFKKLVPDIQVALFSAT 205
Cdd:cd17942 160 QIIKLLPKRRQTMLFSAT 177
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
17-220 |
4.08e-35 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 129.77 E-value: 4.08e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 17 NTEEIVDTFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLI----NYDYVAC 92
Cdd:cd18051 15 NCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIyeqgPGESLPS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 93 Q------------ALILAPTRELAQQIQKVVLALGDYLKVKchACV--GGTVVREDIDKLKQGVHMVVGTPGRVYDMIDK 158
Cdd:cd18051 95 EsgyygrrkqyplALVLAPTRELASQIYDEARKFAYRSRVR--PCVvyGGADIGQQMRDLERGCHLLVATPGRLVDMLER 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 457874044 159 RHLGVDRLKLFILDEADEMLSRGFKAQIYEVFKKL-VP---DIQVALFSATMPQEILELTTRFMRD 220
Cdd:cd18051 173 GKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDtMPptgERQTLMFSATFPKEIQMLARDFLDN 238
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
35-226 |
7.21e-35 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 127.41 E-value: 7.21e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 35 LRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLIN------YDYVACqaLILAPTRELAQQIQ 108
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYrerwtpEDGLGA--LIISPTRELAMQIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 109 KVVLALGDYLKVKCHACVGGTVVREDIDKLKQgVHMVVGTPGRVYDMIDKR-HLGVDRLKLFILDEADEMLSRGFKAQIY 187
Cdd:cd17941 80 EVLRKVGKYHSFSAGLIIGGKDVKEEKERINR-MNILVCTPGRLLQHMDETpGFDTSNLQMLVLDEADRILDMGFKETLD 158
|
170 180 190
....*....|....*....|....*....|....*....
gi 457874044 188 EVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTILV 226
Cdd:cd17941 159 AIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
34-221 |
1.00e-34 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 127.20 E-value: 1.00e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLqlINYDYVACQ--------ALILAPTRELAQ 105
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGF--IHLDLQPIPreqrngpgVLVLTPTRELAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 106 QIQ-KVVLALGDYLKVKChaCVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKA 184
Cdd:cd17958 79 QIEaECSKYSYKGLKSVC--VYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEP 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 457874044 185 QIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDP 221
Cdd:cd17958 157 QIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDP 193
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
42-224 |
1.01e-31 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 119.61 E-value: 1.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 42 GFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATF---VISSLQLINYDY---VACQALILAPTRELAQQIQKVVLALG 115
Cdd:cd17949 10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYllpIIQRLLSLEPRVdrsDGTLALVLVPTRELALQIYEVLEKLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 116 DylkvKCHACVGGTVV---REDIDK--LKQGVHMVVGTPGRVYDMIDK-RHLGVDRLKLFILDEADEMLSRGFKAQIYEV 189
Cdd:cd17949 90 K----PFHWIVPGYLIggeKRKSEKarLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLLDMGFEKDITKI 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 457874044 190 FKKL-------------VPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd17949 166 LELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
34-230 |
3.91e-31 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 118.50 E-value: 3.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKP-ILNGYDTIGQAQSGTGKTATFVISSLQ---------LINYDYVACQALILAPTREL 103
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILErllsqkssnGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 104 AQQIQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKL---FILDEADEMLSR 180
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLANLKSlrfLVLDEADRMLEK 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 457874044 181 GFKAQIYEVFKKL-------VPDIQVALFSATMpQEILELTTRFMRDPKTILVKKDE 230
Cdd:cd17946 161 GHFAELEKILELLnkdragkKRKRQTFVFSATL-TLDHQLPLKLNSKKKKKKKEKKQ 216
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
33-219 |
4.98e-31 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 117.26 E-value: 4.98e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 33 KLL--RGIySYGFEkpsaIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYV------ACQALILAPTRELA 104
Cdd:cd17944 3 KLLqaRGV-TYLFP----IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQprkrgrAPKVLVLAPTRELA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 105 QQIQKVVLALGDYLKVKCHacVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGFKA 184
Cdd:cd17944 78 NQVTKDFKDITRKLSVACF--YGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAE 155
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 457874044 185 QIYEV----FKKLVPD-IQVALFSATMPQEILELTTRFMR 219
