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Conserved domains on  [gi|446723270|ref|WP_000800583|]
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sensor histidine kinase [Streptococcus pneumoniae]

Protein Classification

sensor histidine kinase( domain architecture ID 11459466)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to a signal; may contain an N-terminal HAMP signaling domain

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524|GO:0000156
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
176-553 7.23e-81

Sensor histidine kinase YesM [Signal transduction mechanisms];


:

Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 260.34  E-value: 7.23e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 176 SDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIFHIGETVDRESENWLVGLTSHGYQVQVAVPKNFVLQGT 255
Cdd:COG2972   73 LLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 256 VTSSALIVGLSLLFIVILYLTLRQTFANYQKQVVDLVESIQVIAQGEeGRRIDISEKDqELLLIAETTNDMLDRLEKNIH 335
Cdd:COG2972  153 FSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGD-LVRLEVSGND-EIGILARSFNEMVERIKELIE 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 336 DIYQLELSQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLRNNISDERET-LLKQELEFCRKYS 414
Cdd:COG2972  231 EVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELvTLEEELELIKSYL 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 415 YLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLA 494
Cdd:COG2972  311 EIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLE 390

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446723270 495 NIREKLSQKyfehqasysDQRQSIGIVNVHERFVLYFGDRYAITIESAEQAGVQYRITI 553
Cdd:COG2972  391 KLLEELSSK---------GEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRI 440
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
176-553 7.23e-81

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 260.34  E-value: 7.23e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 176 SDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIFHIGETVDRESENWLVGLTSHGYQVQVAVPKNFVLQGT 255
Cdd:COG2972   73 LLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 256 VTSSALIVGLSLLFIVILYLTLRQTFANYQKQVVDLVESIQVIAQGEeGRRIDISEKDqELLLIAETTNDMLDRLEKNIH 335
Cdd:COG2972  153 FSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGD-LVRLEVSGND-EIGILARSFNEMVERIKELIE 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 336 DIYQLELSQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLRNNISDERET-LLKQELEFCRKYS 414
Cdd:COG2972  231 EVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELvTLEEELELIKSYL 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 415 YLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLA 494
Cdd:COG2972  311 EIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLE 390

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446723270 495 NIREKLSQKyfehqasysDQRQSIGIVNVHERFVLYFGDRYAITIESAEQAGVQYRITI 553
Cdd:COG2972  391 KLLEELSSK---------GEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRI 440
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 440-554 2.89e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 157.61  E-value: 2.89e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 440 IPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSaEKLANIREKLsqkyfehqasySDQRQSIG 519
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGID-PKVLNILGKK-----------PKEGNGIG 68

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446723270 520 IVNVHERFVLYFGDRYAITIESAEQAGVQYRITIQ 554
Cdd:cd16924   69 LYNVHQRLILLFGEDYGIHIASEPDKGTRITFTIP 103
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 347-425 4.25e-21

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 87.50  E-value: 4.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270  347 ANMRALQAQINPHFMYNTLEFLRMYAvMQSQDELADIIYEFSSLLRNNISDERETL-LKQELEFCRKYSYLCMVRYPKSI 425
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLA-IEDPEEAAEMILKLSDLLRYSLYEGEELVtLEEELEFLENYLEIQKIRFGDRL 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 445-553 3.94e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 51.50  E-value: 3.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270   445 LQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLSQkyfEHQASYSDQRQSIGIVNVH 524
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFR---TDKRSRKIGGTGLGLSIVK 82

                           90       100
                   ....*....|....*....|....*....
gi 446723270   525 eRFVLYFGDRyaITIESAEQAGVQYRITI 553
Cdd:smart00387  83 -KLVELHGGE--ISVESEPGGGTTFTITL 108
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
176-553 7.23e-81

