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Conserved domains on  [gi|446909172|ref|WP_000986428|]
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iron ABC transporter permease [Escherichia coli]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 24-325 2.96e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 243.82  E-value: 2.96e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  24 GIGARFIAPQTVLQAFLHFDPQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPHILGLNAGAALAVVA 103
Cdd:COG0609    3 SLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 104 ASALGLAFPVGRPLLASTGGALLFLLILLLSSAGRSGLTPMKVTLCGVALSAFVSSITAAILIL-DEQTLLAMRTWLAGD 182
Cdd:COG0609   83 AIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 183 LAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAGPIGFVGLLVP 262
Cdd:COG0609  163 LAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVP 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446909172 263 QIVRRLVSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIMATRM 325
Cdd:COG0609  243 HIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 24-325 2.96e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 243.82  E-value: 2.96e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  24 GIGARFIAPQTVLQAFLHFDPQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPHILGLNAGAALAVVA 103
Cdd:COG0609    3 SLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 104 ASALGLAFPVGRPLLASTGGALLFLLILLLSSAGRSGLTPMKVTLCGVALSAFVSSITAAILIL-DEQTLLAMRTWLAGD 182
Cdd:COG0609   83 AIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 183 LAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAGPIGFVGLLVP 262
Cdd:COG0609  163 LAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVP 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446909172 263 QIVRRLVSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIMATRM 325
Cdd:COG0609  243 HIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 14-324 2.55e-68

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 215.85  E-value: 2.55e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   14 LLLVGCVVYPGIGARFIAPQTVLQAFLHFDpQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPHILGL 93
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGD-DSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   94 NAGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLSSAGRSGLTPMKVTLCGVALSAFVSSITAAILIL-DEQTL 172
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  173 LAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAG 252
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446909172  253 PIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIMATR 324
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-325 5.59e-52

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 181.58  E-value: 5.59e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   1 MMRTGLVTVIFLALLLVGCVVYPGIGARFIAPQTVLQAFLHFDPQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAV 80
Cdd:PRK10577   7 RRRARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  81 IRNPLGEPHILGLNAGAALAVVAASALGLAFP-VGRPLLASTGGALLFLLILLLssAGRSGLTPMKVTLCGVALSAFVSS 159
Cdd:PRK10577  87 LRNPLASPTTLGVAAGAQLALVLATLFAPALLaLASQLAAFAGGLLAAALVFAL--AGGKRLSPLRLVLAGMVVSLYLGA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 160 ITAAILILDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLA 239
Cdd:PRK10577 165 LTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALAL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 240 IALLCGAAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTL--FTPHELATGVMTALVGAPV 317
Cdd:PRK10577 245 AVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPL 324


                 ....*...
gi 446909172 318 FVIMATRM 325
Cdd:PRK10577 325 LLWLLPRL 332
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 60-321 4.24e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 141.16  E-value: 4.24e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  60 LAAALLTGASLGVAGALLQAVIRNPLGEPHILGLN-AGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLSSagR 138
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGIShGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLAS--R 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 139 SGLTPMKVTLCGVALSAFVSSITAAILILDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALG 218
Cdd:cd06550   79 GGLSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 219 DRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTL 298
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|...
gi 446909172 299 FtPHELATGVMTALVGAPVFVIM 321
Cdd:cd06550  239 L-PSELPVGPVTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 24-325 2.96e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 243.82  E-value: 2.96e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  24 GIGARFIAPQTVLQAFLHFDPQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPHILGLNAGAALAVVA 103
Cdd:COG0609    3 SLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 104 ASALGLAFPVGRPLLASTGGALLFLLILLLSSAGRSGLTPMKVTLCGVALSAFVSSITAAILIL-DEQTLLAMRTWLAGD 182
Cdd:COG0609   83 AIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 183 LAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAGPIGFVGLLVP 262
Cdd:COG0609  163 LAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVP 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446909172 263 QIVRRLVSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIMATRM 325
Cdd:COG0609  243 HIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 14-324 2.55e-68

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 215.85  E-value: 2.55e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   14 LLLVGCVVYPGIGARFIAPQTVLQAFLHFDpQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPHILGL 93
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGD-DSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   94 NAGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLSSAGRSGLTPMKVTLCGVALSAFVSSITAAILIL-DEQTL 172
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  173 LAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAG 252
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446909172  253 PIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIMATR 324
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 3-325 9.94e-57

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 186.87  E-value: 9.94e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   3 RTGLVTVIFLALLLVGCVVYPGIGARFIAPQTVLQAFLHFDPQnFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIR 82
Cdd:COG4779   21 RALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDP-GASFVVLELRLPRALAALLVGAALGLSGAIFQSLTR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  83 NPLGEPHILGLNAGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLssAGRSGLTPMKVTLCGVALSAFVSSITA 162
Cdd:COG4779  100 NPLASPDIIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLL--AWRGGVSGYRLILVGIGVSAMLTAVNS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 163 AILI-LDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIA 241
Cdd:COG4779  178 YLLTrADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAV 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 242 LLCGAAVSIAGPIGFVGLLVPQIVRRLVSADlRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIM 321
Cdd:COG4779  258 ALAAVATAAAGPIAFVALAAPQIARRLTRSP-GPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWL 336


