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Conserved domains on  [gi|446781130|ref|WP_000858386|]
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MULTISPECIES: Tol-Pal system beta propeller repeat protein TolB [Acinetobacter]

Protein Classification

Tol-Pal system beta propeller repeat protein TolB( domain architecture ID 11495503)

Tol-Pal system beta propeller repeat protein TolB is part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Gene Ontology:  GO:0042597|GO:0007049|GO:0017038|GO:0051301
PubMed:  32152098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 19-423 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 528.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130   19 PLAPTAAFAQLHLEIAKAPDQAPKIAIVPFNNDNGLYP----------IVETDLNRSGRFTSSSKN--LPANAAINQIQA 86
Cdd:TIGR02800   1 LAVSTPAAADLTIEITKGGASALPIAVAPFSNDGGGSPdanlgesiaeVIANDLKRSGLFSPVDKAglPSNPIAESQVNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130   87 SDWQAAGIPYVVTGQIKQTADG-FEVHYQLYDVQKQQ-YLLNELLNVPASRIRQAGHMVSDAIYQALTGIPGDFSGRIAY 164
Cdd:TIGR02800  81 AAWQALGADALVVGSVTPNGNGrYTVRFRLYDVVSGQlQLLGKQYTVTASQLRRVAHRIADAIYEKLTGERGAFSTRIAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  165 VLRNPATPaeRYTLQIADTDGEQPKTVLSSRDPILSPAWTPDAKKIAYVSFETKRPAIYLQDLSTGTREVLTSFKGLNGA 244
Cdd:TIGR02800 161 VSKSGKSR--RYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDLATGQREKVASFPGMNGA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  245 PSFSPDGKSMLFTASMNGNPEIYQMDLSTRQVKRMTNDSGIDTEARYTPDGKAFIFTSDRGGSPQIYRYDFGNGSVKRLT 324
Cdd:TIGR02800 239 PAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGSPQIYMMDADGGEVRRLT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  325 FKGSFNARGTLSADGKKIALVHRpSGSNYKVAIQDINTGIVNILTPTSLDESPSFSPNGQMVVYATREGNRGLLSIMSTD 404
Cdd:TIGR02800 319 FRGGYNASPSWSPDGDLIAFVHR-EGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILYATTRGGRGVLGLVSTD 397

                         410
                  ....*....|....*....
gi 446781130  405 GRFRMNLPSEQGEVREPAW 423
Cdd:TIGR02800 398 GRFRARLPLGNGDVREPAW 416
 
Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 19-423 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 528.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130   19 PLAPTAAFAQLHLEIAKAPDQAPKIAIVPFNNDNGLYP----------IVETDLNRSGRFTSSSKN--LPANAAINQIQA 86
Cdd:TIGR02800   1 LAVSTPAAADLTIEITKGGASALPIAVAPFSNDGGGSPdanlgesiaeVIANDLKRSGLFSPVDKAglPSNPIAESQVNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130   87 SDWQAAGIPYVVTGQIKQTADG-FEVHYQLYDVQKQQ-YLLNELLNVPASRIRQAGHMVSDAIYQALTGIPGDFSGRIAY 164
Cdd:TIGR02800  81 AAWQALGADALVVGSVTPNGNGrYTVRFRLYDVVSGQlQLLGKQYTVTASQLRRVAHRIADAIYEKLTGERGAFSTRIAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  165 VLRNPATPaeRYTLQIADTDGEQPKTVLSSRDPILSPAWTPDAKKIAYVSFETKRPAIYLQDLSTGTREVLTSFKGLNGA 244
Cdd:TIGR02800 161 VSKSGKSR--RYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDLATGQREKVASFPGMNGA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  245 PSFSPDGKSMLFTASMNGNPEIYQMDLSTRQVKRMTNDSGIDTEARYTPDGKAFIFTSDRGGSPQIYRYDFGNGSVKRLT 324
Cdd:TIGR02800 239 PAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGSPQIYMMDADGGEVRRLT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  325 FKGSFNARGTLSADGKKIALVHRpSGSNYKVAIQDINTGIVNILTPTSLDESPSFSPNGQMVVYATREGNRGLLSIMSTD 404
Cdd:TIGR02800 319 FRGGYNASPSWSPDGDLIAFVHR-EGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILYATTRGGRGVLGLVSTD 397

                         410
                  ....*....|....*....
gi 446781130  405 GRFRMNLPSEQGEVREPAW 423
Cdd:TIGR02800 398 GRFRARLPLGNGDVREPAW 416
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 254-406 4.30e-46

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 156.37  E-value: 4.30e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 254 MLFTASMNGNPEIYQMDLSTRQVKRMTNDSGIDTEARYTPDGKAFIFTSDRGGSPQIYRYDFGNGSVKRLTFKGSFNARG 333
Cdd:COG0823    1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446781130 334 TLSADGKKIALVHRPSGsNYKVAIQDINTGIVNILTPTSLdeSPSFSPNGQMVVYATREGNRGLLSIMSTDGR 406
Cdd:COG0823   81 SWSPDGKRLAFVSRSDG-RFDIYVLDLDGGAPRRLTDGPG--SPSWSPDGRRIVFSSDRGGRPDLYVVDLDGR 150
tolB PRK01029
Tol-Pal system protein TolB;
73-423 9.81e-32

Tol-Pal system protein TolB;


Pssm-ID: 234889 [Multi-domain]  Cd Length: 428  Bit Score: 125.26  E-value: 9.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  73 KNLPANAAINQIQASDWQAAGIPYVVTGQIKQT----ADGFEVHYQLYDVQKQQYLlnellnvpaSRIRQAGHMVSDAIY 148
Cdd:PRK01029  65 FDLALGDLLQPTKESKESSAPLFIFIEAHYPELvfslKKEGKNPQKLFSLELSGDL---------SKDRQKIHEAADTIH 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 149 QALTGIPGDFSGRIAYVLRNPATPAERYTLQI--ADTDGEQPKTVLSSRDPILSPAWTPDAKKIA--YVSFETKRPAIYL 224
Cdd:PRK01029 136 YALTGVPGISSGKIIFSLSTTNSDTELKQGELwsVDYDGQNLRPLTQEHSLSITPTWMHIGSGFPylYVSYKLGVPKIFL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 225 QDLSTGTREVLTSFKGLNGAPSFSPDGKSMLFTASMNGNPEIYQMDLSTRQ-----VKRMTNDS-GIDTEARYTPDGKAF 298
Cdd:PRK01029 216 GSLENPAGKKILALQGNQLMPTFSPRKKLLAFISDRYGNPDLFIQSFSLETgaigkPRRLLNEAfGTQGNPSFSPDGTRL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 299 IFTSDRGGSPQIY--RYDFGNGSVKRLTFKGSFNARGTLSADGKKIALVHRPSGSNyKVAIQDINTGIVNILTPTSLD-E 375
Cdd:PRK01029 296 VFVSNKDGRPRIYimQIDPEGQSPRLLTKKYRNSSCPAWSPDGKKIAFCSVIKGVR-QICVYDLATGRDYQLTTSPENkE 374

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446781130 376 SPSFSPNGQMVVYATreGNRG-----LLSIMSTDGRfrmNLPSEQGEVREPAW 423
Cdd:PRK01029 375 SPSWAIDSLHLVYSA--GNSNeselyLISLITKKTR---KIVIGSGEKRFPSW 422
TolB_N pfam04052
TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent ...
 29-124 1.82e-22

TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.


Pssm-ID: 461148  Cd Length: 105  Bit Score: 91.53  E-value: 1.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130   29 LHLEIAKAPDQAPKIAIVPFNNDNG------LYPIVETDLNRSGRFtsssKNLPANAAIN------QIQASDWQAAGIPY 96
Cdd:pfam04052   1 LRIEITGGGDTALPIAVVPFQGEGGadlpqdISEVIAADLERSGLF----RPIDPAAFPQrptsdsEVDFADWRALGADA 76

                          90       100
                  ....*....|....*....|....*....
gi 446781130   97 VVTGQIKQTADG-FEVHYQLYDVQKQQYL 124
Cdd:pfam04052  77 LVTGSVTRGGDGrYKVEFRLYDVVKGKQL 105
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-351 2.47e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 177 TLQIADTDGEQPKTVLSS-RDPILSPAWTPDAKKIAYVSFETKrpaIYLQDLSTGtrEVLTSFKGLNG---APSFSPDGK 252
Cdd:cd00200  116 TIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGT---IKLWDLRTG--KCVATLTGHTGevnSVAFSPDGE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 253 SMLFTASmngNPEIYQMDLST-RQVKRMTNDSGIDTEARYTPDGKaFIFTSDRGGSpqIYRYDFGNGSVKRlTFKGSFNA 331
Cdd:cd00200  191 KLLSSSS---DGTIKLWDLSTgKCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGT--IRVWDLRTGECVQ-TLSGHTNS 263

                        170       180
                 ....*....|....*....|
gi 446781130 332 RGTLSADGKKIALVhrpSGS 351
Cdd:cd00200  264 VTSLAWSPDGKRLA---SGS 280
 
Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 19-423 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 528.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130   19 PLAPTAAFAQLHLEIAKAPDQAPKIAIVPFNNDNGLYP----------IVETDLNRSGRFTSSSKN--LPANAAINQIQA 86
Cdd:TIGR02800   1 LAVSTPAAADLTIEITKGGASALPIAVAPFSNDGGGSPdanlgesiaeVIANDLKRSGLFSPVDKAglPSNPIAESQVNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130   87 SDWQAAGIPYVVTGQIKQTADG-FEVHYQLYDVQKQQ-YLLNELLNVPASRIRQAGHMVSDAIYQALTGIPGDFSGRIAY 164
Cdd:TIGR02800  81 AAWQALGADALVVGSVTPNGNGrYTVRFRLYDVVSGQlQLLGKQYTVTASQLRRVAHRIADAIYEKLTGERGAFSTRIAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  165 VLRNPATPaeRYTLQIADTDGEQPKTVLSSRDPILSPAWTPDAKKIAYVSFETKRPAIYLQDLSTGTREVLTSFKGLNGA 244
Cdd:TIGR02800 161 VSKSGKSR--RYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDLATGQREKVASFPGMNGA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  245 PSFSPDGKSMLFTASMNGNPEIYQMDLSTRQVKRMTNDSGIDTEARYTPDGKAFIFTSDRGGSPQIYRYDFGNGSVKRLT 324
Cdd:TIGR02800 239 PAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGSPQIYMMDADGGEVRRLT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  325 FKGSFNARGTLSADGKKIALVHRpSGSNYKVAIQDINTGIVNILTPTSLDESPSFSPNGQMVVYATREGNRGLLSIMSTD 404
Cdd:TIGR02800 319 FRGGYNASPSWSPDGDLIAFVHR-EGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILYATTRGGRGVLGLVSTD 397

                         410
                  ....*....|....*....
gi 446781130  405 GRFRMNLPSEQGEVREPAW 423
Cdd:TIGR02800 398 GRFRARLPLGNGDVREPAW 416
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 254-406 4.30e-46

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 156.37  E-value: 4.30e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 254 MLFTASMNGNPEIYQMDLSTRQVKRMTNDSGIDTEARYTPDGKAFIFTSDRGGSPQIYRYDFGNGSVKRLTFKGSFNARG 333
Cdd:COG0823    1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446781130 334 TLSADGKKIALVHRPSGsNYKVAIQDINTGIVNILTPTSLdeSPSFSPNGQMVVYATREGNRGLLSIMSTDGR 406
Cdd:COG0823   81 SWSPDGKRLAFVSRSDG-RFDIYVLDLDGGAPRRLTDGPG--SPSWSPDGRRIVFSSDRGGRPDLYVVDLDGR 150
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 180-324 1.64e-34

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 125.94  E-value: 1.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 180 IADTDGEQPKTVLSSRDPILSPAWTPDAKKIAYVSFETKRPAIYLQDLSTGTREVLTSFKGLNGAPSFSPDGKSMLFTAS 259
Cdd:COG0823   15 VVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446781130 260 MNGNPEIYQMDLSTRQVKRMTNDSGidtEARYTPDGKAFIFTSDRGGSPQIYRYDFgNGSVKRLT 324
Cdd:COG0823   95 SDGRFDIYVLDLDGGAPRRLTDGPG---SPSWSPDGRRIVFSSDRGGRPDLYVVDL-DGRKRRLT 155
tolB PRK01029
Tol-Pal system protein TolB;
73-423 9.81e-32

Tol-Pal system protein TolB;