Cdd:cd17944 156 QVEEIlsvsYKKDSEDnPQTLLFSATCPDWVYNVAKKYMK 195
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
276-357 |
1.79e-29 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 109.22 E-value: 1.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 276 DILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGR 355
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 457874044 356 FG 357
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
24-224 |
1.16e-28 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 111.35 E-value: 1.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 24 TFDALGLNEKLLRGIYSYGFEKPSAIQQRGIKPILNG--YDTIGQAQSGTGKTATFVISSLQLINYDYVACQALILAPTR 101
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 102 ELAQQIQKVVLALGD-YLKVKCHACVGGtvvrediDKLKQGV----HMVVGTPGRVYDMIDKRHLgVD--RLKLFILDEA 174
Cdd:cd18047 82 ELALQTGKVIEQMGKfYPELKLAYAVRG-------NKLERGQkiseQIVIGTPGTVLDWCSKLKF-IDpkKIKVFVLDEA 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 457874044 175 DEML-SRGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTI 224
Cdd:cd18047 154 DVMIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
34-213 |
2.32e-22 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 94.74 E-value: 2.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 34 LLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACQ-------ALILAPTRELAQQ 106
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEgpfnaprGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 107 IQKVVLALGDYLKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEADEMLSRGF---- 182
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFnekl 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 457874044 183 -----KAQIYEVFK----KLVPDIQVALFSATMPQEILEL 213
Cdd:cd17948 161 shflrRFPLASRRSentdGLDPGTQLVLVSATMPSGVGEV 200
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
60-205 |
2.16e-18 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 81.30 E-value: 2.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 60 GYDTIGQAQSGTGKTATFVISSLQLInyDYVACQALILAPTRELAQQIQKVVLALGDyLKVKCHACVGGTVVREDIDKLK 139
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLL--LKKGKKVLVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 457874044 140 QGVHMVVGTPGRVYDMI-DKRHLGVDRLKLFILDEADEMLSRGFKAQI--YEVFKKLVPDIQVALFSAT 205
Cdd:cd00046 78 GDADIIIATPDMLLNLLlREDRLFLKDLKLIIVDEAHALLIDSRGALIldLAVRKAGLKNAQVILLSAT 146
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
29-363 |
6.28e-16 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 79.49 E-value: 6.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 29 GLNEKLLRGIYSYGFEKPSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACqALILAPTRELAQ-QI 107
Cdd:COG1205 40 WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPGAT-ALYLYPTKALARdQL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 108 QKVV-LALGDYLKVKCHACVGGT--VVREDIdklKQGVHMVVGTPgrvyDMIdkrHLGV-----------DRLKLFILDE 173
Cdd:COG1205 119 RRLReLAEALGLGVRVATYDGDTppEERRWI---REHPDIVLTNP----DML---HYGLlphhtrwarffRNLRYVVIDE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 174 ADEMlsRG-FKAQIYEVFKKLV-------PDIQVALFSATM--PQEILE-LTTRFM---------RDPKTILVKKDELTL 233
Cdd:COG1205 189 AHTY--RGvFGSHVANVLRRLRricrhygSDPQFILASATIgnPAEHAErLTGRPVtvvdedgspRGERTFVLWNPPLVD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 234 EGIRQFYVAvekeewkldTLCDLYETLTI--TQSIIYCNTRKKVDILTQEMHNRLFT------VSCMHGDMDQKDRDLIM 305
Cdd:COG1205 267 DGIRRSALA---------EAARLLADLVRegLRTLVFTRSRRGAELLARYARRALREpdladrVAAYRAGYLPEERREIE 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 457874044 306 REFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAI 363
Cdd:COG1205 338 RGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVV 395
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
70-368 |
2.51e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 77.76 E-value: 2.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 70 GTGKT--ATFVISSLQLINydyvacQALILAPTRELAQQIQKvvlalgDYLKVKCHACVGGTvvREDIDKlkqgvHMVVG 147
Cdd:COG1061 110 GTGKTvlALALAAELLRGK------RVLVLVPRRELLEQWAE------ELRRFLGDPLAGGG--KKDSDA-----PITVA 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 148 TPGRVYDMIDKRHLGvDRLKLFILDEADEMLSRGFKAqiyevfkklvpdiqvaLFSATMPQEILELT-TRFMRDPKTILV 226
Cdd:COG1061 171 TYQSLARRAHLDELG-DRFGLVIIDEAHHAGAPSYRR----------------ILEAFPAAYRLGLTaTPFRSDGREILL 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 227 KKD-----ELTL-EGIRQFYVA-----------------------------VEKEEWKLDTLCDLYETLT-ITQSIIYCN 270
Cdd:COG1061 234 FLFdgivyEYSLkEAIEDGYLAppeyygirvdltderaeydalserlrealAADAERKDKILRELLREHPdDRKTLVFCS 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 271 TRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRI 350
Cdd:COG1061 314 SVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRL 393
|
330 340
....*....|....*....|.
