|
Name |
Accession |
Description |
Interval |
E-value |
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
46-495 |
0e+00 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 604.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQK 125
Cdd:cd16147 1 RPNIVLILTDDQDVELGSMDPMPKTKKLLADQGTTFTNAFVTTPLCCPSRASILTGQYAHNHGVTNNSPPGGGYPKFWQN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 126 IQEPNTFPAILRSmCGYQTFFAGKYLNEYGAPdaGGLEHVPLGWSYWYALEKNSKYYNYTLSiNGKARKHGENYSVDYLT 205
Cdd:cd16147 81 GLERSTLPVWLQE-AGYRTAYAGKYLNGYGVP--GGVSYVPPGWDEWDGLVGNSTYYNYTLS-NGGNGKHGVSYPGDYLT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 206 DVLANVSLDFLDYKSNF-EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFN--IHGTNKHWLIRQAKTPMTnsSI 282
Cdd:cd16147 157 DVIANKALDFLRRAAADdKPFFLVVAPPAPHGPFTPAPRYANLFPNVTAPPRPPPNnpDVSDKPHWLRRLPPLNPT--QI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 283 QFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPN 362
Cdd:cd16147 235 AYIDELYRKRLRTLQSVDDLVERLVNTLEATGQLDNTYIIYTSDNGYHLGQHRLPPGKRTPYEEDIRVPLLVRGPGIPAG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 363 QTSKMLVANIDLGPTILDIAGYDLnKTQMDGMSllpilrgasnltwrsdvlveyqgegrnvtdptcpslspgvsqcfpdc 442
Cdd:cd16147 315 VTVDQLVSNIDLAPTILDLAGAPP-PSDMDGRS----------------------------------------------- 346
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 4504061 443 vCEDAYNNTYACVRTMSALWNLQYCEFDdqEVFVEVYNLTADPDQITNIAKTI 495
Cdd:cd16147 347 -CGDSNNNTYKCVRTVDDTYNLLYFEWC--TGFRELYDLTTDPYQLTNLAGDL 396
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
45-510 |
3.48e-92 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 289.04 E-value: 3.48e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 45 RRPNVVLLLTDDQ-DEVLGGMT-PLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNtlEGNcSS 120
Cdd:cd16031 1 KRPNIIFILTDDHrYDALGCYGnPIVKTPNIdrLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGVTDN--NGP-LF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 121 KSWQKiqepnTFPAILRSMcGYQTFFAGKylneYGAPDAGGLEhvPLGWSYWYALEKNSKYYNYTLSINGKARKHGEnys 200
Cdd:cd16031 78 DASQP-----TYPKLLRKA-GYQTAFIGK----WHLGSGGDLP--PPGFDYWVSFPGQGSYYDPEFIENGKRVGQKG--- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 201 vdYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNI-HGTNK-HWLiRQAKtpmt 278
Cdd:cd16031 143 --YVTDIITDKALDFLKERDKDKPFCLSLSFKAPHRPFTPAPRHRGLYEDVTIPEPETFDDdDYAGRpEWA-REQR---- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 279 NSSIQFLDNAFRKRW----------QTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLpIDKRQLYEFDI 348
Cdd:cd16031 216 NRIRGVLDGRFDTPEkyqrymkdylRTVTGVDDNVGRILDYLEEQGLADNTIIIYTSDNGFFLGEHGL-FDKRLMYEESI 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 349 KVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKtQMDGMSLLPILRGASNLTWRSDVLVEYQGEGrnvtdpt 427
Cdd:cd16031 295 RVPLIIRDPRlIKAGTVVDALVLNIDFAPTILDLAGVPIPE-DMQGRSLLPLLEGEKPVDWRKEFYYEYYEEP------- 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 428 cpslspgvsqcfpdcvcedAYNNTYAC--VRTmsALWNL-QYCEFDDQEvfvEVYNLTADPDQITNIAKtiDPE---LLG 501
Cdd:cd16031 367 -------------------NFHNVPTHegVRT--ERYKYiYYYGVWDEE---ELYDLKKDPLELNNLAN--DPEyaeVLK 420
|
....*....
gi 4504061 502 KMNYRLMML 510
Cdd:cd16031 421 ELRKRLEEL 429
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
41-503 |
2.48e-82 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 262.12 E-value: 2.48e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 41 AAGTRRPNVVLLLTDDQ--DEV--LGGmtPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTL 114
Cdd:COG3119 18 AAAAKRPNILFILADDLgyGDLgcYGN--PLIKTPNIdrLAAEGVRFTNAYVTSPVCSPSRASLLTGRYPHRTGVTDNGE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 115 EGNCSSKSWQKiqepnTFPAILRSMcGYQTFFAGKYlneygapdaggleHVplgwsywyaleknskyynytlsingkark 194
Cdd:COG3119 96 GYNGGLPPDEP-----TLAELLKEA-GYRTALFGKW-------------HL----------------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 195 hgenysvdYLTDVLANVSLDFLD--YKSNfEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRq 272
Cdd:COG3119 128 --------YLTDLLTDKAIDFLErqADKD-KPFFLYLAFNAPHAPYQAPEEYLDKYDGKDIPLPPNLAPRDLTEEELRR- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 273 aktpmtnssiqfldnAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPL 352
Cdd:COG3119 198 ---------------ARAAYAAMIEEVDDQVGRLLDALEELGLADNTIVVFTSDNGPSLGEHGLRGGKGTLYEGGIRVPL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 353 LVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKTqMDGMSLLPILRGASNlTWRSDVLVEYQGEGRNvtdptcpsl 431
Cdd:COG3119 263 IVRWPGkIKAGSVSDALVSLIDLLPTLLDLAGVPIPED-LDGRSLLPLLTGEKA-EWRDYLYWEYPRGGGN--------- 331
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504061 432 spgvsqcfpdcvcedaynntyACVRTmsalWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTiDPELLGKM 503
Cdd:COG3119 332 ---------------------RAIRT----GRWKLIRYYDDDGPWELYDLKNDPGETNNLAAD-YPEVVAEL 377
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
47-384 |
7.40e-60 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 200.34 E-value: 7.40e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQ---DEVLGG----MTPLKKTKAligEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLegncs 119
Cdd:pfam00884 1 PNVVLVLGESLrapDLGLYGyprpTTPFLDRLA---EEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVSTP----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 120 sksWQKIQEPNTFPAILRSMcGYQTFFAGKYL---NEYGAPDAGGLEHVpLGWSYWYALEKNSKYYNYTLSINGkarkhg 196
Cdd:pfam00884 73 ---VGLPRTEPSLPDLLKRA-GYNTGAIGKWHlgwYNNQSPCNLGFDKF-FGRNTGSDLYADPPDVPYNCSGGG------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 197 enysvdYLTDVLANVSLDFLDYKSnfEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAprnknfnihgtnkhwlirqaktp 276
Cdd:pfam00884 142 ------VSDEALLDEALEFLDNND--KPFFLVLHTLGSHGPPYYPDRYPEKYATFKP----------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 277 mtnsSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPID---KRQLYEFDIKVPLL 353
Cdd:pfam00884 191 ----SSCSEEQLLNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTSDHGESLGEGGGYLHggkYDNAPEGGYRVPLL 266
|
330 340 350
....*....|....*....|....*....|..
gi 4504061 354 VRGPG-IKPNQTSKMLVANIDLGPTILDIAGY 384
Cdd:pfam00884 267 IWSPGgKAKGQKSEALVSHVDLFPTILDLAGI 298
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
47-508 |
6.62e-59 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 201.62 E-value: 6.62e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDqdevLGGM-----------TP----LKKTkaligemGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVN 111
Cdd:cd16144 1 PNIVLILVDD----LGWAdlgcygskfyeTPnidrLAKE-------GMRFTQAYAAAPVCSPSRASILTGQYPARLGITD 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 112 NTLEGNCSSKSWQKIQEPN---------TFPAILRSmCGYQTFFAGKY---LNEYGAP--------DAGGLEHVPLGWSY 171
Cdd:cd16144 70 VIPGRRGPPDNTKLIPPPSttrlpleevTIAEALKD-AGYATAHFGKWhlgGEGGYGPedqgfdvnIGGTGNGGPPSYYF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 172 WYaleknsKYYNYTLSINGKArkhgenysvDYLTDVLANVSLDFLDyKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNV 251
Cdd:cd16144 149 PP------GKPNPDLEDGPEG---------EYLTDRLTDEAIDFIE-QNKDKPFFLYLSHYAVHTPIQARPELIEKYEKK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 252 FAPRNKnfnihgtnKHWLIRQAktpmtnssiqfldnafrkrwqTLL-SVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYH 330
Cdd:cd16144 213 KKGLRK--------GQKNPVYA---------------------AMIeSLDESVGRILDALEELGLADNTLVIFTSDNGGL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 331 TGQFSLPID-------KRQLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPILR 401
Cdd:cd16144 264 STRGGPPTSnaplrggKGSLYEGGIRVPLIVRWPGvIKPGSVSDVPVIGTDLYPTFLELAGGPLPPPQhLDGVSLVPLLK 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 402 GaSNLTWRSDVLVEYqgegrnvtdptcpslspgvsqcFPdcvcedAYNNTYAcvRTMSAL----WNL-QYceFDDQEvfV 476
Cdd:cd16144 344 G-GEADLPRRALFWH----------------------FP------HYHGQGG--RPASAIrkgdWKLiEF--YEDGR--V 388
|
490 500 510
....*....|....*....|....*....|..
gi 4504061 477 EVYNLTADPDQITNIAKTiDPELLGKMNYRLM 508
Cdd:cd16144 389 ELYNLKNDIGETNNLAAE-MPEKAAELKKKLD 419
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
47-395 |
2.34e-55 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 186.10 E-value: 2.34e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQD-EVLGGM-TPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKs 122
Cdd:cd16022 1 PNILLIMTDDLGyDDLGCYgNPDIKTPNLdrLAAEGVRFTNAYVASPVCSPSRASLLTGRYPHRHGVRGNVGNGGGLPP- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 123 wqkiqEPNTFPAILRSMcGYQTFFAGKylneygapdagglehvplgwsyWyaleknskyynytlsingkarkHGEnysvd 202
Cdd:cd16022 80 -----DEPTLAELLKEA-GYRTALIGK----------------------W----------------------HDE----- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 203 yltdvlanvSLDFLDYKSNFEPFFMMIATPAPHSPWTAApqyqkafqnvfaprnknfnihgtnkhwlirqaktpmtnssi 282
Cdd:cd16022 105 ---------AIDFIERRDKDKPFFLYVSFNAPHPPFAYY----------------------------------------- 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 283 qfldnAFrkrwqtLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPG-IKP 361
Cdd:cd16022 135 -----AM------VSAIDDQIGRILDALEELGLLDNTLIVFTSDHGDMLGDHGLRGKKGSLYEGGIRVPFIVRWPGkIPA 203
|
330 340 350
....*....|....*....|....*....|....
gi 4504061 362 NQTSKMLVANIDLGPTILDIAGYDLNKTqMDGMS 395
Cdd:cd16022 204 GQVSDALVSLLDLLPTLLDLAGIEPPEG-LDGRS 236
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
47-498 |
9.24e-55 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 189.26 E-value: 9.24e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQDEVLGG-MTPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSW 123
Cdd:cd16027 1 PNILWIIADDLSPDLGGyGGNVVKTPNLdrLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGAHGLRSRGFPLPDGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 124 QkiqepnTFPAILRSMcGYQTFFAGKylneygapdagglehvplgwsywyaleknsKYYNYTLSINGKARKHGENYSVDY 203
Cdd:cd16027 81 K------TLPELLREA-GYYTGLIGK------------------------------THYNPDAVFPFDDEMRGPDDGGRN 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 204 LTDVLANVSlDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAF--QNVFAPRNknfnihgtnkhwlirQAKTPMTNSS 281
Cdd:cd16027 124 AWDYASNAA-DFLNRAKKGQPFFLWFGFHDPHRPYPPGDGEEPGYdpEKVKVPPY---------------LPDTPEVRED 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 282 I-QFLDNAFRkrwqtllsVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYhtgqfSLPIDKRQLYEFDIKVPLLVRGPG-I 359
Cdd:cd16027 188 LaDYYDEIER--------LDQQVGEILDELEEDGLLDNTIVIFTSDHGM-----PFPRAKGTLYDSGLRVPLIVRWPGkI 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 360 KPNQTSKMLVANIDLGPTILDIAGYDLNKtQMDGMSLLPILRGaSNLTWRSDVLVEYqgegrnvtdptcpslspgvsqcf 439
Cdd:cd16027 255 KPGSVSDALVSFIDLAPTLLDLAGIEPPE-YLQGRSFLPLLKG-EKDPGRDYVFAER----------------------- 309
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504061 440 pdcvceDAYNNTYACVRTMSA-----LWNLQYcefddqevfVEVYNLTADPDQITNIAKtiDPE 498
Cdd:cd16027 310 ------DRHDETYDPIRSVRTgrykyIRNYMP---------EELYDLKNDPDELNNLAD--DPE 356
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-498 |
2.24e-53 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 186.66 E-value: 2.24e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQ--DEVLGGMTPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKS 122
Cdd:cd16033 1 PNILFIMTDQQryDTLGCYGNPIVKTPNIdrLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVENAGAYSRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 123 WQKIQEpnTFPAILRSMcGYQTFFAGKYlneYGAPDAGGLEHvplGWSYWyaleknskyynytlsingkarkHGENYSVD 202
Cdd:cd16033 81 LPPGVE--TFSEDLREA-GYRNGYVGKW---HVGPEETPLDY---GFDEY----------------------LPVETTIE 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 203 YLtdvLANVSLDFL-DYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTnss 281
Cdd:cd16033 130 YF---LADRAIEMLeELAADDKPFFLRVNFWGPHDPYIPPEPYLDMYDPEDIPLPESFADDFEDKPYIYRRERKRWG--- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 282 iqfLDNAFRKRWQTLLS--------VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLpIDKRQ-LYEFDIKVPL 352
Cdd:cd16033 204 ---VDTEDEEDWKEIIAhywgyitlIDDAIGRILDALEELGLADDTLVIFTSDHGDALGAHRL-WDKGPfMYEETYRIPL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 353 LVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYD-LNKTqmDGMSLLPILRGASNLTWRSDVLVEYQGEGrnvtdptcps 430
Cdd:cd16033 280 IIKWPGvIAAGQVVDEFVSLLDLAPTILDLAGVDvPPKV--DGRSLLPLLRGEQPEDWRDEVVTEYNGHE---------- 347
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504061 431 lSPGVSQcfpdcvcedaynntyaCVRTMSalWNLQYCEFDdqevFVEVYNLTADPDQITNIAKtiDPE 498
Cdd:cd16033 348 -FYLPQR----------------MVRTDR--YKYVFNGFD----IDELYDLESDPYELNNLID--DPE 390
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-491 |
3.11e-53 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 185.85 E-value: 3.11e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTD----------DQDEVLggmTP----LKKTkaligemGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVn 111
Cdd:cd16034 1 KPNILFIFADqhraqalgcaGDDPVK---TPnldrLAKE-------GVVFTNAVSNYPVCSPYRASLLTGQYPLTNGVF- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 112 ntleGNCSSKSwqkiQEPNTFPAILRSMcGYQTFFAGKY-LNEYGAPDAGGLEHVP-----LGWSYWYALEKNSKYYNYT 185
Cdd:cd16034 70 ----GNDVPLP----PDAPTIADVLKDA-GYRTGYIGKWhLDGPERNDGRADDYTPpperrHGFDYWKGYECNHDHNNPH 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 186 LSINGKARKHGENYSVDYLTDVLanvsLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQyqkAFQNVFAPRNKnfnihgt 264
Cdd:cd16034 141 YYDDDGKRIYIKGYSPDAETDLA----IEYLEnQADKDKPFALVLSWNPPHDPYTTAPE---EYLDMYDPKKL------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 265 nkhwLIRQaktpmtNSSIQFLDNAFRKRWQT-----LLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNG---YHTGQFSl 336
Cdd:cd16034 207 ----LLRP------NVPEDKKEEAGLREDLRgyyamITALDDNIGRLLDALKELGLLENTIVVFTSDHGdmlGSHGLMN- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 337 pidKRQLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKTqMDGMSLLPILRGASNLTWRSDVLVE 415
Cdd:cd16034 276 ---KQVPYEESIRVPFIIRYPGkIKAGRVVDLLINTVDIMPTLLGLCGLPIPDT-VEGRDLSPLLLGGKDDEPDSVLLQC 351
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504061 416 YQGEGRNvtdptcpslspgvsqcfpdcvcEDAYNNTYACVRTMsalwnlQY---CEFDDQEVFvevYNLTADPDQITNI 491
Cdd:cd16034 352 FVPFGGG----------------------SARDGGEWRGVRTD------RYtyvRDKNGPWLL---FDNEKDPYQLNNL 399
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
47-503 |
3.41e-45 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 164.26 E-value: 3.41e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQDEVLGGMT--PLKKTKAL--IGEMGMTFSSAYVpSALCCPSRASILTGKYPHNHHVVNNTLEGNcssks 122
Cdd:cd16146 1 PNVILILTDDQGYGDLGFHgnPILKTPNLdrLAAESVRFTNFHV-SPVCAPTRAALLTGRYPFRTGVWHTILGRE----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 123 wqkIQEPN--TFPAILRSmCGYQTFFAGKYLN--EYG-APDAGGLEHV---PLGWSYWYALEKNSKYYNYTLSINGKARK 194
Cdd:cd16146 75 ---RMRLDetTLAEVFKD-AGYRTGIFGKWHLgdNYPyRPQDRGFDEVlghGGGGIGQYPDYWGNDYFDDTYYHNGKFVK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 195 H-GenysvdYLTDVLANVSLDFLDYKSNfEPFFMMIATPAPHSPWTAAPQYqkafqnvFAPrnknfnihgtnkhwlirqa 273
Cdd:cd16146 151 TeG------YCTDVFFDEAIDFIEENKD-KPFFAYLATNAPHGPLQVPDKY-------LDP------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 274 ktpmtnssiqFLDNAFRKRWQTLL----SVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGqfslpIDKR-------- 341
Cdd:cd16146 198 ----------YKDMGLDDKLAAFYgmieNIDDNVGRLLAKLKELGLEENTIVIFMSDNGPAGG-----VPKRfnagmrgk 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 342 --QLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKT-QMDGMSLLPILRGASNLtWRSDVLVEYQ 417
Cdd:cd16146 263 kgSVYEGGHRVPFFIRWPGkILAGKDVDTLTAHIDLLPTLLDLCGVKLPEGiKLDGRSLLPLLKGESDP-WPERTLFTHS 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 418 GegrNVTDPTcpslspgvsqcfpdcvceDAYNNTyacvrtmsALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIdP 497
Cdd:cd16146 342 G---RWPPPP------------------KKKRNA--------AVRTGRWRLVSPKGFQPELYDIENDPGEENDVADEH-P 391
|
....*.
