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Conserved domains on  [gi|446925862|ref|WP_001003118|]
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MULTISPECIES: lysozyme [Enterobacteriaceae]

Protein Classification

lysozyme( domain architecture ID 13014134)

lysozyme, also called endolysin or muramidase, hydrolyzes (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
endolysin_R21-like cd16900
endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria ...
 18-170 8.01e-57

endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria phage P21 has an N-terminal SAR (signal-arrest-release) domain that anchors the endolysin to the membrane in an inactive form, which act to prevent premature lysis of the infected bacterium. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


:

Pssm-ID: 381619 [Multi-domain]  Cd Length: 142  Bit Score: 175.05  E-value: 8.01e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862  18 GAGASApeiLDQFLDEKEGNHTTAYRDGAGIWTICRGAIlvdGKPVIPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPL 97
Cdd:cd16900    2 GALALA---AAALVGPWEGLRLTAYRDPVGVWTVCYGHT---GGDVKPGMRYTPAECDALLAKDLQEAAAAVDRCVKVPL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446925862  98 TEPQKAGIASFCpYNIGPGKCFPSTFYKRINAGDRKGACEAIRWWIKDGGRdcrirsnNCYGQVSRRDQESAL 170
Cdd:cd16900   76 PDPQRAALASFA-YNVGVGAFCRSTLLRKLNAGDRRGACDELTRWVYAGGR-------VLRGLVNRREAERAL 140
 
Name Accession Description Interval E-value
endolysin_R21-like cd16900
endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria ...
 18-170 8.01e-57

endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria phage P21 has an N-terminal SAR (signal-arrest-release) domain that anchors the endolysin to the membrane in an inactive form, which act to prevent premature lysis of the infected bacterium. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381619 [Multi-domain]  Cd Length: 142  Bit Score: 175.05  E-value: 8.01e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862  18 GAGASApeiLDQFLDEKEGNHTTAYRDGAGIWTICRGAIlvdGKPVIPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPL 97
Cdd:cd16900    2 GALALA---AAALVGPWEGLRLTAYRDPVGVWTVCYGHT---GGDVKPGMRYTPAECDALLAKDLQEAAAAVDRCVKVPL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446925862  98 TEPQKAGIASFCpYNIGPGKCFPSTFYKRINAGDRKGACEAIRWWIKDGGRdcrirsnNCYGQVSRRDQESAL 170
Cdd:cd16900   76 PDPQRAALASFA-YNVGVGAFCRSTLLRKLNAGDRRGACDELTRWVYAGGR-------VLRGLVNRREAERAL 140
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
21-176 8.96e-53

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 165.01  E-value: 8.96e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862  21 ASAPEILDQFLDEKEGNHTTAYRDGAGIWTICRGailVDGKPVIPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPLTEP 100
Cdd:COG3772    2 MKTSAAGLALIKEFEGFRLKAYRDPAGVWTIGYG---HTGKDVKPGDTITEEEAEALLAADLAKAEAAVRRLVKVPLTQN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446925862 101 QKAGIASFCpYNIGPGKCFPSTFYKRINAGDRKGACEAIRWWIKDGGRDCRirsnncyGQVSRRDQESALACWDID 176
Cdd:COG3772   79 QFDALVSFA-YNVGAGAFCRSTLLRKLNAGDYAGACDELLRWVYAGGKVLP-------GLVRRREAERALCLGGLY 146
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 48-165 2.31e-30

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 106.67  E-value: 2.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862   48 IWTICRGailVDGKPVIPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPLTEPQKAGIASFCPYNIGPGKCFPSTFYKRI 127
Cdd:pfam00959   1 YWTIGIG---HNGKDVSPHPRATKSEAAGRLQIDLDTAERCINQYHKVKDFNPNQQDALVSLAFNVGCGKRGFSTLLRAG 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 446925862  128 NAGDRKGACEAIRWWIKDGgrdcrirsNNCYGQVSRRD 165
Cdd:pfam00959  78 NIGQWIKACSAIWKSLKAG--------KVYNGLVNRRE 107
 