gi 457874044 351 GR---SGRFGRKGVAINFVTN 368
Cdd:COG1061 394 GRglrPAPGKEDALVYDFVGN 414
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
46-225 |
5.17e-15 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 73.82 E-value: 5.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 46 PSAIQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVAC-QALILAPTRELAQQIQKVVLALGDYLKVKCHA 124
Cdd:cd17956 22 PWLLPSSKSTPPYRPGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPRlRALIVVPTKELVQQVYKVFESLCKGTGLKVVS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 125 CVGGTVVREDIDKLKQGVH--------MVVGTPGRVYDMID-KRHLGVDRLKLFILDEADEMLSRGF------------- 182
Cdd:cd17956 102 LSGQKSFKKEQKLLLVDTSgrylsrvdILVATPGRLVDHLNsTPGFTLKHLRFLVIDEADRLLNQSFqdwletvmkalgr 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 457874044 183 -------KAQIYEVFKKLVPDIQVALFSATMPQEILELTTRFMRDPKTIL 225
Cdd:cd17956 182 ptapdlgSFGDANLLERSVRPLQKLLFSATLTRDPEKLSSLKLHRPRLFT 231
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
45-217 |
1.77e-14 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 72.79 E-value: 1.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 45 KPSAIQQRGIkPILNGYDTIGQ-----------------AQSGTGKTATFVISslqLINY-------------------- 87
Cdd:cd17965 30 KPSPIQTLAI-KKLLKTLMRKVtkqtsneepklevfllaAETGSGKTLAYLAP---LLDYlkrqeqepfeeaeeeyesak 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 88 DYVACQALILAPTRELAQQIQKVVLALGDY--LKVKCHACVGGTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDR 165
Cdd:cd17965 106 DTGRPRSVILVPTHELVEQVYSVLKKLSHTvkLGIKTFSSGFGPSYQRLQLAFKGRIDILVTTPGKLASLAKSRPKILSR 185
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 457874044 166 LKLFILDEADEMLSRGFKAQIYEVFKKLVPDIQVALFSATMPQEILELTTRF 217
Cdd:cd17965 186 VTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKL 237
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
266-365 |
4.67e-14 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 68.77 E-value: 4.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 266 IIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDT 345
Cdd:cd18794 34 IIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMES 113
|
90 100
....*....|....*....|
gi 457874044 346 YIHRIGRSGRFGRKGVAINF 365
Cdd:cd18794 114 YYQESGRAGRDGLPSECILF 133
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
190-363 |
3.94e-13 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 70.55 E-value: 3.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 190 FKKLVPDIQVALFSATMP----QEILE-LttrFMRDPKTIL--VKKDELTLEgIRQFYVAvEKEEWKLDTLCDLYEtlti 262
Cdd:COG0514 160 LRERLPNVPVLALTATATprvrADIAEqL---GLEDPRVFVgsFDRPNLRLE-VVPKPPD-DKLAQLLDFLKEHPG---- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 263 tQS-IIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPC 341
Cdd:COG0514 231 -GSgIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPK 309
|
170 180
....*....|....*....|..
