|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
5-421 |
9.18e-75 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 239.72 E-value: 9.18e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 85 SQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVN 164
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 165 FLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILA-------KYLPIKKIIKRMTWKISAQIWNLALPSAGERL 233
Cdd:cd13137 161 VLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLLflllrgrLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 234 MMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILIS 313
Cdd:cd13137 241 LRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 314 SFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGILF 393
Cdd:cd13137 321 LLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVL 400
|
410 420
....*....|....*....|....*...
gi 447193458 394 ELGLLGVWMATIADNIFRWLFLKVHYHR 421
Cdd:cd13137 401 GLGLTGIWLAMFVDTIVRAILLLYRFRK 428
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-421 |
1.21e-73 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 237.01 E-value: 1.21e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 4 SKEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISV 83
Cdd:cd13134 2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFV 163
Cdd:cd13134 82 AGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 164 NFLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILAKYLPIKKIIK-------RMTWKISAQIWNLALPSAGER 232
Cdd:cd13134 162 NILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRfrlkdlrPFPKKLLKKILKIGLPSAGEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 233 LMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILI 312
Cdd:cd13134 242 LSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 313 SSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGIL 392
Cdd:cd13134 322 ALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLGIV 401
|
410 420
....*....|....*....|....*....
gi 447193458 393 FELGLLGVWMATIADNIFRWLFLKVHYHR 421
Cdd:cd13134 402 LGLGLLGVWIAFAADEWVRGIIMLWRWRS 430
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
5-415 |
5.84e-71 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 229.65 E-value: 5.84e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 85 SQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVN 164
Cdd:COG0534 88 GQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 165 FLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGICILAKYL-------PIKKIIKRMTWKISAQIWNLALPSAGERLMMRA 237
Cdd:COG0534 168 VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLfrkrsllRLRLRDLRPDRKILKRILRIGLPAGLQQLAESL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 238 GDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSFML 317
Cdd:COG0534 248 GFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLF 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 318 LAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGILFeLGL 397
Cdd:COG0534 328 LFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLG-LGL 406
|
410
....*....|....*...
gi 447193458 398 LGVWMATIADNIFRWLFL 415
Cdd:COG0534 407 TGVWLALPIGEVLRALLL 424
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
5-425 |
4.52e-47 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 166.87 E-value: 4.52e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLG-VVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISV 83
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLgVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFV 163
Cdd:cd13138 83 VGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 164 NFLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGICILAKYLPIKKIIK-------RMTWKISAQIWNLALPSAGERLMMR 236
Cdd:cd13138 163 CVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFklslkdfRFDKEILKEILKIGLPSALQQSLVS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 237 AGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSFM 316
Cdd:cd13138 243 ISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 317 LLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGILFELG 396
Cdd:cd13138 323 FFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGLG 402
|
410 420
....*....|....*....|....*....
gi 447193458 397 LLGVWMATIADNIFRWLFLKVHYHRYIQK 425
Cdd:cd13138 403 LFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-409 |
2.02e-45 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 162.75 E-value: 2.02e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 10 LAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVCSQAIF 89
Cdd:cd13142 16 LAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 90 LTLLIGAILGIISIVF-GQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVNFLNA 168
Cdd:cd13142 96 FVIILSLILAVLGYILsRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFGSVLLNV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 169 VLSGFAIFEW----RYGLVGVAVSTLIAR----LIGICILAKYLPIKKIIKRMT---WKISAQIWNLALPSAGERLMMRA 237
Cdd:cd13142 176 ILDPLLIFGIgpfpGLGVAGAALATVISRgiaaVIGLYLLFKGRVGLKISLRDLkpdWEWLKKIFRIGLPSSIEQSARAL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 238 GDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSFML 317
Cdd:cd13142 256 GFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAF 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 318 LAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGILFELGL 397
Cdd:cd13142 336 LFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGV 415
|
410
....*....|..
gi 447193458 398 LGVWMATIADNI 409
Cdd:cd13142 416 TGIWIAMAISNI 427
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-403 |
5.15e-43 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 156.62 E-value: 5.15e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 7 IIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVCSQ 86
Cdd:cd13139 16 IFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 87 AIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVNFL 166
Cdd:cd13139 96 AILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 167 NAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILAKYL-PIKKIIK------RMTWKISAQIWNLALPSAGERLMM 235
Cdd:cd13139 176 NIILDPLFIFGLgpipAMGVTGAAIATTIGRSIGVLYQLYHLfKGKGRIQirrrhlKLDWAIIKKIIKIAVGGILQFLIA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 236 RAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSF 315
Cdd:cd13139 256 SSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLV 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 316 MLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGILFEL 395
Cdd:cd13139 336 FFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNL 415
|
....*...