gi 4504061 498 ELLGKM 503
Cdd:cd16146 392 EVVKRL 397
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
45-425 |
7.68e-44 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 159.65 E-value: 7.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 45 RRPNVVLLLTDDQ--DEV--LGGM---TP-LKKtkaLIGEmGMTFSSAYVP----SALCCPSRASILTGKYphnhhVVNN 112
Cdd:cd16155 1 KKPNILFILADDQraDTIgaLGNPeiqTPnLDR---LARR-GTSFTNAYNMggwsGAVCVPSRAMLMTGRT-----LFHA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 113 TLEGNCSSKSwqkiqEPNTFPAILRSmCGYQTFFAGKYLNEYgapdagglehvplgwsywyaleknskyynytlsingka 192
Cdd:cd16155 72 PEGGKAAIPS-----DDKTWPETFKK-AGYRTFATGKWHNGF-------------------------------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 193 rkhgenysvdyltdvlANVSLDFL-DYKSNFEPFFMMIATPAPHSPWTAAPQYQK--AFQNV-----FAPRNKNFNIHGT 264
Cdd:cd16155 108 ----------------ADAAIEFLeEYKDGDKPFFMYVAFTAPHDPRQAPPEYLDmyPPETIplpenFLPQHPFDNGEGT 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 265 NKHWLIrqAKTPMTNSSIQfldnAFRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLpIDKRQL 343
Cdd:cd16155 172 VRDEQL--APFPRTPEAVR----QHLAEYYAMIThLDAQIGRILDALEASGELDNTIIVFTSDHGLAVGSHGL-MGKQNL 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 344 YEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTqMDGMSLLPILRGASNlTWRSDVLVEYQGEGRNV 423
Cdd:cd16155 245 YEHSMRVPLIISGPGIPKGKRRDALVYLQDVFPTLCELAGIEIPES-VEGKSLLPVIRGEKK-AVRDTLYGAYRDGQRAI 322
|
..
gi 4504061 424 TD 425
Cdd:cd16155 323 RD 324
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
47-492 |
1.31e-42 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 156.98 E-value: 1.31e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDqdevLG-------GMTPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGN 117
Cdd:cd16143 1 PNIVIILADD----LGygdiscyNPDSKIPTPNIdrLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSRLKGGVLGGF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 118 CSSkswqkIQEPN--TFPAILRSMcGYQTFFAGKYlneygapdaggleHvpLGWSyWYALEKNSKYYNYTLSIN-GKARK 194
Cdd:cd16143 77 SPP-----LIEPDrvTLAKMLKQA-GYRTAMVGKW-------------H--LGLD-WKKKDGKKAATGTGKDVDySKPIK 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 195 HGEN-YSVDY--------LTDVLANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQYQKafqnvfaprNKNFNIHGT 264
Cdd:cd16143 135 GGPLdHGFDYyfgipaseVLPTLTDKAVEFIDqHAKKDKPFFLYFALPAPHTPIVPSPEFQG---------KSGAGPYGD 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 265 nkhwLIRQaktpmtnssiqfldnafrkrwqtllsVDDLVEKLVKRLEFTGELNNTYIFYTSDNG---YHTGQFSLPID-- 339
Cdd:cd16143 206 ----FVYE--------------------------LDWVVGRILDALKELGLAENTLVIFTSDNGpspYADYKELEKFGhd 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 340 --------KRQLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPILRGASNLTWR 409
Cdd:cd16143 256 psgplrgmKADIYEGGHRVPFIVRWPGkIPAGSVSDQLVSLTDLFATLAAIVGQKLPDNAaEDSFSFLPALLGPKKQEVR 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 410 SDVlveyqgegrnvtdptcpslspgvsqcfpdcVCEDAyNNTYA--------CVRTMSALWNLQYCEFDDQEVFVEVYNL 481
Cdd:cd16143 336 ESL------------------------------VHHSG-NGSFAirkgdwklIDGTGSGGFSYPRGKEKLGLPPGQLYNL 384
|
490
....*....|.
gi 4504061 482 TADPDQITNIA 492
Cdd:cd16143 385 STDPGESNNLY 395
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
47-402 |
1.05e-41 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 155.06 E-value: 1.05e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDqdevLG-GMT-----PLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKyphnhHVVNNTLEGNC 118
Cdd:cd16145 1 PNIIFILADD----LGyGDLgcygqKKIKTPNLdrLAAEGMRFTQHYAGAPVCAPSRASLLTGL-----HTGHTRVRGNS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 119 SSKSWQKIQEPN-TFPAILRSmCGYQTFFAGKY----LNEYGAPDAGG-------LEHVPLGWSYWYALEKNSKYYNYT- 185
Cdd:cd16145 72 EPGGQDPLPPDDvTLAEVLKK-AGYATAAFGKWglggPGTPGHPTKQGfdyfygyLDQVHAHNYYPEYLWRNGEKVPLPn 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 186 -----LSINGKARKHGENYSvdylTDVLANVSLDFLDYKSNfEPFFMMIATPAPHSPWtAAPQYQKAFQNVFAPRnknfn 260
Cdd:cd16145 151 nvippLDEGNNAGGGGGTYS----HDLFTDEALDFIRENKD-KPFFLYLAYTLPHAPL-QVPDDGPYKYKPKDPG----- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 261 iHGTNKHWlirqaktpmtnssiqfldNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHT-GQFSLPI 338
Cdd:cd16145 220 -IYAYLPW------------------PQPEKAYAAMVTrLDRDVGRILALLKELGIDENTLVVFTSDNGPHSeGGSEHDP 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504061 339 D-----------KRQLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLnKTQMDGMSLLPILRG 402
Cdd:cd16145 281 DffdsngplrgyKRSLYEGGIRVPFIARWPGkIPAGSVSDHPSAFWDFMPTLADLAGAEP-PEDIDGISLLPTLLG 355
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
46-498 |
3.77e-41 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 153.88 E-value: 3.77e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDD---QDEVLGG---MTP----LKKtkaligeMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNtle 115
Cdd:cd16030 2 KPNVLFIAVDDlrpWLGCYGGhpaKTPnidrLAA-------RGVLFTNAYCQQPVCGPSRASLLTGRRPDTTGVYDN--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 116 gncsSKSWQKIQePN--TFPAILRSMcGYQTFFAGK---YLNEYGAPDagglehvPLGWSYWYALEKNSKYYNYTLSING 190
Cdd:cd16030 72 ----NSYFRKVA-PDavTLPQYFKEN-GYTTAGVGKifhPGIPDGDDD-------PASWDEPPNPPGPEKYPPGKLCPGK 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 191 KARKHGENYSV------------DYLTdvlANVSLDFLDYKSNF-EPFFMMIATPAPHSPWTAAPQYQKAFqnvfaPRNK 257
Cdd:cd16030 139 KGGKGGGGGPAweaadvpdeaypDGKV---ADEAIEQLRKLKDSdKPFFLAVGFYKPHLPFVAPKKYFDLY-----PLES 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 258 NFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRK----------RWQTLLS--------VDDLVEKLVKRLEFTGELNNT 319
Cdd:cd16030 211 IPLPNPFDPIDLPEVAWNDLDDLPKYGDIPALNPgdpkgplpdeQARELRQayyasvsyVDAQVGRVLDALEELGLADNT 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 320 YIFYTSDNGYH---TGQFSlpidKRQLYEFDIKVPLLVRGPGIK-PNQTSKMLVANIDLGPTILDIAGYDLNKtQMDGMS 395
Cdd:cd16030 291 IVVLWSDHGWHlgeHGHWG----KHTLFEEATRVPLIIRAPGVTkPGKVTDALVELVDIYPTLAELAGLPAPP-CLEGKS 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 396 LLPILRGaSNLTWRSDVLVEYQGEGRNvtdptcpslspGVSqcfpdcvcedaynntyacVRTmsALWNL-QYCEFDDqEV 474
Cdd:cd16030 366 LVPLLKN-PSAKWKDAAFSQYPRPSIM-----------GYS------------------IRT--ERYRYtEWVDFDK-VG 412
|
490 500
....*....|....*....|....
