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Conserved domains on  [gi|446985331|ref|WP_001062587|]
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MULTISPECIES: recombinase family protein [Bacilli]

Protein Classification

recombinase family protein( domain architecture ID 10132964)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0015074|GO:0000150|GO:0003677|GO:0006310
PubMed:  11972771|16077726|9348666|21645851|26104451
SCOP:  3000065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 3-132 3.84e-41

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


:

Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 135.69  E-value: 3.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   3 KIGYARVSSKEQNLDRQLQALQ---GVSKVFSDKLSGQSVERPQLQAMLNYIREGDIVIVTELDRLGRNNKELTELMNQI 79
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKaagECDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446985331  80 QIKGATLEVLNLpsmnGIEDENlrrLINSLVIELYKYQAESERKKIKERQAQG 132
Cdd:cd03768   81 REKGVSLRSLTE----GIDTST---PSGKLMLTILGAFAEFERELIRERTKEG 126
 
Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 3-132 3.84e-41

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 135.69  E-value: 3.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   3 KIGYARVSSKEQNLDRQLQALQ---GVSKVFSDKLSGQSVERPQLQAMLNYIREGDIVIVTELDRLGRNNKELTELMNQI 79
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKaagECDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446985331  80 QIKGATLEVLNLpsmnGIEDENlrrLINSLVIELYKYQAESERKKIKERQAQG 132
Cdd:cd03768   81 REKGVSLRSLTE----GIDTST---PSGKLMLTILGAFAEFERELIRERTKEG 126
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-176 9.45e-35

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 126.68  E-value: 9.45e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   1 MAKIGYARVSSKEQ---NLDRQLQALQ--------GVSKVFSDK-LSGQSVERPQLQAMLNYIREG--DIVIVTELDRLG 66
Cdd:COG1961    2 MRAAGYARVSTDDQeglSLERQREALRayaekagwEIVRIYVDEgVSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331  67 RNNKELTELMNQIQIKGATLEVLNlpsmngiEDENLRRLINSLVIELYKYQAESERKKIKERQAQGIEIAKKKGKFKG-- 144
Cdd:COG1961   82 RNLADLLELVEELKERGVRLISLT-------EGIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGrp 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446985331 145 ----RQHKFKENDPR----LKHAFDLFLNGLSDKEVEEQT 176
Cdd:COG1961  155 pygyRDPKKLVIDEEeaevVRRIFELYLEGKSLREIAREL 194
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 4-141 3.58e-32

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 113.52  E-value: 3.58e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331    4 IGYARVSSKEQN--LDRQLQALQ------GVSKVFSDK-LSGQSVERPQLQAMLNYIRE--GDIVIVTELDRLGRNNKEL 72
Cdd:pfam00239   2 IGYARVSTEDQDdsLERQLEALRayaacnGKIVEFEDKgVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRDL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446985331   73 TELMNQIQIKGATLEVLNlpsmngiEDENLRRLINSLVIELYKYQAESERKKIKERQAQGIEIAKKKGK 141
Cdd:pfam00239  82 LTLVEELREKGVDLVSLD-------EGIDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGK 143
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 4-142 1.40e-31

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 111.95  E-value: 1.40e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331     4 IGYARVSSKEQ---NLDRQLQALQG--------VSKVFSDK-LSGQSVERPQLQAMLNYIREGDI--VIVTELDRLGRNN 69
Cdd:smart00857   2 AGYARVSTDDQadgSLERQLEALRAyaerngweVVRIYEDEgVSGKKADRPGLQRLLADLRAGDIdvLVVYKLDRLGRSL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446985331    70 KELTELMNQIQIKGATLEVLNLPsmngieDENLRRLINSLVIELYKYQAESERKKIKERQAQGIEIAKKKGKF 142
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLKEG------ILDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGRW 148
recomb_XisF NF041201
fdxN element excision recombinase XisF;
3-141 7.81e-15

fdxN element excision recombinase XisF;