gi 457874044 342 SPDTYIHRIGRSGRFGRKGVAI 363
Cdd:COG0514 310 SIEAYYQEIGRAGRDGLPAEAL 331
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
30-365 |
1.66e-12 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 68.97 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 30 LNEKLLRGIYSYGFEKPSaiQQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYdyvacqALILAPTRELAQQIQK 109
Cdd:PRK11057 12 LAKQVLQETFGYQQFRPG--QQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLDGL------TLVVSPLISLMKDQVD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 110 VVLALGdylkVKChACVGGTVVRED----IDKLKQG-VHMVVGTPGRVY--DMIDkrHLGVDRLKLFILDEADEMLSRG- 181
Cdd:PRK11057 84 QLLANG----VAA-ACLNSTQTREQqlevMAGCRTGqIKLLYIAPERLMmdNFLE--HLAHWNPALLAVDEAHCISQWGh 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 182 -FKAQIYEV--FKKLVPDIQVALFSATMP----QEILELTTrfMRDPktiLVKKDELTLEGIRqfYVAVEKEEwKLDTLC 254
Cdd:PRK11057 157 dFRPEYAALgqLRQRFPTLPFMALTATADdttrQDIVRLLG--LNDP---LIQISSFDRPNIR--YTLVEKFK-PLDQLM 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 255 DLYETLTITQSIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLV 334
Cdd:PRK11057 229 RYVQEQRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFV 308
|
330 340 350
....*....|....*....|....*....|.
gi 457874044 335 INYDLPCSPDTYIHRIGRSGRFGRKGVAINF 365
Cdd:PRK11057 309 VHFDIPRNIESYYQETGRAGRDGLPAEAMLF 339
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
249-357 |
4.13e-11 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 60.18 E-value: 4.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 249 KLDTLCDLYETLTITQ--SIIYCNTRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGST--RVLVTTDLLAR 324
Cdd:cd18793 12 KLEALLELLEELREPGekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDirVFLLSTKAGGV 91
|
90 100 110
....*....|....*....|....*....|...
gi 457874044 325 GIDVQQVSLVINYDLPCSPDTYIHRIGRSGRFG 357
Cdd:cd18793 92 GLNLTAANRVILYDPWWNPAVEEQAIDRAHRIG 124
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
240-352 |
1.66e-10 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 58.76 E-value: 1.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 240 YVAVEKEEWKLDTLCDLYETLTITQSIIYCNTRKKVDILTQEMHN-----RLFTVSCMHG----------DMDQKDRDLI 304
Cdd:cd18802 3 IVVIPKLQKLIEILREYFPKTPDFRGIIFVERRATAVVLSRLLKEhpstlAFIRCGFLIGrgnssqrkrsLMTQRKQKET 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 457874044 305 MREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGR 352
Cdd:cd18802 83 LDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
265-355 |
5.93e-09 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 54.58 E-value: 5.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 265 SIIYCNTRKKVDILTQEMHNRL------FTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYD 338
Cdd:cd18796 41 TLVFTNTRSQAERLAQRLRELCpdrvppDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIG 120
|
90
....*....|....*..
gi 457874044 339 LPCSPDTYIHRIGRSGR 355
Cdd:cd18796 121 SPKSVARLLQRLGRSGH 137
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
296-360 |
6.41e-09 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 54.28 E-value: 6.41e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 457874044 296 MDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRfGRKG 360
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQG 137
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
296-363 |
8.54e-09 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 57.43 E-value: 8.54e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 457874044 296 MDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRFGRKGVAI 363
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGRVVV 462
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
264-363 |
2.52e-08 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 52.64 E-value: 2.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 264 QSIIYCNTRKKVDILTQEMHNRL-------FTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVIN 336
Cdd:cd18797 37 KTIVFCRSRKLAELLLRYLKARLveegplaSKVASYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVL 116
|
90 100
....*....|....*....|....*..
