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Conserved domains on  [gi|4505293|ref|NP_002457|]
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myb-related protein B isoform 1 [Homo sapiens]

Protein Classification

SANT and Cmyb_C domain-containing protein( domain architecture ID 13851054)

SANT and Cmyb_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 451-594 4.12e-56

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 188.34  E-value: 4.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293    451 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQK-HAAFVTPD-QKYSMDNTPHTPTPFKNALE- 527
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4505293    528 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGlRRSPIKKVRKSLALDIVDED 594
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKE 150
PLN03091 super family cl33633
hypothetical protein; Provisional
 81-197 3.51e-29

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 121.62  E-value: 3.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293    81 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 158
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 4505293   159 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGF-------LSESKDCK 197
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdpnthkpLSEVENGE 136
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 2.00e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 82.36  E-value: 2.00e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4505293     34 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 451-594 4.12e-56

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 188.34  E-value: 4.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293    451 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQK-HAAFVTPD-QKYSMDNTPHTPTPFKNALE- 527
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4505293    528 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGlRRSPIKKVRKSLALDIVDED 594
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKE 150
PLN03091 PLN03091
hypothetical protein; Provisional
 81-197 3.51e-29

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 121.62  E-value: 3.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293    81 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 158
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 4505293   159 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGF-------LSESKDCK 197
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdpnthkpLSEVENGE 136
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 80-195 1.29e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 117.58  E-value: 1.29e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293   80 DLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAE 159
Cdd:COG5147  17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4505293  160 IAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKD 195
Cdd:COG5147  97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN 132
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 2.00e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 82.36  E-value: 2.00e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4505293     34 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 86-144 2.72e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 79.28  E-value: 2.72e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4505293     86 WTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDR 144
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
83-131 3.70e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 75.34  E-value: 3.70e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 4505293      83 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNP 131
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 85-129 1.11e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 74.15  E-value: 1.11e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 4505293   85 PWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHL 129
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
31-79 3.88e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 66.86  E-value: 3.88e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 4505293      31 KVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNP 79
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 33-77 1.43e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 1.43e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 4505293   33 KWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVL 77
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 451-594 4.12e-56

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 188.34  E-value: 4.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293    451 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQK-HAAFVTPD-QKYSMDNTPHTPTPFKNALE- 527
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4505293    528 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGlRRSPIKKVRKSLALDIVDED 594
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKE 150
PLN03091 PLN03091
hypothetical protein; Provisional
 81-197 3.51e-29

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 121.62  E-value: 3.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293    81 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 158
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 4505293   159 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGF-------LSESKDCK 197
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdpnthkpLSEVENGE 136
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 80-195 1.29e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 117.58  E-value: 1.29e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293   80 DLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAE 159
Cdd:COG5147  17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4505293  160 IAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKD 195
Cdd:COG5147  97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN 132
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 83-184 6.39e-26

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 107.09  E-value: 6.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293    83 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKG-RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIA 161
Cdd:PLN03212  25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                         90       100
                 ....*....|....*....|...
gi 4505293   162 KMLPGRTDNAVKNHWNSTIKRKV 184
Cdd:PLN03212 105 GRIPGRTDNEIKNYWNTHLRKKL 127
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 2.00e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 82.36  E-value: 2.00e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4505293     34 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 86-144 2.72e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 79.28  E-value: 2.72e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4505293     86 WTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDR 144
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
83-131 3.70e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 75.34  E-value: 3.70e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 4505293      83 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNP 131
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 83-129 8.26e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.46  E-value: 8.26e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 4505293     83 KGPWTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHL 129
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 85-129 1.11e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 74.15  E-value: 1.11e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 4505293   85 PWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHL 129
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 135-178 9.37e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 71.38  E-value: 9.37e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4505293    135 KSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNS 178
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
31-79 3.88e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 66.86  E-value: 3.88e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 4505293      31 KVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNP 79
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 33-77 1.43e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 1.43e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 4505293   33 KWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVL 77
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 138-177 9.62e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 62.98  E-value: 9.62e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 4505293  138 WTEEEDRIICEAHKVLG-NRWAEIAKMLPGRTDNAVKNHWN 177
Cdd:cd00167   2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
135-182 1.36e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 62.63  E-value: 1.36e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 4505293     135 KSCWTEEEDRIICEAHKVLG-NRWAEIAKMLPGRTDNAVKNHWNSTIKR 182
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 31-77 2.05e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 61.75  E-value: 2.05e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 4505293     31 KVKWTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVL 77
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGN-RWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 138-189 4.59e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 53.08  E-value: 4.59e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4505293    138 WTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGF 189
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPW 52
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 79-125 5.74e-08

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 49.62  E-value: 5.74e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 4505293   79 PDLVKGPWTKEEDQKVIELVKKYGTkQWTLIAKhLKGRLGKQCRERW 125
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPT-QWRTIAP-IVGRTAQQCLERY 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 85-127 3.90e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.18  E-value: 3.90e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 4505293   85 PWTKEEDQKVIELVKKYGTKQWTLIAKH---LKGRLGKQCRERWHN 127
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 32-79 4.30e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 41.40  E-value: 4.30e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 4505293   32 VKWTHEEDEQLRALVRQFGQQDWKFLASHFP---NRTDQQCQYRWlRVLNP 79
Cdd:cd11660   1 RKWTDEEDEALVEGVEKYGVGNWAKILKDYFfvnNRTSVDLKDKW-RNLKK 50
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 131-170 1.01e-04

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 40.37  E-value: 1.01e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 4505293  131 PEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLpGRTDN 170
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 24-181 1.43e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 45.16  E-value: 1.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293   24 EQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWL-----------------RVLNPDLVKGPW 86
Cdd:COG5147 215 SEINKAFKKGETLALEQEINEYKEKKGLSRKQFCERIWSTDRDEDKFWPNIykklpyrdkksiykhlrRKYNIFEQRGKW 294

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505293   87 TKEEDQKVIELVKKYGtKQWTLIAKhLKGRLGKQCRERWHNHLNP--EVKKSCWT-EEEDRIIC-------EAHKVLGNR 156
Cdd:COG5147 295 TKEEEQELAKLVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDKvvnemrlEAQQSSRIL 372

                       170       180
                ....*....|....*....|....*
gi 4505293  157 WAEIAKMLPGRTDNAVKNHWNSTIK 181
Cdd:COG5147 373 WLLIAQNIRNRLQHHCRDKYGVLIS 397
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 86-136 6.34e-03

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 35.72  E-value: 6.34e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4505293   86 WTKEEDQKVI----ELVKKYGTKQ-----WTLIAKHLK----GRLGKQCRERWhNHLNPEVKKS 136
Cdd:cd12203   3 WPREETLSLIrlrrEMESRFQETKskkalWEEIAAKMRelgyNRSAKQCKEKW-ENLNKYYKKV 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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