gi 4504061 475 FVEVYNLTADPDQITNIAKtiDPE 498
Cdd:cd16030 413 AEELYDHKNDPNEWKNLAN--DPE 434
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
50-498 |
1.19e-35 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 138.93 E-value: 1.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 50 VLLLTDDQ---DEVLGGMTPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCsskswq 124
Cdd:cd16028 3 VLFITADQwraDCLSCLGHPLVKTPNLdrLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLMNHRSVWNGTPLDA------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 125 kiqEPNTFPAILRSMcGYQTFFAGKylNEYgAPDAGGLEHV-PLGWSYWYALEKnskyYNYTLSINGKARKHGEnysVDY 203
Cdd:cd16028 77 ---RHLTLALELRKA-GYDPALFGY--TDT-SPDPRGLAPLdPRLLSYELAMPG----FDPVDRLDEYPAEDSD---TAF 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 204 LTDVLanvsLDFLDYKSNfEPFFMMIATPAPHSPWTAAPQYQKAFQN-VFAPRNKNFN------IHGTNKHWLIRQAKTP 276
Cdd:cd16028 143 LTDRA----IEYLDERQD-EPWFLHLSYIRPHPPFVAPAPYHALYDPaDVPPPIRAESlaaeaaQHPLLAAFLERIESLS 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 277 --MTNSSIQFLDNAFRKRWQT----LLS-VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLpIDKRQLYEFDIK 349
Cdd:cd16028 218 fsPGAANAADLDDEEVAQMRAtylgLIAeVDDHLGRLFDYLKETGQWDDTLIVFTSDHGEQLGDHWL-WGKDGFFDQAYR 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 350 VPLLVRGPGIKPNQTSKMLVAN----IDLGPTILDIAGYDLnKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTD 425
Cdd:cd16028 297 VPLIVRDPRREADATRGQVVDAftesVDVMPTILDWLGGEI-PHQCDGRSLLPLLAGAQPSDWRDAVHYEYDFRDVSTRR 375
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504061 426 PTCP-SLSPGvsqcfpDCVCEDAYNNTYACVrtmsalwnlQYCEFDDQevfveVYNLTADPDQITNIAKtiDPE 498
Cdd:cd16028 376 PQEAlGLSPD------ECSLAVIRDERWKYV---------HFAALPPL-----LFDLKNDPGELRDLAA--DPA 427
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-423 |
1.28e-35 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 135.75 E-value: 1.28e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDD-QDEVLGGM-TPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNT--LEGncss 120
Cdd:cd16037 1 PNILIIMSDEhNPDAMGCYgHPVVRTPNLdrLAARGTRFENAYTPSPICVPSRASFLTGRYVHETGVWDNAdpYDG---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 121 kswqkiqEPNTFPAILRSMcGYQTFFAGKylneygapdagglehvplgwsywyaleknskyynytLSINGKARKHGENYs 200
Cdd:cd16037 77 -------DVPSWGHALRAA-GYETVLIGK------------------------------------LHFRGEDQRHGFRY- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 201 vdylTDVLANVSLDFL-DYKSNFEPFFMMIATPAPHSPWTAAPQ-YQKafqnvfaprnknfnihgtnkhwlirqaktpmt 278
Cdd:cd16037 112 ----DRDVTEAAVDWLrEEAADDKPWFLFVGFVAPHFPLIAPQEfYDL-------------------------------- 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 279 nssiqFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLpIDKRQLYEFDIKVPLLVRGPG 358
Cdd:cd16037 156 -----YVRRARAAYYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSDHGDMLGERGL-WGKSTMYEESVRVPMIISGPG 229
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504061 359 IKPNQTSKMLVANIDLGPTILDIAGYDLNKTQmDGMSLLPILRGASNltWRSDVLVEYQGEGRNV 423
Cdd:cd16037 230 IPAGKRVKTPVSLVDLAPTILEAAGAPPPPDL-DGRSLLPLAEGPDD--PDRVVFSEYHAHGSPS 291
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-410 |
1.85e-35 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 136.58 E-value: 1.85e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDD-QDEVLGGMTPLK-KTKAL--IGEMGMTFSSAYVpSALCCPSRASILTGKYPHNHHVVNNTLEGNcssks 122
Cdd:cd16151 1 PNIILIMADDlGYECIGCYGGESyKTPNIdaLAAEGVRFNNAYA-QPLCTPSRVQLMTGKYNFRNYVVFGYLDPK----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 123 wQKiqepnTFPAILRSmCGYQTFFAGKY--LNEYGAPDAggLEHVplG---WSYWYALEKNSKYYNYTLSI----NGKAR 193
Cdd:cd16151 75 -QK-----TFGHLLKD-AGYATAIAGKWqlGGGRGDGDY--PHEF--GfdeYCLWQLTETGEKYSRPATPTfnirNGKLL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 194 KHGENysvDYLTDVLANVSLDFLDYKSNfEPFFMMIATPAPHSPWTAAPQyqkafqnvfaprnknfnihgtNKHWlirqa 273
Cdd:cd16151 144 ETTEG---DYGPDLFADFLIDFIERNKD-QPFFAYYPMVLVHDPFVPTPD---------------------SPDW----- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 274 ktpmtnssiQFLDNAFRKRWQTLL----SVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPID------KRQL 343
Cdd:cd16151 194 ---------DPDDKRKKDDPEYFPdmvaYMDKLVGKLVDKLEELGLRENTIIIFTGDNGTHRPITSRTNGrevrggKGKT 264
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504061 344 YEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDL-NKTQMDGMSLLPILRGASNLTWRS 410
Cdd:cd16151 265 TDAGTHVPLIVNWPGlIPAGGVSDDLVDFSDFLPTLAELAGAPLpEDYPLDGRSFAPQLLGKTGSPRRE 333
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-513 |
7.18e-33 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 130.43 E-value: 7.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDD-QDEVLGGM-TPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHnhhvVNntleGNCSSKS 122
Cdd:cd16150 1 PNIVIFVADQlRADSLGHLgNPAAVTPNLdaLAAEGVRFSNAYCQNPVCSPSRCSFLTGWYPH----VN----GHRTLHH 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 123 WQKIQEPNtfpaILRSM--CGYQTFFAGK--YLNEYGAPDAgglehvplgwsywyaleknskyynYTLSingkarkhgen 198
Cdd:cd16150 73 LLRPDEPN----LLKTLkdAGYHVAWAGKndDLPGEFAAEA------------------------YCDS----------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 199 ysvDYLTdvlANVSLDFLDYKSNFEPFFMMIATPAPHSPWTA-APQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKtpm 277
Cdd:cd16150 114 ---DEAC---VRTAIDWLRNRRPDKPFCLYLPLIFPHPPYGVeEPWFSMIDREKLPPRRPPGLRAKGKPSMLEGIEK--- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 278 tnssiQFLDNAFRKRWQTLLSV--------DDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLpIDKRQ--LYEFD 347
Cdd:cd16150 185 -----QGLDRWSEERWRELRATylgmvsrlDHQFGRLLEALKETGLYDDTAVFFFSDHGDYTGDYGL-VEKWPntFEDCL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 348 IKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMdGMSLLPILRGASnLTWRSDVLVEyqGeGRNVTDPT 427
Cdd:cd16150 259 TRVPLIIKPPGGPAGGVSDALVELVDIPPTLLDLAGIPLSHTHF-GRSLLPVLAGET-EEHRDAVFSE--G-GRLHGEEQ 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 428 CPSLSPGVSQCFPDC--VCEDAYNNTYAC-VRTMSalWNLQYCEFDDQevfvEVYNLTADPDQITNIAKtiDP---ELLG 501
Cdd:cd16150 334 AMEGGHGPYDLKWPRllQQEEPPEHTKAVmIRTRR--YKYVYRLYEPD----ELYDLEADPLELHNLIG--DPayaEIIA 405
|
490
....*....|....
gi 4504061 502 KMNYRLM--MLQSC 513
Cdd:cd16150 406 EMKQRLLrwMVETS 419
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-415 |
7.92e-31 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 123.49 E-value: 7.92e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDDQ--DEVLGGMTPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTlegncssk 121
Cdd:cd16152 1 KPNVIVFFTDQQrwDTLGCYGQPLDLTPNLdaLAEEGVLFENAFTPQPVCGPARACLQTGLYPTETGCFRNG-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 122 swqkIQEPNTFPAILRSM--CGYQTFFAGKylneygapdagglehvplgwsyWyaleknskyynytlsingkarkHGENY 199
Cdd:cd16152 73 ----IPLPADEKTLAHYFrdAGYETGYVGK----------------------W----------------------HLAGY 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 200 SVDYLTDvLAnvsLDFLDYKSNFEPFFMMIATPAPHspwtaapqyqkaFQNV---------FAPRNKNFNIHGtnkhwli 270
Cdd:cd16152 105 RVDALTD-FA---IDYLDNRQKDKPFFLFLSYLEPH------------HQNDrdryvapegSAERFANFWVPP------- 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 271 rqaktpmtnssiqflDNAFRK-RWQTLL--------SVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYH----TGQFslp 337
Cdd:cd16152 162 ---------------DLAALPgDWAEELpdylgcceRLDENVGRIRDALKELGLYDNTIIVFTSDHGCHfrtrNAEY--- 223
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504061 338 idKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTqMDGMSLLPILRGASNlTWRSDVLVE 415
Cdd:cd16152 224 --KRSCHESSIRVPLVIYGPGFNGGGRVEELVSLIDLPPTLLDAAGIDVPEE-MQGRSLLPLVDGKVE-DWRNEVFIQ 297
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
46-405 |