gi 447193458 396 GLLGVWMA 403
Cdd:cd13139 416 GPKGVFIA 423
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
11-415 |
4.66e-37 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 139.77 E-value: 4.66e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 11 AIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVCSQAIFL 90
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 91 TLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVNFLNAVL 170
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 171 SGFAIFEW---RYGLVGVAVSTLIARLIGICILAKYLPIKKII-------KRMTWKISAQIWNLALPSAGERLMMRAGDV 240
Cdd:cd12082 161 DPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKIlkfklslLKPDLELLRRLLRIGLPSAIQNSLLSLGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 241 VIVAIVVQL-GTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSFMLLA 319
Cdd:cd12082 241 IIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 320 GKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGILFeLGLLG 399
Cdd:cd12082 321 PEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG-LGLYG 399
|
410
....*....|....*.
gi 447193458 400 VWMATIADNIFRWLFL 415
Cdd:cd12082 400 IWLALVISLILAALVL 415
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
7-403 |
3.32e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 129.17 E-value: 3.32e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 7 IIQLAIPAMIENILQMLMGVVDNYLVAQLG-VVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVCS 85
Cdd:cd13143 6 FLKFALPAIIGMLVNGLYNIVDGIFVGHGVgALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 86 QAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVNF 165
Cdd:cd13143 86 TALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 166 LNAVLSGFAIFEWRYGLVGVAVSTLIARLIGICILAKY-------LPIKKIIKRMTWKISAQIWNLALPSAGERLMMRAG 238
Cdd:cd13143 166 LNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYffrgkslLKLSLLRFKLSLKIIKEILALGFPSFLMQLSSSVV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 239 DVVIVAIVVQLGTNV-VAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSFML 317
Cdd:cd13143 246 TIVLNLTLLGYGGDIgVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 318 LAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGILFelGL 397
Cdd:cd13143 326 LFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRLF--GL 403
|
....*.
gi 447193458 398 LGVWMA 403
Cdd:cd13143 404 DGIWLA 409
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
5-406 |
9.17e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 128.00 E-value: 9.17e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:cd13131 3 RALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 85 SQAIFLTLLIGAILGIIsIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVN 164
Cdd:cd13131 83 RQGLWLALLLSLPLMLL-LWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 165 FLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILAKYL---------PIKKIIKRMTWKISAQIWNLALPSAGE 231
Cdd:cd13131 162 VLNIPLNYVLIFGKfglpALGGAGAGLATAIVYWLMFLALAFYIrrhkrfrryRLFARFWRPDWARLKELLRLGLPIGLT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 232 rLMMRAGDVVIVAIVV-QLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMI 310
Cdd:cd13131 242 -IFFEVSLFAAVALLMgRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 311 LISSFMLLAGKPLTQLFTNNPSAIK--GSLIVILLSF-----VGVPAtigtlvyTAAWQGLGNAKLPFYTTTIGMWLIRV 383
Cdd:cd13131 321 LTALLLLLFPEQIAGLYTNDPAVIAlaASLLVFAALFqlfdgIQVVA-------AGALRGYKDTRVPFLLALISYWGIGL 393
|
410 420
....*....|....*....|...
gi 447193458 384 VLGYLLGILFELGLLGVWMATIA 406
Cdd:cd13131 394 PLGYLLAFTTGLGAFGVWIGLII 416
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-403 |
1.69e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 127.64 E-value: 1.69e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKsLAGSEKDDAIS-V 83
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQ-YNGAGRYSRIGrV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFV 163
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 164 NFLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILAKYLPIKKIIKRM--------TWKISAQIWNLALPSAGE 231
Cdd:cd13133 164 VVVNIVLDYALIFGKlgfpAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFglrrawrfDRELLRRILRLGLPSGLQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 232 RLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMIL 311
Cdd:cd13133 244 FFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 312 ISSFMLLAGKPLTQLFTNNPS----AIKGSLIVILLSFVGVPATIGtLVYTAAWQGLGNAKLPFYTTTIGMWLIrVVLGY 387
Cdd:cd13133 324 LGILFLLFPELLLSIFTPGADfaliAELAVPLLRFVAAYILFDALA-LVFAGALRGAGDTRFVMLAELIVAWLY-LLPPA 401
|
410
....*....|....*.
gi 447193458 388 LLGILFELGLLGVWMA 403
Cdd:cd13133 402 YLLVVLGAGLAGAWTV 417
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
13-347 |
4.69e-32 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 124.28 E-value: 4.69e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 13 PAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVCSQAIFLTL 92
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 93 LIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVNFLNAVLSG 172
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 173 FAIFEW--RYGLVGVAVSTLIARLIGICILAKYLPIKK-------IIKRMTWKISAQIWNLALPSAGERLMMRAGDVVIV 243
Cdd:TIGR00797 161 ILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKkiglkweGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 244 AIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSFMLLAGKPL 323
Cdd:TIGR00797 241 LLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREFI 320
|
330 340
....*....|....*....|....