gi 457874044 337 YDLPCSPDTYIHRIGRSGRFGRKGVAI 363
Cdd:cd18797 117 AGYPGSLASLWQQAGRAGRRGKDSLVI 143
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
280-362 |
2.57e-08 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 52.73 E-value: 2.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 280 QEMHNRLFT-------VSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDlpcspdtyIHRIGR 352
Cdd:cd18811 48 VAMYEYLKErfrpelnVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNATVMVIED--------AERFGL 119
|
90
....*....|....*.
gi 457874044 353 S------GRFGRKGVA 362
Cdd:cd18811 120 SqlhqlrGRVGRGDHQ 135
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
210-367 |
4.60e-08 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 55.23 E-value: 4.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 210 ILELTTRFMR---DPKtiLVKKDELTLEGirqfyvavekEEWKLDTLCDLYETLTITQS--IIYCNTRKKVDILTQEMHN 284
Cdd:COG0553 504 ILAALTRLRQicsHPA--LLLEEGAELSG----------RSAKLEALLELLEELLAEGEkvLVFSQFTDTLDLLEERLEE 571
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 285 RLFTVSCMHGDMDQKDRDLIMREFRSGS--TRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRFG-RKGV 361
Cdd:COG0553 572 RGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGqTRDV 651
|
....*..
gi 457874044 362 -AINFVT 367
Cdd:COG0553 652 qVYKLVA 658
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
260-366 |
1.09e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 48.85 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 260 LTITQSIIYCNTRKKVDILTQEMhnrlftvscmhgdmdqkdrdlimrefrsgstRVLVTTDLLARGIDVQQVSLVINYDL 339
Cdd:cd18785 1 VMVVKIIVFTNSIEHAEEIASSL-------------------------------EILVATNVLGEGIDVPSLDTVIFFDP 49
|
90 100
....*....|....*....|....*...
gi 457874044 340 PCSPDTYIHRIGRSGRFG-RKGVAINFV 366
Cdd:cd18785 50 PSSAASYIQRVGRAGRGGkDEGEVILFV 77
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
94-326 |
1.24e-07 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 53.36 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 94 ALILAPTRELAQQI-QKVVLALGDY-LKVKCHacvggTVVREDIDKLKQGVHMVVGTPGRVYDMIDKRHLGVDRLKLFIL 171
Cdd:COG1204 69 ALYIVPLRALASEKyREFKRDFEELgIKVGVS-----TGDYDSDDEWLGRYDILVATPEKLDSLLRNGPSWLRDVDLVVV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 172 DEA----DEmlSRGFkaqIYEV----FKKLVPDIQVALFSATM--PQEILE-LTTRFMRD-----PKTILVKKDeltleG 235
Cdd:COG1204 144 DEAhlidDE--SRGP---TLEVllarLRRLNPEAQIVALSATIgnAEEIAEwLDAELVKSdwrpvPLNEGVLYD-----G 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 236 IRQFyvaVEKEEWKLDTLCDL-YETLTI-TQSIIYCNTRKKV----DILTQEMHNRLFT--------------------- 288
Cdd:COG1204 214 VLRF---DDGSRRSKDPTLALaLDLLEEgGQVLVFVSSRRDAeslaKKLADELKRRLTPeereeleelaeellevseeth 290
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 457874044 289 -----VSCM-------HGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGI 326
Cdd:COG1204 291 tneklADCLekgvafhHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGV 340
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
168-359 |
2.89e-07 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 52.05 E-value: 2.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 168 LFILDEADEMLS--RGFKAQIYEVFKKLvpDIQVALFSATMPQEILELTtrfmrdPKTILVKKDE-LTLEGIRQFYVAVE 244
