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Conserved domains on  [gi|4502679|ref|NP_001771|]
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CD63 antigen isoform A [Homo sapiens]

Protein Classification

CD63 antigen( domain architecture ID 13626528)

CD63 antigen is a tetraspanin family protein that functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades; tetraspanins are transmembrane (TM) glycoproteins with four TM segments that facilitate the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Symbol:  CD63
Gene Ontology:  GO:0005886
PubMed:  15763890|11756464|19709882|18930046
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 105-203 5.44e-64

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


:

Pssm-ID: 239419  Cd Length: 99  Bit Score: 194.23  E-value: 5.44e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEK 184
Cdd:cd03166   1 YVFRDKVMSEFNDSFNQMISNYNKTNDFRKILDRMQKDLKCCGANNYTDWENIPSLDTDSVPDSCCINVTKGCGINFDEK 80

                        90
                ....*....|....*....
gi 4502679  185 AIHKEGCVEKIGGWLRKNV 203
Cdd:cd03166  81 VIHLEGCVTKIEGWLKKNI 99
Tetraspanin pfam00335
Tetraspanin family;
10-229 1.07e-36

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 127.44  E-value: 1.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679     10 VKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIF 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679     90 LSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKN-----NHTASILDRMQADFKCCGaanytdwekipsmsknr 164
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDwldlySCLNSALDSLQSEFGCCG----------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502679    165 vpdsccinvtvgcginfnekaihkeGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVK 229
Cdd:pfam00335 144 -------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 105-203 5.44e-64

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 194.23  E-value: 5.44e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEK 184
Cdd:cd03166   1 YVFRDKVMSEFNDSFNQMISNYNKTNDFRKILDRMQKDLKCCGANNYTDWENIPSLDTDSVPDSCCINVTKGCGINFDEK 80

                        90
                ....*....|....*....
gi 4502679  185 AIHKEGCVEKIGGWLRKNV 203
Cdd:cd03166  81 VIHLEGCVTKIEGWLKKNI 99
Tetraspanin pfam00335
Tetraspanin family;
10-229 1.07e-36

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 127.44  E-value: 1.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679     10 VKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIF 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679     90 LSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKN-----NHTASILDRMQADFKCCGaanytdwekipsmsknr 164
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDwldlySCLNSALDSLQSEFGCCG----------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502679    165 vpdsccinvtvgcginfnekaihkeGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVK 229
Cdd:pfam00335 144 -------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 105-203 5.44e-64

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 194.23  E-value: 5.44e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEK 184
Cdd:cd03166   1 YVFRDKVMSEFNDSFNQMISNYNKTNDFRKILDRMQKDLKCCGANNYTDWENIPSLDTDSVPDSCCINVTKGCGINFDEK 80

                        90
                ....*....|....*....
gi 4502679  185 AIHKEGCVEKIGGWLRKNV 203
Cdd:cd03166  81 VIHLEGCVTKIEGWLKKNI 99
Tetraspanin pfam00335
Tetraspanin family;
10-229 1.07e-36

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 127.44  E-value: 1.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679     10 VKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIF 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679     90 LSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKN-----NHTASILDRMQADFKCCGaanytdwekipsmsknr 164
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDwldlySCLNSALDSLQSEFGCCG----------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502679    165 vpdsccinvtvgcginfnekaihkeGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVK 229
Cdd:pfam00335 144 -------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 105-202 5.13e-24

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 92.04  E-value: 5.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENYPKNNH--TASILDRMQADFKCCGAANYTDWEKIpsMSKNRVPDSCCINVTVGCGINFN 182
Cdd:cd03165   1 FVFREKVDLTAKDDLKEGLELYGTRNNrgLTNAWDITQTEFRCCGVTNYTDWYEV--LGENRVPDSCCQEDSQDCGRNPT 78