gi 447193458 324 TQLFTNNPSAIkgSLIVILLSFVG 347
Cdd:TIGR00797 321 ARLFTNDPEVL--ELAAIYLIFVA 342
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
5-411 |
2.07e-30 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 122.15 E-value: 2.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:PRK10189 29 REITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 85 SQAIFLTLLIGAILGIISIVFGQTFFKLLG--TTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIF 162
Cdd:PRK10189 109 RQSLVIMTLFAVLLAVLIHFFGEQIIDLVAgdATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 163 VNFLNAVLSGFAI---FEWR-YGLVGVAVSTLIARLIG-ICIL---------AKYLPIKKIIKRMTWKISAQIWNLALPS 228
Cdd:PRK10189 189 MNILNIIISSILIyglFSWQgLGFVGAGLGLTISRYIGaVAIIwvlmigfnpALRISLKSYFKPLNFAIIWEVMGIGIPA 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 229 AGERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVL 308
Cdd:PRK10189 269 SIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRHVFWLSTLG 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 309 MILISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYL 388
Cdd:PRK10189 349 LTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYAMWVSMLGMWGCRVVAGYI 428
|
410 420
....*....|....*....|...
gi 447193458 389 LGILFELGLLGVWMATIADNIFR 411
Cdd:PRK10189 429 LGIMLGFGVVGVWMGMFLDWAVR 451
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
5-421 |
4.06e-29 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 117.66 E-value: 4.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNII--TVYqAIFIALGASIASLLAKSLAGSEKDDAIS 82
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIfnTLF-WLFGFLRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 83 VCSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVG-GGVVTLGMLTTLGSFLRVQgQPRLPMYVSI 161
Cdd:cd13136 82 LLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRIlGAPAVLLNYVATGWFRGLQ-DTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 162 FVNFLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGiCILAKYLpIKKIIKRMTWKISAQIWNLA----LPSAGERLMMRA 237
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLG-ALLGLWL-LRRRVRLLGKSLSRRLPSKAalkrLFKLNRDIFIRT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 238 GDVVIV-----AIVVQLGTNVVAGNAIgetLTQFNYMPGL---GIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLM 309
Cdd:cd13136 239 LALLAAflfftALAARLGDVILAANQI---LLQFWLLSSYfldGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 310 ILISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKlpfyttTIGMWLIRVVLGYLL 389
Cdd:cd13136 316 VLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTR------YLRNSMLVSLAVFLP 389
|
410 420 430
....*....|....*....|....*....|....*
gi 447193458 390 GILF---ELGLLGVWMATIADNIFRWLFLKVHYHR 421
Cdd:cd13136 390 LLFLlvpLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-403 |
1.40e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 116.56 E-value: 1.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 1 MRYSKEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDA 80
Cdd:cd13144 4 GPVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 81 ISVCSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVS 160
Cdd:cd13144 84 NKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 161 IFVNFLNAVLSGFAIFEW----RYGLVGVAVSTLIARLI-GICILAKYLPIKKIIK------RMTWKISAQIWNLALPSA 229
Cdd:cd13144 164 LIGAIINIILDPILIFGLfgfpAMGIAGAAIATVIGQILaMFLAFFFLLRKNKDVQpdlrlfRPSLRIIKEIYAVGLPSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 230 GERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLM 309
Cdd:cd13144 244 IMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 310 ILISSFMLLAGKPLTQLFTNNPSAI---KGSLIVILLSFVGVPATIgtlVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLG 386
Cdd:cd13144 324 LAGGLLFQLFPDQLLGLFNASEEMLaigVPALRIISLSFLFAALSI---ILSGLFQALGRGVYSLIISVARQLVVLLPLA 400
|
410
....*....|....*..
gi 447193458 387 YLLGILFelGLLGVWMA 403
Cdd:cd13144 401 WLLAKMF--GLNGVWWS 415
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-415 |
3.78e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 115.39 E-value: 3.78e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 4 SKEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISV 83
Cdd:cd13145 8 PKLIRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFV 163
Cdd:cd13145 88 AAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 164 NFLNAVLSGFAIFEWRY----GLVGVAVSTLIARLIGICILAKYLPIKKIIKRMTWK-------ISAQIWNLALPSAGER 232
Cdd:cd13145 168 FFLNIILDPLFIFGGGGipamGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRdfiprldVYKEILKQGFPASLNM 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 233 LMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILI 312
Cdd:cd13145 248 MTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 313 SSFMLLAGKPLTQLFTNNPSAIK-GSLIVILLSFVGvPATIGTLVYTAAWQGLgnaKLPFYTTTIGmwLIRVVLG----- 386
Cdd:cd13145 328 TVFLLFFAEPLMSLFTNDPAVIAiGAGYLRIDALIF-YAYVVLFISVSVLQGL---KRPIFALWIG--LYRQLVGpalvf 401
|
410 420
....*....|....*....|....*....
