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Conserved domains on  [gi|446458867|ref|WP_000536721|]
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MULTISPECIES: indole-3-glycerol phosphate synthase TrpC [Bacillus]

Protein Classification

indole-3-glycerol phosphate synthase TrpC( domain architecture ID 10011355)

indole-3-glycerol-phosphate synthase (IGPS) TrpC is an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water

EC:  4.1.1.48
Gene Ontology:  GO:0004425|GO:0000162

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-250 4.41e-123

indole-3-glycerol phosphate synthase TrpC;


:

Pssm-ID: 234710  Cd Length: 260  Bit Score: 350.61  E-value: 4.41e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   1 MGTILDKIVNQKKKEVAALYETYTPVKEKRK------TRSLVKAL--EQFTVIAEVKRASPSKGDINLHVDVRKQVKTYE 72
Cdd:PRK00278   1 MMDILDKIVAYKREEVAARKAQVPLAELKARaaaappPRDFAAALraGKPAVIAEVKKASPSKGVIREDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  73 ECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKG 152
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 153 LEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLV 232
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLV-VSESGIFTPEDLKRLAKAGADAVLV 239

                        250
                 ....*....|....*...
gi 446458867 233 GEALMTSSSIHTFFEDCK 250
Cdd:PRK00278 240 GESLMRADDPGAALRELL 257
 
Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-250 4.41e-123

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 350.61  E-value: 4.41e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   1 MGTILDKIVNQKKKEVAALYETYTPVKEKRK------TRSLVKAL--EQFTVIAEVKRASPSKGDINLHVDVRKQVKTYE 72
Cdd:PRK00278   1 MMDILDKIVAYKREEVAARKAQVPLAELKARaaaappPRDFAAALraGKPAVIAEVKKASPSKGVIREDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  73 ECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKG 152
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 153 LEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLV 232
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLV-VSESGIFTPEDLKRLAKAGADAVLV 239

                        250
                 ....*....|....*...
gi 446458867 233 GEALMTSSSIHTFFEDCK 250
Cdd:PRK00278 240 GESLMRADDPGAALRELL 257
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 3-242 1.42e-117

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 336.23  E-value: 1.42e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   3 TILDKIVNQKKKEVAALYETYTP------VKEKRKTRSLVKALE---QFTVIAEVKRASPSKGDINLHVDVRKQVKTYEE 73
Cdd:COG0134    2 TILDKIVAHKREEVAARKARVPLaelearAAAAPPPRDFAAALRaagGPAVIAEIKKASPSKGLIREDFDPAEIARAYEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  74 CGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGL 153
Cdd:COG0134   82 GGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLGM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 154 EAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLVG 233
Cdd:COG0134  162 DVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLV-VSESGIRTPEDVARLAAAGADAFLVG 240


                 ....*....
gi 446458867 234 EALMTSSSI 242
Cdd:COG0134  241 EALMRAPDP 249
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 36-248 2.18e-109

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 314.02  E-value: 2.18e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  36 VKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDK 115
Cdd:cd00331    5 LKRPGGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAGAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDFIIDP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 116 IQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEK 195
Cdd:cd00331   85 YQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLNTTER 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446458867 196 LGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLVGEALMTSSSIHTFFED 248
Cdd:cd00331  165 LAPLIPKDVIL-VSESGISTPEDVKRLAEAGADAVLIGESLMRAPDPGAALRE 216
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
5-248 4.89e-92

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 271.48  E-value: 4.89e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867    5 LDKIVNQKKKEVAAL-----YETYTPVKEKRKTRSLVKALEQFT----VIAEVKRASPSKGDINLHVDVRKQVKTYEECG 75
Cdd:pfam00218   1 LEKIVADKRAEVAARkarppLADLQAAARAPPTRSFYDALRESRgrpaLIAEVKKASPSKGLIREDFDPAEIARVYEAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   76 AGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEA 155
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  156 IVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLVGEA 235
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLL-VAESGIYTPADVRELKEHGANAFLVGES 239

                         250
                  ....*....|...
gi 446458867  236 LMTSSSIHTFFED 248
Cdd:pfam00218 240 LMRQEDVRAAIRE 252
Indglycph_syn_Halo_TrpC NF041303
indole-3-glycerol phosphate synthase;
33-237 8.16e-43

indole-3-glycerol phosphate synthase;