Cdd:cd09639 126 LLIFDEVHFYDEytLALILAVLEVLKDN--DVPILLMSATLPKFLKEYA------EKIGYVEENEpLDLKPNERAPFIKI 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 245 KEEWKLD--TLCDLYETLTITQSI-IYCNTRKKvdilTQEMHNRL------FTVSCMHGDMDQKDR----DLIMREFRSG 311
Cdd:cd09639 198 ESDKVGEisSLERLLEFIKKGGSVaIIVNTVDR----AQEFYQQLkekgpeEEIMLIHSRFTEKDRakkeAELLLEFKKS 273
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 457874044 312 STRVLVTTDLLARGIDVQQVSLVINydlPCSPDTYIHRIGRSGRFGRK 359
Cdd:cd09639 274 EKFVIVATQVIEASLDISVDVMITE---LAPIDSLIQRLGRLHRYGEK 318
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
264-363 |
2.50e-06 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 46.78 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 264 QSIIYCNTRKKVDILTQEM-----HnrlftvscmHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIdvqqvslvinyD 338
Cdd:cd18795 45 PVLVFCSSRKECEKTAKDLagiafH---------HAGLTREDRELVEELFREGLIKVLVATSTLAAGV-----------N 104
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 457874044 339 LPC-------------------SPDTYIHRIGRSGR--FGRKGVAI 363
Cdd:cd18795 105 LPArtviikgtqrydgkgyrelSPLEYLQMIGRAGRpgFDTRGEAI 150
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
50-209 |
5.91e-06 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 46.42 E-value: 5.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 50 QQRGIKPILNGYDTIGQAQSGTGKTATFVISSLQLINYDYVACqALILAPTRELAQ-QIQKV-VLALGDYLKVKCHACVG 127
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGSR-ALYLYPTKALAQdQLRSLrELLEQLGLGIRVATYDG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 128 GTVVREDIDKLKQGVHMVVGTPgrvyDMIdkrHLGVDR-----------LKLFILDEAdEMLSRGFKAQIYEVFKKL--- 193
Cdd:cd17923 84 DTPREERRAIIRNPPRILLTNP----DML---HYALLPhhdrwarflrnLRYVVLDEA-HTYRGVFGSHVALLLRRLrrl 155
|
170 180
....*....|....*....|..
gi 457874044 194 ----VPDIQVALFSATM--PQE 209
Cdd:cd17923 156 crryGADPQFILTSATIgnPAE 177
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
265-368 |
8.08e-06 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 48.17 E-value: 8.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 265 SIIYCNTRKKVDILTQEMhNRLF-----TVSCMHGDMDQKDRDLIMREFRSGSTRVLVTT---DLlarGIDVQQVSLVIN 336
Cdd:COG1201 275 TLVFTNTRSQAERLFQRL-NELNpedalPIAAHHGSLSREQRLEVEEALKAGELRAVVATsslEL---GIDIGDVDLVIQ 350
|
90 100 110
....*....|....*....|....*....|...
gi 457874044 337 YDLPCSPDTYIHRIGRSG-RFGRKGVAINFVTN 368
Cdd:COG1201 351 VGSPKSVARLLQRIGRAGhRVGEVSKGRLVPTH 383
|
|
| PRK10917 |
PRK10917 |
ATP-dependent DNA helicase RecG; Provisional |
70-328 |
8.49e-06 |
|
ATP-dependent DNA helicase RecG; Provisional
Pssm-ID: 236794 [Multi-domain] Cd Length: 681 Bit Score: 47.84 E-value: 8.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 70 GTGKTATFVISSLQLINYDYvacQALILAPTRELAQQI-QKVVLALGDY-LKVkchACVGGTV---VREDI-DKLKQG-V 142
Cdd:PRK10917 292 GSGKTVVAALAALAAIEAGY---QAALMAPTEILAEQHyENLKKLLEPLgIRV---ALLTGSLkgkERREIlEAIASGeA 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 143 HMVVGT-----PGRVYD-----MIDKRH-LGVD-RLKLfildeademLSRGFKaqiyevfkklvPDIQValFSAT----- 205
Cdd:PRK10917 366 DIVIGThaliqDDVEFHnlglvIIDEQHrFGVEqRLAL---------REKGEN-----------PHVLV--MTATpiprt 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 206 ----------------MPqeilelttrFMRDP-KTILVKKDELT--LEGI-------RQFYVA---VEKEEwKLD--TLC 254
Cdd:PRK10917 424 lamtaygdldvsvideLP---------PGRKPiTTVVIPDSRRDevYERIreeiakgRQAYVVcplIEESE-KLDlqSAE 493