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 260.34  E-value: 7.23e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 176 SDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIFHIGETVDRESENWLVGLTSHGYQVQVAVPKNFVLQGT 255
Cdd:COG2972   73 LLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 256 VTSSALIVGLSLLFIVILYLTLRQTFANYQKQVVDLVESIQVIAQGEeGRRIDISEKDqELLLIAETTNDMLDRLEKNIH 335
Cdd:COG2972  153 FSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGD-LVRLEVSGND-EIGILARSFNEMVERIKELIE 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 336 DIYQLELSQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLRNNISDERET-LLKQELEFCRKYS 414
Cdd:COG2972  231 EVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELvTLEEELELIKSYL 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 415 YLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLA 494
Cdd:COG2972  311 EIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLE 390

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446723270 495 NIREKLSQKyfehqasysDQRQSIGIVNVHERFVLYFGDRYAITIESAEQAGVQYRITI 553
Cdd:COG2972  391 KLLEELSSK---------GEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRI 440
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 440-554 2.89e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 157.61  E-value: 2.89e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 440 IPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSaEKLANIREKLsqkyfehqasySDQRQSIG 519
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGID-PKVLNILGKK-----------PKEGNGIG 68

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446723270 520 IVNVHERFVLYFGDRYAITIESAEQAGVQYRITIQ 554
Cdd:cd16924   69 LYNVHQRLILLFGEDYGIHIASEPDKGTRITFTIP 103
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
230-553 2.03e-45

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 163.50  E-value: 2.03e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 230 NWLVGLTSHGYQVQVAVPKNFVLQGTVTSSALIVGLSLLFIVILYLTLRQTFANYQKQVVDLVESIQVIAQGEEGRRIDI 309
Cdd:COG3275   42 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 310 SEKDQELLLIAETTNDMLDRLEKNIHDIYQLELSQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSqDELADIIYEFSS 389
Cdd:COG3275  122 LLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDP-EKARELLLKLSD 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 390 LLRNNI--SDERETLLKQELEFCRKYSYLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVDHRRTDNVIS 467
Cdd:COG3275  201 LLRYSLyeSDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTIS 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 468 IKALKQDGFVEILVVDNGRGMSAEKlanireklsqkyfehqasySDQRQSIGIVNVHERFVLYFGDRYAITIESAEQAGV 547
Cdd:COG3275  281 ISIEVEGDRLVIEVENNGVGIQPKK-------------------KKKGSGIGLKNVRERLELLYGDKYSLEIESTDGGGT 341


                 ....*.
gi 446723270 548 QYRITI 553
Cdd:COG3275  342 KVTLKI 347
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 347-425 4.25e-21

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 87.50  E-value: 4.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270  347 ANMRALQAQINPHFMYNTLEFLRMYAvMQSQDELADIIYEFSSLLRNNISDERETL-LKQELEFCRKYSYLCMVRYPKSI 425
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLA-IEDPEEAAEMILKLSDLLRYSLYEGEELVtLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 440-554 4.96e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 70.93  E-value: 4.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 440 IPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLSqkyfehqasysdqrQSIG 519
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIRSS--------------NGLG 66

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446723270 520 IVNVHERFVLYFGDRYAITIESAEQAGVqyRITIQ 554
Cdd:cd16956   67 LNLVDKRLRQAFGNDYGLDIECAPGEGT--RITIR 99
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 440-553 8.05e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 67.45  E-value: 8.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 440 IPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLanirEKLSQKYFEhqasySDQRQSIG 519
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERL----DLLGKTTVT-----SEKGTGTA 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446723270 520 IVNVHERFVLYFGDRYAITIESAEQAGVQYRITI 553
Cdd:cd16957   72 LENLNRRLIGLFGSEACLHIESEVHGGTEVWFVI 105
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 440-546 9.82e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 61.71  E-value: 9.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 440 IPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQ-DGFVEILVVDNGRGMSAEKLANIREKLSqkyfehqasysdQRQSI 518
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKQlKNRLHIAVEDNGIGISPKVIERVEQDEM------------PGNKI 68

                         90       100
                 ....*....|....*....|....*...
gi 446723270 519 GIVNVHERFVLYFGdrYAITIESAEQAG 546
Cdd:cd16955   69 GLLNVHQRLKLGYG--EGLHIRSRPDPG 94
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 445-553 3.94e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 51.50  E-value: 3.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270   445 LQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLSQkyfEHQASYSDQRQSIGIVNVH 524
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFR---TDKRSRKIGGTGLGLSIVK 82

