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Conserved domains on  [gi|4557655|ref|NP_000406|]
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islet amyloid polypeptide preproprotein [Homo sapiens]

Protein Classification

adrenomedullin/calcitonin family protein( domain architecture ID 11989841)

adrenomedullin/calcitonin family protein similar to human calcitonin that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
27-73 1.71e-17

Calcitonin / CGRP / IAPP family;


:

Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 71.32  E-value: 1.71e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 4557655     27 SHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKR 73
Cdd:pfam00214  83 THIRQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRR 129
 
Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
27-73 1.71e-17

Calcitonin / CGRP / IAPP family;


Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 71.32  E-value: 1.71e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 4557655     27 SHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKR 73
Cdd:pfam00214  83 THIRQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRR 129
CALCITONIN smart00113
calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and ...
 32-73 4.89e-11

calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and amylin. They are short polypeptide hormones.


Pssm-ID: 128423  Cd Length: 38  Bit Score: 52.53  E-value: 4.89e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4557655     32 KRKCNTATCATQRLANFLVHSSNnfgaiLSSTNVGSNTYGKR 73
Cdd:smart00113  1 KRCCNLSTCVLGRLADDLNRSHT-----YSPTNVGSGTPGKK 37
 
Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
27-73 1.71e-17

Calcitonin / CGRP / IAPP family;


Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 71.32  E-value: 1.71e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 4557655     27 SHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKR 73
Cdd:pfam00214  83 THIRQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRR 129
CALCITONIN smart00113
calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and ...
 32-73 4.89e-11

calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and amylin. They are short polypeptide hormones.


Pssm-ID: 128423  Cd Length: 38  Bit Score: 52.53  E-value: 4.89e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4557655     32 KRKCNTATCATQRLANFLVHSSNnfgaiLSSTNVGSNTYGKR 73
Cdd:smart00113  1 KRCCNLSTCVLGRLADDLNRSHT-----YSPTNVGSGTPGKK 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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