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 457874044 255 DLYETLTitqsiiycntrkkvdiltqemhNRLF--TVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDV 328
Cdd:PRK10917 494 ETYEELQ----------------------EAFPelRVGLLHGRMKPAEKDAVMAAFKAGEIDILVATTVIEVGVDV 547
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
271-355 |
2.30e-05 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 44.54 E-value: 2.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 271 TRKKVDILTQEMHNRLFTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYD-----LPCSPDT 345
Cdd:cd18790 36 TKRMAEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDadkegFLRSETS 115
|
90
....*....|
gi 457874044 346 YIHRIGRSGR 355
Cdd:cd18790 116 LIQTIGRAAR 125
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
293-354 |
2.80e-05 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 46.46 E-value: 2.80e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 457874044 293 HGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSG 354
Cdd:PRK09751 308 HGSVSKEQRAITEQALKSGELRCVVATSSLELGIDMGAVDLVIQVATPLSVASGLQRIGRAG 369
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
280-363 |
3.33e-05 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 43.79 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 280 QEMHNRLFT------VSCMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDlpcsPDTY----IHR 349
Cdd:cd18792 48 EALAEELKElvpearVALLHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIED----ADRFglsqLHQ 123
|
90
....*....|....*
gi 457874044 350 I-GRSGRFGRKGVAI 363
Cdd:cd18792 124 LrGRVGRGKHQSYCY 138
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
266-359 |
3.53e-05 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 46.04 E-value: 3.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 266 IIYCNTR---KKVDILTQEM-HNRLFtvscMHGDMDQKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLVINYDLPC 341
Cdd:PLN03137 684 IIYCLSRmdcEKVAERLQEFgHKAAF----YHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPK 759
|
90
....*....|....*...
gi 457874044 342 SPDTYIHRIGRSGRFGRK 359
Cdd:PLN03137 760 SIEGYHQECGRAGRDGQR 777
|
|
| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
280-319 |
4.23e-05 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 45.81 E-value: 4.23e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 457874044 280 QEMHNRL------FTVSCMHGDMDQKDRDLIMREFRSGSTRVLVTT 319
Cdd:COG1200 491 EETYEELreafpgLRVGLLHGRMKPAEKDAVMAAFKAGEIDVLVAT 536
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
249-360 |
1.54e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 44.09 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 249 KLDTLCDLY-ETLTITQS---IIYCNTRKKVDILTQEMHNRLFTV------SCMHGD--MDQKDRDLIMREFRSGSTRVL 316
Cdd:PRK13766 348 KLEKLREIVkEQLGKNPDsriIVFTQYRDTAEKIVDLLEKEGIKAvrfvgqASKDGDkgMSQKEQIEILDKFRAGEFNVL 427
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 457874044 317 VTTDLLARGIDVQQVSLVINYDLPCSPDTYIHRIGRSGRfGRKG 360
Cdd:PRK13766 428 VSTSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGR-QEEG 470
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
67-208 |
1.95e-04 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 41.86 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 67 AQSGTGKTATFVISSLQLINYdyVACQALILAPTRELAQQI------------QKVVLALGDYlkvkchacvggtvvRED 134