1.22e-30 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 123.44 E-value: 1.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDDQ---D-EVLGGmtPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPH---NHHVVNNTLEG 116
Cdd:cd16026 1 KPNIVVILADDLgygDlGCYGS--PLIKTPNIdrLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVrvgLPGVVGPPGSK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 117 NCSSKSwqkiqEPnTFPAILRSmCGYQTFFAGKYlneygapDAGGL-EHVPL--GWSYWYAL-----EKNSKYYNYTLSI 188
Cdd:cd16026 79 GGLPPD-----EI-TIAEVLKK-AGYRTALVGKW-------HLGHQpEFLPTrhGFDEYFGIpysndMWPFPLYRNDPPG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 189 NGKARKHGENY---SVDY--LTDVLANVSLDFLDYKSNfEPFFMMIATPAPHSPwtaapqyqkafqnVFAPrnKNFnihg 263
Cdd:cd16026 145 PLPPLMENEEVieqPADQssLTQRYTDEAVDFIERNKD-QPFFLYLAHTMPHVP-------------LFAS--EKF---- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 264 tnkhwlirqaktpmtnssiqfldnAFRKRWQ----TLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNG-----YHTGQF 334
Cdd:cd16026 205 ------------------------KGRSGAGlygdVVEELDWSVGRILDALKELGLEENTLVIFTSDNGpwleyGGHGGS 260
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504061 335 SLPID--KRQLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKTQM-DGMSLLPILRGASN 405
Cdd:cd16026 261 AGPLRggKGTTWEGGVRVPFIAWWPGvIPAGTVSDELASTMDLLPTLAALAGAPLPEDRViDGKDISPLLLGGSK 335
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
78-486 |
3.73e-30 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 120.38 E-value: 3.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 78 GMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSskswqkiqEPnTFPAILRSMcGYQTFFAGKYlnEYGAP 157
Cdd:cd16032 36 GVVFDNAYCNSPLCAPSRASMMTGRLPSRIGAYDNAAEFPAD--------IP-TFAHYLRAA-GYRTALSGKM--HFVGP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 158 DagglehvplgwsywyaleknskyynytlsingkaRKHGENY-------SVDYLTDvLANVSLDfldyksnfEPFFMMIA 230
Cdd:cd16032 104 D----------------------------------QLHGFDYdeevafkAVQKLYD-LARGEDG--------RPFFLTVS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 231 TPAPHSPWTAAPQYQkafqnvfaprnknfnihgtnkHWLIRQAktpmtnssiqfldnafRKRWQTLLS-VDDLVEKLVKR 309
Cdd:cd16032 141 FTHPHDPYVIPQEYW---------------------DLYVRRA----------------RRAYYGMVSyVDDKVGQLLDT 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 310 LEFTGELNNTYIFYTSDNGYHTGQFSLPIdKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNK- 388
Cdd:cd16032 184 LERTGLADDTIVIFTSDHGDMLGERGLWY-KMSFFEGSARVPLIISAPGRFAPRRVAEPVSLVDLLPTLVDLAGGGTAPh 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 389 -TQMDGMSLLPILRGASNLtWRSDVLVEYQGEGrnvtdptcpSLSPgvsqcfpdcvcedaynntyaCVRTMSALWNLQYC 467
Cdd:cd16032 263 vPPLDGRSLLPLLEGGDSG-GEDEVISEYLAEG---------AVAP--------------------CVMIRRGRWKFIYC 312
|
410 420
....*....|....*....|
gi 4504061 468 EFD-DQevfveVYNLTADPD 486
Cdd:cd16032 313 PGDpDQ-----LFDLEADPL 327
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
46-404 |
4.73e-30 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 121.78 E-value: 4.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDD----QDEVLGG--MTP-LKKtkalIGEMGMTFSSAYVpSALCCPSRASILTGkypHNHHVVNN-TLEGN 117
Cdd:cd16025 2 RPNILLILADDlgfsDLGCFGGeiPTPnLDA----LAAEGLRFTNFHT-TALCSPTRAALLTG---RNHHQVGMgTMAEL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 118 CSSKSWQKIQEPN---TFPAILRsMCGYQTFFAGKYlneygapdaggleHvpLGwsywyaleknskyynytlsingkark 194
Cdd:cd16025 74 ATGKPGYEGYLPDsaaTIAEVLK-DAGYHTYMSGKW-------------H--LG-------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 195 hGENYsvdYLTDVLANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVF-----APRNKNFNihgtnkhw 268
Cdd:cd16025 112 -PDDY---YSTDDLTDKAIEYIDeQKAPDKPFFLYLAFGAPHAPLQAPKEWIDKYKGKYdagwdALREERLE-------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 269 liRQ-------AKTPMT--NSSIQFLD--NAFRKRWQTLL---------SVDDLVEKLVKRLEFTGELNNTYIFYTSDNG 328
Cdd:cd16025 180 --RQkelglipADTKLTprPPGVPAWDslSPEEKKLEARRmevyaamveHMDQQIGRLIDYLKELGELDNTLIIFLSDNG 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 329 --YHTG--QFS---LPIDKRQLYEFDIKVPLLVRGPG--IKPNQTSKMLVANIDLGPTILDIAGYDLNKT-------QMD 392
Cdd:cd16025 258 asAEPGwaNASntpFRLYKQASHEGGIRTPLIVSWPKgiKAKGGIRHQFAHVIDIAPTILELAGVEYPKTvngvpqlPLD 337
|
410
....*....|..
gi 4504061 393 GMSLLPILRGAS 404
Cdd:cd16025 338 GVSLLPTLDGAA 349
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
47-416 |
1.83e-27 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 115.56 E-value: 1.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQD-EVLGGMTPLK-KTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKS 122
Cdd:cd16156 1 KQFIFIMTDTQRwDMVGCYGNKAmKTPNLdrLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTNGSWTNCMALGDNVKT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 123 WQKIQEPNtfpailrsmcGYQTFFAGKYLNEYGapDAGGLEHVPLGW--SYWYALEknskyyNY---------TLSINGK 191
Cdd:cd16156 81 IGQRLSDN----------GIHTAYIGKWHLDGG--DYFGNGICPQGWdpDYWYDMR------NYldelteeerRKSRRGL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 192 ARKHGENYSVDY-LTDVLANVSLDFLDYKSNfEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLI 270
Cdd:cd16156 143 TSLEAEGIKEEFtYGHRCTNRALDFIEKHKD-EDFFLVVSYDEPHHPFLCPKPYASMYKDFEFPKGENAYDDLENKPLHQ 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 271 R--------QAKTPMTNSSIQFLD-NAFrkrwqtllsVDDLVEKLVKRLEFTGElnNTYIFYTSDNGYHTGQFSLPIDKR 341
Cdd:cd16156 222 RlwagakphEDGDKGTIKHPLYFGcNSF---------VDYEIGRVLDAADEIAE--DAWVIYTSDHGDMLGAHKLWAKGP 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504061 342 QLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKtQMDGMSLLPILRgASNLTWRSDVLVEY 416
Cdd:cd16156 291 AVYDEITNIPLIIRGKGgEKAGTVTDTPVSHIDLAPTILDYAGIPQPK-VLEGESILATIE-DPEIPENRGVFVEF 364
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
78-398 |
6.90e-27 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 109.94 E-value: 6.90e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 78 GMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEgncsskswqkiQEPNTFPAILRSMcGYQTF-FAGkylneyga 156
Cdd:cd16148 36 GVVFDNHYSGSNPTLPSRFSLFTGLYPFYHGVWGGPLE-----------PDDPTLAEILRKA-GYYTAaVSS-------- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 157 pdaggleHVPLGWSYWYAleknsKYYNYTLSINGKARKHGENYsvDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHS 236
Cdd:cd16148 96 -------NPHLFGGPGFD-----RGFDTFEDFRGQEGDPGEEG--DERAERVTDRALEWLDRNADDDPFFLFLHYFDPHE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 237 PWtaapQYqkafqnvfaprnknfnihgtnkhwlirqaktpmtnssiqflDNAfrkrwqtLLSVDDLVEKLVKRLEFTGEL 316
Cdd:cd16148 162 PY----LY-----------------------------------------DAE-------VRYVDEQIGRLLDKLKELGLL 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 317 NNTYIFYTSDNG--------YHTGQFSLpidkrqlYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNK 388
Cdd:cd16148 190 EDTLVIVTSDHGeefgehglYWGHGSNL-------YDEQLHVPLIIRWPGKEPGKRVDALVSHIDIAPTLLDLLGVEPPD 262
|
330
....*....|
gi 4504061 389 TqMDGMSLLP 398
Cdd:cd16148 263 Y-SDGRSLLP 271
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
47-404 |
1.64e-26 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 111.49 E-value: 1.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDqdevLG-----------GMTPlkKTKALIGEmGMTFSSAYVpSALCCPSRASILTGKYPHNH---HVVNN 112
Cdd:cd16029 1 PHIVFILADD----LGwndvgfhgsdqIKTP--NLDALAAD-GVILNNYYV-QPICTPSRAALMTGRYPIHTgmqHGVIL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 113 TLEGNCSSKSwqkiqEPnTFPAILRSmCGYQTFFAGKYLNEYGAPdagglEHVPLG----------------WSYWYALE 176
Cdd:cd16029 73 AGEPYGLPLN-----ET-LLPQYLKE-LGYATHLVGKWHLGFYTW-----EYTPTNrgfdsfygyyggaedyYTHTSGGA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 177 KNskYYNYTLSINGKARKHGENysvDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPrn 256
Cdd:cd16029 141 ND--YGNDDLRDNEEPAWDYNG---TYSTDLFTDRAVDIIENHDPSKPLFLYLAFQAVHAPLQVPPEYADPYEDKFAH-- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 257 knfnihgtnkhwlirqaktpmtnssIQFLDnafRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFS 335
