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Conserved domains on  [gi|446939487|ref|WP_001016743|]
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MULTISPECIES: hydrogenase expression/formation C-terminal domain-containing protein [Salmonella]

Protein Classification

HupH_C and rubredoxin domain-containing protein( domain architecture ID 11649463)

HupH_C and rubredoxin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HupH_C pfam04809
HupH hydrogenase expression protein, C-terminal conserved region; This family represents a ...
 169-275 3.44e-49

HupH hydrogenase expression protein, C-terminal conserved region; This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.


:

Pssm-ID: 428133  Cd Length: 109  Bit Score: 160.79  E-value: 3.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446939487  169 NGAFIAHEIAERVK--QPVKEPHIINLTLLPVNDADREYLDHFLGEGCSAIFSRGYGKCRIVSTHFPGVWRVNYFNDMNT 246
Cdd:pfam04809   1 NAPALLAEIAEALAalRPGGEPHVINLTLLPLTPEDLEFLDEVLGEGEVTILSRGYGNCRITETAVPGVWRVRYFNSEDK 80

                          90       100
                  ....*....|....*....|....*....
gi 446939487  247 LLQDMIEIADIPDIAVAGIDDIEDAYAGL 275
Cdd:pfam04809  81 LILDTIEIADVPEVALAAPEDIADSAERL 109
NorV COG1773
Flavorubredoxin [Inorganic ion transport and metabolism];
295-345 1.99e-23

Flavorubredoxin [Inorganic ion transport and metabolism];


:

Pssm-ID: 441379 [Multi-domain]  Cd Length: 53  Bit Score: 91.38  E-value: 1.99e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446939487 295 RMECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGFMVID 345
Cdd:COG1773    3 KYQCKVCGYVYDPAEGDPENGIPPGTPFEDLPDDWVCPVCGAGKEDFEPVE 53
HupH_C super family cl04768
HupH hydrogenase expression protein, C-terminal conserved region; This family represents a ...
 89-145 8.65e-10

HupH hydrogenase expression protein, C-terminal conserved region; This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.


The actual alignment was detected with superfamily member pfam04809:

Pssm-ID: 428133  Cd Length: 109  Bit Score: 55.63  E-value: 8.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446939487   89 LLDQLLGEGEISarvLLSDGKEQ-RIQETVFTGVWRVREYNADQQRVADEIIIGPIPE 145
Cdd:pfam04809  39 FLDEVLGEGEVT---ILSRGYGNcRITETAVPGVWRVRYFNSEDKLILDTIEIADVPE 93
 
Name Accession Description Interval E-value
HupH_C pfam04809
HupH hydrogenase expression protein, C-terminal conserved region; This family represents a ...
 169-275 3.44e-49

HupH hydrogenase expression protein, C-terminal conserved region; This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.


Pssm-ID: 428133  Cd Length: 109  Bit Score: 160.79  E-value: 3.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446939487  169 NGAFIAHEIAERVK--QPVKEPHIINLTLLPVNDADREYLDHFLGEGCSAIFSRGYGKCRIVSTHFPGVWRVNYFNDMNT 246
Cdd:pfam04809   1 NAPALLAEIAEALAalRPGGEPHVINLTLLPLTPEDLEFLDEVLGEGEVTILSRGYGNCRITETAVPGVWRVRYFNSEDK 80

                          90       100
                  ....*....|....*....|....*....
gi 446939487  247 LLQDMIEIADIPDIAVAGIDDIEDAYAGL 275
Cdd:pfam04809  81 LILDTIEIADVPEVALAAPEDIADSAERL 109
NorV COG1773
Flavorubredoxin [Inorganic ion transport and metabolism];
295-345 1.99e-23

Flavorubredoxin [Inorganic ion transport and metabolism];


Pssm-ID: 441379 [Multi-domain]  Cd Length: 53  Bit Score: 91.38  E-value: 1.99e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446939487 295 RMECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGFMVID 345
Cdd:COG1773    3 KYQCKVCGYVYDPAEGDPENGIPPGTPFEDLPDDWVCPVCGAGKEDFEPVE 53
rubredoxin cd00730
Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are ...
 295-344 5.42e-22

Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are believed to be involved in electron transfer.


Pssm-ID: 238372 [Multi-domain]  Cd Length: 50  Bit Score: 87.36  E-value: 5.42e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446939487 295 RMECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGFMVI 344
Cdd:cd00730    1 KYECRICGYIYDPAEGDPDEGIPPGTPFEDLPDDWVCPVCGAGKDDFEPL 50
Rubredoxin pfam00301
Rubredoxin;
296-341 8.53e-20

Rubredoxin;


Pssm-ID: 459752 [Multi-domain]  Cd Length: 46  Bit Score: 81.53  E-value: 8.53e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446939487  296 MECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGF 341
Cdd:pfam00301   1 YECKVCGYVYDPAKGDPDNGIPPGTPFEDLPDDWVCPDCGAGKDQF 46
PRK05452 PRK05452
anaerobic nitric oxide reductase flavorubredoxin; Provisional
 295-344 1.72e-10

anaerobic nitric oxide reductase flavorubredoxin; Provisional


Pssm-ID: 235475 [Multi-domain]  Cd Length: 479  Bit Score: 62.08  E-value: 1.72e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446939487 295 RMECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGFMVI 344
Cdd:PRK05452 425 RMQCSVCQWIYDPAKGEPMQDVAPGTPWSEVPDNFLCPECSLGKDVFDEL 474
HupH_C pfam04809
HupH hydrogenase expression protein, C-terminal conserved region; This family represents a ...
 89-145 8.65e-10

HupH hydrogenase expression protein, C-terminal conserved region; This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.


