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Conserved domains on  [gi|446863477|ref|WP_000940733|]
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GTP-sensing pleiotropic transcriptional regulator CodY [Streptococcus pneumoniae]

Protein Classification

codY_Gpos family protein( domain architecture ID 11494992)

codY_Gpos family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
codY_Gpos TIGR02787
GTP-sensing transcriptional pleiotropic repressor CodY; This model represents the full length ...
 4-257 4.41e-156

GTP-sensing transcriptional pleiotropic repressor CodY; This model represents the full length of CodY, a pleiotropic repressor in Bacillus subtilis and other Firmicutes (low-GC Gram-positive bacteria) that responds to intracellular levels of GTP and branched chain amino acids. The C-terminal helix-turn-helix DNA-binding region is modeled by pfam08222 in Pfam. [Regulatory functions, DNA interactions]


:

Pssm-ID: 131834  Cd Length: 251  Bit Score: 434.16  E-value: 4.41e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477    4 LLEKTRKITSILKRSeeqLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGA 83
Cdd:TIGR02787   1 LLEKTRRINSILQKS---AQTELPFNEMAEVLADVIDCNAYVISRKGRLLGYSLTYKTNNDRVEQFFQDRKFPEEYNSAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   84 NMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQR 163
Cdd:TIGR02787  78 MMIYDTEANIPVDSELTVFPEESRDLFPKGLTTIVPIYGGGERLGTLILARSDKEFNDDDLVLAEYAATVVGMELLRAQA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477  164 EEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKG 243
Cdd:TIGR02787 158 EEIEEEARKKAAVQMAINTLSYSELEAVEHIFEELDGNEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKG 237

                         250
                  ....*....|....
gi 446863477  244 TYLKVLISDIFEEV 257
Cdd:TIGR02787 238 TYIKVLNDKLIEEL 251
 
Name Accession Description Interval E-value
codY_Gpos TIGR02787
GTP-sensing transcriptional pleiotropic repressor CodY; This model represents the full length ...
 4-257 4.41e-156

GTP-sensing transcriptional pleiotropic repressor CodY; This model represents the full length of CodY, a pleiotropic repressor in Bacillus subtilis and other Firmicutes (low-GC Gram-positive bacteria) that responds to intracellular levels of GTP and branched chain amino acids. The C-terminal helix-turn-helix DNA-binding region is modeled by pfam08222 in Pfam. [Regulatory functions, DNA interactions]


Pssm-ID: 131834  Cd Length: 251  Bit Score: 434.16  E-value: 4.41e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477    4 LLEKTRKITSILKRSeeqLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGA 83
Cdd:TIGR02787   1 LLEKTRRINSILQKS---AQTELPFNEMAEVLADVIDCNAYVISRKGRLLGYSLTYKTNNDRVEQFFQDRKFPEEYNSAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   84 NMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQR 163
Cdd:TIGR02787  78 MMIYDTEANIPVDSELTVFPEESRDLFPKGLTTIVPIYGGGERLGTLILARSDKEFNDDDLVLAEYAATVVGMELLRAQA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477  164 EEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKG 243
Cdd:TIGR02787 158 EEIEEEARKKAAVQMAINTLSYSELEAVEHIFEELDGNEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKG 237

                         250
                  ....*....|....
gi 446863477  244 TYLKVLISDIFEEV 257
Cdd:TIGR02787 238 TYIKVLNDKLIEEL 251
PRK04158 PRK04158
GTP-sensing pleiotropic transcriptional regulator CodY;
1-259 7.63e-150

GTP-sensing pleiotropic transcriptional regulator CodY;


Pssm-ID: 235230 [Multi-domain]  Cd Length: 256  Bit Score: 418.42  E-value: 7.63e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   1 MAHLLEKTRKITSILKRSEEQlqdELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYV 80
Cdd:PRK04158   1 MMSLLEKTRKINRLLQKSAGE---PVDFNEMAEVLSDVIDCNVYIVSRKGKILGYSMKEKIENDRVEQMLEERQFPEEYN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477  81 QGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLN 160
Cdd:PRK04158  78 EKLLNVYETEANLDVESELTVFPVENKCLFPDKLTTIVPIIGGGERLGTLILARFDKEFTDDDLILAEYAATVVGMEILR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477 161 FQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG 240
Cdd:PRK04158 158 EKAEEIEEEARKKAVVQMAINTLSYSELEAVEHIFEELDGNEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLG 237

                        250
                 ....*....|....*....
gi 446863477 241 MKGTYLKVLISDIFEEVKK 259
Cdd:PRK04158 238 MKGTYIKVLNDKLLDELKK 256
CodY COG4465
GTP-sensing pleiotropic transcriptional regulator CodY [Transcription];
1-260 2.87e-138

GTP-sensing pleiotropic transcriptional regulator CodY [Transcription];