Cdd:cd16029 214 -------------------------IKDED---RRTYAAMVSaLDESVGNVVDALKAKGMLDNTLIVFTSDNGGPTGGGD 265
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504061 336 L----PI--DKRQLYEFDIKVPLLVRGPGIKPN--QTSKMLVANIDLGPTILDIAGYDLN-KTQMDGMSLLPILRGAS 404
Cdd:cd16029 266 GgsnyPLrgGKNTLWEGGVRVPAFVWSPLLPPKrgTVSDGLMHVTDWLPTLLSLAGGDPDdLPPLDGVDQWDALSGGA 343
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-416 |
7.16e-26 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 108.06 E-value: 7.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQ-----------DEVLGGMTPLKKtkaligeMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTle 115
Cdd:cd16035 1 PNILLILTDQErypppwpagwaALNLPARERLAA-------NGLSFENHYTAACMCSPSRSTLYTGLHPQQTGVTDTL-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 116 gncsSKSWQKiQEPNTFPAI---LRSMcGYQTFFAGKylneygapdagglehvplgwsyWYALEKNSKYYNYTLSINGKA 192
Cdd:cd16035 72 ----GSPMQP-LLSPDVPTLghmLRAA-GYYTAYKGK----------------------WHLSGAAGGGYKRDPGIAAQA 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 193 rkhgenysVDYLTDVLANVSLDfldyksnfEPFFMMIATPAPH---SPWTAAPQYQkafqnvfapRNKNFnihgtnKHWL 269
Cdd:cd16035 124 --------VEWLRERGAKNADG--------KPWFLVVSLVNPHdimFPPDDEERWR---------RFRNF------YYNL 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 270 IRQaktpmtnssiqfldnafrkrwqtllsVDDLVEKLVKRLEFTGELNNTYIFYTSDNG----YHTGqfslpidKRQ--- 342
Cdd:cd16035 173 IRD--------------------------VDRQIGRVLDALDASGLADNTIVVFTSDHGemggAHGL-------RGKgfn 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 343 LYEFDIKVPLLVRGPGIKPN-QTSKMLVANIDLGPTILDIAGYDLNKTQMD-----GMSLLPILRGASNLTWRSDVLVEY 416
Cdd:cd16035 220 AYEEALHVPLIISHPDLFGTgQTTDALTSHIDLLPTLLGLAGVDAEARATEapplpGRDLSPLLTDADADAVRDGILFTY 299
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-386 |
1.77e-25 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 105.40 E-value: 1.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQDE-VLGG-MTPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSK- 121
Cdd:cd16149 1 PNILFILTDDQGPwALGCyGNSEAVTPNLdrLAAEGVRFENFFCTSPVCSPARASLLTGRMPSQHGIHDWIVEGSHGKTk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 122 ---SWQKIQEpnTFPAILRSMcGYQTFFAGKYlneygapdaggleHVplgwsywyaleknskyynytlsingkarkhGEN 198
Cdd:cd16149 81 kpeGYLEGQT--TLPEVLQDA-GYRCGLSGKW-------------HL------------------------------GDD 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 199 ysvdyltdvlanvSLDFLD--YKSNfEPFFMMIATPAPHSPWtaapQYqkafqnvFAprnknfnihgtnkhwlirqaktp 276
Cdd:cd16149 115 -------------AADFLRrrAEAE-KPFFLSVNYTAPHSPW----GY-------FA----------------------- 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 277 mtnssiqfldnafrkrwqTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQ----------FSLpidkrQLYEF 346
Cdd:cd16149 147 ------------------AVTGVDRNVGRLLDELEELGLTENTLVIFTSDNGFNMGHhgiwgkgngtFPL-----NMYDN 203
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 4504061 347 DIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDL 386
Cdd:cd16149 204 SVKVPFIIRWPGvVPAGRVVDSLVSAYDFFPTLLELAGVDP 244
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-421 |
2.17e-24 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 104.74 E-value: 2.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQ----DEVLGGMTPLKKTKAL--IGEMGMTFSSAYVPSAlCCPSRASILTGKYPHNHHV--VNNTLEGNC 118
Cdd:cd16154 1 PNILLIIADDQgldsSAQYSLSSDLPVTPTLdsLANSGIVFDNLWATPA-CSPTRATILTGKYGFRTGVlaVPDELLLSE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 119 SSKSWQKIQEPNTfpailrsmCGYQTFFAGKYL---NEYGAPDAGGLEHvplgwsYWYALEKN-SKYYNYTLSINGKARK 194
Cdd:cd16154 80 ETLLQLLIKDATT--------AGYSSAVIGKWHlggNDNSPNNPGGIPY------YAGILGGGvQDYYNWNLTNNGQTTN 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 195 HGEnysvdYLTDVLANVSLDFLDYKSnfEPFFMMIATPAPHSPwtaapqyqkaFQnvfAPRNKNFNIHGTNKHWLIRQAK 274
Cdd:cd16154 146 STE-----YATTKLTNLAIDWIDQQT--KPWFLWLAYNAPHTP----------FH---LPPAELHSRSLLGDSADIEANP 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 275 TPMTNSSIQFLDNAFRKrwqTLLSVDDlveklvkrleftGELNNTYIFYTSDNGyhT-GQ-----FSLPIDKRQLYEFDI 348
Cdd:cd16154 206 RPYYLAAIEAMDTEIGR---LLASIDE------------EERENTIIIFIGDNG--TpGQvvdlpYTRNHAKGSLYEGGI 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504061 349 KVPLLVRGPGI-KPNQTSKMLVANIDLGPTILDIAGYDLNKtQMDGMSLLPILRGaSNLTWRSDVLVEYQGEGR 421
Cdd:cd16154 269 NVPLIVSGAGVeRANERESALVNATDLYATIAELAGVDAAE-IHDSVSFKPLLSD-VNASTRQYNYTEYESPTT 340
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
41-409 |
2.78e-24 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 105.91 E-value: 2.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 41 AAGTRRPNVVLLLTDDQ-DEVLGGM------TPlkKTKALIGEmGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNnt 113
Cdd:PRK13759 1 MVQTKKPNIILIMVDQMrGDCLGCNgnkaveTP--NLDMLASE-GYNFENAYSAVPSCTPARAALLTGLSQWHHGRVG-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 114 lEGNCSSKSWqkiqePNTFPAILRSMcGYQTFFAGKyLNEYGAPDAGGLEHVPL--GWS------------------YWY 173
Cdd:PRK13759 76 -YGDVVPWNY-----KNTLPQEFRDA-GYYTQCIGK-MHVFPQRNLLGFHNVLLhdGYLhsgrnedksqfdfvsdylAWL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 174 ---ALEKNSKYYNYTLSING-KAR--KHGENYsvdYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKA 247
Cdd:PRK13759 148 rekAPGKDPDLTDIGWDCNSwVARpwDLEERL---HPTNWVGSESIEFLRRRDPTKPFFLKMSFARPHSPYDPPKRYFDM 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 248 FQNVFAPRNKNFNIHGTNKHWLIRQAKT-PMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSD 326
Cdd:PRK13759 225 YKDADIPDPHIGDWEYAEDQDPEGGSIDaLRGNLGEEYARRARAAYYGLITHIDHQIGRFLQALKEFGLLDNTIILFVSD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 327 NGYHTGQFSLpIDKRQLYEFDIKVPLLVRGPG--IKPN--QTSKMLVANIDLGPTILDIAGYDLNKTqMDGMSLLPILRG 402
Cdd:PRK13759 305 HGDMLGDHYL-FRKGYPYEGSAHIPFIIYDPGglLAGNrgTVIDQVVELRDIMPTLLDLAGGTIPDD-VDGRSLKNLIFG 382
|
....*..
gi 4504061 403 ASNlTWR 409
Cdd:PRK13759 383 QYE-GWR 388
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
46-402 |
9.98e-24 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 104.05 E-value: 9.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDDQD----EVLGGMTplkKTKALIGEM---GMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNntleGNC 118
Cdd:cd16160 1 KPNIVLFFADDMGygdlASYGHPT---QERGPIDDMaaeGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMYG----GTR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 119 SSKSWQKIQEPN---TFPAILRSMcGYQTFFAGKY---LNEYGAPDAGGLEH----------VPLG-------WSYWYAL 175
Cdd:cd16160 74 VFLPWDIGGLPKtevTMAEALKEA-GYTTGMVGKWhlgINENNHSDGAHLPShhgfdfvgtnLPFTnswacddTGRHVDF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 176 EKNSK---YYNYTlsINGKARKHgenysvDYLTDVLANVSLDFLdYKSNFEPFFMMIATPAPHSPWTAAPQyqkafqnvF 252
Cdd:cd16160 153 PDRSAcflYYNDT--IVEQPIQH------EHLTETLVGDAKSFI-EDNQENPFFLYFSFPQTHTPLFASKR--------F 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 253 APRNKNfNIHGtnkhwlirqaktpmtnssiqflDNAFRKRWQtllsvddlVEKLVKRLEFTGELNNTYIFYTSDNGYH-- 330
Cdd:cd16160 216 KGKSKR-GRYG----------------------DNINEMSWA--------VGEVLDTLVDTGLDQNTLVFFLSDHGPHve 264
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504061 331 ---TGQFSLPID--KRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDL-NKTQMDGMSLLPILRG 402
Cdd:cd16160 265 yclEGGSTGGLKggKGNSWEGGIRVPFIAYWPGTIKPRVSHEVVSTMDIFPTFVDLAGGTLpTDRIYDGLSITDLLLG 342
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
47-410 |
5.20e-20 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 91.83 E-value: 5.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDD----------QDEVLGGMTP-LKKtkalIGEMGMTFSSAYV-PSalCCPSRASILTGKYPHNHHVVNNTL 114
Cdd:cd16142 1 PNILVILGDDigwgdlgcygGGIGRGAPTPnIDR----LAKEGLRFTSFYVePS--CTPGRAAFITGRHPIRTGLTTVGL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 115 EGncsSKSWQKIQEPnTFPAILRSMcGYQTFFAGKylNEYGAPDagglEHVPL--GWSYWYAleknskYYNYTLsingka 192