gi 447193458 387 YLLGILFELGLLGVWMATIADNIFRWLFL 415
Cdd:cd13145 402 WLLVNVLGLGVTGIWWGIFTIVWSAAIIA 430
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-425 |
7.22e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 114.54 E-value: 7.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 4 SKEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISV 83
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKS-VAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIF 162
Cdd:cd13140 84 ARNALQLNLLLGILYGLLLLLFAKPLIGFFNLGDAeVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 163 VNFLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILAKYLPIKK-------IIKRMTWKISAQIWNLALPSAGE 231
Cdd:cd13140 164 GLVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKKKKglflkirILKRPDRKYIKEILKLGLPVALQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 232 RLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMIL 311
Cdd:cd13140 244 SILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 312 ISSFMLLAGKPLTQLFTNNPSAIK-GSLIVILLSFVGVPATIgTLVYTAAWQGLGNAKLPFyTTTIGMWLIRVVLGYLLG 390
Cdd:cd13140 324 ATLLLFFFGEPLFSLFIPDPETIAiGVDYLRILGFSQLFMCL-EITTTGAFNGLGRTKPPA-IISIVFNGLRIPLALLLS 401
|
410 420 430
....*....|....*....|....*....|....*
gi 447193458 391 IlFELGLLGVWMATIADNIFRWLFLKVHYHRYIQK 425
Cdd:cd13140 402 P-TGLGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-388 |
1.84e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 113.57 E-value: 1.84e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:cd13141 11 KHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 85 SQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVN 164
Cdd:cd13141 91 NQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 165 FLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILA-------KYLPIKKIIKRMTWKISAQIWNLALPSAGERL 233
Cdd:cd13141 171 LLNIILAPILITGWgtgrALGVAGAGLASSISVAIAVVLLLyyflrleKYLRLDLALWRPDLPTWKRLLKIGLPSGGEFL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 234 MMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILIS 313
Cdd:cd13141 251 LTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTALMLVLT 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447193458 314 SFMLLAGKPLTQLFTNNPSAIKGSliVILLSFVGVPATIGTLVYTAA--WQGLGNAKLPFYTTTIGMWLIRVVLGYL 388
Cdd:cd13141 331 LLCQLVPELLVTPFSDDAAVIAVA--ATFLRYVSWNFVAAGLVFTCSgmFQALGNTWPSLLSSASRLLTFALPVIWL 405
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
5-409 |
9.05e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 111.48 E-value: 9.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 85 SQAIFLTLLIGAILGIISIVFGQTFFKLLGTtKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVN 164
Cdd:cd13147 89 VHSILLGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 165 FLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGICILA--------KYLPIKKIIKRMTWKISAQIWNLALPSAGERLMMR 236
Cdd:cd13147 168 ILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLywffvkkdTYVSLSLKNFKFDKKIVKDILKVGIPASLEQLIMS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 237 AGDVVIVAIVVQL-GTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSF 315
Cdd:cd13147 248 VLMIILNLILVIVaGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAIL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 316 MLLAGKPLTQLFTNNPSA------IKGSLIVILLSFVGVPATIGTlvyTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLL 389
Cdd:cd13147 328 IFIFAPQIAYLFTYSEESahlapeIVAFLRIMCLFLPFVPFGMMS---SSMFQGIGKGLTSLIITILRELIFQVLFAYLF 404
|
410 420
....*....|....*....|
gi 447193458 390 GILFELGLLGVWMATIADNI 409
Cdd:cd13147 405 AIVLGLGLFGVWWGIVLGNA 424
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-421 |
1.02e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 111.23 E-value: 1.02e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 85 SQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVN 164
Cdd:cd13135 81 ISSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 165 FLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILAKYLPIKKIIK---RMTWKISAQIWN------LALPSAGE 231
Cdd:cd13135 161 LLNVILDYVLIFGNfgfpRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTfklSNTKVLKANIRPykftikLGLPLGGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 232 RLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMIL 311
Cdd:cd13135 241 EFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 312 ISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMwLIRVVLGYLLGI 391
Cdd:cd13135 321 AAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGT-IIVVSVALLLIF 399
|
410 420 430
....*....|....*....|....*....|
gi 447193458 392 LFELGLLGVWMATIADNIFRWLFLKVHYHR 421
Cdd:cd13135 400 VFKLGLAGVYITLFIDEIIRAIINFLKYRK 429
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-410 |
3.56e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 95.16 E-value: 3.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 7 IIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQaIFIALGASI----ASLLAKSLAGSEKDDAIS 82
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVGGIGLVFPLGM-IFLALGNGIqvgvSSLLARAIGAQRAKELDQ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 83 VCSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIF 162
Cdd:cd13146 89 AADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 163 VNFLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGIC-------ILAKYLPIKKIIKRMTWKISAQIWNLALPSAGERLMM 235
Cdd:cd13146 169 GTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLyllyvflIGKSNVTIHIKLSNISSSVIVEILRVGLPQMLLQLIS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 236 RAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSF 315
Cdd:cd13146 249 SISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 316 MLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGILFEL 395
Cdd:cd13146 329 YVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGK 408
|
410
....*....|....*
gi 447193458 396 GLLGVWMATIADNIF 410
Cdd:cd13146 409 GITGVYFGIVSANFF 423
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-409 |
9.15e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 93.91 E-value: 9.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 4 SKEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISV 83
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFV 163
Cdd:cd13149 88 ATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 164 NFLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGIC------------ILAKYLPIKKIIKrmTWKisaQIWNLALP 227
Cdd:cd13149 168 ALVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGaalyflhyhhrlIDFSEPSLKALFR--SWK---DILSIGIP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 228 SAGERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLV 307
Cdd:cd13149 243 AALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 308 LMILISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLpfyttTIGMWLIRVVLGY 387
Cdd:cd13149 323 YGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLY-----SLGLNLIRVFLLY 397
|
410 420
....*....|....*....|....*.