Pssm-ID: 443562  Cd Length: 259  Bit Score: 389.13  E-value: 2.87e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   1 MAHLLEKTRKITSILKRSEEQlqdELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVE-QFFQTKIFPDDY 79
Cdd:COG4465    1 MMSLLEKTRKINKLLQKSAGE---PVDFKEMAEVLSEVLDANVYIVSRKGKILGYALLEEFECDRMEdEMLEEKRFPEEY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477  80 VQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLL 159
Cdd:COG4465   78 NEKLLKINETKANIPIDSDLCVFPVEERCLFPNKLTTIVPIYGGGERLGTLILARFDEEFTDEDLILAEYGATVVGMEIL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477 160 NFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSL 239
Cdd:COG4465  158 REKAEEIEEEARKKAVVQMAIGTLSYSELEAVEHIFEELDGKEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSL 237

                        250       260
                 ....*....|....*....|.
gi 446863477 240 GMKGTYLKVLISDIFEEVKKR 260
Cdd:COG4465  238 GMKGTYIKVLNDKLLEELKKL 258
CodY pfam06018
CodY GAF-like domain; This domain is a GAF-like domain found at the N-terminus of several ...
 3-182 3.56e-96

CodY GAF-like domain; This domain is a GAF-like domain found at the N-terminus of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. This domain is involved in GTP binding and also branched chain amino acids (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk.


Pssm-ID: 399189  Cd Length: 177  Bit Score: 279.53  E-value: 3.56e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477    3 HLLEKTRKITSILKRSeeqLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQG 82
Cdd:pfam06018   1 TLLEKTRKINSILQKS---LGKPVPFNEMAETLADVIECNVYIVSRKGKLLGYSLTYKTENDRVKQFFEDRKFPEEYTSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   83 ANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQ 162
Cdd:pfam06018  78 LLNVYETSANLPIDSELTVFPVENKELFPNGLTTIVPIYGGGERLGTLILARVDKEFTDDDLILAEYAATVVGMEILREK 157

                         170       180
                  ....*....|....*....|
gi 446863477  163 REEDEKNIRRRTAVTMAVNT 182
Cdd:pfam06018 158 AEEIEEEARKKAVVQMAINT 177
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 193-245 1.88e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.20  E-value: 1.88e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446863477 193 AILGELNgnEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTY 245
Cdd:cd00090   11 RILRLLL--EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYY 61
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
202-237 7.67e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 37.19  E-value: 7.67e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 446863477   202 EGKLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 202-237 5.14e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 35.13  E-value: 5.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 446863477 202 EGKLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:NF033788  22 EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR 57
 
Name Accession Description Interval E-value
codY_Gpos TIGR02787
GTP-sensing transcriptional pleiotropic repressor CodY; This model represents the full length ...
 4-257 4.41e-156

GTP-sensing transcriptional pleiotropic repressor CodY; This model represents the full length of CodY, a pleiotropic repressor in Bacillus subtilis and other Firmicutes (low-GC Gram-positive bacteria) that responds to intracellular levels of GTP and branched chain amino acids. The C-terminal helix-turn-helix DNA-binding region is modeled by pfam08222 in Pfam. [Regulatory functions, DNA interactions]


Pssm-ID: 131834  Cd Length: 251  Bit Score: 434.16  E-value: 4.41e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477    4 LLEKTRKITSILKRSeeqLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGA 83
Cdd:TIGR02787   1 LLEKTRRINSILQKS---AQTELPFNEMAEVLADVIDCNAYVISRKGRLLGYSLTYKTNNDRVEQFFQDRKFPEEYNSAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   84 NMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQR 163
Cdd:TIGR02787  78 MMIYDTEANIPVDSELTVFPEESRDLFPKGLTTIVPIYGGGERLGTLILARSDKEFNDDDLVLAEYAATVVGMELLRAQA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477  164 EEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKG 243
Cdd:TIGR02787 158 EEIEEEARKKAAVQMAINTLSYSELEAVEHIFEELDGNEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKG 237

                         250
                  ....*....|....
gi 446863477  244 TYLKVLISDIFEEV 257
Cdd:TIGR02787 238 TYIKVLNDKLIEEL 251
PRK04158 PRK04158
GTP-sensing pleiotropic transcriptional regulator CodY;
1-259 7.63e-150

GTP-sensing pleiotropic transcriptional regulator CodY;


Pssm-ID: 235230 [Multi-domain]  Cd Length: 256  Bit Score: 418.42  E-value: 7.63e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   1 MAHLLEKTRKITSILKRSEEQlqdELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYV 80
Cdd:PRK04158   1 MMSLLEKTRKINRLLQKSAGE---PVDFNEMAEVLSDVIDCNVYIVSRKGKILGYSMKEKIENDRVEQMLEERQFPEEYN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477  81 QGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLN 160
Cdd:PRK04158  78 EKLLNVYETEANLDVESELTVFPVENKCLFPDKLTTIVPIIGGGERLGTLILARFDKEFTDDDLILAEYAATVVGMEILR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477 161 FQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG 240
Cdd:PRK04158 158 EKAEEIEEEARKKAVVQMAINTLSYSELEAVEHIFEELDGNEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLG 237