Pssm-ID: 469105 [Multi-domain]  Cd Length: 463  Bit Score: 71.92  E-value: 7.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   3 KIGYARVSSKEQN-----LDRQLQALQ--GVSKVFSDKLSGQSVERPQLQAMLNYIREGDI--VIVTELDRLGRNNKELT 73
Cdd:NF041201   1 IVGYARVSTREQAddghaLEQQIARLKkaGASEIFFDIESGRSDKRKGFNQLLKLVKSGKVteIIITRIDRLTRSVVTIY 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331  74 ELMNQIQIKGATLEVLNLPS--MNGIEDENLRRLINSLvielykyqAESERKKIKERQAQGIEIAKKKGK 141
Cdd:NF041201  81 KAIEVLQKKGVKLVILDAPLddLSSPGGWFTINQLAAL--------AEFESRLLSERVRHGLEYFREQKK 142
transpos_IS607 NF033518
IS607 family transposase;
4-90 9.76e-10

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 55.72  E-value: 9.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   4 IGYARVSSKEQ--NLDRQLQAL------QG--VSKVFSDKLSGQSVERPQLQAMLNYIREGDI--VIVTELDRLGRNNKE 71
Cdd:NF033518  57 VIYARVSSADQkdDLERQVARLtqyataKGwqVDEVVTDIGSGLNEKRKGLLKLLDDILNGEVsrVVVEHKDRLTRFGFE 136

                         90
                 ....*....|....*....
gi 446985331  72 LteLMNQIQIKGATLEVLN 90
Cdd:NF033518 137 Y--LEALFKANGVEIVVVN 153
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
4-157 5.33e-07

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 48.17  E-value: 5.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   4 IGYARVSSKEQNLDRQLQALQG--------VSKVFSDKLSG-QSVERPQLQAMLNYIREGDIVIVTELDRLGRNNKELTE 74
Cdd:PRK13413   3 YAYIRVSTDKQTVENQRFEITNfaeknnltIDKWIEETISGtKSYKDRKLGKLLKKMRKGDILIVSELSRLGRNLMEIMS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331  75 LMNQIQIKgatlEVLNLPSMNGIEdenLRRLINSLVIEL-YKYQAESERKKIKER--------QAQGIEIAKKKGKfKGR 145
Cdd:PRK13413  83 ILNICMEK----EVIVYTIKEGYE---LGDDINSKVLAFaFGLSAEIERNLISQRtkealarkKAEGVTLGRPKGS-TPK 154

                        170
                 ....*....|..
gi 446985331 146 QHKFKENDPRLK 157
Cdd:PRK13413 155 KYKLTGKEEKIK 166
 
Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 3-132 3.84e-41

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 135.69  E-value: 3.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   3 KIGYARVSSKEQNLDRQLQALQ---GVSKVFSDKLSGQSVERPQLQAMLNYIREGDIVIVTELDRLGRNNKELTELMNQI 79
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKaagECDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446985331  80 QIKGATLEVLNLpsmnGIEDENlrrLINSLVIELYKYQAESERKKIKERQAQG 132
Cdd:cd03768   81 REKGVSLRSLTE----GIDTST---PSGKLMLTILGAFAEFERELIRERTKEG 126
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-176 9.45e-35

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 126.68  E-value: 9.45e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   1 MAKIGYARVSSKEQ---NLDRQLQALQ--------GVSKVFSDK-LSGQSVERPQLQAMLNYIREG--DIVIVTELDRLG 66
Cdd:COG1961    2 MRAAGYARVSTDDQeglSLERQREALRayaekagwEIVRIYVDEgVSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331  67 RNNKELTELMNQIQIKGATLEVLNlpsmngiEDENLRRLINSLVIELYKYQAESERKKIKERQAQGIEIAKKKGKFKG-- 144
Cdd:COG1961   82 RNLADLLELVEELKERGVRLISLT-------EGIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGrp 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446985331 145 ----RQHKFKENDPR----LKHAFDLFLNGLSDKEVEEQT 176
Cdd:COG1961  155 pygyRDPKKLVIDEEeaevVRRIFELYLEGKSLREIAREL 194
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 4-141 3.58e-32

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 113.52  E-value: 3.58e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331    4 IGYARVSSKEQN--LDRQLQALQ------GVSKVFSDK-LSGQSVERPQLQAMLNYIRE--GDIVIVTELDRLGRNNKEL 72
Cdd:pfam00239   2 IGYARVSTEDQDdsLERQLEALRayaacnGKIVEFEDKgVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRDL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446985331   73 TELMNQIQIKGATLEVLNlpsmngiEDENLRRLINSLVIELYKYQAESERKKIKERQAQGIEIAKKKGK 141
Cdd:pfam00239  82 LTLVEELREKGVDLVSLD-------EGIDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGK 143
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 4-142 1.40e-31

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 111.95  E-value: 1.40e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331     4 IGYARVSSKEQ---NLDRQLQALQG--------VSKVFSDK-LSGQSVERPQLQAMLNYIREGDI--VIVTELDRLGRNN 69
Cdd:smart00857   2 AGYARVSTDDQadgSLERQLEALRAyaerngweVVRIYEDEgVSGKKADRPGLQRLLADLRAGDIdvLVVYKLDRLGRSL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446985331    70 KELTELMNQIQIKGATLEVLNLPsmngieDENLRRLINSLVIELYKYQAESERKKIKERQAQGIEIAKKKGKF 142
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLKEG------ILDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGRW 148
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 6-132 2.92e-18

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 77.30  E-value: 2.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   6 YARVSSKEQN----LDRQLQALQG--------VSKVFSDKLSG--QSVERPQLQAMLNYIREG--DIVIVTELDRLGRNN 69
Cdd:cd00338    2 YARVSTDKQEqgdsLERQREALREyaarngleVVGEYEDAGSSatSLVDRPGLQRLLADVKAGkiDVVLVEKLDRLSRNL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446985331  70 KELTELMNQIQIKGATL----EVLNLPSMNGIedenlrrlinsLVIELYKYQAESERKKIKERQAQG 132
Cdd:cd00338   82 VDLLELLELLEAHGVRVvtadGEIDLDSEDGR-----------LMLGILAAMAEEESKLISERTKRG 137
recomb_XisF NF041201
fdxN element excision recombinase XisF;
3-141 7.81e-15

fdxN element excision recombinase XisF;


Pssm-ID: 469105 [Multi-domain]  Cd Length: 463  Bit Score: 71.92  E-value: 7.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   3 KIGYARVSSKEQN-----LDRQLQALQ--GVSKVFSDKLSGQSVERPQLQAMLNYIREGDI--VIVTELDRLGRNNKELT 73
Cdd:NF041201   1 IVGYARVSTREQAddghaLEQQIARLKkaGASEIFFDIESGRSDKRKGFNQLLKLVKSGKVteIIITRIDRLTRSVVTIY 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331  74 ELMNQIQIKGATLEVLNLPS--MNGIEDENLRRLINSLvielykyqAESERKKIKERQAQGIEIAKKKGK 141
Cdd:NF041201  81 KAIEVLQKKGVKLVILDAPLddLSSPGGWFTINQLAAL--------AEFESRLLSERVRHGLEYFREQKK 142
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 5-132 6.07e-14

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 66.19  E-value: 6.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   5 GYARVSSKEQNLDRQLQALQGVSKVFSDKL--------SGQSVERPQLQAMLNYIREGDIVIVTELDRLGR-NNKELTEL 75
Cdd:cd03767    3 AYLRASTDEQDATRAKESLEAFATERGFYIagfyvenaSGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRlPLDDWETL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446985331  76 MNQIQIKGATLEVLNLPS----MNGIEDENLRRL---INSLVIELYKYQAESERKKIKERQAQG 132
Cdd:cd03767   83 KASIAAKGLRVVSLDLPTshsaLAAEDNDFTGRIlsaINDMLLDLLAAMARKDYEDRRERQKQG 146
transpos_IS607 NF033518
IS607 family transposase;
4-90 9.76e-10

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 55.72  E-value: 9.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   4 IGYARVSSKEQ--NLDRQLQAL------QG--VSKVFSDKLSGQSVERPQLQAMLNYIREGDI--VIVTELDRLGRNNKE 71
Cdd:NF033518  57 VIYARVSSADQkdDLERQVARLtqyataKGwqVDEVVTDIGSGLNEKRKGLLKLLDDILNGEVsrVVVEHKDRLTRFGFE 136

                         90
                 ....*....|....*....
gi 446985331  72 LteLMNQIQIKGATLEVLN 90
Cdd:NF033518 137 Y--LEALFKANGVEIVVVN 153
COG2452 COG2452
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];
4-127 4.15e-09

Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];


Pssm-ID: 441988 [Multi-domain]  Cd Length: 178  Bit Score: 53.84  E-value: 4.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   4 IGYARVSSKEQ--NLDRQLQALQG-------VSKVFSDKLSGQSVERPQLQAMLNYIrEGDIVIVTELDRLGRNNKELTE 74
Cdd:COG2452   51 VIYARVSSADQkdDLERQVERLEEyatakgyQDEVIKDVGSGLNYKRKGLLKLLERI-EVERVVVEHKDRLARFGFELLE 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446985331  75 LMNQIQikGATLEVLNLPSMngiEDENLRRL---INSLVIELYKyqAESERKKIKE 127
Cdd:COG2452  130 ALCEAY--GVEIVVVNQESP---EQELVEDLiaiITSFSARLYG--LRSYKKAVKE 178
SR_IS607_transposase_like cd03769
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ...
 4-74 4.23e-09

Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.


Pssm-ID: 239738  Cd Length: 134  Bit Score: 52.65  E-value: 4.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   4 IGYARVSSKEQ--NLDRQLQALQ-------GVSKVFSDKLSGQSVERPQLQAMLNYIREG--DIVIVTELDRLGRNNKEL 72
Cdd:cd03769    2 VLYARVSSHDQkdDLERQIERLEayataqgWIVEVIKDIGSGLNEKRKGLLKLLEDVLAGkvERVVITYKDRLARFGFEL 81


                 ..
gi 446985331  73 TE 74
Cdd:cd03769   82 LE 83
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
4-157 5.33e-07

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 48.17  E-value: 5.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331   4 IGYARVSSKEQNLDRQLQALQG--------VSKVFSDKLSG-QSVERPQLQAMLNYIREGDIVIVTELDRLGRNNKELTE 74
Cdd:PRK13413   3 YAYIRVSTDKQTVENQRFEITNfaeknnltIDKWIEETISGtKSYKDRKLGKLLKKMRKGDILIVSELSRLGRNLMEIMS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446985331  75 LMNQIQIKgatlEVLNLPSMNGIEdenLRRLINSLVIEL-YKYQAESERKKIKER--------QAQGIEIAKKKGKfKGR 145
Cdd:PRK13413  83 ILNICMEK----EVIVYTIKEGYE---LGDDINSKVLAFaFGLSAEIERNLISQRtkealarkKAEGVTLGRPKGS-TPK 154

                        170
                 ....*....|..
gi 446985331 146 QHKFKENDPRLK 157
Cdd:PRK13413 155 KYKLTGKEEKIK 166
SR_TndX_transposase cd03770
Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of ...
 32-69 3.63e-04

Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. TndX mediates the excision and circularization of the conjugative transposon Tn5397 from Clostridium difficile. TnpX is responsible for the movement of the nonconjugative chloramphenicol resistance elements of the Tn4451/3 family. Mobile genetic elements such as transposons are important vehicles for the transmission of virulence and antibiotic resistance in many microorganisms.


Pssm-ID: 239739 [Multi-domain]  Cd Length: 140  Bit Score: 39.27  E-value: 3.63e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 446985331  32 DKLSGQSVERPQLQAMLNYIREG--DIVIVTELDRLGRNN 69
Cdd:cd03770   45 DGFSGTTFDRPGFNRMIEDIEAGkiDIVIVKDMSRLGRNY 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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