Cdd:cd17921 24 APTSSGKTLIAELAILRALAT--SGGKAVYIAPTRALVNQKeadlrerfgplgKNVGLLTGDP--------------SVN 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 457874044 135 IDKLKQGvHMVVGTPGRVYDMIDK-RHLGVDRLKLFILDEAdEMLSRGFKAQIYEV----FKKLVPDIQVALFSATMPQ 208
Cdd:cd17921 88 KLLLAEA-DILVATPEKLDLLLRNgGERLIQDVRLVVVDEA-HLIGDGERGVVLELllsrLLRINKNARFVGLSATLPN 164
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
45-148 |
1.16e-03 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 39.71 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 45 KPSAIQQRGIKPILNGY------DTIGQAQSGTGKTATFVISSLqlINYDYVAcQALILAPTRELAQQIQKVVLALgdYL 118
Cdd:cd17918 15 SLTKDQAQAIKDIEKDLhspepmDRLLSGDVGSGKTLVALGAAL--LAYKNGK-QVAILVPTEILAHQHYEEARKF--LP 89
|
90 100 110
....*....|....*....|....*....|
gi 457874044 119 KVKCHACVGGTvvREDIdklKQGVHMVVGT 148
Cdd:cd17918 90 FINVELVTGGT--KAQI---LSGISLLVGT 114
|
|
| SF2_C_priA |
cd18804 |
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication ... |
298-363 |
2.78e-03 |
|
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication factor Y or primosomal protein N', is a 3'-->5' DNA helicase that acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. PriA is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350191 [Multi-domain] Cd Length: 238 Bit Score: 39.15 E-value: 2.78e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 457874044 298 QKDRDLIMREFRSGSTRVLVTTDLLARGIDVQQVSLV--INYD-LPCSPD--------TYIHRI-GRSGRFGRKGVAI 363
Cdd:cd18804 130 KGALEKLLDQFERGEIDILIGTQMIAKGLDFPNVTLVgiLNADsGLNSPDfraserafQLLTQVsGRAGRGDKPGKVI 207
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
50-205 |
4.73e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 37.65 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 50 QQRGIKPILNGY---DTIGQAQS--GTGKTATfvisSLQLINY---DYVACQALILAPTRELAQQiqkvvlALGDYLKV- 120
Cdd:pfam04851 8 QIEAIENLLESIkngQKRGLIVMatGSGKTLT----AAKLIARlfkKGPIKKVLFLVPRKDLLEQ------ALEEFKKFl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 121 KCHACVGGTVVREDIDKLKQGVHMVVGTPGRVY--DMIDKRHLGVDRLKLFILDEADEMLSRGFKaQIYEVFKKLvpdIQ 198
Cdd:pfam04851 78 PNYVEIGEIISGDKKDESVDDNKIVVTTIQSLYkaLELASLELLPDFFDVIIIDEAHRSGASSYR-NILEYFKPA---FL 153
|
....*..
gi 457874044 199 VAlFSAT 205
Cdd:pfam04851 154 LG-LTAT 159
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
70-174 |
5.41e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 37.63 E-value: 5.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 70 GTGKT--ATFVISSL--QLINYDYVACQALILAPTRELAQQIQKvvlALGDYLKVKCHACVGGTVV----REDIDKLKQG 141
Cdd:cd18034 26 GSGKTliAVMLIKEMgeLNRKEKNPKKRAVFLVPTVPLVAQQAE---AIRSHTDLKVGEYSGEMGVdkwtKERWKEELEK 102
|
90 100 110
....*....|....*....|....*....|...
gi 457874044 142 VHMVVGTPGRVYDMIDKRHLGVDRLKLFILDEA 174
Cdd:cd18034 103 YDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| PRK05580 |
PRK05580 |
primosome assembly protein PriA; Validated |
300-363 |
8.21e-03 |
|
primosome assembly protein PriA; Validated
Pssm-ID: 235514 [Multi-domain] Cd Length: 679 Bit Score: 38.21 E-value: 8.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 457874044 300 DRDLIMR---------EFRSGSTRVLVTTDLLARGIDVQQVSLV--INYDLPC-SPD---------TYIHRIGRSGRFGR 358
Cdd:PRK05580 459 DRDTTRRkgaleqllaQFARGEADILIGTQMLAKGHDFPNVTLVgvLDADLGLfSPDfrasertfqLLTQVAGRAGRAEK 538
|
....*
gi 457874044 359 KGVAI 363
Cdd:PRK05580 539 PGEVL 543
|
|
| |