Cdd:cd16142 75 PG---SPGGLPPWEP-TLAELLKDA-GYATAQFGK--WHLGDED----GRLPTdhGFDEFYG------NLYHTI------ 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 193 rkhgENYSVDYltdvlanvSLDFLD--YKSNfEPFFMMIATPAPHSPWTAAPQYQkafqnvfaprnknfnihGTNKHWLi 270
Cdd:cd16142 132 ----DEEIVDK--------AIDFIKrnAKAD-KPFFLYVNFTKMHFPTLPSPEFE-----------------GKSSGKG- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 271 rqaktpmtnssiQFLDnafrkrwqTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHtgQFSLPI--------DKRQ 342
Cdd:cd16142 181 ------------KYAD--------SMVELDDHVGQILDALDELGIADNTIVIFTTDNGPE--QDVWPDggytpfrgEKGT 238
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504061 343 LYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDL-------NKTQMDGMSLLPILRGASNLTWRS 410
Cdd:cd16142 239 TWEGGVRVPAIVRWPGkIKPGRVSNEIVSHLDWFPTLAALAGAPDpkdkllgKDRHIDGVDQSPFLLGKSEKSRRS 314
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
46-404 |
2.54e-19 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 89.84 E-value: 2.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDD---QDEVLGGMTPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPhnhhvVNNTLEGNCSS 120
Cdd:cd16161 1 KPNFLLLFADDlgwGDLGANWAPNAILTPNLdkLAAEGTRFVDWYSAASVCSPSRASLMTGRLG-----LRNGVGHNFLP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 121 KSWQKIQ-EPNTFPAILRSMcGYQTFFAGKY-LNEYGApdaggleHVPlgwsywyalekNSKYYNYTLSINgkarkhgen 198
Cdd:cd16161 76 TSVGGLPlNETTLAEVLRQA-GYATGMIGKWhLGQREA-------YLP-----------NSRGFDYYFGIP--------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 199 YSVD-YLTDVLANVSLDFLDYKSNF-EPFFMMIATPAPHSPWTAAPQYQkafqnvfaprnknfnihgtnkhwlirqaktP 276
Cdd:cd16161 128 FSHDsSLADRYAQFATDFIQRASAKdRPFFLYAALAHVHVPLANLPRFQ------------------------------S 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 277 MTNSSIQFLDnafrkrwqTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNG---------------YHTGQFSLPIDKR 341
Cdd:cd16161 178 PTSGRGPYGD--------ALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGpwevkcelavgpgtgDWQGNLGGSVAKA 249
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504061 342 QLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKTQM-DGMSLLPILRGAS 404
Cdd:cd16161 250 STWEGGHREPAIVYWPGrIPANSTSAALVSTLDIFPTVVALAGASLPPGRIyDGKDLSPVLFGGS 314
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
46-400 |
1.61e-18 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 88.29 E-value: 1.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDDQD----EVLGgmTPLKKTKAL--IGEMGMTFSSAYVPSALCCPSRASILTGKYPhnhhVVNNTLEGNCS 119
Cdd:cd16157 1 KPNIILMLMDDMGwgdlGVFG--EPSRETPNLdrMAAEGMLFTDFYSANPLCSPSRAALLTGRLP----IRNGFYTTNAH 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 120 SKSWQKIQE-----PNT---FPAILRSmCGYQTFFAGKY--------------LNE--------YGAPDAGGLEHVPLgW 169
Cdd:cd16157 75 ARNAYTPQNivggiPDSeilLPELLKK-AGYRNKIVGKWhlghrpqyhplkhgFDEwfgapnchFGPYDNKAYPNIPV-Y 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 170 SYWyalEKNSKYYNyTLSINgkaRKHGENYsvdyLTDVLANVSLDFLDYKSNF-EPFFMMIATPAPHSPWTAAPQYQkaf 248
Cdd:cd16157 153 RDW---EMIGRYYE-EFKID---KKTGESN----LTQIYLQEALEFIEKQHDAqKPFFLYWAPDATHAPVYASKPFL--- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 249 qnvfaprnknfnihGTNKHWLIRQAktpmtnssiqfldnafrkrwqtLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNG 328
Cdd:cd16157 219 --------------GTSQRGLYGDA----------------------VMELDSSVGKILESLKSLGIENNTFVFFSSDNG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 329 YHTgqFSLPID----------KRQLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNK-TQMDGMSL 396
Cdd:cd16157 263 AAL--ISAPEQggsngpflcgKQTTFEGGMREPAIAWWPGhIKPGQVSHQLGSLMDLFTTSLALAGLPIPSdRAIDGIDL 340
|
....
gi 4504061 397 LPIL 400
Cdd:cd16157 341 LPVL 344
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-396 |
3.01e-18 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 85.12 E-value: 3.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDDQ--DEV--LGGMTPLKKTKAL----------IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVN 111
Cdd:cd16153 1 KPNILWIITDDQrvDSLscYNNAHTGKSESRLgyvespnidaLAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHRTGVYG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 112 NtlegncsSKSWQKIQEPN-TFPAILRsMCGYQTFFAGKylneygapdagglehvplgwsywyaleknskyynytlsing 190
Cdd:cd16153 81 F-------EAAHPALDHGLpTFPEVLK-KAGYQTASFGK----------------------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 191 karKHGENYsvdylTDVLANVSLDFLDYKSNFE-------PFFMMIATPAPHSPwtaapqyqkafqnVFAPrnknfnihg 263
Cdd:cd16153 112 ---SHLEAF-----QRYLKNANQSYKSFWGKIAkgadsdkPFFVRLSFLQPHTP-------------VLPP--------- 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 264 tnKHWliRQaktpmtnssiQFLDNAFrkrwqtLLSVDDLVEKLVKRLEFTGELN---NTYIFYTSDNGYHTGQFSLpIDK 340
Cdd:cd16153 162 --KEF--RD----------RFDYYAF------CAYGDAQVGRAVEAFKAYSLKQdrdYTIVYVTGDHGWHLGEQGI-LAK 220
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 341 RQLYEFDIKVPLLVRGPGIKPNQTSKM---LVANIDLGPTILDIAGYDLNK-TQMDGMSL 396
Cdd:cd16153 221 FTFWPQSHRVPLIVVSSDKLKAPAGKVrhdFVEFVDLAPTLLAAAGVDVDApDYLDGRDL 280
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
47-400 |
7.11e-18 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 86.34 E-value: 7.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDqdevLG-----------GMTP-LKKTKAligeMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTL 114
Cdd:cd16158 2 PNIVLLFADD----LGygdlgcyghpsSSTPnLDRLAA----NGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYPGVF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 115 EGNcsSKSWQKIQEpNTFPAILRSMcGYQTFFAGKYlneygapdaggleHVPLGwsywyaleKNSKYynytLSIN-GKAR 193
Cdd:cd16158 74 YPG--SRGGLPLNE-TTIAEVLKTV-GYQTAMVGKW-------------HLGVG--------LNGTY----LPTHqGFDH 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 194 KHGENYSVDY-----LTDVLANVSLdFLDYKSNFEP---FFMMIATPAPHSPWTAAPQYQKA---FQNVFAPRNKNFNIH 262
Cdd:cd16158 125 YLGIPYSHDQgpcqnLTCFPPNIPC-FGGCDQGEVPcplFYNESIVQQPVDLLTLEERYAKFakdFIADNAKEGKPFFLY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 263 GTNKHWLIRQ-AKTPMTNSSIQ--FLDnafrkrwqTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFS---- 335
Cdd:cd16158 204 YASHHTHYPQfAGQKFAGRSSRgpFGD--------ALAELDGSVGELLQTLKENGIDNNTLVFFTSDNGPSTMRKSrggn 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504061 336 ---LPIDKRQLYEFDIKVPLLVRGPG-IKPNQTSKmLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
Cdd:cd16158 276 aglLKCGKGTTYEGGVREPAIAYWPGrIKPGVTHE-LASTLDILPTIAKLAGAPLPNVTLDGVDMSPIL 343
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
47-418 |
1.84e-17 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 84.13 E-value: 1.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDDQDEVLGGMtPLKKTKAL-----IGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSK 121
Cdd:cd16171 1 PNVVMVMSDSFDGRLTFR-PGNQVVDLpyinfMKQHGSVFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNYKGLDPNYP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 122 SWQKIQEPNtfpailrsmcGYQTffagkylNEYGAPDAGGLEHvplgwSYWYALEKNSKYYNYTLSINGKARKhgeNYSV 201
Cdd:cd16171 80 TWMDRLEKH----------GYHT-------QKYGKLDYTSGHH-----SVSNRVEAWTRDVPFLLRQEGRPTV---NLVG 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 202 DYLTDVLANVSLDFLDYKSNF---------EPFFMMIATPAPHsPWtAAPQYQKAFQNVfapRNknfnihgtnkhwlIRQ 272
Cdd:cd16171 135 DRSTVRVMLKDWQNTDKAVHWirkeapnltQPFALYLGLNLPH-PY-PSPSMGENFGSI---RN-------------IRA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 273 AKTPMTNSSiqfldnafrkrwqtllsvDDLVEKLVKRLEFTGELNNTYIFYTSDNGyhtgqfSLPIDKRQ-----LYEFD 347
Cdd:cd16171 197 FYYAMCAET------------------DAMLGEIISALKDTGLLDKTYVFFTSDHG------ELAMEHRQfykmsMYEGS 252
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504061 348 IKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTqMDGMSLLPILRGASNLTWRSD------VLVEYQG 418