                           90       100
                   ....*....|....*....|....*....
gi 446723270   525 eRFVLYFGDRyaITIESAEQAGVQYRITI 553
Cdd:smart00387  83 -KLVELHGGE--ISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 445-553 5.97e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 48.13  E-value: 5.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270  445 LQPLVENYFAHGVDHRRTDNVISIKaLKQDGFVEILVVDNGRGMSAEKLANIREKLSQKyfehqASYSDQRQSIGIVNVH 524
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTA-----DKRGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*....
gi 446723270  525 eRFVLYFGDRyaITIESAEQAGVQYRITI 553
Cdd:pfam02518  80 -KLVELLGGT--ITVESEPGGGTTVTLTL 105
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
365-553 2.23e-05

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 46.05  E-value: 2.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 365 LEFLRMYAVM--QSQDELADIIYEFSSLLRNNISD---------ERETLLKQEL---EFCRKYSYLCMVRYP-KSIAYGF 429
Cdd:COG2205   38 AELLLDEEDLspEERRELLEIIRESAERLLRLIEDlldlsrlesGKLSLELEPVdlaELLEEAVEELRPLAEeKGIRLEL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 430 KIDPELENMKIPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLsqkyfeHQA 509
Cdd:COG2205  118 DLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERF------YRG 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446723270 510 SYSDQRQSIG--------IVNVHErfvlyfGDryaITIESAEQAGVQYRITI 553
Cdd:COG2205  192 DNSRGEGGTGlglaivkrIVEAHG------GT---IWVESEPGGGTTFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
423-553 7.01e-05

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 45.28  E-value: 7.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 423 KSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIreklsq 502
Cdd:COG0642  202 KGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERI------ 275

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446723270 503 kyFE--HQASYSDQRQSIG--------IVNVHErfvlyfGDryaITIESAEQAGVQYRITI 553
Cdd:COG0642  276 --FEpfFRTDPSRRGGGTGlglaivkrIVELHG------GT---IEVESEPGKGTTFTVTL 325
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
286-331 3.30e-03

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 35.69  E-value: 3.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 446723270   286 KQVVDLVESIQVIAQGEEGRRIDISEKDqELLLIAETTNDMLDRLE 331
Cdd:smart00304   5 RPLRRLAEAAQRIADGDLTVRLPVDGRD-EIGELARAFNEMADRLE 49
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 155-556 5.73e-03

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 39.48  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 155 IRAEDFKPAGNSFAIPVSDPVSDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIFHIGETVDRESENWLVG 234
Cdd:COG3850   18 LLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 235 LTSHGYQVQVAVPKNFVLQGTVTSSALIVGLSLLFIVILYLTLRQTfanyqKQVVDLVESIQVIAQGEEGRRIDISEKDq 314
Cdd:COG3850   98 LLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIV-----RPLRRLTQAAERIARGDFDARVPVSGRD- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 315 ELLLIAETTNDMLDRLEKNIHDI------YQLELSQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFS 388
Cdd:COG3850  172 ELGTLARAFNRMADELQELYAELeeeeelEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAES 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 389 SLLRNNISDERETLLKQELEFCRKYSYLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENyfAHGVDHRRTDNVISI 468
Cdd:COG3850  252 ELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAAL--LLLLLLQAIANASLL 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723270 469 KALKQDGFVEILVVDNGRGMSAEKLANIREKLSQKYFEHQASYSDQRQSIGIVNVHERFVLYFGDRYAITIESAEQAGVQ 548
Cdd:COG3850  330 LIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGG 409


                 ....*...
gi 446723270 549 YRITIQDE 556
Cdd:COG3850  410 VAGEGGLV 417
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 466-498 6.62e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 39.17  E-value: 6.62e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 446723270 466 ISIKALKQDGFVEILVVDNGRGMSAEKLANIRE 498
Cdd:COG5000  339 IEVSTRREDGRVRIEVSDNGPGIPEEVLERIFE 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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