Pssm-ID: 234889 [Multi-domain]  Cd Length: 428  Bit Score: 125.26  E-value: 9.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  73 KNLPANAAINQIQASDWQAAGIPYVVTGQIKQT----ADGFEVHYQLYDVQKQQYLlnellnvpaSRIRQAGHMVSDAIY 148
Cdd:PRK01029  65 FDLALGDLLQPTKESKESSAPLFIFIEAHYPELvfslKKEGKNPQKLFSLELSGDL---------SKDRQKIHEAADTIH 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 149 QALTGIPGDFSGRIAYVLRNPATPAERYTLQI--ADTDGEQPKTVLSSRDPILSPAWTPDAKKIA--YVSFETKRPAIYL 224
Cdd:PRK01029 136 YALTGVPGISSGKIIFSLSTTNSDTELKQGELwsVDYDGQNLRPLTQEHSLSITPTWMHIGSGFPylYVSYKLGVPKIFL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 225 QDLSTGTREVLTSFKGLNGAPSFSPDGKSMLFTASMNGNPEIYQMDLSTRQ-----VKRMTNDS-GIDTEARYTPDGKAF 298
Cdd:PRK01029 216 GSLENPAGKKILALQGNQLMPTFSPRKKLLAFISDRYGNPDLFIQSFSLETgaigkPRRLLNEAfGTQGNPSFSPDGTRL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 299 IFTSDRGGSPQIY--RYDFGNGSVKRLTFKGSFNARGTLSADGKKIALVHRPSGSNyKVAIQDINTGIVNILTPTSLD-E 375
Cdd:PRK01029 296 VFVSNKDGRPRIYimQIDPEGQSPRLLTKKYRNSSCPAWSPDGKKIAFCSVIKGVR-QICVYDLATGRDYQLTTSPENkE 374

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446781130 376 SPSFSPNGQMVVYATreGNRG-----LLSIMSTDGRfrmNLPSEQGEVREPAW 423
Cdd:PRK01029 375 SPSWAIDSLHLVYSA--GNSNeselyLISLITKKTR---KIVIGSGEKRFPSW 422
tolB PRK04043
Tol-Pal system protein TolB;
201-400 7.45e-29

Tol-Pal system protein TolB;


Pssm-ID: 235212 [Multi-domain]  Cd Length: 419  Bit Score: 117.02  E-value: 7.45e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 201 PAWTPDA-KKIAYVSFETKRPAIYLQDLSTGTREVLTSFKGLNGAPSFSPDGKSMLFTASMNGNPEIYQMDLSTRQVKRM 279
Cdd:PRK04043 193 PKWANKEqTAFYYTSYGERKPTLYKYNLYTGKKEKIASSQGMLVVSDVSKDGSKLLLTMAPKGQPDIYLYDTNTKTLTQI 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 280 TNDSGIDTEARYTPDGKAFIFTSDRGGSPQIYRYDFGNGSVKRLTFKGSFNArgTLSADGKKIALVHRPS----GSN-YK 354
Cdd:PRK04043 273 TNYPGIDVNGNFVEDDKRIVFVSDRLGYPNIFMKKLNSGSVEQVVFHGKNNS--SVSTYKNYIVYSSRETnnefGKNtFN 350

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446781130 355 VAIQDINTGIVNILTPTSLDESPSFSPNGQMVVYATREGNRGLLSI 400
Cdd:PRK04043 351 LYLISTNSDYIRRLTANGVNQFPRFSSDGGSIMFIKYLGNQSALGI 396
TolB_N pfam04052
TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent ...
 29-124 1.82e-22

TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.


Pssm-ID: 461148  Cd Length: 105  Bit Score: 91.53  E-value: 1.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130   29 LHLEIAKAPDQAPKIAIVPFNNDNG------LYPIVETDLNRSGRFtsssKNLPANAAIN------QIQASDWQAAGIPY 96
Cdd:pfam04052   1 LRIEITGGGDTALPIAVVPFQGEGGadlpqdISEVIAADLERSGLF----RPIDPAAFPQrptsdsEVDFADWRALGADA 76

                          90       100
                  ....*....|....*....|....*....
gi 446781130   97 VVTGQIKQTADG-FEVHYQLYDVQKQQYL 124
Cdd:pfam04052  77 LVTGSVTRGGDGrYKVEFRLYDVVKGKQL 105
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 178-283 1.35e-19

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 85.11  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 178 LQIADTDGEQPKTVLSSRDPILSPAWTPDAKKIAYVSFETKRPAIYLQDLSTGTREVLTSFkglNGAPSFSPDGKSMLFT 257
Cdd:COG0823   57 IYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRSDGRFDIYVLDLDGGAPRRLTDG---PGSPSWSPDGRRIVFS 133

                         90       100
                 ....*....|....*....|....*.
gi 446781130 258 ASMNGNPEIYQMDLSTRQvKRMTNDS 283
Cdd:COG0823  134 SDRGGRPDLYVVDLDGRK-RRLTPAS 158
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 175-322 1.74e-19

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 91.25  E-value: 1.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  175 RYTLQIADTDGEQPKTVLSSRDP--ILSPAWTPDAKKIAYVSfetKRPAIYLQDLSTGT-REVLTS-FKGLNGAPSFSPD 250
Cdd:COG4946   366 EYELYIAPADGSGEPKQLTLGDLgrVFNPVWSPDGKKIAFTD---NRGRLWVVDLASGKvRKVDTDgYGDGISDLAWSPD 442

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446781130  251 GKSMLFTASM-NGNPEIYQMDLSTRQVKRMTNDSGIDTEARYTPDGKAFIFTSDRGGSPQIYRYDFGNGSVKR 322
Cdd:COG4946   443 SKWLAYSKPGpNQLSQIFLYDVETGKTVQLTDGRYDDGSPAFSPDGKYLYFLSSRDFNPTYGDLDFDLAFPRT 515
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 222-425 1.36e-18

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 88.56  E-value: 1.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  222 IYLQDLSTGT----------------REVLTSFKGLNGApSFSPDGKSMLFTAsmNGnpEIYQMDLSTRQVKRMTNDSGI 285
Cdd:COG4946   269 LYLLDLASGEprklnitlagdfpqrrPRWVDVSGYLTSF-ALSPDGKRVAFEA--RG--EVFTVPAEKGPTRNLTNTPGV 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  286 -DTEARYTPDGKAFIFTSDRGGSPQIYRYDF-GNGSVKRLT-FKGSFNARGTLSADGKKIALVHRpsgsNYKVAIQDINT 362
Cdd:COG4946   344 rERLPAWSPDGKSIAYFSDASGEYELYIAPAdGSGEPKQLTlGDLGRVFNPVWSPDGKKIAFTDN----RGRLWVVDLAS 419

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446781130  363 G-IVNILTPTSLDE--SPSFSPNGQMVVYATREGNR----GLLSIMS------TDGRFrmnlpseqgEVREPAWAP 425
Cdd:COG4946   420 GkVRKVDTDGYGDGisDLAWSPDSKWLAYSKPGPNQlsqiFLYDVETgktvqlTDGRY---------DDGSPAFSP 486
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 180-425 2.14e-17

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 84.70  E-value: 2.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  180 IADTDGEQPK--TVLSSRDPILspAWTPDAKKIAYVS----FETKRPAIYLQDLSTGTREVLTSfkGLNGAPSFSPDGKS 253
Cdd:COG4946    89 VMPAEGGEPKrlTYHPANDRVV--GWTPDGKSVLFASnrgsPPSRSNQLYTVPVDGGLPERLPL--PPAGDGSFSPDGKK 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  254 MLFTASMNG-----------NPEIYQMDLSTRQVKRMTNDSGIDTEAryTPDGKAFIFTSDRGGSPQIYRYDFGNGSVKR 322
Cdd:COG4946   165 LAYTRIGREfrtwkryrggtAGDIWIYDLGTGEFTRLTDFGGNDRNP--MWIGDRIYFLSDRDGTFNLYSYDPDGKDLRQ 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  323 LT-FKGsFNARGtLSADGKKIAL-----VHR---PSGSNYKVAIqDINTGIVNiLTPTSLD-----ESPSFSPNGQMVVY 388
Cdd:COG4946   243 LThFKD-FDVRF-PSTDGGRIVYeqggdLYLldlASGEPRKLNI-TLAGDFPQ-RRPRWVDvsgylTSFALSPDGKRVAF 318

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 446781130  389 ATregnRGLLSIMSTDGRFRMNLPSEQGE-VREPAWAP 425
Cdd:COG4946   319 EA----RGEVFTVPAEKGPTRNLTNTPGVrERLPAWSP 352
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 222-382 3.60e-17