Pssm-ID: 469200  Cd Length: 250  Bit Score: 145.89  E-value: 8.16e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  33 RSLVKALE------QFTVIAEVKRASPSKgDINLHVDVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPL 106
Cdd:NF041303  32 RSLPDAFAaaeadgRVPVIAEVKPTSPTT-DGTRDDDPVELAEAMVAGGAAALSVLTEPEHFGGSPETLRRVREAVDVPV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 107 LCKDFIIDKIQIDrAYEAgaDIILLIvAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTF 186
Cdd:NF041303 111 LRKDFLLREAQLD-AVEA--DVVLLI-ARFVGDDLEGLVAAARERGFQPLVEVHTRAELERALDAGADIIGVNNRDLAKL 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446458867 187 EVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALM 237
Cdd:NF041303 187 EVDLGTFESVAPHVPDDDVTLIAESGISTPADVRRMREAGADALLVGSAIM 237
TIGR00007 TIGR00007
phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; This protein family ...
 188-236 4.08e-03

phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; This protein family consists of HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, the enzyme catalyzing the fourth step in histidine biosynthesis. It is closely related to the enzyme HisF for the sixth step. Examples of this enzyme in Actinobacteria have been found to be bifunctional, also possessing phosphoribosylanthranilate isomerase activity; the trusted cutoff here has now been raised to 275.0 to exclude the bifunctional group, now represented by model TIGR01919. HisA from Lactococcus lactis was reported to be inactive (MEDLINE:93322317). [Amino acid biosynthesis, Histidine family]


Pssm-ID: 272850 [Multi-domain]  Cd Length: 230  Bit Score: 37.56  E-value: 4.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 446458867  188 VDLSQTEKLGKRLNEEKllwISESGIHSKEDIIRVKRAGAKGVLVGEAL 236
Cdd:TIGR00007 176 PNFELTKELVKAVNVPV---IASGGVSSIDDLIALKKLGVYGVIVGKAL 221
 
Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-250 4.41e-123

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 350.61  E-value: 4.41e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   1 MGTILDKIVNQKKKEVAALYETYTPVKEKRK------TRSLVKAL--EQFTVIAEVKRASPSKGDINLHVDVRKQVKTYE 72
Cdd:PRK00278   1 MMDILDKIVAYKREEVAARKAQVPLAELKARaaaappPRDFAAALraGKPAVIAEVKKASPSKGVIREDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  73 ECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKG 152
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 153 LEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLV 232
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLV-VSESGIFTPEDLKRLAKAGADAVLV 239

                        250
                 ....*....|....*...
gi 446458867 233 GEALMTSSSIHTFFEDCK 250
Cdd:PRK00278 240 GESLMRADDPGAALRELL 257
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 3-242 1.42e-117

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 336.23  E-value: 1.42e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   3 TILDKIVNQKKKEVAALYETYTP------VKEKRKTRSLVKALE---QFTVIAEVKRASPSKGDINLHVDVRKQVKTYEE 73
Cdd:COG0134    2 TILDKIVAHKREEVAARKARVPLaelearAAAAPPPRDFAAALRaagGPAVIAEIKKASPSKGLIREDFDPAEIARAYEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  74 CGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGL 153
Cdd:COG0134   82 GGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLGM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 154 EAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLVG 233
Cdd:COG0134  162 DVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLV-VSESGIRTPEDVARLAAAGADAFLVG 240


                 ....*....
gi 446458867 234 EALMTSSSI 242
Cdd:COG0134  241 EALMRAPDP 249
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 36-248 2.18e-109

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 314.02  E-value: 2.18e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  36 VKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDK 115
Cdd:cd00331    5 LKRPGGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAGAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDFIIDP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 116 IQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEK 195
Cdd:cd00331   85 YQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLNTTER 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446458867 196 LGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLVGEALMTSSSIHTFFED 248
Cdd:cd00331  165 LAPLIPKDVIL-VSESGISTPEDVKRLAEAGADAVLIGESLMRAPDPGAALRE 216
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
5-248 4.89e-92

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 271.48  E-value: 4.89e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867    5 LDKIVNQKKKEVAAL-----YETYTPVKEKRKTRSLVKALEQFT----VIAEVKRASPSKGDINLHVDVRKQVKTYEECG 75
Cdd:pfam00218   1 LEKIVADKRAEVAARkarppLADLQAAARAPPTRSFYDALRESRgrpaLIAEVKKASPSKGLIREDFDPAEIARVYEAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   76 AGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEA 155
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  156 IVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLwISESGIHSKEDIIRVKRAGAKGVLVGEA 235
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLL-VAESGIYTPADVRELKEHGANAFLVGES 239

