Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of ...
291-993
0e+00
Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.
:
Pssm-ID: 238517 [Multi-domain] Cd Length: 693 Bit Score: 800.45 E-value: 0e+00
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
1037-1067
1.11e-03
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]
:
Pssm-ID: 273478 [Multi-domain] Cd Length: 34 Bit Score: 37.45 E-value: 1.11e-03
Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of ...
291-993
0e+00
Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.
Pssm-ID: 238517 [Multi-domain] Cd Length: 693 Bit Score: 800.45 E-value: 0e+00
Polysaccharide lyase family 8, N terminal alpha-helical domain; This family consists of a ...
299-621
1.46e-159
Polysaccharide lyase family 8, N terminal alpha-helical domain; This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Pssm-ID: 429830 Cd Length: 323 Bit Score: 474.59 E-value: 1.46e-159
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
1037-1067
1.11e-03
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]
Pssm-ID: 273478 [Multi-domain] Cd Length: 34 Bit Score: 37.45 E-value: 1.11e-03
Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of ...
291-993
0e+00
Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.
Pssm-ID: 238517 [Multi-domain] Cd Length: 693 Bit Score: 800.45 E-value: 0e+00
Polysaccharide lyase family 8, N terminal alpha-helical domain; This family consists of a ...
299-621
1.46e-159
Polysaccharide lyase family 8, N terminal alpha-helical domain; This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Pssm-ID: 429830 Cd Length: 323 Bit Score: 474.59 E-value: 1.46e-159
Polysaccharide lyase family 8, super-sandwich domain; This family consists of a group of ...
664-920
7.85e-87
Polysaccharide lyase family 8, super-sandwich domain; This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Pssm-ID: 460521 Cd Length: 249 Bit Score: 279.93 E-value: 7.85e-87
Polysaccharide lyase family 8, C-terminal beta-sandwich domain; This family consists of a ...
934-1001
1.35e-13
Polysaccharide lyase family 8, C-terminal beta-sandwich domain; This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Pssm-ID: 460736 [Multi-domain] Cd Length: 69 Bit Score: 66.49 E-value: 1.35e-13
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
1037-1067
1.11e-03
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]
Pssm-ID: 273478 [Multi-domain] Cd Length: 34 Bit Score: 37.45 E-value: 1.11e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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