gi 447193458 388 L----LGILFeLGLLGVWMATIADNI 409
Cdd:cd13149 398 IplayVGSHL-LGFAGVFIGALAGNL 422
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-403 |
2.03e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 90.02 E-value: 2.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 7 IIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAI-FIALGASIASLLAKSLAGSEKDDAISVCS 85
Cdd:cd13148 14 LLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMsNGAMGGGVSSAIARALGAGDRERAEALVW 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 86 QAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVNF 165
Cdd:cd13148 94 HALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGAV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 166 LNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILAKYL-------PIKKIIKRMTWKISAQIWNLALPSAGERLM 234
Cdd:cd13148 174 VQIPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLasgrsrlRLRLRALRLERRLFRDILRVGLLAALSPLQ 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 235 MRAGDVVIVAIVVQLGTNVVAGNAIGETLtQFNYMP---GLGIATATIILTAkyVGQKNRESIEETIQSSYYIGLVLMIL 311
Cdd:cd13148 254 TNLTVLLLTGLVGRFGTAALAGYGIGSRL-EFLLIPlvfGLGAAMTAMVGMN--IGAGQIARARRIAWTGALMAAVLAGA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 312 ISSFMLLAGKPLTQLFTNNPSAIKGSLIVI-----LLSFVGvpatIGTLVYTAAwQGLGNAKLPFYTTTIGMwLIRVVLG 386
Cdd:cd13148 331 IGLVLALFPELWLGLFTHDPAVLAAGASYLrivgpFYGFFG----LGLALYFAS-QGAGRMLWPVLAGTLRL-LIAAGGG 404
|
410
....*....|....*..
gi 447193458 387 YLLGILFELGLLGVWMA 403
Cdd:cd13148 405 WIAVALFGAGLAGLFAA 421
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
4-406 |
1.59e-18 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 87.24 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 4 SKEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISV 83
Cdd:cd13132 2 AKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFV 163
Cdd:cd13132 82 YLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 164 NFLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGICILAKYLPIKKIIKRMTWKISAQIW-------NLALPSAgerLMM- 235
Cdd:cd13132 162 LLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFrgwgpflKLAIPSA---LMLc 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 236 ---RAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILI 312
Cdd:cd13132 239 lewWAFEILVLLAGLLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 313 SSFMLLAGKPLTQLFTNNPSAIKG-SLIVILLSFVGVPATIGTlVYTAAWQGLGNAKLPFYTTTIGMWLIRVVLGYLLGI 391
Cdd:cd13132 319 AILLLVLRDVWAYLFTSDEEVIALvADLLPILALFQIFDGLQA-VLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAF 397
|
410
....*....|....*
gi 447193458 392 LFELGLLGVWMATIA 406
Cdd:cd13132 398 VLGLGLKGLWIGLIA 412
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
216-405 |
2.42e-17 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 83.65 E-value: 2.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 216 KISAQIWNLALPSAGERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIE 295
Cdd:COG0534 5 PILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEAR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 296 ETIQSSYYIGLVLMILISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTT 375
Cdd:COG0534 85 RVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164
|
170 180 190
....*....|....*....|....*....|
gi 447193458 376 IGMwLIRVVLGYLLGILFELGLLGVWMATI 405
Cdd:COG0534 165 IGN-VLNIVLDPLLIFGGGLGVAGAALATV 193
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
227-388 |
2.57e-16 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 76.06 E-value: 2.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 227 PSAGERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGL 306
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 307 VLMILISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMwLIRVVLG 386
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LLNIPLN 159
|
..
gi 447193458 387 YL 388
Cdd:pfam01554 160 YL 161
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
13-171 |
2.35e-15 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 73.37 E-value: 2.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 13 PAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVCSQAIFLTL 92
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447193458 93 LIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVNFLNAVLS 171
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
1-406 |
6.02e-14 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 73.31 E-value: 6.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 1 MRYSKEIIQ---LAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNI----ITVYQAIFIALGASIASLLaksla 73
Cdd:PRK01766 5 QKYKSEARQllaLALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIwlpvILFGHGLLLALTPIVAQLN----- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 74 GSEKDDAIS-VCSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQ 152
Cdd:PRK01766 80 GAGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 153 PRLPMYVSIFVNFLNAVLSGFAIFEW----RYGLVGVAVSTLIAR----LIGICILAKYLPIKKI-----IKRMTWKISA 219
Cdd:PRK01766 160 TKPTMVIGFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIVYwvmfLAMLIYIKRARRFRDFrlfkgLYKPDWAVIK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 220 QIWNLALPSAGERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQ 299
Cdd:PRK01766 240 RLLKLGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 300 SSYYIGLVLMILISSFMLLAGKPLTQLFTNNPSAIkgSLIVILLSFVGV---PATIGTLVyTAAWQGLGNAKLPFYTTTI 376
Cdd:PRK01766 320 IGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVV--ALASHLLLFAALfqfSDAIQVIG-SGALRGYKDTRVIFFITFI 396
|
410 420 430
....*....|....*....|....*....|
gi 447193458 377 GMWLIRVVLGYLLGILFELGLLGVWMATIA 406
Cdd:PRK01766 397 AYWVLGLPLGYILALTDPMGPFGFWIGLII 426
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-192 |
1.79e-12 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 68.63 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 1 MRYSKEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDA 80
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 81 ISVCSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVS 160
Cdd:COG0534 305 RRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIIS 384
|
170 180 190
....*....|....*....|....*....|..