                 ....
gi 446909172 322 ATRM 325
Cdd:COG4779  337 LIRE 340
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-325 5.59e-52

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 181.58  E-value: 5.59e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   1 MMRTGLVTVIFLALLLVGCVVYPGIGARFIAPQTVLQAFLHFDPQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAV 80
Cdd:PRK10577   7 RRRARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  81 IRNPLGEPHILGLNAGAALAVVAASALGLAFP-VGRPLLASTGGALLFLLILLLssAGRSGLTPMKVTLCGVALSAFVSS 159
Cdd:PRK10577  87 LRNPLASPTTLGVAAGAQLALVLATLFAPALLaLASQLAAFAGGLLAAALVFAL--AGGKRLSPLRLVLAGMVVSLYLGA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 160 ITAAILILDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLA 239
Cdd:PRK10577 165 LTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALAL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 240 IALLCGAAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTL--FTPHELATGVMTALVGAPV 317
Cdd:PRK10577 245 AVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPL 324


                 ....*...
gi 446909172 318 FVIMATRM 325
Cdd:PRK10577 325 LLWLLPRL 332
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
3-324 2.02e-50

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 170.26  E-value: 2.02e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   3 RTGLVTVIFLALLLVGCVVYPGIGarfIAPQTVLQAFLHFDPQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIR 82
Cdd:PRK11228   1 LWGLPVAALIGLFWLSLFCYSAIP---ISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  83 NPLGEPHILGLNAGAALAVVAASALGLAFPVGRP--LLASTGGALLFLLILLLSSAGRSGLTPMKVTLCGVALSAFVSSI 160
Cdd:PRK11228  78 NPLASPSLLGINSGAALAMALTSALSPTPFAGYSlaFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMAL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 161 TAAILILDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAI 240
Cdd:PRK11228 158 TRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 241 ALLCGAAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVI 320
Cdd:PRK11228 238 LLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVW 317


                 ....
gi 446909172 321 MATR 324
Cdd:PRK11228 318 LARR 321
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
12-324 3.30e-47

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 162.18  E-value: 3.30e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  12 LALLLVGCVVYPGIGARFIAPQTVLQAFLHFDpQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPHIL 91
Cdd:PRK10441  17 LLLLIIATALSLLIGAKSLPASVVLEALSGTC-QSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  92 GLNAGAALAVVA-ASALGLAFPVGRPLLASTGGALLFLLILLLSSAGRSGLTPMKVTLCGVALSAFVSSITAAILILDEQ 170
Cdd:PRK10441  96 GVNAGASFAIVLgAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPD 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 171 TLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAAVSI 250
Cdd:PRK10441 176 VYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAV 255

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446909172 251 AGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARtLFTPHELATGVMTALVGAPVFVIMATR 324
Cdd:PRK10441 256 VGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGR-LLVPGELRVSVVSAFIGAPVLIFLVRR 328
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
42-325 3.42e-43

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 150.97  E-value: 3.42e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  42 FDPQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPHILGLNAGAALAVVAASALGLAFPV-GRPLLAS 120
Cdd:PRK09777  37 WQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSLPVmWLPLLAF 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 121 TGGALLFLLILLLssAGRSglTPMKVTLCGVALSAFVSSITAAILILDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLG 200
Cdd:PRK09777 117 IGGMAGLILLKML--AGTH--QPMKLALTGVALSALWASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWLIL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 201 GFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLS 280
Cdd:PRK09777 193 LLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVS 272

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446909172 281 ACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIMATRM 325
Cdd:PRK09777 273 ALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRM 317
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 10-324 1.02e-41

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 147.31  E-value: 1.02e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  10 IFLALLLVGCVVYPGIGARFIAPQTVLQAFLHFdpqnfdhnVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPH 89
Cdd:COG4139   17 LLLLLLLLLFVLSLCAGEVWIPPTQWLSEAWQL--------FVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  90 ILGL-NAGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLSSagRSGLTPMKVTLCGVALSAFVSSI-TAAILIL 167
Cdd:COG4139   89 LLGIsNGAGVGLVLVVLLGGGLLPPWLLSLAAIAGALLVTLLLLAFA--RRRLSNARLLLIGVALGIICSAImTWAVYFS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 168 DEQTLLAMRTWLAGDLAGQDWATLGTSaWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAA 247
Cdd:COG4139  167 SSLDLRQLMYWMMGSFGGVDWRQLWLL-LALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVS 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446909172 248 VSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIMATR 324
Cdd:COG4139  246 VALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLR 322
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
55-324 1.31e-40

