NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|449455728|ref|XP_004145603|]
View 

protein PLASTID MOVEMENT IMPAIRED 1 [Cucumis sativus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NT-C2 super family cl11025
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 132-283 3.02e-09

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


The actual alignment was detected with superfamily member pfam10358:

Pssm-ID: 463058  Cd Length: 143  Bit Score: 56.17  E-value: 3.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449455728  132 GMQKMSCLFSVEVVTVQGLPASmnGLRLSVCVRKKETKDGAVNTMPSRVSQGAADFEETLFLKCHVYctpGNGKPMKFEP 211
Cdd:pfam10358   1 KKRKPKFQFVLTIHELQNLPLV--GGELFVKWRRGDKKGSSGTTEKALVNNGRAIFNEEFSIPVTLF---LDKKGGKYEE 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449455728  212 RP--FWIYAFAVDAQELDFGRSPVDLSKLIEESIEKSYEgtrirqwdfSFNLAGKAKAG-ELVVKLGFQIMEKDG 283
Cdd:pfam10358  76 KLleFSVYKVTKKGKKKVLGKASIDLAEYANLKKKPTTV---------RFLLKKSSKKNaTLSLSIQVLPLGEDP 141
 
Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 132-283 3.02e-09

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


Pssm-ID: 463058  Cd Length: 143  Bit Score: 56.17  E-value: 3.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449455728  132 GMQKMSCLFSVEVVTVQGLPASmnGLRLSVCVRKKETKDGAVNTMPSRVSQGAADFEETLFLKCHVYctpGNGKPMKFEP 211
Cdd:pfam10358   1 KKRKPKFQFVLTIHELQNLPLV--GGELFVKWRRGDKKGSSGTTEKALVNNGRAIFNEEFSIPVTLF---LDKKGGKYEE 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449455728  212 RP--FWIYAFAVDAQELDFGRSPVDLSKLIEESIEKSYEgtrirqwdfSFNLAGKAKAG-ELVVKLGFQIMEKDG 283
Cdd:pfam10358  76 KLleFSVYKVTKKGKKKVLGKASIDLAEYANLKKKPTTV---------RFLLKKSSKKNaTLSLSIQVLPLGEDP 141
 
Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 132-283 3.02e-09

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


Pssm-ID: 463058  Cd Length: 143  Bit Score: 56.17  E-value: 3.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449455728  132 GMQKMSCLFSVEVVTVQGLPASmnGLRLSVCVRKKETKDGAVNTMPSRVSQGAADFEETLFLKCHVYctpGNGKPMKFEP 211
Cdd:pfam10358   1 KKRKPKFQFVLTIHELQNLPLV--GGELFVKWRRGDKKGSSGTTEKALVNNGRAIFNEEFSIPVTLF---LDKKGGKYEE 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449455728  212 RP--FWIYAFAVDAQELDFGRSPVDLSKLIEESIEKSYEgtrirqwdfSFNLAGKAKAG-ELVVKLGFQIMEKDG 283
Cdd:pfam10358  76 KLleFSVYKVTKKGKKKVLGKASIDLAEYANLKKKPTTV---------RFLLKKSSKKNaTLSLSIQVLPLGEDP 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH