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Conserved domains on  [gi|446360971|ref|WP_000438826|]
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MULTISPECIES: BrnT family toxin [Bacteria]

Protein Classification

BrnT family toxin( domain architecture ID 10516178)

BrnT family toxin is the ribonuclease toxin component of a type II toxin-antitoxin (TA) system, similar to Brucella abortus BrnT that adopts a RelE-like fold

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2929 COG2929
Uncharacterized conserved protein, DUF497 family [Function unknown];
5-95 7.19e-34

Uncharacterized conserved protein, DUF497 family [Function unknown];


:

Pssm-ID: 442173  Cd Length: 92  Bit Score: 111.86  E-value: 7.19e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446360971  5 FEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQD-RHTNGEERWQTIGRVKGVLMLLVAHTIFDeddcEIIRIISARQ 83
Cdd:COG2929   3 FEWDEAKAAANLAKHGVSFEEAEEVFFDPPLLVVEDpRHSYGEDRFIAIGLIDGGRLLVVVFTERG----DAIRIISARK 78

                        90
                ....*....|..
gi 446360971 84 VTKAERNKYEHG 95
Cdd:COG2929  79 ANRKERKRYEQR 90
 
Name Accession Description Interval E-value
COG2929 COG2929
Uncharacterized conserved protein, DUF497 family [Function unknown];
5-95 7.19e-34

Uncharacterized conserved protein, DUF497 family [Function unknown];


Pssm-ID: 442173  Cd Length: 92  Bit Score: 111.86  E-value: 7.19e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446360971  5 FEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQD-RHTNGEERWQTIGRVKGVLMLLVAHTIFDeddcEIIRIISARQ 83
Cdd:COG2929   3 FEWDEAKAAANLAKHGVSFEEAEEVFFDPPLLVVEDpRHSYGEDRFIAIGLIDGGRLLVVVFTERG----DAIRIISARK 78

                        90
                ....*....|..
gi 446360971 84 VTKAERNKYEHG 95
Cdd:COG2929  79 ANRKERKRYEQR 90
BrnT_toxin pfam04365
Ribonuclease toxin, BrnT, of type II toxin-antitoxin system; BrnT is a ribonuclease toxin of a ...
 7-88 2.11e-29

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system; BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.


Pssm-ID: 461277  Cd Length: 77  Bit Score: 99.88  E-value: 2.11e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446360971   7 WDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLmLLVAHTIFDEDdceiIRIISARQVTK 86
Cdd:pfam04365  1 WDEAKAASNLRKHGVSFEEAAEVFFDPLALEIPDRRHSGEDRFIAIGTIDGRL-LVVVFTERGDK----IRIISARKATK 75


                 ..
gi 446360971  87 AE 88
Cdd:pfam04365 76 KE 77
 
Name Accession Description Interval E-value
COG2929 COG2929
Uncharacterized conserved protein, DUF497 family [Function unknown];
5-95 7.19e-34

Uncharacterized conserved protein, DUF497 family [Function unknown];


Pssm-ID: 442173  Cd Length: 92  Bit Score: 111.86  E-value: 7.19e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446360971  5 FEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQD-RHTNGEERWQTIGRVKGVLMLLVAHTIFDeddcEIIRIISARQ 83
Cdd:COG2929   3 FEWDEAKAAANLAKHGVSFEEAEEVFFDPPLLVVEDpRHSYGEDRFIAIGLIDGGRLLVVVFTERG----DAIRIISARK 78

                        90
                ....*....|..
gi 446360971 84 VTKAERNKYEHG 95
Cdd:COG2929  79 ANRKERKRYEQR 90
BrnT_toxin pfam04365
Ribonuclease toxin, BrnT, of type II toxin-antitoxin system; BrnT is a ribonuclease toxin of a ...
 7-88 2.11e-29

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system; BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.


Pssm-ID: 461277  Cd Length: 77  Bit Score: 99.88  E-value: 2.11e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446360971   7 WDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLmLLVAHTIFDEDdceiIRIISARQVTK 86
Cdd:pfam04365  1 WDEAKAASNLRKHGVSFEEAAEVFFDPLALEIPDRRHSGEDRFIAIGTIDGRL-LVVVFTERGDK----IRIISARKATK 75


                 ..
gi 446360971  87 AE 88
Cdd:pfam04365 76 KE 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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