gi 447193458 161 IFVNFLNAVLSGFAIFEWRYGLVGVAVSTLIA 192
Cdd:COG0534 385 LLRLWLVRLPLAYLLAFLGLGLTGVWLALPIG 416
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
227-413 |
1.28e-10 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 62.26 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 227 PSAGERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGL 306
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 307 VLMILISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPFYTTTIGMwLIRVVLG 386
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGN-VINIILN 159
|
170 180
....*....|....*....|....*..
gi 447193458 387 YLLgILFELGLLGVWMATIADNIFRWL 413
Cdd:TIGR00797 160 YIL-IFGKFGFLGIVGAALATVISYWL 185
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
59-415 |
2.08e-08 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 55.92 E-value: 2.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 59 ALGASIASLLAKSLAGSEKDDAISVCSQAIFLTLLIGAILGIISIVFGQTFFKLL--GTTKSVAQVGGLYLAIVGGGVVT 136
Cdd:cd13123 49 ALSAAFVPVFSEYLEKEGEEEARRFASRVLTLLLLVLLLLTLLGILFAPLLVKLLapGFSGDKFELAVALTRIMFPYLLF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 137 LGMLTTLGSFLRVQGQPRLPMYVSIFVNFLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGICILAKYLPIKKIIKRMTWK 216
Cdd:cd13123 129 ISLSALLGGILNAHGRFFAPALAPVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLD 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 217 IS----AQIWNLALPSAGERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYmpGL-GIATATIILT--AKYVGQK 289
Cdd:cd13123 209 FRdpgvRRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLYQLPL--GIfGVAIATALLPrlSRLAAAG 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 290 NRESIEETIQSSYYIGLVLMILISSFMLLAGKPLTQL------FTNNpSAIKGSLIVILLSfVGVPATIGTLVYTAAWQG 363
Cdd:cd13123 287 DLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLlfergaFTAE-DTLMTASALAAYA-LGLPAFALVKLLSRAFYA 364
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447193458 364 LGNAKLPFYTTTIGMwLIRVVLGYLLGilFELGLLGVWMATIADNIFRWLFL 415
Cdd:cd13123 365 LKDTKTPVKIAVIAV-AVNILLNLLLI--KPLGHVGLALATSLSAWVNALLL 413
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
59-423 |
1.23e-07 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 53.62 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 59 ALGASIASLLAKSLAGSEKDDAISVCSQAIFLTLLIGAILGIISIVFGQTFFKLL--GTTKSVAQVGGLYLAIVGGGVVT 136
Cdd:COG0728 56 ALSAAFVPVLAEALEKEGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLapGFDPEKFALAVALTRIMFPYILF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 137 LGMLTTLGSFLRVQGQPRLPMYVSIFVNFLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGICILAKYLPIKKIIKRMTWK 216
Cdd:COG0728 136 IGLSALLGGVLNARGRFAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFD 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 217 IS----AQIWNLALPSAGERLMMRAGDVVIVAIVVQLGTNVVAGNAIGETLTQFNYmpGL-GIATATIILT--AKYVGQK 289
Cdd:COG0728 216 LRdpgvRRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPL--GLfGVAIGTALLPrlSRAAAAG 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 290 NRESIEETIQSSYYIGLVLMILISSFMLLAGKPLTQLFTN----NPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLG 365
Cdd:COG0728 294 DLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFErgafTAEDTALTALALAAYALGLPAFALVKVLARAFYARQ 373
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447193458 366 NAKLPFYTTTIGMwLIRVVLGYLLgiLFELGLLGVWMATIADNIFRWLFLKVHYHRYI 423
Cdd:COG0728 374 DTRTPVRIAVIAV-VVNIVLNLLL--VPPLGHAGLALATSLSALVNALLLLVLLRRRL 428
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
257-406 |
3.78e-07 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 52.08 E-value: 3.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 257 NAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMILISSFMLLAGKPLTQLFTNNPSaikG 336
Cdd:cd13124 273 TGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE---G 349
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 337 SLIVILLSFVGVPATIgTLVYTAAWQGLGNAKLPFYTTTIGMwLIRVVLGYLLGILFelGLLGVWMATIA 406
Cdd:cd13124 350 GLILQILAPSILFLSL-QQVTAAILQGLGKVKIPVINLLIGL-LVKIVLNYVLIPIF--GIYGAAIATVI 415
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
7-201 |
2.75e-06 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 49.18 E-value: 2.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 7 IIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGV-SVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVCS 85
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIySAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 86 QAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAqvGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVNF 165
Cdd:COG2244 255 KALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAV 332
|
170 180 190
....*....|....*....|....*....|....*.
gi 447193458 166 LNAVLSGFAIfeWRYGLVGVAVSTLIARLIGICILA 201
Cdd:COG2244 333 LNLVLNLLLI--PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
2-201 |
3.13e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 49.24 E-value: 3.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 2 RYSKEIIQLAIPAMIEN-ILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDA 80
Cdd:cd12082 216 ELLRRLLRIGLPSAIQNsLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRA 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 81 ISVCSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVS 160
Cdd:cd12082 296 RRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVS 375
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 447193458 161 IFVNFLNAVLSGFAIFEWRYGLVGVAVSTLIARLIGICILA 201
Cdd:cd12082 376 LLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLL 416
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-162 |
8.90e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 47.57 E-value: 8.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:cd13142 237 KKIFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIV 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447193458 85 SQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIF 162
Cdd:cd13142 317 KKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISIL 394
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
5-229 |
1.20e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 47.45 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIF-IALGASIASLLAKSLAGSEKDDAISV 83
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFgVAIGTALLPRLSRAAAAGDLEEFRRT 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFG----QTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYV 159
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIVLAepivRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRI 381
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 160 SIFVNFLNAVLSgfAIFEWRYGLVGVAVSTLIARLIGICILAKYLpIKKIIKRMTWKISAQIWNLALPSA 229
Cdd:COG0728 382 AVIAVVVNIVLN--LLLVPPLGHAGLALATSLSALVNALLLLVLL-RRRLGGLPLRGILRTLLKLLLASL 448
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
5-204 |
2.11e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 46.38 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGV-SVANNIITVYQAIFIALGASIASLLAKsLAGSEKDDAISV 83
Cdd:cd13128 206 KELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIyNAAYRIAELLLFIPSAISTALFPRISE-LYKNDKDELKKL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAqvGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFV 163
Cdd:cd13128 285 LKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP--AALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIG 362
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 447193458 164 NFLNAVLSGFAIFewRYGLVGVAVSTLIARLIGICILAKYL 204
Cdd:cd13128 363 ALLNVILNLLLIP--KYGIIGAAIATLISEFIIFILLLYLL 401
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
5-401 |
3.05e-05 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 45.89 E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:PRK00187 10 KAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGATRLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 85 SQAIFLTLLIGAILGIIsIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYVSIFVN 164
Cdd:PRK00187 90 QAGLWLAWLLALVAALL-LWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAGA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 165 FLNAVLSGFAIFEW----RYGLVGVAVSTLIARLIGICILAKYL---------PIKKIIKRMTWKISAQIWNLALPSAGE 231
Cdd:PRK00187 169 VANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIrrhpayaayPLRKGLSRPSRAALRELWRLGLPIGGT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 232 rLMMRAGDVVIVAIVV-QLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYVGQKNRESIEETIQSSYYIGLVLMI 310
Cdd:PRK00187 249 -YAVEVGLFTFAALCMgALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVML 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 311 LISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATI----GT-LVYTAAWQGLGNAKLPFYTTTIGMWLIRVVL 385
Cdd:PRK00187 328 LFAGLFWLLPEAIIGLFLDRNDPAFAEIVQLAVSLLAVAAWFelfdGTqTIAMGAIRGLKDARTTFLIGLACYWLVGAPL 407
|
410
....*....|....*.
gi 447193458 386 GYLLGILFELGLLGVW 401
Cdd:PRK00187 408 AWLLAFTLGWGAVGVW 423
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
5-205 |
3.30e-05 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 45.74 E-value: 3.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIF-IALGASIASLLAKSLAGSEKDDAISV 83
Cdd:pfam03023 197 KRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYADRIYQLPLGIFgVSISTVLLPRLSRHAADGDWDEFRDL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLIG----AILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYV 159
Cdd:pfam03023 277 LDQAIRLTLLLMipvsFGLLVLSIPIVSLLFERGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKI 356
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 447193458 160 SIFVNFLNAVLSGFAIFewRYGLVGVAVSTLIARLIGICILAKYLP 205
Cdd:pfam03023 357 SLISAVLNILLSLLLLP--PLGVAGLALATSLSSLIGLVFLYYILR 400
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
2-204 |
7.50e-05 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 44.77 E-value: 7.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 2 RYSKEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAI---FIALGASIAS--------LLAK 70