                         250
                  ....*....|...
gi 446458867  236 LMTSSSIHTFFED 248
Cdd:pfam00218 240 LMRQEDVRAAIRE 252
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 1-237 5.78e-64

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 206.20  E-value: 5.78e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   1 MGTILDKIVNQKKKEVAALyETYTP---VKEK--RKTRSLVKALEQFTV--IAEVKRASPSKGDINLHVDVRKQVKTYEE 73
Cdd:PRK09427   3 MPTVLAKIVADKAIWVAAR-KQQQPlasFQNEiqPSDRSFYDALKGPKTafILECKKASPSKGLIRDDFDPAEIARVYKH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  74 cGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGL 153
Cdd:PRK09427  82 -YASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 154 EAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLwISESGIHSKEDIIRVKRaGAKGVLVG 233
Cdd:PRK09427 161 GVLTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIV-ISESGIYTHAQVRELSP-FANGFLIG 238


                 ....
gi 446458867 234 EALM 237
Cdd:PRK09427 239 SSLM 242
PLN02460 PLN02460
indole-3-glycerol-phosphate synthase
 4-240 7.41e-59

indole-3-glycerol-phosphate synthase


Pssm-ID: 215254  Cd Length: 338  Bit Score: 189.60  E-value: 7.41e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   4 ILDKIVNQKKKEVAALYETyTPVKEKRK-------TRSLVKALE-------QFTVIAEVKRASPSKGDINLHVDVRKQVK 69
Cdd:PLN02460  68 ILEEIVWYKDVEVAQMKER-KPLYLLKKalqnappARDFVGALRaahkrtgQPGLIAEVKKASPSRGVLRENFDPVEIAQ 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  70 TYEECGAGAVSVLTDGQFFKGSFYDLQTAREES-SIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYV 148
Cdd:PLN02460 147 AYEKGGAACLSVLTDEKYFQGSFENLEAIRNAGvKCPLLCKEFIVDAWQIYYARSKGADAILLIAAVLPDLDIKYMLKIC 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 149 LEKGLEAIVEVHDEQELEIAIQLNP-HVIGINNRNLKTFEVDLSQTEKL-----GKRLNEEKLLWISESGIHSKEDIIRV 222
Cdd:PLN02460 227 KSLGMAALIEVHDEREMDRVLGIEGvELIGINNRSLETFEVDISNTKKLlegerGEQIREKGIIVVGESGLFTPDDVAYV 306

                        250
                 ....*....|....*...
gi 446458867 223 KRAGAKGVLVGEALMTSS 240
Cdd:PLN02460 307 QNAGVKAVLVGESLVKQD 324
PRK13957 PRK13957
indole-3-glycerol-phosphate synthase; Provisional
 1-247 2.35e-49

indole-3-glycerol-phosphate synthase; Provisional


Pssm-ID: 140013  Cd Length: 247  Bit Score: 162.74  E-value: 2.35e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   1 MGTILDKIVNQKKKEVAALYETYT------PVKEKRKTRSlvkaleqFTVIAEVKRASPSKGDINLHVDVRKQVKTYEEC 74
Cdd:PRK13957   1 MHRVLREIIETKQNEIEKISRWDPlpdrglPLRDSLKSRS-------FSIIAECKRKSPSAGELRADYHPVQIAKTYETL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  75 GAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLE 154
Cdd:PRK13957  74 GASAISVLTDQSYFGGSLEDLKSVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPSQIKSFLKHASSLGMD 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 155 AIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLnEEKLLWISESGIHSKEDIIRVkRAGAKGVLVGE 234
Cdd:PRK13957 154 VLVEVHTEDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVAAFL-PPNIVKVGESGIESRSDLDKF-RKLVDAALIGT 231

                        250
                 ....*....|....
gi 446458867 235 ALMTSSSI-HTFFE 247
Cdd:PRK13957 232 YFMEKKDIrKAWLS 245
PRK13802 PRK13802
bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional
 3-241 9.24e-47

bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 184335 [Multi-domain]  Cd Length: 695  Bit Score: 165.20  E-value: 9.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867   3 TILDKIV-----NQKKKEV--------AALYETYTPVKEKRktrsLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVK 69
Cdd:PRK13802   2 SVLDELVagaleDQRTRELtvsleevkKAAAAAPAPIDATR----WLKRADGIPVIAEIKRASPSKGHLSDIPDPAALAR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  70 TYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVL 149
Cdd:PRK13802  78 EYEQGGASAISVLTEGRRFLGSLDDFDKVRAAVHIPVLRKDFIVTDYQIWEARAHGADLVLLIVAALDDAQLKHLLDLAH 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 150 EKGLEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEkLLWISESGIHSKEDIIRVKRAGAKG 229
Cdd:PRK13802 158 ELGMTVLVETHTREEIERAIAAGAKVIGINARNLKDLKVDVNKYNELAADLPDD-VIKVAESGVFGAVEVEDYARAGADA 236