Pssm-ID: 428133  Cd Length: 109  Bit Score: 55.63  E-value: 8.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446939487   89 LLDQLLGEGEISarvLLSDGKEQ-RIQETVFTGVWRVREYNADQQRVADEIIIGPIPE 145
Cdd:pfam04809  39 FLDEVLGEGEVT---ILSRGYGNcRITETAVPGVWRVRYFNSEDKLILDTIEIADVPE 93
 
Name Accession Description Interval E-value
HupH_C pfam04809
HupH hydrogenase expression protein, C-terminal conserved region; This family represents a ...
 169-275 3.44e-49

HupH hydrogenase expression protein, C-terminal conserved region; This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.


Pssm-ID: 428133  Cd Length: 109  Bit Score: 160.79  E-value: 3.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446939487  169 NGAFIAHEIAERVK--QPVKEPHIINLTLLPVNDADREYLDHFLGEGCSAIFSRGYGKCRIVSTHFPGVWRVNYFNDMNT 246
Cdd:pfam04809   1 NAPALLAEIAEALAalRPGGEPHVINLTLLPLTPEDLEFLDEVLGEGEVTILSRGYGNCRITETAVPGVWRVRYFNSEDK 80

                          90       100
                  ....*....|....*....|....*....
gi 446939487  247 LLQDMIEIADIPDIAVAGIDDIEDAYAGL 275
Cdd:pfam04809  81 LILDTIEIADVPEVALAAPEDIADSAERL 109
NorV COG1773
Flavorubredoxin [Inorganic ion transport and metabolism];
295-345 1.99e-23

Flavorubredoxin [Inorganic ion transport and metabolism];


Pssm-ID: 441379 [Multi-domain]  Cd Length: 53  Bit Score: 91.38  E-value: 1.99e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446939487 295 RMECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGFMVID 345
Cdd:COG1773    3 KYQCKVCGYVYDPAEGDPENGIPPGTPFEDLPDDWVCPVCGAGKEDFEPVE 53
rubredoxin cd00730
Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are ...
 295-344 5.42e-22

Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are believed to be involved in electron transfer.


Pssm-ID: 238372 [Multi-domain]  Cd Length: 50  Bit Score: 87.36  E-value: 5.42e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446939487 295 RMECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGFMVI 344
Cdd:cd00730    1 KYECRICGYIYDPAEGDPDEGIPPGTPFEDLPDDWVCPVCGAGKDDFEPL 50
Rubredoxin pfam00301
Rubredoxin;
296-341 8.53e-20

Rubredoxin;


Pssm-ID: 459752 [Multi-domain]  Cd Length: 46  Bit Score: 81.53  E-value: 8.53e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446939487  296 MECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGF 341
Cdd:pfam00301   1 YECKVCGYVYDPAKGDPDNGIPPGTPFEDLPDDWVCPDCGAGKDQF 46
PRK05452 PRK05452
anaerobic nitric oxide reductase flavorubredoxin; Provisional
 295-344 1.72e-10

anaerobic nitric oxide reductase flavorubredoxin; Provisional


Pssm-ID: 235475 [Multi-domain]  Cd Length: 479  Bit Score: 62.08  E-value: 1.72e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446939487 295 RMECKVCWWVYDPALGDDVWQIPPGVPFNQLPDYWCCPVCETSKSGFMVI 344
Cdd:PRK05452 425 RMQCSVCQWIYDPAKGEPMQDVAPGTPWSEVPDNFLCPECSLGKDVFDEL 474
HupH_C pfam04809
HupH hydrogenase expression protein, C-terminal conserved region; This family represents a ...
 89-145 8.65e-10

HupH hydrogenase expression protein, C-terminal conserved region; This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.


Pssm-ID: 428133  Cd Length: 109  Bit Score: 55.63  E-value: 8.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446939487   89 LLDQLLGEGEISarvLLSDGKEQ-RIQETVFTGVWRVREYNADQQRVADEIIIGPIPE 145
Cdd:pfam04809  39 FLDEVLGEGEVT---ILSRGYGNcRITETAVPGVWRVRYFNSEDKLILDTIEIADVPE 93
rubredoxin_like cd00350
Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family ...
 295-344 8.18e-06

Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and ferredoxin-thioredoxin reductase. In rubredoxin, the iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc and believed to be involved in electron transfer. Rubrerythrins and nigerythrins are small homodimeric proteins, generally consisting of 2 domains: a rubredoxin domain C-terminal to a non-sulfur, oxo-bridged diiron site in the N-terminal rubrerythrin domain. Rubrerythrins and nigerythrins have putative peroxide activity.


Pssm-ID: 238210 [Multi-domain]  Cd Length: 33  Bit Score: 42.15  E-value: 8.18e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446939487 295 RMECKVCWWVYDPALGDdvwqippgvpfnqlpdyWCCPVCETSKSGFMVI 344
Cdd:cd00350    1 KYVCPVCGYIYDGEEAP-----------------WVCPVCGAPKDKFEKL 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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