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Conserved domains on  [gi|446838926|ref|WP_000916182|]
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MULTISPECIES: TrbC/VirB2 family protein [Gammaproteobacteria]

Protein Classification

TrbC/VirB2 family protein( domain architecture ID 10522976)

TrbC/VirB2 family protein may function a major pilus subunit; similar to type IV secretion system protein PtlA, which is a component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrbC pfam04956
TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein ...
 1-97 3.81e-14

TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains VIRB2 type IV secretion proteins. This alignment contains two predicted transmembrane helices.


:

Pssm-ID: 398559  Cd Length: 98  Bit Score: 62.24  E-value: 3.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838926   1 MLKLNLNKRYLTLSLFMAALMLCVAEPAFADDVSTKTTGFLQKIIDFLT-DIRKPAITIIALVIGYIAIFSRQHTSWIVP 79
Cdd:pfam04956  1 MKLLKRKLRRLALALALAALLLLLASPAFAQGSGDPVETALQNIVDSLTgPIARVIATIAIIIAGIMLAFGRLSWRTLVY 80

                         90
                 ....*....|....*...
gi 446838926  80 LVIGIIIFIVAPYIPDWL 97
Cdd:pfam04956 81 VVIGIVIIFGASTIVSTL 98
 
Name Accession Description Interval E-value
TrbC pfam04956
TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein ...
 1-97 3.81e-14

TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains VIRB2 type IV secretion proteins. This alignment contains two predicted transmembrane helices.


Pssm-ID: 398559  Cd Length: 98  Bit Score: 62.24  E-value: 3.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838926   1 MLKLNLNKRYLTLSLFMAALMLCVAEPAFADDVSTKTTGFLQKIIDFLT-DIRKPAITIIALVIGYIAIFSRQHTSWIVP 79
Cdd:pfam04956  1 MKLLKRKLRRLALALALAALLLLLASPAFAQGSGDPVETALQNIVDSLTgPIARVIATIAIIIAGIMLAFGRLSWRTLVY 80

                         90
                 ....*....|....*...
gi 446838926  80 LVIGIIIFIVAPYIPDWL 97
Cdd:pfam04956 81 VVIGIVIIFGASTIVSTL 98
VirB2 COG3838
Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and ...
 1-93 1.42e-03

Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443049  Cd Length: 109  Bit Score: 34.93  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838926   1 MLKLNLNKRYLTLSLFMAALMLCVAEPAFADDVSTKTTGFLQKIIDFLTDIRKPAITIIALVI-GYIAIFSRQHTS--WI 77
Cdd:COG3838    1 MKFLSMPLRRRLLLLALAALLLLLASPAFAAGSGMPWEGPLQQIVNSLTGPVAKAIAVIAIIVaGLMLAFGELNGGfrRA 80

                         90
                 ....*....|....*.
gi 446838926  78 VPLVIGIIIFIVAPYI 93
Cdd:COG3838   81 IQVVLGISIAFGASSI 96
 
Name Accession Description Interval E-value
TrbC pfam04956
TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein ...
 1-97 3.81e-14

TrbC/VIRB2 pilin; TrbC is a pilin found in bacterial type IV secretion systems. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains VIRB2 type IV secretion proteins. This alignment contains two predicted transmembrane helices.


Pssm-ID: 398559  Cd Length: 98  Bit Score: 62.24  E-value: 3.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838926   1 MLKLNLNKRYLTLSLFMAALMLCVAEPAFADDVSTKTTGFLQKIIDFLT-DIRKPAITIIALVIGYIAIFSRQHTSWIVP 79
Cdd:pfam04956  1 MKLLKRKLRRLALALALAALLLLLASPAFAQGSGDPVETALQNIVDSLTgPIARVIATIAIIIAGIMLAFGRLSWRTLVY 80

                         90
                 ....*....|....*...
gi 446838926  80 LVIGIIIFIVAPYIPDWL 97
Cdd:pfam04956 81 VVIGIVIIFGASTIVSTL 98
VirB2 COG3838
Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and ...
 1-93 1.42e-03

Type IV secretory pathway, VirB2 component (pilin) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443049  Cd Length: 109  Bit Score: 34.93  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838926   1 MLKLNLNKRYLTLSLFMAALMLCVAEPAFADDVSTKTTGFLQKIIDFLTDIRKPAITIIALVI-GYIAIFSRQHTS--WI 77
Cdd:COG3838    1 MKFLSMPLRRRLLLLALAALLLLLASPAFAAGSGMPWEGPLQQIVNSLTGPVAKAIAVIAIIVaGLMLAFGELNGGfrRA 80

                         90
                 ....*....|....*.
gi 446838926  78 VPLVIGIIIFIVAPYI 93
Cdd:COG3838   81 IQVVLGISIAFGASSI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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