                        250
                 ....*....|..
gi 446458867 230 VLVGEALMTSSS 241
Cdd:PRK13802 237 VLVGEGVATADD 248
Indglycph_syn_Halo_TrpC NF041303
indole-3-glycerol phosphate synthase;
33-237 8.16e-43

indole-3-glycerol phosphate synthase;


Pssm-ID: 469200  Cd Length: 250  Bit Score: 145.89  E-value: 8.16e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  33 RSLVKALE------QFTVIAEVKRASPSKgDINLHVDVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPL 106
Cdd:NF041303  32 RSLPDAFAaaeadgRVPVIAEVKPTSPTT-DGTRDDDPVELAEAMVAGGAAALSVLTEPEHFGGSPETLRRVREAVDVPV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 107 LCKDFIIDKIQIDrAYEAgaDIILLIvAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTF 186
Cdd:NF041303 111 LRKDFLLREAQLD-AVEA--DVVLLI-ARFVGDDLEGLVAAARERGFQPLVEVHTRAELERALDAGADIIGVNNRDLAKL 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446458867 187 EVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALM 237
Cdd:NF041303 187 EVDLGTFESVAPHVPDDDVTLIAESGISTPADVRRMREAGADALLVGSAIM 237
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
 63-233 5.36e-08

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 51.82  E-value: 5.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867  63 DVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQT----AREESSIPLLCKDFIID-----KIQIDRAYEAGADIILLIV 133
Cdd:cd04722   13 DPVELAKAAAEAGADAIIVGTRSSDPEEAETDDKEvlkeVAAETDLPLGVQLAINDaaaavDIAAAAARAAGADGVEIHG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458867 134 AA-----LTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTF--EVDLSQTEKLGKRLNEEKLL 206
Cdd:cd04722   93 AVgylarEDLELIRELREAVPDVKVVVKLSPTGELAAAAAEEAGVDEVGLGNGGGGGGgrDAVPIADLLLILAKRGSKVP 172

                        170       180
                 ....*....|....*....|....*..
gi 446458867 207 WISESGIHSKEDIIRVKRAGAKGVLVG 233
Cdd:cd04722  173 VIAGGGINDPEDAAEALALGADGVIVG 199
His_biosynth pfam00977
Histidine biosynthesis protein; Proteins involved in steps 4 and 6 of the histidine ...
 188-236 2.78e-03

Histidine biosynthesis protein; Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in this family. Histidine is formed by several complex and distinct biochemical reactions catalyzed by eight enzymes. The enzymes in this Pfam entry are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes. The structure of HisA is known to be a TIM barrel fold. In some archaeal HisA proteins the TIM barrel is composed of two tandem repeats of a half barrel. This family belong to the common phosphate binding site TIM barrel family.


Pssm-ID: 425971  Cd Length: 228  Bit Score: 37.84  E-value: 2.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 446458867  188 VDLSQTEKLGKRLNEEkllWISESGIHSKEDIIRVKRAGAKGVLVGEAL 236
Cdd:pfam00977 177 PDLELTRELAEAVNIP---VIASGGVGSLEDLKELFTEGVDGVIAGSAL 222
TIGR00007 TIGR00007
phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; This protein family ...
 188-236 4.08e-03

phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; This protein family consists of HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, the enzyme catalyzing the fourth step in histidine biosynthesis. It is closely related to the enzyme HisF for the sixth step. Examples of this enzyme in Actinobacteria have been found to be bifunctional, also possessing phosphoribosylanthranilate isomerase activity; the trusted cutoff here has now been raised to 275.0 to exclude the bifunctional group, now represented by model TIGR01919. HisA from Lactococcus lactis was reported to be inactive (MEDLINE:93322317). [Amino acid biosynthesis, Histidine family]


Pssm-ID: 272850 [Multi-domain]  Cd Length: 230  Bit Score: 37.56  E-value: 4.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 446458867  188 VDLSQTEKLGKRLNEEKllwISESGIHSKEDIIRVKRAGAKGVLVGEAL 236
Cdd:TIGR00007 176 PNFELTKELVKAVNVPV---IASGGVSSIDDLIALKKLGVYGVIVGKAL 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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