Cdd:cd13124 221 EILKELLSYAIPITLSSLILPLLQLIDSFTVPRRLQAAGLSESEATALYGILTGRaqpLVQLPTVIATalstslvpAISE 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 71 SLAGSEKDDAISVCSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSvaqvGGLYLAIVGGGVVTLGMLTTLGSFLRVQ 150
Cdd:cd13124 301 AYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTAAILQGL 376
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 447193458 151 GQPRLPMYVSIFVNFLNAVLSGFAIfeWRYGLVGVAVSTLIARLIGICILAKYL 204
Cdd:cd13124 377 GKVKIPVINLLIGLLVKIVLNYVLI--PIFGIYGAAIATVIGFLVAALLNLRAL 428
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
5-131 |
1.22e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 43.77 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIFIALGASIASLLAKSLAGSEKDDAISVC 84
Cdd:TIGR00797 216 KRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVA 295
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 447193458 85 SQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVG 131
Cdd:TIGR00797 296 RVALKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
272-410 |
2.29e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 43.27 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 272 LGIATATIIltAKYVGQKNRESIEETIQSSYYIGLVLMILISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPAT 351
Cdd:cd13143 60 IGVGGASLI--SRRLGAGDREKANRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFT 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 447193458 352 IGTLVYTAAWQGLGNAKLPFYTTTIGMwLIRVVLGYLLGILFELGLLGVWMATIADNIF 410
Cdd:cd13143 138 ILSSVLNNLLRAEGKPKLAMLGMLIGA-VLNIILDPLFIFVLGLGIAGAALATVIAQLI 195
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
55-415 |
4.73e-04 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 42.14 E-value: 4.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 55 AIFIALGasIASLLAKSLAGSEKDDAISVCSQAIFLTLLIGAILGIISIVFGQTFFKLLGTTKsvaqvggLYLAIVGGGV 134
Cdd:cd13128 49 SIFADLG--LPTALVREIARYRKEKIREIISTSLVLKLILGILALLLLFLFAFLIAFYDPELV-------LLLYILALSL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 135 VTLGMLTTLGSFLRVQGQPRLPMYVSIFVNFLNAVLSGFAIFEWrYGLVGVAVSTLIARLIGIcILAKYLPIKKIIKRMT 214
Cdd:cd13128 120 PFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILVLLG-GGLIGFALAYLIASVLSA-ILLLYIYRKKILLPKF 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 215 WKISAQIWN--------LALPSAGERLMMRAGDVVIVAIvvqLGTNVVAGNAIGETLTQFNYMPGLGIATATIILTAKYv 286
Cdd:cd13128 198 FSFDLKLAKellrfsipLALSGIFSLIYTRIDTIMLGYF---LGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISEL- 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 287 GQKNRESIEETIQSSYYIGLVLMILISSFMLLAGKPLTQLFTNN---PSAIkgSLIVILLSFVgvpATIGTLVYTAAWQG 363
Cdd:cd13128 274 YKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEeylPAAL--VLQILAWGFL---FIFLNGIFGSILQA 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447193458 364 LGNAKLPFYTTTIGMwLIRVVLGYLLgiLFELGLLGVWMATIADNIFRWLFL 415
Cdd:cd13128 349 IGKQKLTLKILLIGA-LLNVILNLLL--IPKYGIIGAAIATLISEFIIFILL 397
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
5-210 |
5.86e-04 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 41.93 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIF-IALGASIASLLAKSLAGSEKDDAISV 83
Cdd:TIGR01695 223 KRFLKLFLPTTLGSSASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFgISLSTVLLPKLSRHASEGNWNELRDL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAIFLTLLI----GAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYV 159
Cdd:TIGR01695 303 LNQGIRLSLLLtipsSFGLLILSIPIVSLLFERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFIN 382
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 447193458 160 SIFVNFLNAVLSGFAIFewRYGLVGVAVSTLIARLIGICILAKYLPIKKII 210
Cdd:TIGR01695 383 SVISVVLNALLSLLLIF--PLGLVGIALATSAASMVSSVLLYLMLNRRLKG 431
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
5-204 |
7.72e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 41.67 E-value: 7.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 5 KEIIQLAIPAMIENILQMLMGVVDNYLVAQLGVVAVSGVSVANNIITVYQAIF-IALGASIASLLAKSLAGSEKDDAISV 83
Cdd:cd13123 215 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLYQLPLGIFgVAIATALLPRLSRLAAAGDLDEFRRT 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 84 CSQAI----FLTLLIGAILGIISIVFGQTFFKLLGTTKSVAQVGGLYLAIVGGGVVTLGMLTTLGSFLRVQGQPRLPMYV 159
Cdd:cd13123 295 LSRGLrlvlFLLLPAAVGLIVLAEPIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKI 374
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 447193458 160 SIFVNFLNAVLSgfAIFEWRYGLVGVAVSTLIARLIGICILAKYL 204
Cdd:cd13123 375 AVIAVAVNILLN--LLLIKPLGHVGLALATSLSAWVNALLLLVLL 417
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
216-405 |
6.70e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 38.44 E-value: 6.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 216 KISAQIWNLALPSAGERLMMRAGDVVIVAIVVQLGTNVVAgnAIGET----LTQFNYMPGLGIATATIIltAKYVGQKNR 291
Cdd:cd13149 6 SIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELA--AISFTfpvvLFLNSLTIGLGIGASAVI--SRAIGAGDR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447193458 292 ESIEETIQSSYYIGLVLMILISSFMLLAGKPLTQLFTNNPSAIKGSLIVILLSFVGVPATIGTLVYTAAWQGLGNAKLPF 371
Cdd:cd13149 82 NKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPS 161
|
170 180 190
....*....|....*....|....*....|....*...
gi 447193458 372 yTTTIGMWLIRVVLGYLL----GILFELGLLGVWMATI 405
Cdd:cd13149 162 -LVMLGAALVNVILDPILifgfGPIPGMGIAGAAIATV 198
|
|
| |
