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Conserved domains on  [gi|446397648|ref|WP_000475503|]
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MULTISPECIES: Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC [Enterobacterales]

Protein Classification

efflux transporter outer membrane subunit( domain architecture ID 11484501)

efflux transporter outer membrane subunit similar to Escherichia coli cation efflux system protein CusC and Salmonella enterica outer membrane lipoprotein SilC

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
1-461 0e+00

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


:

Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 863.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   1 MFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFFVDPQVTRLIGEALTNNRDLRM 80
Cdd:PRK09837   1 MSPCKLLPFSVALALTGCVSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYQNTGWRTFFVDNQVKTLISEALVNNRDLRM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  81 AALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDADRQNYFASEEARR 160
Cdd:PRK09837  81 ATLKVQEARAQYRLTDADRYPQLNGEGSGSWSGNLKGDTATTREYSTGLNLSFDLDFFGRLKNMSEAERQNYLASEEAQR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 161 AVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQAN 240
Cdd:PRK09837 161 AVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRADIAKRQGELAQAN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 241 NALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASST 320
Cdd:PRK09837 241 NALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSSS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 321 ELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLD 400
Cdd:PRK09837 321 DLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLA 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446397648 401 SLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE 461
Cdd:PRK09837 401 SLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEISLFTALGGGWQE 461
 
Name Accession Description Interval E-value
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
1-461 0e+00

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 863.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   1 MFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFFVDPQVTRLIGEALTNNRDLRM 80
Cdd:PRK09837   1 MSPCKLLPFSVALALTGCVSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYQNTGWRTFFVDNQVKTLISEALVNNRDLRM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  81 AALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDADRQNYFASEEARR 160
Cdd:PRK09837  81 ATLKVQEARAQYRLTDADRYPQLNGEGSGSWSGNLKGDTATTREYSTGLNLSFDLDFFGRLKNMSEAERQNYLASEEAQR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 161 AVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQAN 240
Cdd:PRK09837 161 AVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRADIAKRQGELAQAN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 241 NALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASST 320
Cdd:PRK09837 241 NALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSSS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 321 ELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLD 400
Cdd:PRK09837 321 DLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLA 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446397648 401 SLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE 461
Cdd:PRK09837 401 SLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEISLFTALGGGWQE 461
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
 13-458 2.74e-98

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 302.79  E-value: 2.74e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   13 FILAGCvSLAPEYQRPAAPVPQQFSLSHNSL---TPAVNG-YQDTGWRNFFVDPQVTRLIGEALTNNRDLRMAALKVEEA 88
Cdd:TIGR01845   5 LLLSGC-AVGPDYARPETPLAAGYLESDPTFggqGRLSAGvWPAVDWWTAFGDPQLNALIEEALADNPDLQVAEARLRAA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   89 RAQFNVTDADRYPQLNASSGITYS------GGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDADRQNYFASEEARRAV 162
Cdd:TIGR01845  84 RANLRAARADFFPSLGLSASATRQkssedaSGTTSGGSLSNTSTLTLDVSYELDLFGKVRRAVESALAQLEAAEADSQAA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  163 HILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNA 242
Cdd:TIGR01845 164 RLTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAGVAAASDVRQAEAAVASAEAELPSLDVQIAQARNA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  243 LQLVLGTY--RALPSEKGMKGGEIAPvKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASST 320
Cdd:TIGR01845 244 LAALLGKGpsRGLAIARPLLLDQLPP-DLPLSLPSDLLRRRPDIRAAERRLAAANAQIGVAKAAFFPSITLSASIGLSAS 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  321 ELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLD 400
Cdd:TIGR01845 323 QLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVE 402

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446397648  401 SLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGG 458
Cdd:TIGR01845 403 QAQEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSDSVALYKALGGG 460
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
65-459 1.08e-78

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 249.18  E-value: 1.08e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  65 TRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQlnassgitysgglkgdkpttqeydarlelsYELDFFGKLKNM 144
Cdd:COG1538    3 DELIERALANNPDLRAARARVEAARAQLRQARAGLLPS------------------------------QELDLGGKRRAR 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 145 SDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIES 224
Cdd:COG1538   53 IEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVLQAEAQLAQ 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 225 TRAEIAKREGDLAQANNALQLVLGtyRALPSEKGMKGGEIAPVKLPPNLS---SQILLQRPDIMEAEYQLKAADANIGAA 301
Cdd:COG1538  133 ARAQLAQAEAQLAQARNALALLLG--LPPPAPLDLPDPLPPLPPLPPSLPglpSEALERRPDLRAAEAQLEAAEAEIGVA 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 302 RAAFFPSITLTSGLSASSTelSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDT 381
Cdd:COG1538  211 RAAFLPSLSLSASYGYSSS--DDLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEVEDA 288

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446397648 382 LALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGW 459
Cdd:COG1538  289 LAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQLYRALGGGW 366
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
 275-456 3.73e-23

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 96.05  E-value: 3.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  275 SQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTElSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLK 354
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNSNN-SESGGDDPGTGEVGLGLSQPLFDGGKRRARVK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  355 LAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQ 434
Cdd:pfam02321  80 AAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEAR 159

                         170       180
                  ....*....|....*....|..
gi 446397648  435 QTILDLTYSRQVNEINLFTALG 456
Cdd:pfam02321 160 LELLNAEADLELALAQLEQLLG 181
 
Name Accession Description Interval E-value
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
1-461 0e+00

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 863.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   1 MFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFFVDPQVTRLIGEALTNNRDLRM 80
Cdd:PRK09837   1 MSPCKLLPFSVALALTGCVSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYQNTGWRTFFVDNQVKTLISEALVNNRDLRM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  81 AALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDADRQNYFASEEARR 160
Cdd:PRK09837  81 ATLKVQEARAQYRLTDADRYPQLNGEGSGSWSGNLKGDTATTREYSTGLNLSFDLDFFGRLKNMSEAERQNYLASEEAQR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 161 AVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQAN 240
Cdd:PRK09837 161 AVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRADIAKRQGELAQAN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 241 NALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASST 320
Cdd:PRK09837 241 NALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSSS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 321 ELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLD 400
Cdd:PRK09837 321 DLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLA 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446397648 401 SLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE 461
Cdd:PRK09837 401 SLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEISLFTALGGGWQE 461
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
 13-458 2.74e-98

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 302.79  E-value: 2.74e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   13 FILAGCvSLAPEYQRPAAPVPQQFSLSHNSL---TPAVNG-YQDTGWRNFFVDPQVTRLIGEALTNNRDLRMAALKVEEA 88
Cdd:TIGR01845   5 LLLSGC-AVGPDYARPETPLAAGYLESDPTFggqGRLSAGvWPAVDWWTAFGDPQLNALIEEALADNPDLQVAEARLRAA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   89 RAQFNVTDADRYPQLNASSGITYS------GGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDADRQNYFASEEARRAV 162
Cdd:TIGR01845  84 RANLRAARADFFPSLGLSASATRQkssedaSGTTSGGSLSNTSTLTLDVSYELDLFGKVRRAVESALAQLEAAEADSQAA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  163 HILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNA 242
Cdd:TIGR01845 164 RLTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAGVAAASDVRQAEAAVASAEAELPSLDVQIAQARNA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  243 LQLVLGTY--RALPSEKGMKGGEIAPvKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASST 320
Cdd:TIGR01845 244 LAALLGKGpsRGLAIARPLLLDQLPP-DLPLSLPSDLLRRRPDIRAAERRLAAANAQIGVAKAAFFPSITLSASIGLSAS 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  321 ELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLD 400
Cdd:TIGR01845 323 QLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVE 402

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446397648  401 SLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGG 458
Cdd:TIGR01845 403 QAQEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSDSVALYKALGGG 460
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
65-459 1.08e-78

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 249.18  E-value: 1.08e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  65 TRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQlnassgitysgglkgdkpttqeydarlelsYELDFFGKLKNM 144
Cdd:COG1538    3 DELIERALANNPDLRAARARVEAARAQLRQARAGLLPS------------------------------QELDLGGKRRAR 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 145 SDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIES 224
Cdd:COG1538   53 IEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVLQAEAQLAQ 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 225 TRAEIAKREGDLAQANNALQLVLGtyRALPSEKGMKGGEIAPVKLPPNLS---SQILLQRPDIMEAEYQLKAADANIGAA 301
Cdd:COG1538  133 ARAQLAQAEAQLAQARNALALLLG--LPPPAPLDLPDPLPPLPPLPPSLPglpSEALERRPDLRAAEAQLEAAEAEIGVA 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 302 RAAFFPSITLTSGLSASSTelSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDT 381
Cdd:COG1538  211 RAAFLPSLSLSASYGYSSS--DDLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEVEDA 288

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446397648 382 LALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGW 459
Cdd:COG1538  289 LAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQLYRALGGGW 366
PRK09915 PRK09915
MdtP family multidrug efflux transporter outer membrane subunit;
4-459 1.06e-42

MdtP family multidrug efflux transporter outer membrane subunit;


Pssm-ID: 182142 [Multi-domain]  Cd Length: 488  Bit Score: 157.35  E-value: 1.06e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   4 LKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLShNSLTPAVNGYQDTGWRNFFVDPQVTRLIGEALTNNRDLRMAAL 83
Cdd:PRK09915  10 LLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLA-DDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGSHTLAEAKL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  84 KVEEARAQFNVTDADRYPQLNASSGIT------------YSG---GLKGDKPTTQEYDARLELSYELDFFGKLKNMSDA- 147
Cdd:PRK09915  89 REEKAQSQADLLDAGSQLQVAALGMLNrqrvsangflspYAMdapALGMDGPYYTEATVGLFAGLDLDLWGVHRSAVAAa 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 148 -DRQNYFASEEArrAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTR 226
Cdd:PRK09915 169 iGAHNAALAETA--AVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARAQILAVD 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 227 AEIAKREGDLAQANNALqlvlgtyRALPSEKGMKGGEIAPVKLP-------PNLSSQILLQRPDIMEAEYQLKAADANIG 299
Cdd:PRK09915 247 KQIAAVKGQITETRESL-------RALIGAGASDMPEIKPVALPrvqtgipATLSYELLARRPDLQAMRWYVQASLDQVD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 300 AARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVS 379
Cdd:PRK09915 320 SARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVA 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 380 DTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGW 459
Cdd:PRK09915 400 VNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGY 479
PRK11459 PRK11459
multidrug resistance outer membrane protein MdtQ; Provisional
 2-459 5.20e-31

multidrug resistance outer membrane protein MdtQ; Provisional


Pssm-ID: 183143 [Multi-domain]  Cd Length: 478  Bit Score: 124.67  E-value: 5.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   2 FKLKLLSISTIFILAGCvslAPEYQRPAAPVPQQFSLSHNSLTPAV--NGYQDTGWRNFFVDPQVTRLIGEALTNNRDLR 79
Cdd:PRK11459   6 FYPAIACLPLLIMLAGC---APMHETRQALSQQTPAAHVDTALPTAlkNGWPDSQWWKAYHDNQLDSLINNALQNAPDMQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  80 MAALKVEEARAQFNVTDADRYPQLNASSGI----TYSGGLKGDKPTTQEYDAR-----------LELSYELDFFGKLKNM 144
Cdd:PRK11459  83 VAEQRIQLAEAQAKAVAAQDGPQLDFSADMerqkMSAEGLMGPFALNDPAAGTtgpwytngtfgLTAGWDLDLWGKNRAE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 145 SDADRQNYFASEEARRAVHILLVSNVSQSYFSQQlAYEQLRIARETLKNYEQSYAFVEQQL--------VTGSTNVLALE 216
Cdd:PRK11459 163 VTARIGTVKARAAEREQTRQLLAGSVARLYWEWQ-TQAALNTVLQQIEKEQNNIIATDRQLyqngitssVEGVETDINAS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 217 QARGQIESTRAEIAKREGDLAQANNALQLVLGTYR-ALPSEKGmkggeiapvKLPPNLSSQILLQRPDIMEAEYQLKAAD 295
Cdd:PRK11459 242 KTRQQLNDVAGKMKIIEARLSALTNTQTKSLKLKPvALPKVAS---------QLPDELGYSLLARRADLQAAHWYIESSL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 296 ANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAF 375
Cdd:PRK11459 313 STIDAAKAAFYPDINLMAFLQQDALHLSDLFRHSAQQMGVTAGLTLPIFDSGRLNANLDIAKAQSNLSIASYNKAVVDAV 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 376 KDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTAL 455
Cdd:PRK11459 393 NDVARAASQVETLAEKNQHQQQIERDALRVVGLAQARFNAGIIAGSRVSEAKIPALRERANGLLLQGQWLDASIQLTSAL 472


                 ....
gi 446397648 456 GGGW 459
Cdd:PRK11459 473 GGGY 476
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
 70-456 1.18e-30

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 122.48  E-value: 1.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   70 EALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYS----GGLKGDKPTTQEYDARLELSYELDFFGKLKNMS 145
Cdd:TIGR01844  11 LALANNPELRAARAQRDAGEEQVAQARAALLPQLGLTANYGYSntypTESRGRNTDLNSGSSTLTLSQPLFDGGSTWNAV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  146 DADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIEST 225
Cdd:TIGR01844  91 RAAEAAALAARETLRATAQDLILRTAEAYMEVLRAQEILALAEANLAALKEQLDLARARFDVGLGTRTDVLQAEARYASA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  226 RAEIAKREGDLAQANNALQLVLGTYralpsEKGMKGGEIAPVKLPPNLSSQI---LLQRPDIMEAEYQLKAADANIGAAR 302
Cdd:TIGR01844 171 RAQLIQAQNNLDDAKAQLRRLVGQP-----ELAPLAVPSFPAELPEPLDQLLeiaEASNPLLLAAQAAVDAARYQVEQAR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  303 AAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTL 382
Cdd:TIGR01844 246 AGHLPTLSLTASTGNSDTSSGGSGNSDSDTYSVGLNVSIPLYQGGATSAQVRQAAHQLNQSRSTLESQKRTVRQQVRNAW 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446397648  383 ALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALG 456
Cdd:TIGR01844 326 SNLNAAAASVQAYEQQVASAQKALDAYRQEYQVGTRTLLDVLNAEQELYQARQELANARYDYLQAQLNLLSATG 399
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
 275-456 3.73e-23

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 96.05  E-value: 3.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  275 SQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTElSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLK 354
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNSNN-SESGGDDPGTGEVGLGLSQPLFDGGKRRARVK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  355 LAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQ 434
Cdd:pfam02321  80 AAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEAR 159

                         170       180
                  ....*....|....*....|..
gi 446397648  435 QTILDLTYSRQVNEINLFTALG 456
Cdd:pfam02321 160 LELLNAEADLELALAQLEQLLG 181
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
62-249 1.43e-15

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 77.77  E-value: 1.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  62 PQVTRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFGKL 141
Cdd:COG1538  177 PSLPGLPSEALERRPDLRAAEAQLEAAEAEIGVARAAFLPSLSLSASYGYSSSDDLFSGGSDTWSVGLSLSLPLFDGGRN 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 142 KNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQ 221
Cdd:COG1538  257 RARVRAAKAQLEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRE 336

                        170       180
                 ....*....|....*....|....*...
gi 446397648 222 IESTRAEIAKREGDLAQANNALQLVLGT 249
Cdd:COG1538  337 LLQAQLNLIQARYDYLLALVQLYRALGG 364
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
 70-248 4.22e-15

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 73.32  E-value: 4.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648   70 EALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITY-SGGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDAD 148
Cdd:pfam02321   2 LALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYnSNNSESGGDDPGTGEVGLGLSQPLFDGGKRRARVKAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  149 RQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAE 228
Cdd:pfam02321  82 KAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEARLE 161

                         170       180
                  ....*....|....*....|
gi 446397648  229 IAKREGDLAQANNALQLVLG 248
Cdd:pfam02321 162 LLNAEADLELALAQLEQLLG 181
tolC PRK09465
outer membrane channel protein; Reviewed
 71-456 1.87e-05

outer membrane channel protein; Reviewed


Pssm-ID: 236529 [Multi-domain]  Cd Length: 446  Bit Score: 46.86  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  71 ALTNNRDLRMAAL-------KVEEARAQFnvtdadrYPQLNASSGITYSGGLKGDKPT-TQEYDARLELSYELDFFGKLK 142
Cdd:PRK09465  32 ARLSNPELLKAAAdrdaafeKINEARSPL-------LPQLGLGAGYTYSNGYRDANGIdSNGTSASLQLTQTIFDMSKWR 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 143 NMSDADRQ------NYFASEEArravhilLVSNVSQSYFsqqlayEQLRiARETLKNYEQSYAFVEQQL----------V 206
Cdd:PRK09465 105 ALTLAEKAagiadvTYQTAQQT-------LILRTATAYF------NVLR-AIDNLSFTEAEKRAIYRQLdqttqrfnvgL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 207 TGSTNVlalEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYralpsEKGMKGGEIAPVKLPPNLSSQILLQRP---- 282
Cdd:PRK09465 171 VAITDV---QNAQAQYDTVLANEVLARNNLDNAYEALRQITGNY-----YPELAVLNTERFSTPKPQSVNALLKEAekrn 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 283 -DIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFT-----SGSGMWNFIPKIEIPIFNAGR-----NKA 351
Cdd:PRK09465 243 lSLLSARLSQDLAREQIRLAQAGHMPTLDLTASYGISDTSYSGANGtqyddSDMGQNKVGLNLSLPLYSGGAvnsqvKQA 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 352 NLKLAEIRQQ-----QSVVnyeQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITlqrarglYASGAVSYIEVLDA 426
Cdd:PRK09465 323 QYNFVGASEQlesahRSVV---QTVRSSFNNINASISSINAYEQAVVSAQSSLDATEAG-------YEVGTRTIVDVLDA 392

                        410       420       430
                 ....*....|....*....|....*....|
gi 446397648 427 ERSLFATQQTILDLTYSRQVNEINLFTALG 456
Cdd:PRK09465 393 TTTLYDAKQQLSNARYNYLINQLNLKQALG 422
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
356-437 6.86e-04

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 41.57  E-value: 6.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648 356 AEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQ 435
Cdd:COG1566   83 AALAQAEAQLAAAEAQLARLEAELGAEAEIAAAEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQA 162


                 ..
gi 446397648 436 TI 437
Cdd:COG1566  163 QL 164
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 345-439 1.30e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 40.87  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397648  345 NAGRNKANLkLAEIRQQQSVVNYEQKIQsafKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVL 424
Cdd:pfam00529  69 KAQAQVARL-QAELDRLQALESELAISR---QDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLV 144

                          90
                  ....*....|....*
gi 446397648  425 DAERsLFATQQTILD 439
Cdd:pfam00529 145 TAGA-LVAQAQANLL 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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