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Conserved domains on  [gi|449439539|ref|XP_004137543|]
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transcription factor MYB62 [Cucumis sativus]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 1000535)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein may be involved in the regulation of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03212 super family cl31985
Transcription repressor MYB5; Provisional
 32-136 5.89e-41

Transcription repressor MYB5; Provisional


The actual alignment was detected with superfamily member PLN03212:

Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 141.75  E-value: 5.89e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449439539  32 AVRRGPWSVDEDSLLIHSISVHGEGRWNLLAIRSGLRRTGKSCRLRWLNYLKPEVKRGNLSPQEQLLILDLHSRWGNRWS 111
Cdd:PLN03212  22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWS 101

                         90       100
                 ....*....|....*....|....*
gi 449439539 112 KIAQQLPGRTDNEIKNYWRTKVQKQ 136
Cdd:PLN03212 102 LIAGRIPGRTDNEIKNYWNTHLRKK 126
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 32-136 5.89e-41

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 141.75  E-value: 5.89e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449439539  32 AVRRGPWSVDEDSLLIHSISVHGEGRWNLLAIRSGLRRTGKSCRLRWLNYLKPEVKRGNLSPQEQLLILDLHSRWGNRWS 111
Cdd:PLN03212  22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWS 101

                         90       100
                 ....*....|....*....|....*
gi 449439539 112 KIAQQLPGRTDNEIKNYWRTKVQKQ 136
Cdd:PLN03212 102 LIAGRIPGRTDNEIKNYWNTHLRKK 126
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 88-131 6.97e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 64.45  E-value: 6.97e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449439539   88 RGNLSPQEQLLILDLHSRWGNRWSKIAQQLPGRTDNEIKNYWRT 131
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 36-129 1.27e-10

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 61.34  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449439539  36 GPWSVDEDSLLIHSISVHGEGRWNLLAIRSGlRRTGKSCRLRWLNYLKPEVKRGNLSPQEQLLILDLHSRWGNRWSKIAQ 115
Cdd:COG5147   21 GSWKRTEDEDLKALVKKLGPNNWSKVASLLI-SSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTIAD 99

                         90
                 ....*....|....
gi 449439539 116 QLPGRTDNEIKNYW 129
Cdd:COG5147  100 YKDRRTAQQCVERY 113
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
35-84 5.76e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.77  E-value: 5.76e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 449439539    35 RGPWSVDEDSLLIHSISVHGEGRWNLLAIRSGlRRTGKSCRLRWLNYLKP 84
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 92-131 4.11e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 51.42  E-value: 4.11e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 449439539  92 SPQEQLLILDLHSRWG-NRWSKIAQQLPGRTDNEIKNYWRT 131
Cdd:cd00167    3 TEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 32-136 5.89e-41

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 141.75  E-value: 5.89e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449439539  32 AVRRGPWSVDEDSLLIHSISVHGEGRWNLLAIRSGLRRTGKSCRLRWLNYLKPEVKRGNLSPQEQLLILDLHSRWGNRWS 111
Cdd:PLN03212  22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWS 101

                         90       100
                 ....*....|....*....|....*
gi 449439539 112 KIAQQLPGRTDNEIKNYWRTKVQKQ 136
Cdd:PLN03212 102 LIAGRIPGRTDNEIKNYWNTHLRKK 126
PLN03091 PLN03091
hypothetical protein; Provisional
 31-146 1.24e-39

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 143.19  E-value: 1.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449439539  31 EAVRRGPWSVDEDSLLIHSISVHGEGRWNLLAIRSGLRRTGKSCRLRWLNYLKPEVKRGNLSPQEQLLILDLHSRWGNRW 110
Cdd:PLN03091  10 QKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 449439539 111 SKIAQQLPGRTDNEIKNYWRTKVQKQAKILNISTNS 146
Cdd:PLN03091  90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNT 125
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 88-131 6.97e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 64.45  E-value: 6.97e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449439539   88 RGNLSPQEQLLILDLHSRWGNRWSKIAQQLPGRTDNEIKNYWRT 131
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 36-129 1.27e-10

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 61.34  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449439539  36 GPWSVDEDSLLIHSISVHGEGRWNLLAIRSGlRRTGKSCRLRWLNYLKPEVKRGNLSPQEQLLILDLHSRWGNRWSKIAQ 115
Cdd:COG5147   21 GSWKRTEDEDLKALVKKLGPNNWSKVASLLI-SSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTIAD 99

                         90
                 ....*....|....
gi 449439539 116 QLPGRTDNEIKNYW 129
Cdd:COG5147  100 YKDRRTAQQCVERY 113
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
35-84 5.76e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.77  E-value: 5.76e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 449439539    35 RGPWSVDEDSLLIHSISVHGEGRWNLLAIRSGlRRTGKSCRLRWLNYLKP 84
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 92-131 4.11e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 51.42  E-value: 4.11e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 449439539  92 SPQEQLLILDLHSRWG-NRWSKIAQQLPGRTDNEIKNYWRT 131
Cdd:cd00167    3 TEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 35-82 4.42e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.35  E-value: 4.42e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 449439539   35 RGPWSVDEDSLLIHSISVHGeGRWNLLAIRSGlRRTGKSCRLRWLNYL 82
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLP-GRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 37-82 5.02e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 51.04  E-value: 5.02e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 449439539  37 PWSVDEDSLLIHSISVHGEGRWNLLAIRSGlRRTGKSCRLRWLNYL 82
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
88-135 1.14e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 50.30  E-value: 1.14e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 449439539    88 RGNLSPQEQLLILDLHSRWG-NRWSKIAQQLPGRTDNEIKNYWRTKVQK 135
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 38-95 2.74e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 43.84  E-value: 2.74e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 449439539   38 WSVDEDSLLIHSISVHGeGRWNLLAIRSGlRRTGKSCRLRWLNYLKPEVKRGNLSPQE 95
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEE 56
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 92-132 1.22e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 39.22  E-value: 1.22e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 449439539   92 SPQEQLLILDLHSRWGNRWSKIAQQLPGRTDNEIKNYWRTK 132
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRK 42
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 37-83 2.19e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 38.32  E-value: 2.19e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 449439539  37 PWSVDEDSLLIHSISVHGEGRWN--LLAIRSGLRRTGKSCRLRWLNYLK 83
Cdd:cd11660    2 KWTDEEDEALVEGVEKYGVGNWAkiLKDYFFVNNRTSVDLKDKWRNLKK 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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