                        90       100
                ....*....|....*....|
gi 4502679  183 EkAIHKEGCVEKIGGWLRKN 202
Cdd:cd03165  79 E-LWWKTGCYEKVQQWLVDN 97
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 105-202 4.25e-23

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 89.49  E-value: 4.25e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEkipsMSKNRVPDSCCINVTVGCGINfnek 184
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYVDDDFQEAMDALQSTFECCGVNGPTDYL----DLRLLVPSSCCKGTDGNCGLN---- 72

                        90
                ....*....|....*...
gi 4502679  185 aIHKEGCVEKIGGWLRKN 202
Cdd:cd03127  73 -LYTEGCLEKLVDFLRSN 89
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 105-203 6.38e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 73.55  E-value: 6.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCiNVTVGCGIN---- 180
Cdd:cd03161   1 FVFRHEIKGTFLRTYNEAVSNYNGDDERSDAVDTVQRTLHCCGVENYTDWLNSPYFLEKGIPLSCC-KNRSDCSPQdlkn 79

                        90       100
                ....*....|....*....|....*
gi 4502679  181 --FNEKAIHKEGCVEKIGGWLRKNV 203
Cdd:cd03161  80 ltKAATKVYQQGCFTLVTSFMEANM 104
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 105-202 1.78e-16

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 72.77  E-value: 1.78e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQM-ENY--PKNNHTASILDRMQADFKCCGAANYTDWEK---IPSMSKN--RVPDSCCINVTVG 176
Cdd:cd03155   1 YTYYQQLEDELKESLKRTMqENYgqSGEEALTLTVDELQQEFKCCGSNNYTDWQDsewINSNEANgrLVPDSCCKTVVDR 80

                        90       100
                ....*....|....*....|....*....
gi 4502679  177 CGI-NFNEKAIHK--EGCVEKIGGWLRKN 202
Cdd:cd03155  81 CGClRDHPSNIYKveGGCIPKLEDFLYDH 109
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 104-195 1.06e-14

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 67.83  E-value: 1.06e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  104 GYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIP---SMSKNRVPDSCCINVTVGCGIN 180
Cdd:cd03163   1 GYVYRAKVEDELNPSIDKVFNKYNGTNAESRAVDYLQRQLQCCGIHNYTDWENTPwfkESKNNSVPLSCCKETFTSCTGS 80

                        90
                ....*....|....*.
gi 4502679  181 FNE-KAIHKEGCVEKI 195
Cdd:cd03163  81 LTQpKDLYQEGCEAKL 96
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 106-202 1.39e-13

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 65.02  E-value: 1.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  106 VFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEK-------IPSMSKNRVPDSCCINVTVG-- 176
Cdd:cd03158   2 IFSNQTIDLLEENIRKAIVHYYDDLDLQNIIDFVQKEFKCCGGDDYRDWSKnmyfncsSPNPEACGVPYSCCIRAKDQev 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4502679  177 ----CGINFNE-------KAIHKEGCVEKIGGWLRKN 202
Cdd:cd03158  82 intmCGYGVQNlerleasKLIYTRGCIDAVVLWIEDN 118
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 106-202 6.94e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 60.62  E-value: 6.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  106 VFRDKVMSEFNNNFRQQMENYPKNNHTASIL-DRMQADFKCCGAANYTDWEKIPSM------SKNRVPDSCCI------N 172
Cdd:cd03156   4 FFKKDLEDSFKNLLKNNYGNYNSTGDAITSTwNRVMIELKCCGVNGPTDFVDSTSFfrqknePNSPYPESCCKrnsnsqI 83

                        90       100       110
                ....*....|....*....|....*....|
gi 4502679  173 VTVGCGINFNEKAIHKEGCVEKIGGWLRKN 202
Cdd:cd03156  84 VDLDCPKLGSPNSYNKKGCYEKLSNPIERY 113
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 105-203 3.75e-11

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 58.55  E-value: 3.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENY---PKNNHTASILDRMQADFKCCGAANYTDWEKiPSMSKNR----VPDSCCINVTVG- 176
Cdd:cd03160   2 YFQRDKLKQEMGDIVEKVIQNYggnPENKTAEEAWDYVQFQLQCCGWTGPQDWTD-NSLIKNSseplYPCSCCNSSATAd 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4502679  177 --------C-GINFNEKAIHKEGCVEKIGGWLRKNV 203
Cdd:cd03160  81 sprpskgfCeAPASLDWPVYQEGCMEKLQSWLNENL 116
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 135-202 1.30e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 54.39  E-value: 1.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  135 ILDRMQADFKCCGAANYTDWEK-------IPSMSKNRVPDSCCIN-------VTVGCGI-------NFNEKAIHKEGCVE 193
Cdd:cd03167  31 LIDQVQLGLQCCGASSYQDWQQnlyfncsSPGVQACSLPASCCIDpredgavVNDQCGFgalgldeDAAQRVVHLGGCGP 110


                ....*....
gi 4502679  194 KIGGWLRKN 202
Cdd:cd03167 111 PLRRWLRGN 119
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 105-204 1.37e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 53.25  E-value: 1.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPsmsknrvPDSCCINVTvgcginfnek 184
Cdd:cd03164   1 FVYEKKLNNYVKEGLTDSLEQYHKDNNTSEAWDMIQSNLQCCGINGTTDWGSGV-------PSSCCSSDT---------- 63

                        90       100
                ....*....|....*....|
gi 4502679  185 AIHKEGCVEKIGGWLRKNVL 204
Cdd:cd03164  64 EYKVEGCYKKLKNWFESNFL 83
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 136-203 1.92e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 50.50  E-value: 1.92e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  136 LDRMQADFKCCGAANYTDWEkipsmsKNRVPDSCCINVTVGC--GINFNEKAIHKEGCVEKIGGWLRKNV 203
Cdd:cd03154  37 LEKFQKELKCCGLVNGADDW------GNDIPASCNCTTTQSDcvVAYYGGSNVYKEPCISKIKDFLKKNL 100
TM4SF12_like_LEL cd03157
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. ...
 140-200 5.52e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human transmembrane 4 superfamily member 12 (TM4SF12).


Pssm-ID: 239410  Cd Length: 103  Bit Score: 49.54  E-value: 5.52e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502679  140 QADFKCCGAANYTDWEKIPSMskNRVPDSCCINVTVGCGINFNEK---AIHKEGCVEKIGGWLR 200
Cdd:cd03157  39 QTEFKCCGVIYFTDWLEMTEM--EWPPDSCCSNQYPGCARQAHYNdlsDLYQEGCGPKIYSFIR 100
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 107-202 1.42e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 43.18  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  107 FRDKVMSEFNNNFRQQMENYPKNNhtasILDRMQADFKCCGAANYTDW---------EKIPSMSKNRVPDSCCIN----- 172
Cdd:cd03159   7 IKDQLTEFLNNNIRAYRDDIDLQN----LIDFLQEYWQCCGARGPDDWnlniyfnctDSNPSRERCGVPFSCCVKdpaed 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 4502679  173 -VTVGCGINFNEKA-------IHKEGCVEKIGGWLRKN 202
Cdd:cd03159  83 vVNTQCGYDVRKKPelelqhhIHTKGCVQAFEKWLQDN 120
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 105-170 4.05e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 36.64  E-value: 4.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502679  105 YVFRDKVMSEFNNNFRQQMENYPKNNHTASI-----LDRMQADFKCCGAANYTDWEKIPSMSK----------------- 162
Cdd:cd03162   1 FIMRGSLEESLKTGLKNAMKFYKDTDTPGRCflkktIDMLQIEFQCCGNNGYRDWFEIQWISNryldfsskevkdriksn 80

                        90
                ....*....|....*
gi 4502679  163 -------NRVPDSCC 170
Cdd:cd03162  81 vdgryltDGVPFSCC 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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