                        250
                 ....*....|....*....
gi 446863477 241 MKGTYLKVLISDIFEEVKK 259
Cdd:PRK04158 238 MKGTYIKVLNDKLLDELKK 256
CodY COG4465
GTP-sensing pleiotropic transcriptional regulator CodY [Transcription];
1-260 2.87e-138

GTP-sensing pleiotropic transcriptional regulator CodY [Transcription];


Pssm-ID: 443562  Cd Length: 259  Bit Score: 389.13  E-value: 2.87e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   1 MAHLLEKTRKITSILKRSEEQlqdELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVE-QFFQTKIFPDDY 79
Cdd:COG4465    1 MMSLLEKTRKINKLLQKSAGE---PVDFKEMAEVLSEVLDANVYIVSRKGKILGYALLEEFECDRMEdEMLEEKRFPEEY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477  80 VQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLL 159
Cdd:COG4465   78 NEKLLKINETKANIPIDSDLCVFPVEERCLFPNKLTTIVPIYGGGERLGTLILARFDEEFTDEDLILAEYGATVVGMEIL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477 160 NFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSL 239
Cdd:COG4465  158 REKAEEIEEEARKKAVVQMAIGTLSYSELEAVEHIFEELDGKEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSL 237

                        250       260
                 ....*....|....*....|.
gi 446863477 240 GMKGTYLKVLISDIFEEVKKR 260
Cdd:COG4465  238 GMKGTYIKVLNDKLLEELKKL 258
CodY pfam06018
CodY GAF-like domain; This domain is a GAF-like domain found at the N-terminus of several ...
 3-182 3.56e-96

CodY GAF-like domain; This domain is a GAF-like domain found at the N-terminus of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. This domain is involved in GTP binding and also branched chain amino acids (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk.


Pssm-ID: 399189  Cd Length: 177  Bit Score: 279.53  E-value: 3.56e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477    3 HLLEKTRKITSILKRSeeqLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQG 82
Cdd:pfam06018   1 TLLEKTRKINSILQKS---LGKPVPFNEMAETLADVIECNVYIVSRKGKLLGYSLTYKTENDRVKQFFEDRKFPEEYTSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477   83 ANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQ 162
Cdd:pfam06018  78 LLNVYETSANLPIDSELTVFPVENKELFPNGLTTIVPIYGGGERLGTLILARVDKEFTDDDLILAEYAATVVGMEILREK 157

                         170       180
                  ....*....|....*....|
gi 446863477  163 REEDEKNIRRRTAVTMAVNT 182
Cdd:pfam06018 158 AEEIEEEARKKAVVQMAINT 177
HTH_CodY pfam08222
CodY helix-turn-helix domain; This family consists of the C-terminal helix-turn-helix domain ...
 202-259 1.68e-26

CodY helix-turn-helix domain; This family consists of the C-terminal helix-turn-helix domain found in several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk.


Pssm-ID: 429871 [Multi-domain]  Cd Length: 61  Bit Score: 97.83  E-value: 1.68e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446863477  202 EGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKK 259
Cdd:pfam08222   2 EGRLTASSIADEIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVINEGFFDELEE 59
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 193-237 5.69e-06

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 42.91  E-value: 5.69e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 446863477  193 AILGELNGNEGkLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:pfam12840  14 RILRALVGDEP-LTASELARRLDISRNTLSYHLRKLEEAGLVEVV 57
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 189-238 3.84e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 40.65  E-value: 3.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446863477  189 RAVSAILGELNGNEGkLTASVIADRIGITRSVIVNALRKLESAGIIESRS 238
Cdd:pfam12802   5 PAQFRVLLALARNPG-LTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 192-237 1.13e-04

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 38.95  E-value: 1.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 446863477  192 SAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGI-IESR 237
Cdd:pfam08279   1 LQILQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGVpIEAE 47
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
170-237 1.40e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 41.11  E-value: 1.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446863477 170 IRRRTAVTMAVNTLSYSELRAVSAIlgelnGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:COG1846   23 LRRALDRALAELGLTPAQFRVLAAL-----AEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVERE 85
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 193-245 1.88e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.20  E-value: 1.88e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446863477 193 AILGELNgnEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTY 245
Cdd:cd00090   11 RILRLLL--EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYY 61
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
193-237 2.76e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 39.10  E-value: 2.76e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446863477 193 AILGELNgnEGKLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:COG0640   24 RILRLLA--EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSR 66
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 193-242 4.65e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.97  E-value: 4.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446863477 193 AILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMK 242
Cdd:COG2512   19 RVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRE 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
202-237 7.67e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 37.19  E-value: 7.67e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 446863477   202 EGKLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
193-235 1.19e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 38.22  E-value: 1.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 446863477 193 AILGELNGNeGKLTASVIADRIGITRSVIVNALRKLESAGIIE 235
Cdd:COG1522    9 RILRLLQED-GRLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
194-245 1.50e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.32  E-value: 1.50e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446863477 194 ILGELNGNEGkLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTY 245
Cdd:COG3398  102 ILLYLLENPG-ATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRY 152
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
188-237 1.51e-03