Name Accession Description Interval E-value
endolysin_R21-like cd16900
endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria ...
 18-170 8.01e-57

endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria phage P21 has an N-terminal SAR (signal-arrest-release) domain that anchors the endolysin to the membrane in an inactive form, which act to prevent premature lysis of the infected bacterium. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381619 [Multi-domain]  Cd Length: 142  Bit Score: 175.05  E-value: 8.01e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862  18 GAGASApeiLDQFLDEKEGNHTTAYRDGAGIWTICRGAIlvdGKPVIPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPL 97
Cdd:cd16900    2 GALALA---AAALVGPWEGLRLTAYRDPVGVWTVCYGHT---GGDVKPGMRYTPAECDALLAKDLQEAAAAVDRCVKVPL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446925862  98 TEPQKAGIASFCpYNIGPGKCFPSTFYKRINAGDRKGACEAIRWWIKDGGRdcrirsnNCYGQVSRRDQESAL 170
Cdd:cd16900   76 PDPQRAALASFA-YNVGVGAFCRSTLLRKLNAGDRRGACDELTRWVYAGGR-------VLRGLVNRREAERAL 140
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
21-176 8.96e-53

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 165.01  E-value: 8.96e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862  21 ASAPEILDQFLDEKEGNHTTAYRDGAGIWTICRGailVDGKPVIPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPLTEP 100
Cdd:COG3772    2 MKTSAAGLALIKEFEGFRLKAYRDPAGVWTIGYG---HTGKDVKPGDTITEEEAEALLAADLAKAEAAVRRLVKVPLTQN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446925862 101 QKAGIASFCpYNIGPGKCFPSTFYKRINAGDRKGACEAIRWWIKDGGRDCRirsnncyGQVSRRDQESALACWDID 176
Cdd:COG3772   79 QFDALVSFA-YNVGAGAFCRSTLLRKLNAGDYAGACDELLRWVYAGGKVLP-------GLVRRREAERALCLGGLY 146
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 48-165 2.31e-30

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 106.67  E-value: 2.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862   48 IWTICRGailVDGKPVIPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPLTEPQKAGIASFCPYNIGPGKCFPSTFYKRI 127
Cdd:pfam00959   1 YWTIGIG---HNGKDVSPHPRATKSEAAGRLQIDLDTAERCINQYHKVKDFNPNQQDALVSLAFNVGCGKRGFSTLLRAG 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 446925862  128 NAGDRKGACEAIRWWIKDGgrdcrirsNNCYGQVSRRD 165
Cdd:pfam00959  78 NIGQWIKACSAIWKSLKAG--------KVYNGLVNRRE 107
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 29-170 1.31e-26

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 97.97  E-value: 1.31e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862  29 QFLDEKEGNHTTAYRDGAGIWTICRGAILVDGkpVIPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPLTEPQKAGIASF 108
Cdd:cd00737    3 DLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVV--VKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVSF 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446925862 109 CpYNIGPGKCFPSTFYKRINAGDRKGACEAIRWWIKDGGRDCRirsnncyGQVSRRDQESAL 170
Cdd:cd00737   81 A-FNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLP-------GLVRRRAAEAAL 134
lyz_P1 cd16901
P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the ...
 9-170 3.53e-15

P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the Escherichia coli periplasm where it is membrane bound and inactive. Activation involves the release from the membrane, an intramolecular thiol-disulfide isomerization and extensive structural rearrangement of the N-terminal region. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381620 [Multi-domain]  Cd Length: 140  Bit Score: 68.40  E-value: 3.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862   9 LSAAVLALIGagasapeildqfldEKEGNHTTAYRDGAGIWTICRGAIlvdgKPVIPGMKLSKEKcdrvnaierdkALAW 88
Cdd:cd16901    2 TSAAGLELIA--------------NAEGCRRDPYKCPAGVPTIGIGST----HGVKPGDRYTDEQ-----------AAKR 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446925862  89 VEKNIR------------VPLTEPQKAGIASFCpYNIGPGKCFPSTFYKRINAGDRKGACEAIRWWIKDGGRDcrirsnn 156
Cdd:cd16901   53 LAKDIKkaercvnrcfngVPLPQGEFDAYVSFA-FNVGCGAFCKSTIYKKLQAGDYAAACNQLPRWVYAGGKV------- 124

                        170
                 ....*....|....
gi 446925862 157 CYGQVSRRDQESAL 170
Cdd:cd16901  125 LPGLVTRRQKERAL 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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