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 150.37  E-value: 1.31e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  55 LRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPHILGLNA-GAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLL 133
Cdd:PRK10577 396 LRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSgAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLL 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 134 ssAGRSGLTPMKVTLCGVALSAFVSSITAAILILDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLN 213
Cdd:PRK10577 476 --ARRGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLD 553

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 214 MLALGDRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADI 293
Cdd:PRK10577 554 LLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADW 633

                        250       260       270
                 ....*....|....*....|....*....|.
gi 446909172 294 IARTLFTPHELATGVMTALVGAPVFVIMATR 324
Cdd:PRK10577 634 LGRTLLFPYQIPAGLLAALIGAPYFLWLLRR 664
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 60-321 4.24e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 141.16  E-value: 4.24e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  60 LAAALLTGASLGVAGALLQAVIRNPLGEPHILGLN-AGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLSSagR 138
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGIShGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLAS--R 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 139 SGLTPMKVTLCGVALSAFVSSITAAILILDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALG 218
Cdd:cd06550   79 GGLSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 219 DRMAQGLGVSVLRTRTFTLLAIALLCGAAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTL 298
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|...
gi 446909172 299 FtPHELATGVMTALVGAPVFVIM 321
Cdd:cd06550  239 L-PSELPVGPVTALLGAPYFLYL 260
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 10-324 4.38e-40

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 143.17  E-value: 4.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  10 IFLALLLVGCVVYPGIGARFIAPQTVLQAFlhfdpqnfDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRNPLGEPH 89
Cdd:PRK03784  20 GLSVLLLLALLLSLCAGEQWISPGDWLSPR--------GELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  90 ILGLNAGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLSSAGRSGLTPMKVTLCGVALSAFVSSI-TAAILILD 168
Cdd:PRK03784  92 LLGVSNGAGVALVAAVLLGQGLLPPWALSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICSALmTWAVYFST 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 169 EQTLLAMRTWLAGDLAGQDWatlgTSAWFSLGGFVLALYLA---PSLNMLALGDRMAQGLGVSVLRTRTFTLLAIALLCG 245
Cdd:PRK03784 172 SLDLRQLMYWMMGGFGGVDW----RQSWLMLALLPVLIWLCcqgRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVG 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446909172 246 AAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVGAPVFVIMATR 324
Cdd:PRK03784 248 VSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLR 326
btuC PRK09535
cobalamin ABC transporter permease BtuC;
4-324 8.03e-40

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 143.35  E-value: 8.03e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   4 TGLVTVIFLALLLVGCVVYPGIGARFIAPqtvlqafLHFDPQNFDHNVIVRLRLPRLAAALLTGASLGVAGALLQAVIRN 83
Cdd:PRK09535  50 VGVAVTTHGVPVLSVGLSLPAPDLEYASP-------FSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRN 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  84 PLGEPHILGLNAGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLssAGRSGLTPMK-VTLCGVALSAFVSSITA 162
Cdd:PRK09535 123 PMADPSIIGVSSGAAVGAVAAIVLPLAVPFGLQAAAFAGALVAAFGVYAI--ATENGRTPVAtLLLAGVAVQTFLGAVIS 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 163 AILILDEQTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTFTLLAIAL 242
Cdd:PRK09535 201 YLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASV 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 243 LCGAAVSIAGPIGFVGLLVPQIVRRLVSADLRVLLPLSACVGALLLLLADIIARTlfTPHELATGVMTALVGAPVFVIMA 322
Cdd:PRK09535 281 VTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYLL 358


                 ..
gi 446909172 323 TR 324
Cdd:PRK09535 359 RT 360
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
1-314 7.32e-31

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 118.66  E-value: 7.32e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172   1 MMRTGLVTVIFLALLLVGCVVYP----GIGARFIAPQTVLQAFLHFDPQNFDHnVIVRLRLPRLAAALLTGASLGVAGAL 76
Cdd:PRK10440   1 MIYVSRRLLITCLLLLAACVAAGlwglRSGAVTLETSQVFAALMGDAPRSMTM-VVTEWRLPRVLMALLIGAALGVSGAI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172  77 LQAVIRNPLGEPHILGLNAGAALAVVAASALGLAFPVGRPLLASTGGALLFLLILLLssAGRSGLTPMKVTLCGVALSAF 156
Cdd:PRK10440  80 FQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDLTAIALAAMAGGIVTSLLVWLL--AWRNGIDTFRLIIIGIGVRAM 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446909172 157 VSSITAAILILDE-QTLLAMRTWLAGDLAGQDWATLGTSAWFSLGGFVLALYLAPSLNMLALGDRMAQGLGVSVLRTRTF 235
Cdd:PRK10440 158 LVAFNTWLLLKASlETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLL 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446909172 236 TLLAIALLCGAAVSIAGPIGFVGLLVPQIVRRLvSADLRVLLPLSACVGALLLLLADIIARTLFTPHELATGVMTALVG 314
Cdd:PRK10440 238 LMLVAVVLTAAATALAGPISFIALVAPHIARRL-SGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLG 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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