Cdd:cd16171 253 SHVPLLIMGPGIKAGQQVSDVVSLVDIYPTMLDIAGVPQPQN-LSGYSLLPLLSESSIKESPSRvphpdwVLSEFHG 328
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
46-407 |
3.42e-15 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 78.10 E-value: 3.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 46 RPNVVLLLTDDqdevLG-------GMTPLKKTKA-LIGEMGMTFSSAYVPSALCCPSRASILTGKYP-------HNHHVV 110
Cdd:cd16159 1 KPNIVLFMADD----LGigdvgcfGNDTIRTPNIdRLAKEGVKLTHHLAAAPLCTPSRAAFLTGRYPirsgmasSHGMRV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 111 NNtlegnCSSKSWQKIQEPNTFPAILRSMcGYQTFFAGKYLNEYGAPDAGGLEHVPL--GWSYwyaleknskYYNYTLSi 188
Cdd:cd16159 77 IL-----FTASSGGLPPNETTFAEVLKQQ-GYSTALIGKWHLGLHCESRNDFCHHPLnhGFDY---------FYGLPLT- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 189 NGKARKHGENYSVDYLTD---------VLANVSLDFLDYKSNFEP----FFMMIATPAPHSPWTAAPQYQKAFqNVFAPR 255
Cdd:cd16159 141 NLKDCGDGSNGEYDLSFDplfplltafVLITALTIFLLLYLGAVSkrffVFLLILSLLFISLFFLLLITNRYF-NCILMR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 256 NknfnihgtnkHWLIRQaktPM---------TNSSIQFLDNAFRKRWQTLLS---------------------------- 298
Cdd:cd16159 220 N----------HEVVEQ---PMslenltqrlTKEAISFLERNKERPFLLVMSflhvhtalftskkfkgrskhgrygdnve 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 299 -VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQfslpIDKRQLYE--------------FD--IKVPLLVRGPG-IK 360
Cdd:cd16159 287 eMDWSVGQILDALDELGLKDNTFVYFTSDNGGHLEE----ISVGGEYGggnggiyggkkmggWEggIRVPTIVRWPGvIP 362
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 4504061 361 PNQTSKMLVANIDLGPTILDIAGYDL-NKTQMDGMSLLPILRGASNLT 407
Cdd:cd16159 363 PGSVIDEPTSLMDIFPTVAALAGAPLpSDRIIDGRDLMPLLTGQEKRS 410
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
47-383 |
1.00e-10 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 62.70 E-value: 1.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLL-----TDDQDEVLGGMTPLKKTKALIGEmGMTFSSAYVPSALCCPSRA--SILTGKYPhnhhvvnntLEGNCS 119
Cdd:cd16015 1 PNVIVILlesfsDPYIDKDVGGEDLTPNLNKLAKE-GLYFGNFYSPGFGGGTANGefEVLTGLPP---------LPLGSG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 120 SKSWQKIQEPNTFPAILRSMcGYQTFFAgkylneYGapdagglehvplGWSYWYALEKNSKYYNYTLSINGKA-RKHGEN 198
Cdd:cd16015 71 SYTLYKLNPLPSLPSILKEQ-GYETIFI------HG------------GDASFYNRDSVYPNLGFDEFYDLEDfPDDEKE 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 199 YSVDYLTD-VLANVSLDFLDyKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHgtnkhwlirqaktpm 277
Cdd:cd16015 132 TNGWGVSDeSLFDQALEELE-ELKKKPFFIFLVTMSNHGPYDLPEEKKDEPLKVEEDKTELENYL--------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 278 tnSSIQFLDNAFRkrwqtllsvdDLVEKLVKRleftGELNNTYIFYTSDngyHTGQFSLPIDKRQLYEFDI-KVPLLVRG 356
Cdd:cd16015 196 --NAIHYTDKALG----------EFIEKLKKS----GLYENTIIVIYGD---HLPSLGSDYDETDEDPLDLyRTPLLIYS 256
|
330 340
....*....|....*....|....*..
gi 4504061 357 PGIKPNQTSKMLVANIDLGPTILDIAG 383
Cdd:cd16015 257 PGLKKPKKIDRVGSQIDIAPTLLDLLG 283
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
47-382 |
1.83e-10 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 61.28 E-value: 1.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 47 PNVVLLLTDD-QDEVLGGMTPLKKTKALIGEMGMTFSSAYV----PSALCCPSRASILTGKYPHNHhvvnntlegncssk 121
Cdd:cd00016 1 KHVVLIVLDGlGADDLGKAGNPAPTTPNLKRLASEGATFNFrsvsPPTSSAPNHAALLTGAYPTLH-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 122 swqkiqepntfpailrsmcgyQTFFAGKYLNEYGAPDAGGLEHVPlgwsywyaleknskyynytlSINGKARKHGenysv 201
Cdd:cd00016 67 ---------------------GYTGNGSADPELPSRAAGKDEDGP--------------------TIPELLKQAG----- 100
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 202 dYLTDVLANvsLDFLDYKSNFEPFFMMIATPAPHSPWtaapqyqkafqnvfaprnknfnihgtnkhwlirQAKTPMTNSS 281
Cdd:cd00016 101 -YRTGVIGL--LKAIDETSKEKPFVLFLHFDGPDGPG---------------------------------HAYGPNTPEY 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 282 IQfldnafrkrwqTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNG---YHTGQFSLPIDKRQLYEFDIKVPLLVRGPG 358
Cdd:cd00016 145 YD-----------AVEEIDERIGKVLDALKKAGDADDTVIIVTADHGgidKGHGGDPKADGKADKSHTGMRVPFIAYGPG 213
|
330 340
....*....|....*....|....
gi 4504061 359 IKPNQTSKMLVANIDLGPTILDIA 382
Cdd:cd00016 214 VKKGGVKHELISQYDIAPTLADLL 237
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
44-397 |
3.62e-10 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 62.36 E-value: 3.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 44 TRRPNVVLLLTDD-QDEVLGGM------TP-LKKtkaLIGEmGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLE 115
Cdd:COG1368 232 AKKPNVVVILLESfSDFFIGALgngkdvTPfLDS---LAKE-SLYFGNFYSQGGRTSRGEFAVLTGLPPLPGGSPYKRPG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 116 GNcsskswqkiqEPNTFPAILRSMcGYQTFFAgkylneYGapdagglehvplGWSYWYALEKNSKY--YNYTLSINGKAR 193
Cdd:COG1368 308 QN----------NFPSLPSILKKQ-GYETSFF------HG------------GDGSFWNRDSFYKNlgFDEFYDREDFDD 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 194 KHGENYSV-DyltDVLANVSLDFLDYKSnfEPFFMMIATPAPHSPWTAAPQYQKafqnvfaprnknfnIHGTNKHWLIRQ 272
Cdd:COG1368 359 PFDGGWGVsD---EDLFDKALEELEKLK--KPFFAFLITLSNHGPYTLPEEDKK--------------IPDYGKTTLNNY 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 273 AKTpmtnssIQFLDNAFRKrwqtllsvddLVEKLVKRleftGELNNTYIFYTSDngyHTGqfslPIDKRQLYEFDI---K 349
Cdd:COG1368 420 LNA------VRYADQALGE----------FIEKLKKS----GWYDNTIFVIYGD---HGP----RSPGKTDYENPLeryR 472
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 4504061 350 VPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLL 397
Cdd:COG1368 473 VPLLIYSPGLKKPKVIDTVGSQIDIAPTLLDLLGIDYPSYYAFGRDLL 520
|
|
| Enpp |
cd16018 |
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
92-383 |
2.32e-05 |
|
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.
Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 46.04 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 92 CPSRASILTGKYPHNHHVVNNTLegncssksWQkiqePNTfpailrsmcgYQTFFAGKYLNE---YGAPdagglehvPLg 168
Cdd:cd16018 47 FPNHYSIVTGLYPESHGIVGNYF--------YD----PKT----------NEEFSDSDWVWDpwwIGGE--------PI- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 169 wsyWYALEKN---------------SKYYNYTLSINGkarkhgeNYSVDYLTDVLANVSLD-FLDYKSNFEPFFMMIATP 232
Cdd:cd16018 96 ---WVTAEKAglktasyfwpgsevaIIGYNPTPIPLG-------GYWQPYNDSFPFEERVDtILEWLDLERPDLILLYFE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 233 AP----HSpwtaapqyqkafqnvFAPRNKNFNihgtnkhwlirqaktpmtnssiqfldnafrkrwQTLLSVDDLVEKLVK 308
Cdd:cd16018 166 EPdsagHK---------------YGPDSPEVN---------------------------------EALKRVDRRLGYLIE 197
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504061 309 RLEFTGELNNTYIFYTSDNGYHT----GQFSlpidkrqlYEFDIKVPLLVRGPGIKPNQTSKMLvANIDLGPTILDIAG 383
Cdd:cd16018 198 ALKERGLLDDTNIIVVSDHGMTDvgthGYDN--------ELPDMRAIFIARGPAFKKGKKLGPF-RNVDIYPLMCNLLG 267
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
84-113 |
2.71e-03 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 40.10 E-value: 2.71e-03
10 20 30
....*....|....*....|....*....|
gi 4504061 84 AYVPSaLCCPSRASILTGKYPHNHHVVNNT 113
Cdd:pfam01663 38 PVFPT-LTFPNHYTLVTGLYPGSHGIVGNT 66
|
|
| ALP_like |
cd16021 |
uncharacterized Alkaline phosphatase subfamily; Alkaline phosphatases are non-specific ... |
283-385 |
4.73e-03 |
|
uncharacterized Alkaline phosphatase subfamily; Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity.
Pssm-ID: 293745 Cd Length: 278 Bit Score: 39.04 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504061 283 QFLdNAFRKR------WQTLLS---------VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQF----------SLP 337
Cdd:cd16021 155 DFI-EAYKDRpkfsffWLSELThdylnglslADEDLLEFLKRLKENGLLDNTFVIFMSDHGLRFGKIretlqgkleeRLP 233
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 4504061 338 IdkrqLYefdIKVP--LLVRGPGIKPN--QTSKMLVANIDLGPTILDIAGYD 385
Cdd:cd16021 234 F----LS---ISLPkwFREKYPEAVANlkKNSNRLTTPFDLHATLLDILNLQ 278
|
|
| |