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 37.90  E-value: 1.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446863477 188 LRAVSAIlgELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:COG1959   10 LRALLYL--ALHPGGEPVTSKEIAERQGISPSYLEKILQKLRKAGLVESV 57
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
163-260 2.00e-03

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 39.06  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446863477 163 REEDEKNIRRRTavtmaVNTLSYSELRAVSAILGELNGNEGKLTASVI-------ADRIGI---TRSVIVNALRKLESAG 232
Cdd:COG1474  280 REKIERDRLLEV-----LRGLPTHEKLVLLAIAELLKDGEDPVRTGEVyeayeelCEELGVdplSYRRVRDYLSELEMLG 354

                         90       100       110
                 ....*....|....*....|....*....|
gi 446863477 233 IIESR--SLGMKGTYLKVLISDIFEEVKKR 260
Cdd:COG1474  355 LIEAEvsSKGRRGRTREISLSVDPEVVLEA 384
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 193-235 2.13e-03

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 36.72  E-value: 2.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 446863477   193 AILGELNGNeGKLTASVIADRIGITRSVIVNALRKLESAGIIE 235
Cdd:smart00344   7 KILEELQKD-ARISLAELAKKVGLSPSTVHNRVKRLEEEGVIK 48
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 204-239 2.59e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 35.51  E-value: 2.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 446863477  204 KLTASVIADRIGITRSVIVNALRKLESAGIIESRSL 239
Cdd:pfam13545  22 PLTQEDLADLLGTTRETVSRVLSELRREGLIERGRI 57
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 183-235 2.89e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 35.57  E-value: 2.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446863477  183 LSYSELRAVSAILgelngNEGKLTASVIADRIGITRSVIVNALRKLESAGIIE 235
Cdd:pfam01978   6 LSEYEAKVYLALL-----KLGPATADEIAEESGVPRSKVYEVLRSLEDKGLVE 53
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
183-237 2.92e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.42  E-value: 2.92e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 446863477   183 LSYSELRAVSAIlgelnGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:smart00347   8 LTPTQFLVLRIL-----YEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRRE 57
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 198-245 3.62e-03

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 36.76  E-value: 3.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 446863477  198 LNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSlGMKGTY 245
Cdd:pfam02082  17 LHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVR-GAGGGY 63
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 202-237 5.14e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 35.13  E-value: 5.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 446863477 202 EGKLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:NF033788  22 EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR 57
HTH_36 pfam13730
Helix-turn-helix domain;
189-234 5.14e-03

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 34.39  E-value: 5.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 446863477  189 RAVSAILGELNGNEGKLTASV--IADRIGITRSVIVNALRKLESAGII 234
Cdd:pfam13730   8 KLLLLILASYANKDGGCFPSVetLAKRLGLSRRTIQRAIKELEELGYL 55
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
186-237 6.02e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 35.32  E-value: 6.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446863477 186 SELRAvsAILGELNGNEgkLTASVIADRIGITRSVIVNALRKLESAGIIESR 237
Cdd:COG4189   18 SETRL--RILRLLAEEP--LNVNELAEALGLPKSTVSYHIRKLEEAGLIRTE 65
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
193-234 6.16e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 33.95  E-value: 6.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446863477  193 AILGELNGNeGKLTASVIADRIGITRSVIVNALRKLESAGII 234
Cdd:pfam13412   5 KILNLLQEN-PRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
183-235 7.54e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 35.71  E-value: 7.54e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446863477 183 LSYSELRavsaILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIE 235
Cdd:COG3355   25 LSETDAE----VYLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVE 73
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 210-247 8.37e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 33.96  E-value: 8.37e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446863477 210 IADRIGITRSVIVNALRKLESAGIIESRSlgMKGTYLK 247
Cdd:cd07377   31 LAEELGVSRTTVREALRELEAEGLVERRP--GRGTFVA 66
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
206-248 9.12e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.01  E-value: 9.12e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 446863477 206 TASVIADRIGITRSVIVNALRKLESAGIIES-RSLGMKGTYLKV 248
Cdd:COG1777   32 YVSELARELGVSRQAVYKHLRKLEEAGLVESyREGREDGRARKY 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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