NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4504897|ref|NP_002257|]
View 

importin subunit alpha-1 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
10-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 526.77  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897   10 PAARLHRFKNKGKDST-EMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVDDIVKGI 85
Cdd:COG5064   7 PEARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897   86 NSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIP 165
Cdd:COG5064  81 FSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  166 AFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLavpDMSSLACGYLRNLTWTLSNLCRNKNPAPP 245
Cdd:COG5064 161 LFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLL---LSSAIHISMLRNATWTLSNLCRGKNPPPD 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  246 IDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTD 325
Cdd:COG5064 238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  326 EQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYT 405
Cdd:COG5064 318 DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNAT 397

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  406 SGGT--VEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEALQN 478
Cdd:COG5064 398 SGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHGLQD 477

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|
gi 4504897  479 HENESVYKASLSLIEKYFSvEEEEDQNVVPETTSEGYTFQVQDGAPGTFN 528
Cdd:COG5064 478 SVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
10-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 526.77  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897   10 PAARLHRFKNKGKDST-EMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVDDIVKGI 85
Cdd:COG5064   7 PEARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897   86 NSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIP 165
Cdd:COG5064  81 FSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  166 AFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLavpDMSSLACGYLRNLTWTLSNLCRNKNPAPP 245
Cdd:COG5064 161 LFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLL---LSSAIHISMLRNATWTLSNLCRGKNPPPD 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  246 IDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTD 325
Cdd:COG5064 238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  326 EQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYT 405
Cdd:COG5064 318 DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNAT 397

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  406 SGGT--VEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEALQN 478
Cdd:COG5064 398 SGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHGLQD 477

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|
gi 4504897  479 HENESVYKASLSLIEKYFSvEEEEDQNVVPETTSEGYTFQVQDGAPGTFN 528
Cdd:COG5064 478 SVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-98 3.22e-37

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 131.89  E-value: 3.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897     13 RLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATsplqenrNNQGTVNWSVDDIVKGINSSNVEN 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSS-------SAESQLLESLPEMVQGVNSDDPEL 73


                  ....*.
gi 4504897     93 QLQATQ 98
Cdd:pfam01749  74 QLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 1.24e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.89  E-value: 1.24e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4504897     151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 78-191 8.59e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 45.48  E-value: 8.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897     78 VDDIVKGINSSNvenqlQATQA-ARKLLSR---EKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSE 153
Cdd:PLN03200  191 VDILVKLLSSGN-----SDAQAnAASLLARlmmAFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSKE 265

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4504897    154 QTKAVVDGGAIPAFISLLASP--------HAH-ISEQAVWALGNIAG 191
Cdd:PLN03200  266 AKQAIADAGGIPALINATVAPskefmqgeFAQaLQENAMGALANICG 312
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
10-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 526.77  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897   10 PAARLHRFKNKGKDST-EMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVDDIVKGI 85
Cdd:COG5064   7 PEARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897   86 NSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIP 165
Cdd:COG5064  81 FSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  166 AFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLavpDMSSLACGYLRNLTWTLSNLCRNKNPAPP 245
Cdd:COG5064 161 LFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLL---LSSAIHISMLRNATWTLSNLCRGKNPPPD 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  246 IDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTD 325
Cdd:COG5064 238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  326 EQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYT 405
Cdd:COG5064 318 DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNAT 397

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  406 SGGT--VEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEALQN 478
Cdd:COG5064 398 SGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHGLQD 477

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|
gi 4504897  479 HENESVYKASLSLIEKYFSvEEEEDQNVVPETTSEGYTFQVQDGAPGTFN 528
Cdd:COG5064 478 SVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-98 3.22e-37

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 131.89  E-value: 3.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897     13 RLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATsplqenrNNQGTVNWSVDDIVKGINSSNVEN 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSS-------SAESQLLESLPEMVQGVNSDDPEL 73


                  ....*.
gi 4504897     93 QLQATQ 98
Cdd:pfam01749  74 QLEATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 462-509 9.06e-21

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 85.33  E-value: 9.06e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4504897    462 IMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEE-EDQNVVPE 509
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEeDDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 324-364 1.88e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 53.23  E-value: 1.88e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4504897    324 TDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 8.15e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 51.30  E-value: 8.15e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4504897    151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 1.24e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.89  E-value: 1.24e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4504897     151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT COG1413
HEAT repeat [General function prediction only];
163-320 3.04e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.71  E-value: 3.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  163 AIPAFISLLASPHAHISEQAVWALGNIaGDGSvfrdlvikygAVDPLLALLAVPDmsslacGYLR-NLTWTLSNLcrnkn 241
Cdd:COG1413  17 AVPALIAALADEDPDVRAAAARALGRL-GDPR----------AVPALLEALKDPD------PEVRaAAAEALGRI----- 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504897  242 pappidAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPnerigmvvktgVVPQLVKLLGASELPIVTPALRAIGNI 320
Cdd:COG1413  75 ------GDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARALGRL 136
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 135-189 8.83e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 48.90  E-value: 8.83e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4504897    135 PIQFESAWALTNIASGTSEQTKAVVDGgAIPAFISLLASPHAHISEQAVWALGNI 189
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-406 2.15e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.06  E-value: 2.15e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4504897    367 QDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTS 406
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 324-364 2.21e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.04  E-value: 2.21e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 4504897     324 TDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 366-406 7.73e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.50  E-value: 7.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 4504897     366 RQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTS 406
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 409-447 1.54e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.75  E-value: 1.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4504897    409 TVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNI 447
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 242-280 3.48e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 43.98  E-value: 3.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4504897    242 PAPPIDAV--EQILPTLVRLLHHDDPEVLADTCWAISYLTD 280
Cdd:pfam00514   1 SPENKQAVieAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 231-278 1.33e-05

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 42.74  E-value: 1.33e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 4504897    231 WTLSNLCrNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYL 278
Cdd:pfam13513   9 LALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 242-280 1.43e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 4504897     242 PAPPIDAVEQ--ILPTLVRLLHHDDPEVLADTCWAISYLTD 280
Cdd:smart00185   1 DDENKQAVVDagGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 109-149 1.53e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.06  E-value: 1.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4504897    109 QPPIDNIIRAGLIPKFVSFLgRTDCSPIQFESAWALTNIAS 149
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
121-275 4.73e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 4.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  121 IPKFVSFLGRTDcSPIQFESAWALTNIAsgtseqtkavvDGGAIPAFISLLASPHAHISEQAVWALGNIAGDgsvfrdlv 200
Cdd:COG1413  18 VPALIAALADED-PDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDP-------- 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504897  201 ikyGAVDPLLALLAVPDMS--SLACGYLRNLtwtlsnlcrnknpappidAVEQILPTLVRLLHHDDPEVLADTCWAI 275
Cdd:COG1413  78 ---EAVPALIAALKDEDPEvrRAAAEALGRL------------------GDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
250-400 5.73e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 5.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897  250 EQILPTLVRLLHHDDPEVLADTCWAISYLTDgpnerigmvvkTGVVPQLVKLLGASELPIVTPALRAIGNIvtGTDEQTQ 329
Cdd:COG1413  15 PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--GDPEAVP 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504897  330 VVIDAgalavfpslLTNPKTNIQKEATWTMSNITAGRqdqiqqvvnhgLVPFLVSVLSKADFKTQKEAVWA 400
Cdd:COG1413  82 ALIAA---------LKDEDPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARA 132
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 282-322 7.66e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.13  E-value: 7.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4504897    282 PNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVT 322
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 108-149 7.88e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.11  E-value: 7.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 4504897     108 KQPPIDNIIRAGLIPKFVSFLGRTDcSPIQFESAWALTNIAS 149
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 282-321 7.88e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.11  E-value: 7.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4504897     282 PNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIV 321
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 78-191 8.59e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 45.48  E-value: 8.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897     78 VDDIVKGINSSNvenqlQATQA-ARKLLSR---EKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSE 153
Cdd:PLN03200  191 VDILVKLLSSGN-----SDAQAnAASLLARlmmAFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSKE 265

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4504897    154 QTKAVVDGGAIPAFISLLASP--------HAH-ISEQAVWALGNIAG 191
Cdd:PLN03200  266 AKQAIADAGGIPALINATVAPskefmqgeFAQaLQENAMGALANICG 312
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 95-365 1.54e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.71  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897     95 QATQAARKLLSREKQPpidniiraglIPKFVSFLgRTDCSPIQFESAWALTNIASGTSEQTKaVVDGGAIPAFISLL--A 172
Cdd:PLN03200   44 KTREEARKAIGSHSQA----------MPLLVSLL-RSGTLGAKVNAAAVLGVLCKEEDLRVK-VLLGGCIPPLLSLLksG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897    173 SPHAHI-SEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAV-PDMSSLACGYLrnlTWTLSNLCRNKNP--APPIDA 248
Cdd:PLN03200  112 SAEAQKaAAEAIYAVSSGGLSDHVGSKIFSTEGVVPSLWDQLQPgNKQDKVVEGLL---TGALRNLCGSTDGfwSATLEA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504897    249 --VEqilpTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLG-ASELPIVTPALRAIGNIVTGTD 325
Cdd:PLN03200  189 ggVD----ILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGqGNEVSVRAEAAGALEALSSQSK 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 4504897    326 EQTQVVIDAGALAVFPSLLTNP-KTNIQKE--------ATWTMSNITAG 365
Cdd:PLN03200  265 EAKQAIADAGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGG 313
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 197-238 2.67e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.59  E-value: 2.67e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4504897    197 RDLVIKYGAVDPLLALLAVPDMSSlacgyLRNLTWTLSNLCR 238
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEV-----QEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 411-447 3.34e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.18  E-value: 3.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 4504897     411 EQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNI 447
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH