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Conserved domains on  [gi|4502199|ref|NP_001648|]
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amphiregulin preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02887 super family cl31518
EGF-like protein; Provisional
 146-186 1.35e-07

EGF-like protein; Provisional


The actual alignment was detected with superfamily member PHA02887:

Pssm-ID: 165214  Cd Length: 126  Bit Score: 49.16  E-value: 1.35e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 4502199   146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSM 186
Cdd:PHA02887  86 CKNDFNDFCINGECMNIIDLDEKFCICNKGYTGIRCDEVSI 126
DivIC super family cl11433
Septum formation initiator; DivIC from B. subtilis is necessary for both vegetative and ...
 210-247 7.76e-03

Septum formation initiator; DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.


The actual alignment was detected with superfamily member pfam04999:

Pssm-ID: 448252  Cd Length: 97  Bit Score: 34.92  E-value: 7.76e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502199    210 AVILTAVAVITVQ-LRRQYVRKYEGEAEERKKLRQENGN 247
Cdd:pfam04999  22 LILLSAVGVVYIThQTRQLTAELDKLLLERDRLDIEWRN 60
 
Name Accession Description Interval E-value
PHA02887 PHA02887
EGF-like protein; Provisional
 146-186 1.35e-07

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 49.16  E-value: 1.35e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 4502199   146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSM 186
Cdd:PHA02887  86 CKNDFNDFCINGECMNIIDLDEKFCICNKGYTGIRCDEVSI 126
FtsL pfam04999
Cell division protein FtsL; In Escherichia coli, nine gene products are known to be essential ...
 210-247 7.76e-03

Cell division protein FtsL; In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood. It has been proposed that FtsL interacts with the DivIC protein pfam04977, however this interaction may be indirect.


Pssm-ID: 428249  Cd Length: 97  Bit Score: 34.92  E-value: 7.76e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502199    210 AVILTAVAVITVQ-LRRQYVRKYEGEAEERKKLRQENGN 247
Cdd:pfam04999  22 LILLSAVGVVYIThQTRQLTAELDKLLLERDRLDIEWRN 60
 
Name Accession Description Interval E-value
PHA02887 PHA02887
EGF-like protein; Provisional
 146-186 1.35e-07

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 49.16  E-value: 1.35e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 4502199   146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSM 186
Cdd:PHA02887  86 CKNDFNDFCINGECMNIIDLDEKFCICNKGYTGIRCDEVSI 126
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 146-181 4.73e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 36.54  E-value: 4.73e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4502199   146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERC 181
Cdd:PHA03099  45 CGPEGDGYCLHGDCIHARDIDGMYCRCSHGYTGIRC 80
FtsL pfam04999
Cell division protein FtsL; In Escherichia coli, nine gene products are known to be essential ...
 210-247 7.76e-03

Cell division protein FtsL; In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood. It has been proposed that FtsL interacts with the DivIC protein pfam04977, however this interaction may be indirect.


Pssm-ID: 428249  Cd Length: 97  Bit Score: 34.92  E-value: 7.76e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502199    210 AVILTAVAVITVQ-LRRQYVRKYEGEAEERKKLRQENGN 247
Cdd:pfam04999  22 LILLSAVGVVYIThQTRQLTAELDKLLLERDRLDIEWRN 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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