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 83.93  E-value: 3.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  222 IYLQDLSTGTREVLTSFKGLNGAPSFSPDGKSMLFTASMNGNPEIYQMDLSTRQVKRMTNDSGIDTEARYTPDGKAFIFT 301
Cdd:COG4946    43 LWTVPADGGRARRLTSHPGYESFPRFSPDGKWIAFTSDYDGNTDVYVMPAEGGEPKRLTYHPANDRVVGWTPDGKSVLFA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  302 SDRG----GSPQIYRYDFGNGSVKRLTFKGSFNarGTLSADGKKIALV-----------HRpSGSNYKVAIQDINTGIV- 365
Cdd:COG4946   123 SNRGsppsRSNQLYTVPVDGGLPERLPLPPAGD--GSFSPDGKKLAYTrigrefrtwkrYR-GGTAGDIWIYDLGTGEFt 199

                         170
                  ....*....|....*..
gi 446781130  366 NILTPTSLDESPSFSPN 382
Cdd:COG4946   200 RLTDFGGNDRNPMWIGD 216
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 177-343 1.13e-14

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 76.23  E-value: 1.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  177 TLQIADTDGEQpktvlssrdpILSPAWTPDAKKIAYVSFETKRPAIYLQDLST-GTREVLTSFK-GLNGAPSFSPDGKSM 254
Cdd:COG4946   334 TRNLTNTPGVR----------ERLPAWSPDGKSIAYFSDASGEYELYIAPADGsGEPKQLTLGDlGRVFNPVWSPDGKKI 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  255 LFTasmNGNPEIYQMDLSTRQVKRMTnDSGIDTEARY---TPDGKAFIFTSDRGGS-PQIYRYDFGNGSVKRLTfKGSFN 330
Cdd:COG4946   404 AFT---DNRGRLWVVDLASGKVRKVD-TDGYGDGISDlawSPDSKWLAYSKPGPNQlSQIFLYDVETGKTVQLT-DGRYD 478

                         170
                  ....*....|....
gi 446781130  331 ARG-TLSADGKKIA 343
Cdd:COG4946   479 DGSpAFSPDGKYLY 492
WD40 COG2319
WD40 repeat [General function prediction only];
133-425 3.92e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 3.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 133 ASRIRQAGHMVSDAIYQALTGIPGDFSGRIAYVLRNP-----ATPAERYTLQIADTDGEQPKTVLSS-RDPILSPAWTPD 206
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPdgrllASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAFSPD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 207 AKKIAYVSFETkrpAIYLQDLSTGtrEVLTSFKGLNGAP---SFSPDGKsMLFTASMNGNPEIYqmDLST-RQVKRMTND 282
Cdd:COG2319  132 GKTLASGSADG---TVRLWDLATG--KLLRTLTGHSGAVtsvAFSPDGK-LLASGSDDGTVRLW--DLATgKLLRTLTGH 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 283 SGIDTEARYTPDGKAFIFTS--------DRGGSPQIYRYDFGNGSVKRLTFkgsfnargtlSADGKKIAlvhrpSGSNYK 354
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSadgtvrlwDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLLA-----SGSADG 268

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446781130 355 -VAIQDINTG-IVNILT-PTSLDESPSFSPNGQMVVYATREGNRGLLSImsTDGRFRMNLPSEQGEVREPAWAP 425
Cdd:COG2319  269 tVRLWDLATGeLLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSP 340
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 159-349 2.14e-13

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 72.38  E-value: 2.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  159 SGRIAYVlrnpatpAERYTLQIADTDGEQPKTVLSSR--DPILSPAWTPDAKKIAYVSFETK-RPAIYLQDLSTGTREVL 235
Cdd:COG4946   400 GKKIAFT-------DNRGRLWVVDLASGKVRKVDTDGygDGISDLAWSPDSKWLAYSKPGPNqLSQIFLYDVETGKTVQL 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  236 TSfKGLN-GAPSFSPDGKSMLFTASMNGNPEIYQMDLSTRQVKRM------------------------------TNDSG 284
Cdd:COG4946   473 TD-GRYDdGSPAFSPDGKYLYFLSSRDFNPTYGDLDFDLAFPRTTriyavplrkdapspfapesdeeaakkeedeKKKKK 551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130  285 -------------IDTE-------------ARY-----TPDGKAFIFTSDRGGS-PQIYRYDFGNGSVKRLT-FKGSFna 331
Cdd:COG4946   552 kkddkkkkpkpvkIDFDgiedrivalpvpaGNYsdlaaGKGGVLYLLEPVEGAPgGTLYRYDLEKRKTETLAdGVSSY-- 629

                         250
                  ....*....|....*...
gi 446781130  332 rgTLSADGKKIALVHRPS 349
Cdd:COG4946   630 --ELSADGKKLLVRSGGR 645
WD40 COG2319
WD40 repeat [General function prediction only];
183-393 2.79e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 2.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 183 TDGEQPKTVLSSRDPILSPAWTPDAKKIAYVSFETKrpaIYLQDLSTGtrEVLTSFKGLNG---APSFSPDGKsMLFTAS 259
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT---VRLWDLATG--KLLRTLTGHSGsvrSVAFSPDGR-LLASGS 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 260 MNGNPEIYqmDLSTRQ-VKRMTNDSGIDTEARYTPDGKaFIFTSDRGGSpqIYRYDFGNGSVKRlTFKGSFNARGTL--S 336
Cdd:COG2319  266 ADGTVRLW--DLATGElLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGT--VRLWDLATGKLLR-TLTGHTGAVRSVafS 339

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446781130 337 ADGKKIAlvhrpSGSNYK-VAIQDINTG-IVNILT-----PTSLdespSFSPNGQMVVYATREG 393
Cdd:COG2319  340 PDGKTLA-----SGSDDGtVRLWDLATGeLLRTLTghtgaVTSV----AFSPDGRTLASGSADG 394
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 276-312 2.84e-09

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 52.13  E-value: 2.84e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 446781130  276 VKRMTNDSGIDTEARYTPDGKAFIFTSDRGGSPQIYR 312
Cdd:pfam07676   1 LGRLTNTPGNETAPSWSPDGKRLAFSSDRDGKPDIYV 37
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 299-425 1.24e-07

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 50.83  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 299 IFTSDRGGSPQIYRYDFGNGSVKRLTfkgsfnargtlsadgkkialvhrpsgsnykvaiqdintgivnilTPTSLDESPS 378
Cdd:COG0823    2 AFTLSRDGNSDIYVVDLDGGEPRRLT--------------------------------------------NSPGIDTSPA 37

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446781130 379 FSPNGQMVVYATREGNRGLLSIMSTDGRFRMNLPSEQGEVREPAWAP 425
Cdd:COG0823   38 WSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSP 84
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 232-268 6.64e-07

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 45.59  E-value: 6.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 446781130  232 REVLTSFKGLNGAPSFSPDGKSMLFTASMNGNPEIYQ 268
Cdd:pfam07676   1 LGRLTNTPGNETAPSWSPDGKRLAFSSDRDGKPDIYV 37
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-351 2.47e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 177 TLQIADTDGEQPKTVLSS-RDPILSPAWTPDAKKIAYVSFETKrpaIYLQDLSTGtrEVLTSFKGLNG---APSFSPDGK 252
Cdd:cd00200  116 TIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGT---IKLWDLRTG--KCVATLTGHTGevnSVAFSPDGE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446781130 253 SMLFTASmngNPEIYQMDLST-RQVKRMTNDSGIDTEARYTPDGKaFIFTSDRGGSpqIYRYDFGNGSVKRlTFKGSFNA 331
Cdd:cd00200  191 KLLSSSS---DGTIKLWDLSTgKCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGT--IRVWDLRTGECVQ-TLSGHTNS 263

                        170       180
                 ....*....|....*....|
gi 446781130 332 RGTLSADGKKIALVhrpSGS 351
Cdd:cd00200  264 VTSLAWSPDGKRLA---SGS 280
Pectate_lyase22 pfam14583
Oligogalacturonate lyase; This is a family of oligogalacturonate lyases, referred to more ...
 220-267 3.67e-03

Oligogalacturonate lyase; This is a family of oligogalacturonate lyases, referred to more generally as pectate lyase family 22. These proteins fold into 7-bladed beta-propellers.


Pssm-ID: 434052 [Multi-domain]  Cd Length: 386  Bit Score: 39.23  E-value: 3.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446781130  220 PAIYLQDLSTGTREVL----TSFKGLNG-------APSFSPDGKSMLFTASMNGNPEIY 267
Cdd:pfam14583 320 PFLYVFNMKNGTQHRVarhdTSWEVFEGdrqvthpHPSFTPDDKQILFTSDVHGKPALY 378
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 188-223 6.18e-03

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 34.41  E-value: 6.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 446781130  188 PKTVLSSRDPILSPAWTPDAKKIAYVSFETKRPAIY 223
Cdd:pfam07676   1 LGRLTNTPGNETAPSWSPDGKRLAFSSDRDGKPDIY 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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